4,254 research outputs found
Coauthor prediction for junior researchers
No full textResearch collaboration can bring in different perspectives and generate more productive results. However, finding an appropriate collaborator can be difficult due to the lacking of sufficient information. Link prediction is a related technique for collaborator discovery; but its focus has been mostly on the core authors who have relatively more publications. We argue that junior researchers actually need more help in finding collaborators. Thus, in this paper, we focus on coauthor prediction for junior researchers. Most of the previous works on coauthor prediction considered global network feature and local network feature separately, or tried to combine local network feature and content feature. But we found a significant improvement by simply combing local network feature and global network feature. We further developed a regularization based approach to incorporate multiple features simultaneously. Experimental results demonstrated that this approach outperformed the simple linear combination of multiple features. We further showed that content features, which were proved to be useful in link prediction, can be easily integrated into our regularization approach. © 2013 Springer-Verlag
Our collaborators, Instructions for the author, Revue objectives, Life Proyect
No full textNuestros Colaboradores, Instrucciones para el Autor, Objetivos de la Revista y Proyecto de Vida de la Revista Páginas No.89Our collaborators, Instructions for the author, Revue objectives, Life Proyect of the Revue Páginas No.8
Waiting times for carotid endarterectomy in UK: observational study.
No full textOBJECTIVES: To assess timeliness of carotid endarterectomy services in the United Kingdom. DESIGN: Observational study with follow-up to March 2008. SETTING: UK hospitals performing carotid endarterectomy. PARTICIPANTS: UK surgeons undertaking carotid endarterectomy from December 2005 to December 2007. MAIN OUTCOME MEASURES: Provision and speed of delivery of appropriate assessments of patients; carotid endarterectomy and operative mortality; 30 day postoperative mortality. RESULTS: 240 (61% of those eligible) consultant surgeons took part from 102 (76%) hospitals and trusts. Of 9913 carotid endarterectomies recorded on hospital episode statistics, 5513 (56%) were included. Of the patients who underwent endarterectomy, 83% had a history of transient ischaemic attack or stroke. Of these recently symptomatic patients, 20% had their operation within two weeks of onset of symptoms and 30% waited more than 12 weeks. Operative mortality was 0.5% during the inpatient stay and 1.0% (95% confidence interval 0.7% to 1.3%) by 30 days. CONCLUSION: Only 20% of symptomatic patients had surgery within the two week target time set by the National Institute for Health and Clinical Excellence (NICE). Although operative mortality rates are comparable with those in other countries, some patients might experience disabling or fatal stroke while waiting for surgery and hence not be included in operative statistics. Major improvements in services are necessary to enable early surgery in appropriate patients in order to prevent strokes
Types of Scientific Collaborators: A Perspective of Author Contribution Network
No full textThe purpose of this study is to investigate interaction between collaborators within individual studies by measuring how they made contributions to their studies. Author contribution network is constructed based on the author contribution statements of 140,000 full-text articles in PloS by viewing every collaborator as a node and a shared contribution as an edge. Three types of contributors are identified: general team-players, factotums, and mavericks. The preliminary result suggests that division of labor widely exists in scientific re-search and the latter two types of collaborators are common in small teams.Made available in DSpace on 2018-07-12T15:28:19Z (GMT). No. of bitstreams: 2
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Previous issue date: 201
Open lower limb fractures in the UK trauma system: a multicentre prospective audit of current practice
No full textIntroduction
Open fractures represent limb-threatening and life-changing injuries. Clear standards define how patients with these injuries should be managed in the UK. The study of open fractures is, therefore, a key measurable example of major trauma management as a whole. This study was conducted to characterise the demographic, assessment and treatment of patients sustaining lower limb open fractures across UK Regional Trauma Networks.
Methods
A prospective, multicentre, audit was conducted according to a prespecified protocol against the relevant British Orthopaedic Association (BOA) & British Association of Plastic, Reconstructive & Aesthetic Surgeons (BAPRAS) standards for Trauma. All UK hospitals treating adults with open fractures were eligible to take part in the study. Patients included were injured during a six month collection period at each site.
