518 research outputs found
Mixed ligand complex equilibria and coordination tendencies of CoII, NiII, Cull and ZnII with L-glutamine/L-citrulline and uracil
No full textDepartment of Chemistry, University of Allahabad, Allahabad-211 002, Uttar Pradesh, India
United Institute of Technology, Naini, Allahabad-211 002, Uttar Pradesh, India
E-mail : [email protected]
Manuscript received online 27 October 2012, revised 16 November 2012, accepted 30 November 2012
The speciation, plausible equilibrium and solution structural study of mixed-ligand complexes of L-glutamine/ L-citrulline and uracil has been investigated by potentiometry involving CuII, ZnII , Nill and CoII metal ions. The overall stability constants of ternary complexes have been determined in biologically relevant conditions and at ionic strength of 0.1 M NaNO3. The models containing different numbers of species were refined by using the computer program SCOGS. The stability constants and complexation equilibria for the best-fit chemical models were arrived at based on statistical parameters. The trend in variation of stability constants of 1 : 1 : 1 L-Gln/L-Cit(A) : MII : uracii(B) evidenced as ACuIIB > AZnIIB > ANiIIB > ACoIIB; is attributed to the electrostatic and non-electrostatic forces
Posterior chamber phakic intraocular lenses in refractive surgery: Preoperative profile and postoperative outcomes
No full textObjective: To assess the pre operative visual, refractive and topographic profile and to analyse postoperative vision, contrast and complications of patients undergoing phakic intraocular lens implantation. Methods: This prospective study enrolled patients that underwent phakic intraocular lens implantation after refractive surgery work up. The corrected pre op and uncorrected post op distance visual acuity, pachymetry, keratometry, topography, white to white, anterior chamber depth, and specular microscopy, along with postoperative anterior chamber angles, corneal and lens status and vaulting of the phakic IOL were recorded at 1 month. Results: 59 eyes of 32 patients with myopia, simple and compound myopic astigmatism underwent posterior chamber phakic IOL. The average sphere corrected was -8.4 D and the average cylinder was -1.5 D with 45.8 +/- 2.2 being the average steep k values. The mean central corneal thickness, WTW and ACD in these patients were 511.9 +/-42,11.44 +/- 0.65 mm, 3.24 +/- 0.33 mm respectively. The average post op UCDVA was 0.1 logmar with most eyes gaining more lines than preop CDVA. The average post op phakic IOL vault wrt the natural lens was 455 micron and average IOP 13.74 +/- 2.8 mmHg. Conclusion: Posterior chamber phakic IOLs are a safe and predictable means of providing good vision especially in high myopes with borderline corneae. Accurate preoperative sizing of the lens is key to optimum results
Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic Metal ions in life sciences ;, v. 19./ Peggy L. Carver.
No full textIn English.Includes bibliographical references and index.Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.Carver, Peggy L. -- Robert, Anne / Benoit-Vical, Françoise / Liu, Yan / Meunier, Bernard -- Crisponi, Guido / Nurchi, Valeria M. / Lachowicz, Joanna I. -- Ward, Roberta J. / Crichton, Robert R. -- Nairz, Manfred / Weiss, Guenter -- Pai, Amy Barton -- Gumienna-Kontecka, Elzbieta / Carver, Peggy L. -- Crans, Debbie C. / Henry, LaRee / Cardiff, Gabriel / Posner, Barry I. -- Maret, Wolfgang -- Erikson, Keith M. / Aschner, Michael -- Bajema, Elizabeth A. / Roberts, Kaleigh F. / Meade, Thomas J. -- Lopez, Jay / Ramchandani, Divya / Vahdat, Linda -- Gambino, Dinorah / Otero Á, Lucía -- Suman, Sigridur G. / Gretarsdottir, Johanna M. -- Frontmatter -- About the Editors -- Historical Development and Perspectives of the Series Metal Ions in Life Sciences -- Preface to Volume 19. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic -- Contents -- Contributors to Volume 19 -- Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series -- Contents of Volumes in the Metal Ions in Life Sciences Series -- 1. Metals in Medicine: The Therapeutic Use of Metal Ions in the Clinic / 2. Small Molecules: The Past or the Future in Drug Innovation? / 3. Iron Chelation for Iron Overload in Thalassemia / 4. Ironing out the Brain / 5. Infections Associated with Iron Administration / 6. Iron Oxide Nanoparticle Formulations for Supplementation / 7.Building a Trojan Horse: Siderophore-Drug Conjugates for the Treatment of Infectious Diseases / 8. Developing Vanadium as an Antidiabetic or Anticancer Drug: A Clinical and Historical Perspective / 9. Chromium Supplementation in Human Health, Metabolic Syndrome, and Diabetes / 10. Manganese: Its Role in Disease and Health / 11. Cobalt-Schiff Base Complexes: Preclinical Research and Potential Therapeutic Uses / 12. Copper Depletion as a Therapeutic Strategy in Cancer / 13. Metal Compounds in the Development of Antiparasitic Agents: Rational Design from Basic Chemistry to the Clinic / 14. Chemical and Clinical Aspects of Metal-Containing Antidotes for Poisoning by Cyanide / Subject Index1 online resource (455 p.)
