1,720,956 research outputs found
Antimalarial activity prediction analysis of sticophus hermanni on plasmodium falciparum hexose transporter (PfHT1)
Full text linkThe objective of this study is to investigate S.hermanni's antimalarial action against PfHT1 utilizing an in silico technique. In silico method, developing a protein target database by searching and collecting the protein target structures from the Protein Data Bank (PDB) and the UNIPROT databases. PfHT1 protein (PDB ID 6m20) with glucose control. Download all ligand structures from the PubChem database. Molecular docking analysis with Molegro virtual docker predicts interactions between ligands and protein targets. The last step was docking visualization to display 3D views and their interactions with the discovery studio program. The control compound beta-D-glucopyranose binds PfHT1 at the active site GLN169, GLN305, ASN341, GLY408, ASN311, and GLN305. All active compounds of S.hermanni were able to bind to PfHT1. This indicates that all active compounds enter the cell via hexose transporter 1 (PfHT1) receptors, such as glucose. All active substances of S.hermanni have antimalaria activity through PfHT1inhibition. Almost all active substances used were similar to the control binding sites, but only quinoxaline used different binding sites. The active substance of S.hermanni has a variety of binding affinities to PfHT1
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Efek Inhibisi Senyawa Aktif Spoge Haliclona sp. terhadap Pertumbuhan Plasmodium falciparum Berdasarkan Studi In Slico
Full text linkMalaria is still a problem in many places, caused by a parasite Plasmodium falciparum spreaded by mosquitoes. Haliclona sp. is a sea sponge that contains active compounds, some of which are Manzamine and Haliclonacyclamine A, and have antimalarial activity. This study aimed to find the potential effects of different active compounds on the sponge Haliclona sp. on the growth of Plasmodium falciparum based on in silico. This was an experimental study using in silico method. The materials were prepared and taken from the PubChem web, predicted the potential of compounds, predicted pathways using Discovery Studio version 21.1.1, molecular docking using Molegro virtual Docker 5.0, predicted ADME using SWISS ADME, and predicted toxicity via Protox web. The results showed that Haliclona sp. contained several active compounds, namely Manzamine and Haliclonacyclamine A. The study of the active compounds in Haliclona sp. showed that there was a link between the Plasmodium falciparum enzymes. The PfTK and PfDHODH enzymes are responsible for breaking down malaria parasites. In the ADME prediction analysis of the active compounds contained in Haliclona sp., Haliclonacyclamine A can meet Lipinski's criteria. The last test performed was a toxicity test where it was found that Haliclonacyclamine
Literature Study: The Effect of Giving Chitosan Water Gel (Hydrogel) on Healing Diabetic Ulcers Based on In Vivo Studies with Animal Models
Full text linkDiabetic ulcers are one of the most common chronic complications and cause infection, gangrene to leg amputation if the treatment given is not appropriate. Chitosan has anti-microbial properties that make the wound area smaller and are anti-inflammatory to reduce pain. Water gel (hydrogel), which is water, is easily absorbed by the skin and penetrates perfectly into the wound so that it provides a moist effect and prevents bacteria from entering. This study aims to determine the effect of giving chitosan water gel (hydrogel) on the healing of diabetic ulcers. This study uses a literature study method by searching for related journals using keywords, then selected based on the last 5 years and indexed in SINTA, Google Scholar or Scopus, and the final results are 13 journals. This study took place in May - November 2021. The results of this study reported that the administration of chitosan water gel (hydrogel) combined with other ingredients for healing diabetic ulcers gave the same results. The results obtained are reducing inflammation, re-epithelializing wounds, accelerating angiogenesis, accelerating the formation of collagen and granulation tissue, and accelerating wound healing. Although all studies have the same results, the healing time produced by each study is different, this is because each ingredient used has a different content. The average wound changes were seen on the 3rd, 5th, 7th day and the wound healed completely on the 14th day. This study concludes that the administration of chitosan water gel (hydrogel) affects the healing of diabetic ulcer wounds in combination with other ingredients. because the time needed to close the wound is faster
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
- …