Results
3 Major Trauma Centres (MTCs) and 5 Trauma Units (TUs) were enrolled, with data collected by 24 collaborators. 239 patients were included, 11 had bilateral open fractures. There were 38 patient datasets collected from TUs and 201 from MTCs. Patients were predominantly male with high energy injuries.
31.3% of patients from MTCs were transferred in from another facility. Antibiotics were given to 41.7% of patients within 1 hour. 74.4% of limbs with open fractures had a splint applied in the emergency department. 85.8% of patients had a documented orthoplastics plan. 41.7% of patients with a high energy injury had their wound debrided within 12 hours.
Discussion
42.3% of patients with open fractures in our cohort were managed at some point in a TU, indicating triage was required within the trauma network. Due to sampling, we may be under-estimating the number of patients passing through TUs, however, we have demonstrated that this cohort exists. These patients are under-represented in many other studies and registries such as the Trauma Audit Research Network (TARN) due to the funding model for data collection that privileges data collection in MTCs.
Conclusion
This study gives extensive new insight into the demographics and management of patients with open lower limb fractures in the UK, demonstrating a widespread involvement of TUs and consistent deviation from national standards
Our collaborators, Instructions for the author, Revue objectives, Institucional repositories and 40 years of the UCP
No full textNuestros Colaboradores, Instrucciones para el Autor, Objetivos de la Revista, Repositorios Institucionales y Los 40 años de la UCP de la Revista Páginas No. 98Our collaborators, Instructions for the author, Revue objectives, Institucional repositories and 40 years of the UCP of the Revue Páginas No.9
The Hymn of the UCPR, Our collaborators, Revue objectives and Instructions for the author
No full textEl Himno de la Universidad Católica Popular del Risaralda, Nuestros Colaboradores, Objetivos de la Revista y Instrucciones para el Autor de la Revista Páginas No.78The Hymn of the Universidad Católica Popular del Risaralda, Our collaborators, Revue Objectives and Instructions for the author of the Revue Páginas No.7
Our collaborators, Instructions for the author, Revue objectives, Institucional repositories and 40 years of the UCP
No full textNuestros Colaboradores, Instrucciones para el Autor, Objetivos de la Revista, Repositorios Institucionales y Los 40 años de la UCP de la Revista Páginas No. 98Our collaborators, Instructions for the author, Revue objectives, Institucional repositories and 40 years of the UCP of the Revue Páginas No.9
Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050
No full textBackground: Antimicrobial resistance (AMR) poses an important global health challenge in the 21st century. A previous study has quantified the global and regional burden of AMR for 2019, followed with additional publications that provided more detailed estimates for several WHO regions by country. To date, there have been no studies that produce comprehensive estimates of AMR burden across locations that encompass historical trends and future forecasts. Methods: We estimated all-age and age-specific deaths and disability-adjusted life-years (DALYs) attributable to and associated with bacterial AMR for 22 pathogens, 84 pathogen–drug combinations, and 11 infectious syndromes in 204 countries and territories from 1990 to 2021. We collected and used multiple cause of death data, hospital discharge data, microbiology data, literature studies, single drug resistance profiles, pharmaceutical sales, antibiotic use surveys, mortality surveillance, linkage data, outpatient and inpatient insurance claims data, and previously published data, covering 520 million individual records or isolates and 19 513 study-location-years. We used statistical modelling to produce estimates of AMR burden for all locations, including those with no data. Our approach leverages the estimation of five broad component quantities: the number of deaths involving sepsis; the proportion of infectious deaths attributable to a given infectious syndrome; the proportion of infectious syndrome deaths attributable to a given pathogen; the percentage of a given pathogen resistant to an antibiotic of interest; and the excess risk of death or duration of an infection associated with this resistance. Using these components, we estimated disease burden attributable to and associated with