In vitro somatic embryogenesis of high yielding varieties of rice (Oryza sativa L.)
No full textRice (Oryza sativa L.) belongs to the family Gramineae and is the staple food for half of the world’s population and occupies almost one-fifth of the total land area covered under cereals. Now-a-days, the production of rice is hampered due to climatic changes. Therefore, it is essential to develop variety which is tolerant to abiotic and biotic stresses. The present investigation was conducted to establish an efficient and simple protocol for regeneration of four agronomically important indica rice varieties (Khandagiri, Udayagiri, Swarna and Pratikhya). Somatic embryogenesis were achieved from immature zygotic embryos on Murashige and Skoog (MS) medium supplemented with 3 mg/l 2,4-D (2,4-dichlorophenoxyacetic acid), 1.0 mg/l kinetin and 3% (w/v) sucrose within 4 weeks of culture. The secondary somatic embryogenesis was also achieved in subsequent subculture on MS medium supplemented with 2 mg/l 2,4-D and 2.0 mg/l kinetin and 200 mg/l L-proline. The percentage of embryogenic calli proliferation were 82.4, 83.7, 88.4 and 84.4 in variety Khandagiri, Udayagiri, Swarna and Pratikhya respectively on MS basal medium supplemented with 3.0 mg/l 2,4-D, 2.0 mg/l Kinetin and 200 mg/l L-proline. Inclusion of higher concentration of L-proline (400 mg/l) in the induction medium, the growth of calli was reduced. The maximum percentage of somatic embryo germination took place in medium supplemented with 2.0 mg/l kinetin, 0.25 mg/l NAA and 50 mg/l adenine sulfate within 4 weeks of culture. The regenerated plantlets were transferred to pots for acclimatization. About 80% of plants were survived in the greenhouse condition.Keywords: Somatic embryogenesis, immature zygotic embryos, Indica rice, plant regenerationAfrican Journal of Biotechnology Vol. 12(42), pp. 6113-611
Efficacy of Newer Insecticides against the Major Sucking Pests of Groundnut (Arachis hypogea L.)
No full textThe field experiments on the efficacy of newer insecticides on sucking insect pests of groundnut was conducted at Regional Agricultural Research Station, Palem, of Nagarkurnool district, Telangana, India during rabi, 2021-22 in a randomized block design with eight treatments viz., Tolfenpyard 15% EC at 1.5ml L-1 and Tolfenpyard 15% EC at 2 ml L-1, Tolfenpyard 15% EC at 2.5ml L-1, Spinetoram 11.7% SC at 0.5ml L-1, Thiamethoxam 12.6+ Lambdacyhalothrin 9.5% ZC at 0.4ml L-1, Clothianidin 50% WDG at 0.3g L-1, Afidopyropen 50g/IDC at 2ml L-1 and Sulfoxaflor 21.89% SC at 0.5ml L-1. Among all the insecticides tested clothianidin @ 0.3g L-1 worked very effectively in reducing the population of leafhoppers and thrips. The other effective treatments were afidopyropen at 2ml L-1 and tolfenpyard @ 2.5ml L-1 followed by tolfenpyard 15 %EC at 2.5ml L-1, tolfenpyard at 2.5ml L-1, thiamethoxam+ lambdacyhalothrin at 0.4ml L-1. The treatment spinetoram at 0.5ml L-1 was less effective on the sucking pest. The highest Incremental Cost Benefit Ratio (ICBR) is recorded from the plots sprayed with clothianidin @ 0.3g L-1 (1.4.83) followed by afidopyrofen @ 2ml L-1 (1:3.94)
HRM Practices in Insurance Companies: A Study of Indian and Multinational Companies
No full textCompetitive advantage of a company can be generated from human resources (HR) and company performance is influenced by a set of effective HRM practices. In this study, we intended to assess the HR practices in insurance companies. Primary data based on 218 respondents from four insurance companies (two multinational-7 branches and two Indian-7 branches) were analyzed to assess HR practices being practiced by insurance companies in India. Six factors from factor analysis were further analyzed. ‘Training and benefits’ was found highly in practice in the insurance companies. Further, ‘performance appraisal,’ ‘selection and socialization of employees,’ and ‘HR planning and recruitment’ were moderately practised in insurance companies. ‘Workforce diversity and contemporary HR practices’ and ‘competitive compensation’ were also practised to some extent. ANOVA results showed that Indian companies did not practise workforce diversity. Compensation practices were found more competitive or performance based in Multinational insurance companies than in Indian ones. The gender effect showed that only competitive compensation was perceived significantly differently by male and female employees/executives. Interactive effects were significant on workforce diversity and contemporary issues, training and benefits, and selection and socialization of employees.competitive compensation, multinational companies, performance appraisal, selection and socialization, training and benefits, workforce diversity
