1,249 research outputs found
A construção da coerência em cenários pedagógicos on-line: uma metodologia para apoiar a transformação de cursos presenciais que migram para a modalidade de educação a distância
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção.A presente pesquisa enquadra-se em um cenário atual de transição, do qual fazem parte diversas universidades que passam a oferecer cursos a distância, utilizando-se das inúmeras vantagens que as novas tecnologias de informação e comunicação proporcionam para este fim. Particularmente, focou-se a discussão em torno do processo de redesign de disciplinas que migram do ensino presencial para a modalidade on-line de educação a distância, entendendo que esse processo implica considerar um conjunto complexo de fatores, sobretudo em se tratando de reutilizar materiais pedagógicos, adaptando-os e transformando-os para a nova modalidade. O termo Reengenharia Pedagógica (RP) foi utilizado para definir esse processo de transformação. A carência de metodologias que orientem a transição entre modalidades de ensino motivou este trabalho de tese. Propõe uma metodologia que apóie o design de cursos a distância, focando o alcance da coerência na construção de cenários pedagógicos. Por coerência entende-se a adequada combinação entre parâmetros de RP durante a composição de um cenário de ensino e aprendizagem a distância. Apoiando-se em abordagens ergonômicas empíricas, três pesquisas qualitativas foram realizadas. Na primeira foram identificados, a partir da análise de situações de ensino presencial, quais elementos e estratégias pedagógicas devem ser modificados (ajustados, suprimidos ou alterados) para transformar uma disciplina para a modalidade on-line. Na segunda pesquisa procurou-se compreender quais são as etapas e as estratégias utilizadas por professores em um processo de RP, observando como eles procedem para realizar a tarefa quando esta é feita sem o apoio de ajudas conceituais. Na terceira pesquisa foi verificado como os professores procedem diante da possibilidade de conduzir o processo examinando um conjunto de dez parâmetros que auxiliam a composição da coerência dos cenários pedagógicos. Estes estudos concluem propondo uma metodologia para RP de cursos a distância, na modalidade on-line
How are teachers being attacked online? On cyberbullying and cyberaggression that targets school educators from the student’s perspective
No full textThe twin phenomena of cyberbullying and cyberaggression are among the most common e-threats. Today, much is known about the aggression and violence mediated by new media and targeted at students. However, there is still an empirical gap in the consideration of the mechanisms and forms of cyberaggression and cyberbullying targeting teachers. The aim of this study is to present 10 types of cyber-attacks that teachers have been subjected to in Poland in the last few years. The types of attacks presented include vilification in the information space (forums and social networking sites), direct attack using social networks, recording teachers without their consent, online blackmail, creation and dissemination of memes, photomontage, latent cyberbullying, destructive actions in the COVID-19 period, the creation of fake profiles, and the use of a digital tool in an offline environment. The subject of the study was the statements of post-secondary school graduates who had encountered such phenomena. The article highlights the need to increase digital safety for teachers
State v. Gamez
No full textDocket Number: 84-0857For access to these documents, please log in or contact the reference staff by emailing [email protected] or by calling 402-280-5541 for help locating the desired item.Appellant brief is cut off
State v. Gamez-Lira
No full textDocket Number: 01-0805264 Neb. 96645 N.W.2d 562For access to these documents, please log in or contact the reference staff by emailing [email protected] or by calling 402-280-5541 for help locating the desired item
Case Report: Refractory Autoimmune Gastritis Responsive to Abatacept in LRBA Deficiency
No full textPrimary immunodeficiency (PID) with immune dysregulation may present with early onset gastrointestinal autoimmune disorders. When gastrointestinal autoimmunity is associated with multiple extraintestinal immune system dysfunction the diagnosis of PID is straightforward. However, with the advent of next generation sequencing technologies, genetic defects in PID genes have been increasingly recognized even when a single or no extraintestinal signs of immune dysregulation are present. A genetic diagnosis is especially important considering the expanding armamentarium of therapies designed to inhibit specific molecular pathways. We describe a boy with early-onset severe, refractory autoimmune gastritis and biallelic mutations in the LRBA gene causing a premature STOP-codon who was successfully treated with CTLA4-Ig, abatacept, with long term clinical and endoscopic remission. The case underscores the importance to consider a monogenetic defect in early onset autoimmune disorders, since the availability of targeted treatments may significantly improve patient prognosis
Isolation and identification of metallotolerant bacteria with a potential biotechnological application
