20 research outputs found
28-Homocastasterone: A Novel Plant Ketosteroid Enhances Tissue Transaminase Catalytic Activity and Gene Expression in Normal and Diabetic Male albino wistar Rat
No full text28-Homocastasterone (28-HC) is a brassinosteroid family phytohormone. Humans were exposed through diet and herbal based folk medicine, although its mammalian cellular influence unknown. Present study investigated 28-HC cellular metabolic enzyme inductivity on tissues in normal and diabetic rats. Induction of diabetes was achieved by single peritoneal injection of STZ (60mg/kg.bwt) followed by 28-HC were feed orally 15 days, daily. At end of 15th day tissues was removed followed by enzyme activity and mRNA expression of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) was analysed. 28-HC treated rat tissues ALT, AST, GGT and ALP catalytic activity and mRNA expression increased significantly (P<0.05). Dietary plant ketosteroid 28-HC augmented transaminase and phosphatase activity in tissues resulted to cellular transamination and phosphorylation status affected by this plant steroid in rat. It is suggested that 28-HC supplemented diets may be suitable for higher energy related work activities in man and animal
Bioconversion efficiency and growth in the white shrimp Penaeus indicus (Milne Edwards), fed with decomposed mangrove leaves
Get PDFFood conversion efficiency and growth in the white shrimp Penaeus indicus fed with decomposed mangrove leaves of Avicennia marina and A. officinalis were monitored under laboratory conditions. It was observed that test animals fed with the decomposed leaves of A. marina had higher assimilation efficiency (87.96%), gross growth efficiency (10.82%), net growth efficiency (12.3%) and relative growth rate (0.0603 g/day) than those fed with A. officinalis. The relatively higher growth registered in the animals fed with decomposed leaves of A. marina was attributed to its high calorific and protein content
Bioconversion efficiency and growth in the white shrimp Penaeus indicus (Milne Edwards), fed with decomposed mangrove leaves
No full textFood conversion efficiency and growth in the white shrimp Penaeus indicus fed with decomposed mangrove leaves of Avicennia marina and A. officinalis were monitored under laboratory conditions. It was observed that test animals fed with the decomposed leaves of A. marina had higher assimilation efficiency (87.96%), gross growth efficiency (10.82%), net growth efficiency (12.3%) and relative growth rate (0.0603 g/day) than those fed with A. officinalis. The relatively higher growth registered in the animals fed with decomposed leaves of A. marina was attributed to its high calorific and protein content
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HOMOCASTASTERONE: A NOVEL PLANT KETOSTEROID INDUCING HAEMATOLOGICAL CHANGES IN NORMAL AND DIABETIC MALE RAT
Get PDFObjective: To study the effect of brassinosteroid keto isoform homocastasterone, in diabetic male wistar rat as an antihyperglycemic factor and to evaluate its effects on the hemodynamic parameters in rat blood.Methods: Diabetes was induced in a group (n=6) of rats with a single peritoneal injection of streptozotocin at 60 mg/kg. bw. With a treatment schedule of 15 consecutive days, control (n=6) and diabetic rats received 666µg/kg bw, of homocastasterone. Circulating blood glucose, cell count, cell indices, and MDA level was assessed.Results: Significant reduction (p<0.05) in blood glucose level and increase inRBCs, WBCs, granulocytes, lymphocytes, monocytes and platelets count(p<0.05) along with improved functional indices for HCT, PCV, MCV, MCH, MCHC, MPV, PDW, PCT in homocastasterone treated diabetic group was noted. A significant reduction in RBC-MDA level (p<0.001) in the treated group was noted.Conclusion: It is suggested that brassinosteroid keto isoform homocastasterone exhibits antiglycemic effect in diabetic rat, and improves RBC, WBC, Platelet counts, haemoglobin level, and cell indices, while reducing peroxidative cell damage in RBCs.Â
Women Empowerment Status in India: Mathematical Modelling and Optimal Control Approach
No full textWomen’s empowerment is essential for the advancement of all women, yet the journey towards achieving it is often hindered by various challenges, such as violence, financial constraints, and cultural beliefs. In some cases, women, influenced by cultural beliefs, may unintentionally impede the progress of other women. Additionally, due to a lack of education, superstitious beliefs can lead to unethical practices within society. Among these, dowry remains a particularly significant issue for women in South Asia. Although dowry, the transfer of cash, jewellery, and other valuable assets from the bride’s family to the groom’s, is officially prohibited in India and Bangladesh and restricted in Pakistan, the practice continues to be prevalent across the region. In rural areas of India, the dowry system frequently discourages parents from supporting their daughters’ pursuit of higher education, thereby presenting a notable barrier to women’s progress and empowerment. In light of this, we propose a deterministic model to address women-related issues, dividing the population into four subclasses: common women, women facing hurdles, stressed women, and empowered women. The model identifies two equilibrium points: the hurdle-free equilibrium point and the non-trivial equilibrium point. We calculate a basic reproduction number and perform sensitivity analysis on key parameters. The local and global stability of these equilibrium points is assessed using the Routh-Hurwitz criteria and Lyapunov’s function. Additionally, we extend this deterministic model to an optimal control problem, determining the optimal control profile to achieve maximum impact within a specified time frame. To validate our model, we conducted a numerical simulation using dowry-related death data from NCRB (National Crime Records Bureau of India) publications for the years 2001-2022. This data is then fitted to our model to forecast dowry-related deaths in the coming years. © The Author(s), under exclusive licence to Springer Nature B.V. 2024.Science Citation Index Expande
Down Regulation of Plasma and Tissue Biomarkers by Homocastasterone
Get PDFHomocastasterone is a ketosteroid and a member of the brassinosteroid family of plant hormones. Earlier studies with 28-homobrasslinolide, an aldosteroid, had indicated that rat blood and tissue biochemical parameters studied were affected by this compound, resulting in altered homeostasis and cellular phosphorylation status, rendering this plant oxysterol inappropriate for high energy related work activities. The use of the ketosteroid in this study presents evidence for renormalization of elevated plasma lipid content in diabetic rat, antiglycemic potency, increase in liver glycogen and glucose level and diminished ALT and AST enzyme activities. A role for this ketosteroid in rat liver gluconeogenesis and in lipid homeostasis is suggested while the aldo and keto forms regulated glucose homeostasis in the rat. The observed differences in the effects of homobrasslinolide and homocastasterone as exogenous oxysterols on normal and diabetic rat plasma lipid level suggests the possibility of differential influence by endogenous aldo and keto oxycholesterol forms on glucose and lipid homeostasis in mammalian physiology
Down Regulation of Plasma and Tissue Biomarkers by Homocastasterone
Get PDFHomocastasterone is a ketosteroid and a member of the brassinosteroid family of plant hormones. Earlier studies with 28-homobrasslinolide, an aldosteroid, had indicated that rat blood and tissue biochemical parameters studied were affected by this compound, resulting in altered homeostasis and cellular phosphorylation status, rendering this plant oxysterol inappropriate for high energy related work activities. The use of the ketosteroid in this study presents evidence for renormalization of elevated plasma lipid content in diabetic rat, antiglycemic potency, increase in liver glycogen and glucose level and diminished ALT and AST enzyme activities. A role for this ketosteroid in rat liver gluconeogenesis and in lipid homeostasis is suggested while the aldo and keto forms regulated glucose homeostasis in the rat. The observed differences in the effects of homobrasslinolide and homocastasterone as exogenous oxysterols on normal and diabetic rat plasma lipid level suggests the possibility of differential influence by endogenous aldo and keto oxycholesterol forms on glucose and lipid homeostasis in mammalian physiology
