369 research outputs found
New Generation Software-Only Architecture for Gaze-Contingent Eyetracking Experimentation
No full textThe author shares 10+ years of experience in eyetracking research. Most crucial technicalities are described, different programming approaches are discussed. Network Time Protocol [19] application to data stream synchronization is reviewed separately, which renders phototransistor on-screen sensors partially redundant in some of psychophysics disciplines (known as TTL hardware).</p
La prueba prohibida ante el tribunal europeo de derechos humanos: luces y sombras del caso zherdev c. Ucrania
No full textThe European Court of Human Rights, like other national and international courts, has analyzed the admissibility of evidence that has been obtained through the violation of fundamental rights. Its posture throughout the years has focused on determining whether the proceedings as a whole, including the way in which the evidence was obtained, were fair according to article 6 of the European Convention on Human Rights. In the judgment of Zherdev v. Ukraine, the Court examined different violations of fundamental rights that resulted in the production of incriminatory evidence used to convict a minor defendant. In the following pages we summarize and analyze the Court’s posture regarding unlawfully obtained evidence, according to the guidelines established in this recent case.El Tribunal Europeo de Derechos Humanos, al igual que otros tribunales nacionales e internacionales, ha analizado la eficacia procesal de las pruebas obtenidas a través de la vulneración de derechos fundamentales. Su postura a través de los años se ha decantado por el análisis de las circunstancias del proceso en su conjunto, para determinar si éste, incluyendo la forma en que se obtuvieron las pruebas, puede ser considerado equitativo conforme al artículo 6 del Convenio Europeo de Der echos Humanos. En el caso Zherdev c. Ucrania, el Tribunal examinó diversas vulneraciones de der echos fundamentales que permitieron obtener pruebas inculpatorias contra un acusado que era menor de edad. En estas páginas sintetizamos y analizamos, a la luz de este reciente caso, la doctrina del Tribunal con relación a las pruebas prohibidas
La prueba prohibida ante el tribunal europeo de derechos humanos: luces y sombras del caso Zherdev C. Ucrania.
No full textEl Tribunal Europeo de Derechos Humanos, al igual que otros tribunales nacionales e internacionales, ha analizado la eficacia procesal de las pruebas obtenidas a través de la vulneración de derechos fundamentales. Su postura a través de los años se ha decantado por el análisis de las circunstancias del proceso en su conjunto, para determinar si éste, incluyendo la forma en que se obtuvieron las pruebas, puede ser considerado equitativo conforme al artículo 6 del Convenio Europeo de Der echos Humanos. En el caso Zherdev c. Ucrania, el Tribunal examinó diversas vulneraciones de der echos fundamentales que permitieron obtener pruebas inculpatorias contra un acusado que era menor de edad. En estas páginas sintetizamos y analizamos, a la luz de este reciente caso, la doctrina del Tribunal con relación a las pruebas prohibidas.The European Court of Human Rights, like other national and international courts, has analyzed the admissibility of evidence that has been obtained through the violation of fundamental rights. Its posture throughout the years has focused on determining whether the proceedings as a whole, including the way in which the evidence was obtained, were fair according to article 6 of the European Convention on Human Rights. In the judgment of Zherdev v. Ukraine, the Court examined different violations of fundamental rights that resulted in the production of incriminatory evidence used to convict a minor defendant. In the following pages we summarize and analyze the Court’s posture regarding unlawfully obtained evidence, according to the guidelines established in this recent case
The Demidoff Church in the San Donato Estate in Florence
No full textThe article is about the decoration of the former Demidoffs’ house church in the villa of San
Donato. A part of it is now located in the church of the Nativity of Christ and St. Nicholas
the Thaumaturge in Florence (architect M. T. Preobrazhensky). The author has suggested the
probable appearance of the house church in the villa of San Donato based on notes of contemporaries,
analysis of the palace’s blueprints and the remaining elements of the decoration.
