2,273 research outputs found

    Kazimierz Goebel (1940-2022)

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    On the 21st of July, 2022, a remarkable mathematician and a former rector of the Maria Curie-Skłodowska University in Lublin (UMCS) – prof. Kazimierz Goebel left u

    [Rezension zu:] Eckart Goebel u. Elisabeth Bronfen (Hg.), Narziss und Eros

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    Rezension zu Eckart Goebel u. Elisabeth Bronfen (Hg.), Narziss und Eros. Bild oder Text? Göttingen (Wallstein Verlag) 2009. (= Manhattan Manuscripts, hg. von Eckart Goebel, Paul Fleming u. John T. Hamilton, Bandnummer: 2), 302 S. 'Narziss und Eros', Band 2 der 'Manhattan Manuscripts', die Eckart Goebel mit Paul Fleming und John T. Hamilton herausgibt, setzt literaturhistorisch bei Ovids Fassung des Narziss-Mythos an und geht zeitgemäß - kontextgebunden - einen großen Schritt über Freud hinaus. Anstatt sich an den Ungereimtheiten, Spannungen und Widersprüchen der Ausführungen Freuds abzuarbeiten, legt der Band ohne viel Aufhebens die Kriterien narzisstischer Persönlichkeitsstörung nach dem Diagnoseklassifikationssystem DSM-N ('Diagnostic and Statistical Manual of Mental Disorders', Fourth Edition) der American Psychiatrie Association zugrunde, holt Eros in den Titel und bringt damit (Un)Ordnung in Ovids und Freuds Ordnungen der Geschlechter

    Friedrich Adolph Wilhelm Diesterweg: Briefe, amtliche Schreiben und Lebensdokumente aus den Jahren 1810 bis 1832. (Sämtliche Werke, II. Abteilung, Bd. 23.) Bearb. v. Sylvia Schütze u. Mitarb. v. Gaby Herchert, Elisabeth Gutjahr und Klaus Goebel. Hrsg. v. Klaus Goebel. Neuwied: Luchterhand 2003. 789 S., EUR 55,–. [Rezension]

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    Rezension zu: Friedrich Adolph Wilhelm Diesterweg: Briefe, amtliche Schreiben und Lebensdokumente aus den Jahren 1810 bis 1832. (Sämtliche Werke, II. Abteilung, Bd. 23.) Bearb. v. Sylvia Schütze u. Mitarb. v. Gaby Herchert, Elisabeth Gutjahr und Klaus Goebel. Hrsg. v. Klaus Goebel. Neuwied: Luchterhand 2003. 789 S., EUR 55,

    Inhibition of host cell apoptosis by Toxoplasma gondii is accompanied by reduced activation of the caspase cascade and alterations of poly(ADP-ribose) polymerase expression

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    The obligate intracellular protozoan parasite Toxoplasma gondii has been shown to protect different cell types from apoptosis induced by a variety of pro-apoptotic treatments. However, the precise cell biological mechanisms of this inhibition remained unknown. As shown in this study, apoptosis In human-derived HL-60 and U937 cells induced by treatment with actinomycin D or TNF-alpha in combination with cycloheximide, respectively, was indeed dose-dependently downregulated by prior infection with T gondii, as determined by DNA fragmentation assays. Cleavage of caspase 3 and caspase 9 after treatment with pro-apoptotic stimuli was considerably diminished by T gondii. Furthermore, release of mitochondrial cytochrome c during apoptosis In HL-60 cells was prevented by intracellular parasites and this was correlated with the absence of DNA strand breaks on the single cell level. Inhibition of cytochrome c release coincided with a twofold upregulation of Mcl-1 protein levels in HL-60 and U937 cells, while Bcl-2 expression did not increase after infection. Parasitic interference with the caspase cascade led to a reduced proteolytic cleavage of the nuclear target molecule protein kinase C delta. In parallel, poly(ADP-ribose) polymerase protein levels were prominently downregulated by T. gondii, irrespective of whether HL-60 and U937 cells had been treated with pro-apototic stimuli or left untreated. However, poly(ADP-ribose) polymerase mRNA levels remained unchanged after infection as determined by RT-PCR analyses. These observations suggest that T gondii has evolved different mechanisms that may contribute to downregulation of host cell apoptosis, namely inhibition of cytochrome c release and subsequent caspase activation as well as downregulation of poly (ADP-ribose) polymerase protein levels

