1,721,058 research outputs found
UPAM: Unified Prompt Attack in Text-to-Image Generation Models Against Both Textual Filters and Visual Checkers
Full text linkText-to-Image (T2I) models have raised security concerns due to their
potential to generate inappropriate or harmful images. In this paper, we
propose UPAM, a novel framework that investigates the robustness of T2I models
from the attack perspective. Unlike most existing attack methods that focus on
deceiving textual defenses, UPAM aims to deceive both textual and visual
defenses in T2I models. UPAM enables gradient-based optimization, offering
greater effectiveness and efficiency than previous methods. Given that T2I
models might not return results due to defense mechanisms, we introduce a
Sphere-Probing Learning (SPL) scheme to support gradient optimization even when
no results are returned. Additionally, we devise a Semantic-Enhancing Learning
(SEL) scheme to finetune UPAM for generating target-aligned images. Our
framework also ensures attack stealthiness. Extensive experiments demonstrate
UPAM's effectiveness and efficiency.Comment: Accepted by ICML202
Simplified monopalmitoyl toll-like receptor 2 ligand mini-UPam for self-adjuvanting neoantigen-based synthetic cancer vaccines
Full text linkSynthetic vaccines, based on antigenic peptides that comprise MHC−I and MHC‐II T‐cell epitopes expressed by tumors, show great promise for the immunotherapy of cancer. For optimal immunogenicity, the synthetic peptides (SPs) should be adjuvanted with suitable immunostimulatory additives. Previously, we have shown that improved immunogenicity in vivo is obtained with vaccine modalities in which an SP is covalently connected to an adjuvanting moiety, typically a ligand to Toll‐like receptor 2 (TLR2). SPs were covalently attached to UPam, which is a derivative of the classic TLR2 ligand Pam3CysSK4. A disadvantage of the triply palmitoylated UPam is its high lipophilicity, which precludes universal adoption of this adjuvant for covalent modification of various antigenic peptides as it renders the synthetic vaccine insoluble in several cases. Here, we report a novel conjugatable TLR2 ligand, mini‐UPam, which contains only one palmitoyl chain, rather than three, and therefore has less impact on the solubility and other physicochemical properties of a synthetic peptide. In this study, we used SPs that contain the clinically relevant neoepitopes identified in a melanoma patient who completely recovered after T‐cell therapy. Homogeneous mini‐UPam‐SP conjugates have been prepared in good yields by stepwise solid‐phase synthesis that employed a mini‐UPam building block pre‐prepared in solution and the standard set of Fmoc‐amino acids. The immunogenicity of the novel mini‐UPam‐SP conjugates was demonstrated by using the cancer patient's T‐cells.Bio-organic Synthesi
UpAM: UPCYCLING VIA ADDITIVE MANUFACTURING – HOW 3D PRINTING CAN ENHANCE CIRCULAR ECONOMY
Full text linkThe University of Luxembourg developed the project upAM upcycling using Additive Manufacturing with the cooperation of FabLab Belval and Luxinnovation. This project was partially financed by Luxembourg National Research Fund Luxembourg (FNR).
An alternative to a linear economy: extracting raw materials, producing, consuming, and discarding of a product, there is another option: Circular Economy (CE): reusing products, repairing, recycling, and upcycling. A concept of a system/process (upAM) is developed to reuse unwanted or un-functional polymers issued from existing products/ systems. Waste prints can be re-printed into new products or systems with the same / higher quality or value than products created from raw materials. The upAM project is, therefore, concentrating on upcycling according to the definition given by author” Upcycling is a process in which used materials are converted into something of a higher value and/or quality in their second life”. This definition is simple and reflects fully the meaning of the upcycling process. This idea is not new; the concept of reused materials/products giving them a new life has been present for hundreds of years as a countermeasure against the lack of raw materials. At the moment, the situation in developed countries is evolving. Society is more aware that unlimited consumption leads to unlimited production of waste. Therefore, collective consciousness of a circular economy occurs, which supports greater resources of productivity aiming to reduce waste and avoid pollution by design, and purposeful reused waste materials and unwanted products. Upcycling via additive manufacturing could be an important part of the circular economy (CE). Obviously, the CE and especially the upcycling process lead to reducing the usage of new raw materials, and it results in a reduction of energy usage, air and water pollution and even greenhouse gas emissions. The development of maker movement and democratisation of FDM technology is also strongly influencing the needs and benefits of the upcycling process. The project upAM is developed to increase this idea so that any individual can produce their products with a higher added value using recycled raw materials via the open technology of FDM 3D Printer.upA
Incidencia de la Universidad para Personas Adultas Mayores -UPAM en la calidad de vida de los adultos mayores, durante el ciclo
No full textThe purpose of the article is to describe the impact of the UPAM on the quality of life of Older Adults, during the March-July 2024 cycle. Understanding quality of life as the satisfaction of Objective, Subjective and Social needs. The study was carried out based on a qualitative methodology with a phenomenological perspective and descriptive scope. The results allow us to point out that older adults who attend UPAM have an optimal quality of life, allowing them to feel happy, valued and autonomous.El artículo tiene como propósito describir la incidencia de la Universidad para Personas Adultas Mayores - UPAM en la calidad de vida de los Adultos Mayores, durante el ciclo marzo-julio 2024. Entendiendo calidad de vida como la satisfacción de las necesidades Objetivas, Subjetivas y Sociales. El estudio se realizó en base a una metodología cualitativa con una perspectiva fenomenológica y de alcance descriptivo. Los resultados permiten señalar que los adultos mayores que asisten a la UPAM presentan una calidad de vida optima, permitiéndoles sentirse felices, valorados y autónomos
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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