512 research outputs found
Recall this Book 56: Merve Emre on Natalia Ginzburg's "The Dry Heart"
No full textLike our podcast, B-Side Books focuses on those moments when books topple off their shelves, open up, and start bellowing at you. The one that buttonholed Merve Emre (Oxford literature professor and author most recently of The Personality Brokers) was a novella by the luminous midcentury Italian pessimist, Natalia Ginzburg. And if you think you know precisely why a mid-century Italian writer would have a dark and bitter view of the world (already thinking of the Nazi shadows in work by Italo Calvino, Primo Levi and Giorgio Bassani) Ginzburg's The Dry Heart will have you thinking again. Merve started her piece by asking that age-old question: "When should a woman kill her husband?
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Full text linkDetecting pathogens and mounting immune responses upon infection is crucial for animal health. However, these responses come at a high metabolic price (McKean and Lazzaro, 2011, Kominsky et al., 2010), and avoiding pathogens before infection may be advantageous. The bacterial endotoxins lipopolysaccharides (LPS) are important immune system infection cues (Abbas et al., 2014), but it remains unknown whether animals possess sensory mechanisms to detect them prior to infection. Here we show that Drosophila melanogaster display strong aversive responses to LPS and that gustatory neurons expressing Gr66a bitter receptors mediate avoidance of LPS in feeding and egg laying assays. We found the expression of the chemosensory cation channel dTRPA1 in these cells to be necessary and sufficient for LPS avoidance. Furthermore, LPS stimulates Drosophila neurons in a TRPA1-dependent manner and activates exogenous dTRPA1 channels in human cells. Our findings demonstrate that flies detect bacterial endotoxins via a gustatory pathway through TRPA1 activation as conserved molecular mechanism.sponsorship: Vlaams Instituut voor Biotechnologie Alessia Soldano Luis Franco Guangda Liu Natalia Mora Emre Yaksi Bassem A Hassanr Fonds Wetenschappelijk Onderzoek G.0702.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0077.15 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0680.10 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0681.10 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0503.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0654.15 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0761.10N Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0596.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0565.07 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar KU Leuven GOA/14/011 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar European Commission IUAP P7/13 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekensr KU Leuven OT/12/091 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar KU Leuven PF-TRPLe Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talavera (Vlaams Instituut voor Biotechnologie, Fonds Wetenschappelijk Onderzoek|G.0702.12, Fonds Wetenschappelijk Onderzoek|G.0077.15, Fonds Wetenschappelijk Onderzoek|G.0680.10, Fonds Wetenschappelijk Onderzoek|G.0681.10, Fonds Wetenschappelijk Onderzoek|G.0503.12, Fonds Wetenschappelijk Onderzoek|G.0654.15, Fonds Wetenschappelijk Onderzoek|G.0761.10N, Fonds Wetenschappelijk Onderzoek|G.0596.12, KU Leuven|GOA/14/011, KU Leuven|OT/12/091, European Commission|IUAP P7/13, KU Leuven PF-TRPLe)status: Publishe
Metabolomic Assessment of Embryo Viability
No full textUyar, Asli/0000-0002-7913-1083Preimplantation embryo metabolism demonstrates distinctive characteristics associated with the developmental potential of embryos. On this basis, metabolite content of culture media was hypothesized to reflect the implantation potential of individual embryos. This hypothesis was tested in consecutive studies reporting a significant association between culture media metabolites and embryo development or clinical pregnancy. The need for a noninvasive, reliable, and rapid embryo assessment strategy promoted metabolomics studies in vitro fertilization (IVF) in an effort to increase success rates of single embryo transfers. With the advance of analytical techniques and bioinformatics, commercial instruments were developed to predict embryo viability using spectroscopic analysis of