130,955 research outputs found
Correction to: RarERN Path: a methodology towards the optimisation of patients’ care pathways in rare and complex diseases developed within the European Reference Networks (Orphanet Journal of Rare Diseases, (2020), 15, 1, (347), 10.1186/s13023-020-01631-1)
No full textFollowing the publication of the original article [1] we were informed that the authors’ given and family names had unfortunately been interchanged. The correct author names are shown here below: Rosaria Talarico, Sara Cannizzo, Valentina Lorenzoni, Diana Marinello, Ilaria Palla, Salvatore Pirri, Simone Ticciati, Leopoldo Trieste, Isotta Triulzi, Enrique Terol, Anna Bucher and Giuseppe Turchetti. The author names have been corrected in the author list of this Correction and updated in the original article
Introduction. Just Needham to Nixon? On writing the history of “science diplomacy”
Get PDFThis introduction examines the growing interest in science diplomacy and the parallel lack of in-depth historical studies on this new concept. In particular, we first show how the recent attention toward science diplomacy has led to a proliferation of hagiographic accounts reflecting the urgency to support its growth rather than truly investigate its ancestry. We then turn to consider how our historical understanding of science diplomacy could be improved, and how this knowledge could equally be of significance to science diplomacy practitioners today. This essay is part of a special issue entitled Science Diplomacy, edited by Giulia Rispoli and Simone Turchetti
R&D and innovative health technologies: towards the definition of a methodology for an Early Assessment
No full textWeil Representation and Metaplectic Groups over an Integral Domain
Get PDFGiven F a locally compact, nondiscrete, non-archimedean field of characteristic ≠ 2 and R an integral domain such that a non-trivial smooth character χ: F → R* exists, we construct the (reduced) metaplectic group attached to χ and R. We show that it is in the expected cases a double cover of the symplectic group over F. Finally, we define a faithful infinite dimensional R-representation of the metaplectic group analogue to the Weil representation in the complex cas
Generating Unstable Resonances for Extraction Schemes Based on Transverse Splitting
No full textA few years ago, a novel multi-turn extraction scheme was proposed, based on particle trapping inside stable resonances. Numerical simulations and experimental tests have confirmed the feasibility of such a scheme for low order resonances. While the third-order resonance is generically unstable and those higher than fourth-order are generically stable, the fourth-order resonance can be either stable or unstable depending on the specifics of the system under consideration. By means of the Normal Form a general approach to control the stability of the fourth-order resonance has been derived. This approach is based on the control of the amplitude detuning and the general form for a lattice with an arbitrary number of sextupole and octupole families is derived in this paper. Numerical simulations have confirmed the analytical results and have shown that, when crossing the unstable fourth-order resonance, the region around the centre of the phase space is depleted and particles are trapped in only the four stable islands. A four-turn extraction could be designed using this technique
Disruptive innovation in Healthcare: breaking the old patterns of business modelling and Health Technology Assessment. Preliminary results for the assessment of an innovative knee Telerehabilitation device in Tuscany.
No full textConceptual study of the coupling of a biorefinery process for hydrothermal liquefaction of microalgae with a concentrating solar power plant
No full textA conceptual analysis of the coupling of a concentrating solar power plant with a chemical process for hydrothermal liquefaction (HTL) of microalgae to biocrude was performed. The two plants were considered coupled by molten salt recirculation that granted energetic supply to the chemical process. Preliminary estimations have been done considering a solar field constituted by 3 linear parabolic solar collectors rows, each 200 m long, using a ternary molten salts mixture as heat transfer fluid, and a chemical plant sized to process 10 kT/y of microalgae. Under adopted conditions, we have estimated a minimum selling prize of the biocrude that is similar to that achieved in non-solar HTL processes. © 2017 Author(s)
La chemioprevenzione del carcinoma mammario
No full textCol termine chemioprevenzione si indica la somministrazione di sosotanze chimiche (farmaci o costituenti della dieta) in grado di impedire lo sviluppo di unaneoplasia invasiva. Poichè un simile approccio potrebbe contribuire alla riduzione dell'incidenza del carcinoma della mammella, sono state intraprese ricerche volte ad accertarne la applicabilità. Gli interventi dietetici proposti per ridurre il rischio di carcinoma della mammella, a tutt'oggi in fase di valutazione, prevedono soprattutto la restrizione dell'apporto di grassi, mentre, per qwuanto riguarda i farmaci, quelli che hanno finora raggiunto la fase clinica di sperimentazione sono tamoxifen, fenretinide (somministrati singolarmente o in associazione) e raloxifene. L'efficacia del tamoxifen nel prevenire il carcinoma mammario, evidenziata dai risultati preliminari di un grandi trial americano, non ha finora trovato conferma nei primi dati relativi a due studi analoghi condotti in Europa. Complessivamente, la chemioprevenzione del carcinoma mammario, pur non essendo ancora un'opzione disponibile nella pratica medica quotidiana, costituisce un'area di ricerca estremamente promettente, che merita di ricevere attenzione e sforzi crescenti
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