Investigations of Jet Quenching in 5.02 TeV Peripheral Pb+Pb Collisions with ATLAS
No full text
The quark-gluon plasma (QGP) is an exotic state of matter consisting of deconfined quarks and gluons. It is theorized that all matter in the universe would have existed in this state for a few millionths of a second just after the Big Bang. Now, QGP is produced in collisions of heavy ions, such as lead (Pb+Pb) and gold (Au+Au), at relativistic energies at CERN’s Large Hadron Collider and BNL’s Relativistic Heavy Ion Collider. The QGP droplets formed in these collisions are too small and too short-lived (lasting for approximately 10−23 seconds) to probe externally. We, therefore, search for signatures of QGP production and properties in the particles captured by detectors. One of these signatures, known as jet quenching, compares the energy loss of high-momentum partons in heavy ion collisions to that in small collision systems, such as proton-proton or deuteron-gold (d+Au), in which no QGP formation is expected. This work addresses the open question of where jet quenching, and thus QGP formation, begins in the spectrum of small to heavy ion collision systems. We present first results derived from new methods of calculating energy loss in peripheral 5.02 TeV Pb+Pb collision data collected by the ATLAS Collaboration, with additional investigations into the validity of these measurements using the ATLAS Zero-Degree Calorimeters.
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Retroperitoneal vs transperitoneal approach for nonruptured open conversion after endovascular aneurysm repair
No full textObjective: Several studies comparing the transperitoneal (TP) and retroperitoneal (RP) approach for abdominal aortic aneurysm (AAA) repair suggest that the RP approach may result in lower rates of perioperative mortality and morbidity. However, data comparing these approaches for open conversion are lacking. This study aims to evaluate the association between the type of approach and outcomes following open conversion after endovascular aneurysm repair (EVAR). Methods: We included all patients who underwent open conversion after EVAR between 2010 and 2022 in the Vascular Quality Initiative. Patients presenting with rupture were excluded. The primary outcome was perioperative mortality. The secondary outcomes included perioperative complications and 5-year mortality. Inverse probability weighting was used to adjust for factors with statistical or clinical significance. Logistic regression was used to assess perioperative mortality and complications in the weighted cohort. The 5-year mortality was evaluated using Kaplan-Meier and Cox regression. Results: We identified 660 patients (39% RP) who underwent open conversion after EVAR. Compared with TP, RP patients were older (75 years [interquartile range, 70-79 years] vs 73.5 years [interquartile range, 68-79 years]; P < .001), and more frequently had prior myocardial infarction (33% vs 22%; P = .002). Compared with the TP approach, the RP approach was used less frequently in cases of associated iliac aneurysm (19% vs 27%; P = .026), but more frequently with associated renal bypass (7.8% vs 1.7%; P < .001) and by high-volume physicians (highest quintile, >7 AAA annually: 41% vs 17%; P < .001) and in high-volume centers (highest quintile, >35 AAA annually: 36% vs 20%; P < .001). RP patients, compared with TP patients, were less likely to have external iliac or femoral distal anastomosis (8.2% vs 21%; P < .001), and an infrarenal clamp (25% vs 36%; P < .001). Unadjusted perioperative mortality was not significantly different between approaches (RP vs TP: 3.8% vs 7.5%; P = .077). After risk adjustment, RP patients had similar odds of perioperative mortality (adjusted odds ratio [aOR], 0.49; 95% confidence interval [CI], 0.22-1.10; P = .082), and lower odds of intestinal ischemia (aOR, 0.26; 95% CI, 0.08-0.86; P = .028) and in-hospital reintervention (aOR, 0.43; 95% CI, 0.22-0.85; P = .015). No significant differences were found in the other perioperative complications or 5-year mortality (aHR, 0.79; 95% CI, 0.47-1.32; P = .37). Conclusions: Our findings suggest that the RP approach may be associated with a lower adjusted odds of perioperative complications compared with the TP approach. The RP approach should be considered for open conversion after EVAR when feasible.</p
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