    Player agency in interactive narrative: audience, actor & author

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    The question motivating this review paper is, how can computer-based interactive narrative be used as a constructivist learn- ing activity? The paper proposes that player agency can be used to link interactive narrative to learner agency in constructivist theory, and to classify approaches to interactive narrative. The traditional question driving research in interactive narrative is, ‘how can an in- teractive narrative deal with a high degree of player agency, while maintaining a coherent and well-formed narrative?’ This question derives from an Aristotelian approach to interactive narrative that, as the question shows, is inherently antagonistic to player agency. Within this approach, player agency must be restricted and manip- ulated to maintain the narrative. Two alternative approaches based on Brecht’s Epic Theatre and Boal’s Theatre of the Oppressed are reviewed. If a Boalian approach to interactive narrative is taken the conflict between narrative and player agency dissolves. The question that emerges from this approach is quite different from the traditional question above, and presents a more useful approach to applying in- teractive narrative as a constructivist learning activity

    Dendrocellus Schmidt-Goebel 1846

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    Dendrocellus Schmidt-Goebel, 1846 Type species: Dendrocellus discolor Schmidt-Goebel, 1846 (= Desera nepalensis Hope, 1831)= Desera Hope, 1831 (nec Dejean, 1825) Type species: Desera nepalensis Hope, 1831 Bousquet (2002) and Liang et al. (2004) have correctly reconstructed the complex nomenclatorial history of this genus, reaching the conclusion that its valid generic name is Dendrocellus Schmidt-Goebel, 1846, instead of Desera Dejean, 1825, as it was frequently considered previously. We only observe that back in 1949 Jeannel already wrote: “Les Dendrocellus Schm. -Goeb. (type: discolor Schm. -Goeb.,= nepalensis Hope) sont généralement classés à tort sous le nom de Desera. … Malgré leurs ongles tarsaux pectinés, ils sont très voisins des Drypta s. str. ” (Jeannel, 1949). So, it seems the french author had already reached the same conclusions. This genus, recently revised by Liang & Kavanaugh (2007), contains 22 species occuring in Africa, Asia and Australia. Systematically it is extremely close to Drypta, differing only in its tarsal claws pectinate instead of smooth. The genitalic characters of both sexes are the same, the external resemblance among members of the two genera is sometimes puzzling and a few species of Dendrocellus show very slight tarsal pectination, sometimes leaving a doubt on their generic pertinence; only a comparative study of all the characters of the species belonging to the two genera will allow to decide whether they can be really maintained as separate genera. Already in 1968 Darlington observed: “ Desera differs from Drypta only in having pectinate tarsal claws. A modern revision of the species is needed to show whether both genera are really monophyletic and distinct” (Darlington, 1968, p. 218). The unique combination of characters distinguishing this genus from the others of the tribe is: pronotal bead absent or very rudimental (fig. 10); punctuation on head and pronotum dense, regular, the punctures usually well distinct from each other; pronotum very feebly constricted towards base; elytral microsculpture well developed; elytral pubescence dense, usually arranged in two-three more or less regular rows; scutellar pore constantly single; intervals flat or slightly convex; tarsal claws slender, more or less pectinate on inner side; two to five evident setae on outer side of stylomere (fig. 8).Published as part of Sciaky, Riccardo & Anichtchenko, Alexander, 2020, Taxonomic notes on the tribe Dryptini Bonelli, 1810 with description of a new genus and species from China (Coleoptera: Carabidae: Dryptini), pp. 522-530 in Zootaxa 4731 (4) on page 524, DOI: 10.11646/zootaxa.4731.4.5, http://zenodo.org/record/366198

    William Goebel: The Politics of Wrath

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    The turbulent career of William Goebel (1856–1900), which culminated in assassination, marked an end-of-the-century struggle for political control of Kentucky. Although populism had become a strong force in the nation, the Louisville and Nashville Railroad and ex-Confederates still dominated the state and its Democratic party. Touting reforms and attaching the railroad monopoly, Goebel challenged this old order. A Yankee in a state that fancied itself southern, Goebel had to depend on a strong organization to win votes. As “The Kenton King” he created a new style of politics. To some he was a progressive reformer; to others, a tyrannical machine boss. His drive for power and his enemies’ fierce opposition aroused violent political factionalism. Goebel’s fateful duel with a rival, his partisan election law, and his ruthless convention tactics led to the bitterly contested gubernatorial election of 1899 that resulted in his murder. Although the full truth about the murder was never revealed in nearly a decade of trials and the advent of progressive politics was long delayed in Kentucky, Goebel’s death did relieve the state’s political turmoil and induce some legal reforms. Using new sources and fresh perspectives, James C. Klotter portrays Goebel’s tumultuous era and discovers the real man within the obscurity of his conflicting images. James C. Klotter is professor of history at Georgetown College and the state historian of Kentucky. He is the author or coauthor of several books, including A New History of Kentucky. A lively account of one of the most bizarre and controversial episodes in Kentucky history. -- Tennessee Historical Quarterlyhttps://uknowledge.uky.edu/upk_political_history/1000/thumbnail.jp
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