No full text: Mining has led to severe environmental pollution in countries with exhaustive mining production and inadequate industrial waste regulation. Microorganisms in contaminated sites, like mine tailings, have adapted to high concentrations of heavy metals, developing the capacity of reducing or removing them from these environments. Therefore, it is essential to thoroughly characterize bacteria present in these sites to find different ways of bioremediation. In this regard, in this study, an enrichment and isolation procedure were performed to isolate bacteria with lower nutritional requirements and high tolerance to Cu(II) and Fe(II) from two Sonoran River basin mining tails. Two Staphylococcus species and a Microbacterium ginsengisoli strain were isolated and identified from the San Felipe de Jesús mining tail. Also, three strains were isolated from the Nacozari de García mining tail: Burkholderia cenocepacia, Sphingomonas sp. and Staphylococcus warneri. Significant microbiological differences were found between the two sites. All these species exhibited tolerance up to 300 mg/L for Cu (II)-Fe (II) solutions, indicating their capacity to grow in these conditions. Moreover, a consortium of isolated bacteria was immobilized in two different biocomposites and the biocomposite with larger pore size achieved greater bacterial immobilization showcasing the potential of these bacteria in biotechnological applications
DNA-binding and in vitro cytotoxic activity of platinum(II) complexes of curcumin and caffeine
No full textThree Pt(II) complexes containing the natural ligands curcumin and caffeine, namely [Pt(curc)(PPh3)(2)]Cl (1), [PtCl(curc)(DMSO)] (2) (curt = deprotonated curcumin) and trans-[Pt(caffeine)Cl-2(DMSO)] (3), were synthesized and fully characterized. The data obtained suggest that, for both 1 and 2, the anion of curcumin is coordinated to the platinum ion via the oxygen atoms of the beta-diketonate moiety. Spectroscopic features reveal that in 2 and 3, a DMSO molecule is S-bonded to the metal centre. For 3, all data indicate a square-planar geometry formed by a 9-N bonded caffeine, two trans chloride anions and a DMSO. The three complexes undergo changes in solution upon incubation for 24 h; 1 and 2 release curcumin while 3 isomerizes from trans to cis configuration. The DNA-binding and cytotoxic properties of 1-3 were evaluated in vitro. Despite their structural similarity, curcuminate-containing 1 and 2 exhibit distinct DNA interactions. While 1 appears to intercalate between nucleobase pairs, inducing the oxidative degradation of the biomolecule, 2 behaves as a groove binder, by means of electrostatic forces. Caffeine-containing 3 exhibits a behaviour that is comparable to that of 2. Complexes 1 and 2 showed moderate to high cytotoxicity and selectivity against several cancer cell lines, while 3 is inactive. Compounds 1 and 2 can be further activated by visible-light irradiation
Controllability of solar-sail orbits in the Earth-Moon system
No full textThe propellantless nature of solar-sail propulsion allows researchers to design completely new sets of orbits unreachable or not-maintainable by means of conventional propulsion. The advantage of this somewhat new type of low-thrust propulsion system becomes more evident for long-duration missions where chemical or electrical rocket engines would run out of onboard reaction mass. Solar sails happen to be particularly well-suited for polar observation missions. One can find several works concerning solar-sail orbits to establish a permanent communication link between a settlement on the lunar South Pole and the Earth. In addition, the literature also encourages the usage of solar sails to monitor the melting of the polar ice caps. However, these solutions employ either complicated steering laws or more than one sailcraft. In addition, little is known about how to perform necessary station-keeping maneuvers to keep the sailcraft bounded to the reference orbits under the effect of dynamic perturbations.This thesis focuses on the orbit control of three types of solar-sail periodic orbits within the Earth-Moon system that have been shown potential for polar observation of either body. One of these orbit types, coined the distant-circular family, is newly introduced in this thesis together with transfersbetween orbits within the family; its remote orbits can achieve continuous coverage of both the Earth's North Pole and the lunar South Pole with just a single sailcraft. Developed mainly under the simplified, but non-autonomous, dynamics of the solar-sail circular restricted three-body problem, the studied orbits are all unstable and require an active control strategy for station-keeping. By slowly migrating the dynamics to a higher fidelity model, we introduce several disturbances, namely those associated with the eccentricity of the Moon's orbit, the plane offset between the ecliptic and the Earth-Moon orbital plane, the Sun's gravity, and the heliocentric eccentricity of the system's barycenter. Two solar-sail architectures, a fixed-shape and heliogyro sails, are compared with respect to the objective of tracking the ideal reference orbits that all use a simple Sun-sail steering law as reference control. To do so, we develop a methodology based on multiple shooting differential correction, weighted least squares, particle swarm optimization (quantitative analysis) and acceleration bubble visualisation (qualitative analysis). We find that the effect of the eccentricity of the Moon's orbit is too large to be considered a perturbation and should be included in the design of the reference orbits. Then, we show that other perturbations can be completely counteracted by the heliogyro, which suggests that pure solar-sail quasi-periodic orbits are maintainable.Aerospace Engineerin
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