surplus culture media. However, despite the initial promising results from proof-of-principal studies, recent randomized controlled trials using commercial instruments failed to show a consistent benefit in improving pregnancy rates when metabolomics is used as an adjunct to morphology. At present, the application of metabolomics technology in clinical IVF laboratory requires the elimination of factors underlying inconsistent findings, when possible, and development of reliable predictive models accounting for all possible sources of bias throughout the embryo selection process.National Institutes of Health (NIH) [R01HD059909]E.S. is supported by award no. R01HD059909 from the National Institutes of Health (NIH)
Approach for siting a support facility for transporting supplies in emergency cases in the Republic of Bulgaria
Full text linkIn this paper, the author determines the most suitable transportation location for intervention in a large scale disaster in the Republic of Bulgaria, by means of the Weber Problem and the Weiszfeld method. The objective is to minimise the cost of transporting emergency supplies across the country by locating a support facility, and thus reaching the area of event at the lowest possible cost. A brief description of the Weiszfeld method is provided in the paper. Further, using recent population data of both provinces and municipalities, the method is applied respectively to obtain the results. They were compared in terms of spatial correspondence and the final facility location was fixed. Erecting the supply site is recommended to help decrease the losses
The impact of assisted reproductive technologies on genomic imprinting and imprinting disorders
No full textUyar, Asli/0000-0002-7913-1083Purpose of reviewGenomic imprinting refers to preferential allele-specific gene expression. DNA methylation-based molecular mechanisms regulate establishment and maintenance of parental imprints during early embryo development and gametogenesis. Because of the coincident timing, a potential association between assisted reproductive technology (ART) procedures and imprinting defects has been investigated in various studies. In this review, we provide an overview of genomic imprinting and present a summary of the relevant clinical data.Recent findingsART procedures affect DNA methylation pattern, parental imprinting status, and imprinted gene expression in the mouse embryo. In humans, several case series suggested an association between ART and imprinting disorders, with a three-fold to six-fold higher prevalence of ART use among children born with Beckwith-Wiedemann syndrome compared to the general population. However, more recent studies failed to support these findings and could not demonstrate an association between imprinting disorders and ARTs, independent of subfertility.SummaryART procedures may affect methylation status of imprinted regions in the DNA, leading to imprinting disorders. Although the low prevalence of imprinting disorders makes it challenging to perform conclusive clinical trials, further studies in large registries are required to determine the real impact of ARTs on their occurrence.National Institutes of Health (NIH) [R01HD059909]E.S. is supported by award no. R01HD059909 from the National Institutes of Health (NIH)
Comparing clusterings and numbers of clusters by aggregation of calibrated clustering validity indexes
No full textAkhanli, Serhat Emre/0000-0001-7173-3277WOS: 000543319300001A key issue in cluster analysis is the choice of an appropriate clustering method and the determination of the best number of clusters. Different clusterings are optimal on the same data set according to different criteria, and the choice of such criteria depends on the context and aim of clustering. Therefore, researchers need to consider what data analytic characteristics the clusters they are aiming at are supposed to have, among others within-cluster homogeneity, between-clusters separation, and stability. Here, a set of internal clustering validity indexes measuring different aspects of clustering quality is proposed, including some indexes from the literature. Users can choose the indexes that are relevant in the application at hand. In order to measure the overall quality of a clustering (for comparing clusterings from different methods and/or different numbers of clusters), the index values are calibrated for aggregation. Calibration is relative to a set of random clusterings on the same data. Two specific aggregated indexes are proposed and compared with existing indexes on simulated and real data.EPSRCEngineering & Physical Sciences Research Council (EPSRC) [EP/K033972/1]The work of the second author was supported by EPSRC grant EP/K033972/1