AMR, which we define based on two counterfactuals; respectively, an alternative scenario in which all drug-resistant infections are replaced by drug-susceptible infections, and an alternative scenario in which all drug-resistant infections were replaced by no infection. Additionally, we produced global and regional forecasts of AMR burden until 2050 for three scenarios: a reference scenario that is a probabilistic forecast of the most likely future; a Gram-negative drug scenario that assumes future drug development that targets Gram-negative pathogens; and a better care scenario that assumes future improvements in health-care quality and access to appropriate antimicrobials. We present final estimates aggregated to the global, super-regional, and regional level. Findings: In 2021, we estimated 4·71 million (95% UI 4·23–5·19) deaths were associated with bacterial AMR, including 1·14 million (1·00–1·28) deaths attributable to bacterial AMR. Trends in AMR mortality over the past 31 years varied substantially by age and location. From 1990 to 2021, deaths from AMR decreased by more than 50% among children younger than 5 years yet increased by over 80% for adults 70 years and older. AMR mortality decreased for children younger than 5 years in all super-regions, whereas AMR mortality in people 5 years and older increased in all super-regions. For both deaths associated with and deaths attributable to AMR, meticillin-resistant Staphylococcus aureus increased the most globally (from 261 000 associated deaths [95% UI 150 000–372 000] and 57 200 attributable deaths [34 100–80 300] in 1990, to 550 000 associated deaths [500 000–600 000] and 130 000 attributable deaths [113 000–146 000] in 2021). Among Gram-negative bacteria, resistance to carbapenems increased more than any other antibiotic class, rising from 619 000 associated deaths (405 000–834 000) in 1990, to 1·03 million associated deaths (909 000–1·16 million) in 2021, and from 127 000 attributable deaths (82 100–171 000) in 1990, to 216 000 (168 000–264 000) attributable deaths in 2021. There was a notable decrease in non-COVID-related infectious disease in 2020 and 2021. Our forecasts show that an estimated 1·91 million (1·56–2·26) deaths attributable to AMR and 8·22 million (6·85–9·65) deaths associated with AMR could occur globally in 2050. Super-regions with the highest all-age AMR mortality rate in 2050 are forecasted to be south Asia and Latin America and the Caribbean. Increases in deaths attributable to AMR will be largest among those 70 years and older (65·9% [61·2–69·8] of all-age deaths attributable to AMR in 2050). In stark contrast to the strong increase in number of deaths due to AMR of 69·6% (51·5–89·2) from 2022 to 2050, the number of DALYs showed a much smaller increase of 9·4% (–6·9 to 29·0) to 46·5 million (37·7 to 57·3) in 2050. Under the better care scenario, across all age groups, 92·0 million deaths (82·8–102·0) could be cumulatively averted between 2025 and 2050, through better care of severe infections and improved access to antibiotics, and under the Gram-negative drug scenario, 11·1 million AMR deaths (9·08–13·2) could be averted through the development of a Gram-negative drug pipeline to prevent AMR deaths. Interpretation: This study presents the first comprehensive assessment of the global burden of AMR from 1990 to 2021, with results forecasted until 2050. Evaluating changing trends in AMR mortality across time and location is necessary to understand how this important global health threat is developing and prepares us to make informed decisions regarding interventions. Our findings show the importance of infection prevention, as shown by the reduction of AMR deaths in those younger than 5 years. Simultaneously, our results underscore the concerning trend of AMR burden among those older than 70 years, alongside a rapidly ageing global community. The opposing trends in the burden of AMR deaths between younger and older individuals explains the moderate future increase in global number of DALYs versus number of deaths. Given the high variability of AMR burden by location and age, it is important that interventions combine infection prevention, vaccination, minimisation of inappropriate antibiotic use in farming and humans, and research into new antibiotics to mitigate the number of AMR deaths that are forecasted for 2050. Funding: UK Department of Health and Social Care's Fleming Fund using UK aid, and the Wellcome Trust
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