The ecclesiastical purpose of the surviving building of the “Demidoffs ex-chapel” has been
questioned and analyzed, based on D. Silvestri’s original sketches, from which it follows that
this is the building of the Odeon — a concert and theater hall. Particular attention is paid to
the carved decoration of the church, made in A. Barbetti’s workshop, to the iconostasis and
the gallery of local and small icons. Local icons of the iconostasis and icons of the apostles executed
in an academic manner by famous religious painter V. V. Vasilyev. However, the gallery
of small icons of the second tier of the iconostasis and the doors-kiots is stylistically close to
the icon-painting of the 17th century. Also, based on historical analysis and analysis of style,
the author sets up a hypothesis that the gallery of small icons from Demidoffs’ church belong
to “Nevyansk” or “Peshekhonovsk” icon-painting schools
Monitoring Antibiotics and Inflammatory Markers in Human Blood: Impact in Choice of Antibiotic Therapy and used Methods
No full textIn the modern world, the problem of antibiotic therapy is acute. Despite the diversity of existing antibiotic drugs, their efficacy decreases as new, resistant forms of pathogenic microorganisms emerge. It is extremely difficult to control such processes and even more difficult to treat severe bacterial infections. In such situations, an individual approach to each patient is required and physicians need parameters to estimate the efficacy of antibiotic therapy. This review discusses the significance of monitoring the content of antibiotics in the blood for this purpose, in combination with the content of inflammatory markers, such as C-reactive protein and procalcitonin. The basic principles of antibiotic therapy, and factors in the resistance of microorganisms to antibiotics, are examined. Approaches to assess the efficacy of antibiotic therapy, as well as methods to detect antibiotics and inflammatory markers in the blood of patients, and comparative assessment of their capabilities and limitations, are described
Network of gold conjugates for enhanced sensitive immunochromatographic assays of troponins
No full textHighly sensitive detection of cardiac troponins I and T (cTnI and cTnT) was completed by immunochromatography with double amplification, through the binding of functionalized gold nanoparticles (GNPs). The robust nature of the approach, based on the formation of nanoparticle networks through the biotin-streptavidin interaction, was confirmed; the choice of the best assay parameters for maximal increase in ICA sensitivity was demonstrated. A bifunctional conjugate of GNPs with biotinylated specific IgG and two auxiliary conjugates, GNP-biotin and GNP-streptavidin, form three-component aggregates in the analytical zone of the test strip. The inclusion of abundant gold labels in the resulting immune complex leads to an amplified colorimetric signal. The limits of detection (LoDs) of cTnI and cTnT were 0.9 and 0.4 ng mL-1, respectively, which is 3 times lower than the LoDs of more commonly used systems. Visual LoDs were 10-fold lower in concentration. The enhancement has been realized both in single and double assay formats; analysis of cTnI and cTnT presented the same characteristics. This journal i
Addendum: Urusov, A.E.; Zherdev, A.V.; Petrakova, A.V.; Sadykhov, E.G.; Koroleva, O.V.; Dzantiev, B.B. Rapid Multiple Immunoenzyme Assay of Mycotoxins. Toxins, 2015, 7, 238-254.
No full textThe authors would like to replace the Acknowledgements section with the following: [...
CLINICAL CASE OF RARE TYPE V OSTEOGENESIS IMPERFECTA
No full textOsteogenesis imperfecta, also known as the brittle bone disease, is a clinically heterogenic hereditary connective tissue disease characterized by brittle bones and high risk of skeletal bone fractures. Other observable symptoms, such as deformities of limb and spinal bones, blue sclerae, dentinogenesis imperfecta and progressive hearing loss vary in severity depending on the type of the disease. According to the original classification by D.O. Silence (1979), there are 4 types of osteogenesis imperfecta; however, the number thereof has multiplied due to discovery of new disease-inducing mutations. Type V osteogenesis imperfecta is distinguished by characteristic clinical radiographic symptoms; also, patients with this type of the disease do not feature a type I collagen gene mutation. Nevertheless, all types of osteogenesis imperfecta, including type V, are characterized by high bone brittleness, frequent fractures and further bone deformities, which is the most common cause of incapacitation of the patients
Value range of solutions to the chordal Loewner equation with restriction on the driving function
No full textWe consider a value range {g(i,T)} of solutions to the chordal Loewner equation with the restriction |λ(t)| <= c on the driving function. We use reachable set methods and the Pontryagin maximum principle
10th anniversary of the journal «Pharmacokinetics and pharmacodynamics»
No full textПеред Вами юбилейный номер журнала «Фармакокинетика и фармакодинамика», который является логическим продолжением журнала «Клиническая фармакокинетика», вышедшего впервые в 2004 году. На первом этапе мы считали, что наиболее важное внимание необходимо уделить исследованиям клинической фармакокинетики (ФК) как для новых фармакологических веществ (на этапе I-й фазы клинических испытаний), так и для широко применяемых в медицинской практике лекарственных средств. Что касается исследований ФК в рамках I-й фазы исследований нового препарата, основной задачей является проверка и перенос данных, полученных при доклиническом изучении его ФК и биотрансформации не менее чем на двух видах экспериментальных животных
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