Nezihe Araz'ın Dertli Dolap ve Jacques Lacarrıere'in Dünyanın Tozu romanlarında kahramanın yolculuğu: "Yunus Emre"
No full textYunus Emre, Türk toplumu için derin bir bilgelik kaynağıdır. Onun, toplumu yüksek değerlere ulaştırmak için, yüzyıllar öncesinden yaktığı aydınlanma ışığı, bugün hâlâ dünyayı aydınlatmaya devam etmektedir. Jacques Lacarrière'in (1925-2005) Dünya'nın Tozu (1999) (La Poussière du Monde) (1997) romanında kahraman "Yunus Emre"'dir. Bir Fransız yazar olan Lacarrière "Yunus Emre"'yle ilgili menkıbeleri öğrendikten sonra "Yunus Emre"'yi kahraman yaptığı bir roman kurgular. Bu romanda yazarın sadece duydukları üzerinden bir kurgu oluşturmadığını görürüz. Yazar aynı zamanda "Yunus Emre"'yi kendi kültür çerçevesinden anlamaya da çalışan sorular sorar. Diğer yandan çocukluğundan beri duyduğu "Yunus Emre" dizeleri ve menkıbelerinin etkisinde olan Türk yazar Nezihe Araz, (1920-2009) Dertli Dolap (1961) romanını çocukluğundan bugüne kalbinde yetiştirdiği bir kahraman olan "Yunus Emre"'nin yaşamı üzerine kurgular. "Yunus Emre"'nin tekâmül yolculuğunu onun dizeleri üzerinden ilerleyen bir kurguyla aktarır. Bu iki romanı ortak noktada buluşturan kahraman "Yunus Emre", insanın kendi özüne yaptığı yolculuğun en önemli temsilcilerinden birisidir. Öze yolculuk, Carl Gustav Jung'a (1875-1961) göre, arketipler aracılığıyla aktarılan bireyleşmenin başka bir ifade biçimidir. Jung'un bu görüşünden yola çıkan Joseph Campbell, yolculuğu ve bireyleşmeyi kahramanın geçirdiği yolculuk aşamaları bağlamında anlamayı ve açıklamayı önerir ve bu süreci "kahramanın sonsuz yolculuğu " olarak adlandırır. Çalışmamızda, Joseph Campbell'in bu modeli çerçevesinde, farklı iki kültüre ait iki yazarın romanlarında ortak kahraman olan "Yunus Emre"nin, kahramanın yolculuğuna ne ölçüde uyum sağladığının ve iki yazardaki "Yunus Emre" algısının farklılığının tespit edilmesi amaçlanmıştır."Yunus Emre" is a deep source of wisdom for Turkish society. The light of enlightenment that he lit centuries ago in order to bring the society to high values still continues to illuminate the world today. In Jacques Lacarrière's novel La Poussière du Monde, the hero is "Yunus Emre. After learning the legends about Yunus Emre, Lacarrière, a French writer, constructs a novel in which he makes Yunus Emre a hero. In this novel, we see that the author does not create a fiction based on only what he hears. The author also asks questions that try to understand Yunus Emre from his own cultural framework. On the other hand, Turkish writer Nezihe Araz, who has been influenced by Yunus Emre verses and legends that she has heard since her childhood, constructs her novel Dertli Dolap on the life of Yunus Emre, a hero whom he raised in her heart from her childhood. She conveys Yunus Emre's journey of evolution with a fiction that proceeds through his verses. Yunus Emre is the hero who brings together these two novels at a common point and he is also one of the most important representatives of the journey which a person makes to his\her own essence. According to Carl Gustav Jung , (1875-1961) journey to the essence is another expression way of individualism which is transmitted through archetypes. Based on this view of Jung, Joseph Campbell, offers to understand and express the journey and individualism with in the context of the journey's periods which the hero has experienced and he names this process as "the hero's endless journey". The aim of our study is to determine to what extent "Yunus Emre", who is the comman hero of the two novels by two novelists from different cultures , adapts to hero's journey and to identify the differences between the "Yunus Emre" perceptions of the two novelists within the framework of Joseph Campbell's this model. Key words: Nezihe Araz, Jacques Lacarrière, Dertli Dolap, Dünyanın Tozu, Yunus Emre, Hero, journey
Nezihe Araz’ın dertli dolap ve Jacques Lacarrıere’in dünyanın tozu romanlarında kahramanın yolculuğu: “Yunus Emre”
