104,936 research outputs found
Identification of a Btk-BAG3 complex induced by oxidative stress. Turco MC: Corresponding Author
No full textWT1 protein is a transcriptional activator of the antiapoptotic bag3 gene. Turco M=Corresponding Author
No full textThe transcription factor WT1 has an oncogenic role in a variety of tumors from different origins including acute lymphoblastic and myeloblastic leukemias. Here we demonstrated that WT1 is able to bind bag3 promoter and to induce bag3 transcription in myeloid leukemia. We also demonstrated that the induction of BAG3 protein is partially responsible for the anti-apoptotic activity of WT1 protein
Degrees of freedom effect on fragmentation in tandem mass spectrometry of singly charged supramolecular aggregates of sodium sulfonates
No full textThe characteristic collision energy (CCE) to obtain 50% fragmentation of positively and negatively single charged non-covalent clusters has been measured. CCE was found to increase linearly with the degrees of freedom (DoF) of the precursor ion, analogously to that observed for synthetic polymers. This suggests that fragmentation behavior (e.g. energy randomization) in covalent molecules and clusters are similar. Analysis of the slope of CCE with molecular size (DoF) indicates that activation energy of fragmentation of these clusters (loss of a monomer unit) is similar to that of the lowest energy fragmentation of protonated leucine-enkephalin. Positively and negatively charged aggregates behave similarly, but the slope of the CCE vs DoF plot is steeper for positive ions, suggesting that these are more stable than their negative counterparts
BAG3 protein controls B- chronic lymphocytic leukemia cell apoptosis. Turco MC: Corresponding Author
No full textDynamic evolution of the oscillatory Belousov-Zhabotinsky reaction upon addition of a non-ionic polymer
No full textThe dynamic evolution of the oscillatory Belousov-Zhabotinsky reaction upon addition of increasing amount of the non-ionic polymer polypropylene glycol with molecular weight 425 g mol(-1) (PPG-425) was investigated in a stirred-batch reactor by monitoring the Ce(IV) absorbance changes. The oscillatory parameters are significantly altered by the presence of the polymer.
The findings obtained in the present work revealed that the PPG-425 is not only more effective, than other polymer previously [R. Lombardo, C. Sbriziolo, M.L. Turco Liveri, K. Pelle, M. Wittmann, Z. Noszticzius, in: J.A. Pojman, Q. Tran-Cong-Miyata (Eds.), Nonlinear Dynamics in Polymeric Systems, American Chemical Society, Washington, DC, 869 (2004) 292] studied, in perturbing the BZ systems but also more capable of producing key radical species, which in turn can be exploited for the preparation of new polymeric materials
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