No full text“Yunus Emre”, Türk toplumu için derin bir bilgelik kaynağıdır. Onun, toplumu yüksek değerlere ulaştırmak için, yüzyıllar öncesinden yaktığı aydınlanma ışığı, bugün hâlâ dünyayı aydınlatmaya devam etmektedir. Jacques Lacarrière’in (1925-2005) Dünya’nın Tozu (1999) (La Poussière du Monde) (1997) romanında kahraman “Yunus Emre”’dir. Bir Fransız yazar olan Lacarrière “Yunus Emre”’yle ilgili menkıbeleri öğrendikten sonra “Yunus Emre”’yi kahraman yaptığı bir roman kurgular. Bu romanda yazarın sadece duydukları üzerinden bir kurgu oluşturmadığını görürüz. Yazar aynı zamanda “Yunus Emre”’yi kendi kültür çerçevesinden anlamaya da çalışan sorular sorar. Diğer yandan çocukluğundan beri duyduğu “Yunus Emre” dizeleri ve menkıbelerinin etkisinde olan Türk yazar Nezihe Araz, (1920-2009) Dertli Dolap (1961) romanını çocukluğundan bugüne kalbinde yetiştirdiği bir kahraman olan “Yunus Emre”’nin yaşamı üzerine kurgular. “Yunus Emre”’nin tekâmül yolculuğunu onun dizeleri üzerinden ilerleyen bir kurguyla aktarır. Bu iki romanı ortak noktada buluşturan kahraman “Yunus Emre”, insanın kendi özüne yaptığı yolculuğun en önemli temsilcilerinden birisidir. Öze yolculuk, Carl Gustav Jung’a (1875-1961) göre, arketipler aracılığıyla aktarılan bireyleşmenin başka bir ifade biçimidir. Jung’un bu görüşünden yola çıkan Joseph Campbell, yolculuğu ve bireyleşmeyi kahramanın geçirdiği yolculuk aşamaları bağlamında anlamayı ve açıklamayı önerir ve bu süreci “kahramanın sonsuz yolculuğu ” olarak adlandırır.
Çalışmamızda, Joseph Campbell’in bu modeli çerçevesinde, farklı iki kültüre ait iki yazarın romanlarında ortak kahraman olan “Yunus Emre”nin, kahramanın yolculuğuna ne ölçüde uyum sağladığının ve iki yazardaki “Yunus Emre” algısının farklılığının tespit edilmesi amaçlanmıştır.“Yunus Emre” is a deep source of wisdom for Turkish society. The light of enlightenment that he lit centuries ago in order to bring the society to high values still continues to illuminate the world today. In Jacques Lacarrière's novel La Poussière du Monde, the hero is “Yunus Emre. After learning the legends about Yunus Emre, Lacarrière, a French writer, constructs a novel in which he makes Yunus Emre a hero. In this novel, we see that the author does not create a fiction based on only what he hears. The author also asks questions that try to understand Yunus Emre from his own cultural framework. On the other hand, Turkish writer Nezihe Araz, who has been influenced by Yunus Emre verses and legends that she has heard since her childhood, constructs her novel Dertli Dolap on the life of Yunus Emre, a hero whom he raised in her heart from her childhood. She conveys Yunus Emre's journey of evolution with a fiction that proceeds through his verses. Yunus Emre is the hero who brings together these two novels at a common point and he is also one of the most important representatives of the journey which a person makes to his\her own essence. According to Carl Gustav Jung , (1875-1961) journey to the essence is another expression way of individualism which is transmitted through archetypes. Based on this view of Jung, Joseph Campbell, offers to understand and express the journey and individualism with in the context of the journey’s periods which the hero has experienced and he names this process as “the hero’s endless journey”.
The aim of our study is to determine to what extent “Yunus Emre”, who is the comman hero of the two novels by two novelists from different cultures , adapts to hero’s journey and to identify the differences between the “Yunus Emre” perceptions of the two novelists within the framework of Joseph Campbell’s this model
World Affairs Lecture Muslim Identity in Peril: Commemorating the Bosnian Genocide
No full textKenan Trebincevic, author of The Bosnia List: A Memoir of War, Exile, and Return, will discuss the war in Bosnia and Muslim identity with Associate Professor of Social Sciences Emre Özsös.The Department of Social Sciences’ World Affairs Lecture Series fulfills FIT’s mission to foster an understanding of diverse cultures and politics within the international as well as domestic perspectives. It also embraces, supports, and expands upon the president’s campus-wide initiative on civility.This lecture is presented in partnership with the Presidential Scholars program
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