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Syndrome des abcès aseptiques. Relation hôte-microbiote.
No full textAseptic Abscess Syndrome is a well-defined anatomo-clinical entity characterized by deep and localized collections of neutrophil polymorphonuclear cells (PMNs). This inflammatory disease typically presents with fever and varying degrees of pain, depending on the location of the abscesses, which are often intra-abdominal. Antibiotic therapy is ineffective in treating this condition. By definition, no microorganisms are found, and the condition responds to anti-inflammatory treatment with corticosteroids. Most patients experience relapses, which significantly impact their quality of life, leading to multiple hospitalizations and immunosuppressive treatment.One of the surprising observations of the past decade is that immune responses in distant sites from the intestines can also be influenced by the intestinal microbiota. The absence of microbiota or dysbiosis affects the expression of autoimmune diseases in remote sites in animal models. As a result, certain diseases require the presence of the microbiota to develop and are improved in patients treated with antibiotics or in germ-free mice.Aseptic Abscess Syndrome can occur in isolation or be associated with numerous diseases, including inflammatory bowel diseases (Crohn's disease or ulcerative colitis), Behçet's disease, rheumatoid arthritis, or neutrophilic dermatoses. Understanding its pathophysiology may shed light on certain phenotypes of these diseases.The pathophysiology of aseptic abscesses is currently poorly understood, and through this study, we aim to demonstrate a potential role of the intestinal and salivary microbiota in modulating the immune system. This concept of 'remote inflammation' could have implications for other pathologies as well.Le syndrome des abcès aseptiques est une entité anatomo-clinique bien individualisée et caractérisée par des collections profondes et circonscrites de polynucléaires neutrophiles (PNN). Cette maladie inflammatoire se manifeste le plus souvent par une fièvre accompagnée d'une symptomatologie douloureuse variable selon la localisation des abcès qui sont volontiers intra-abdominaux. L'antibiothérapie est inefficace. Par définition, aucun germe n'est retrouvé et ils sont sensibles au traitement anti inflammatoire par corticoïdes. Les patients rechutent majoritairement et leur qualité de vie est impactée (multiples hospitalisations, traitement immunosuppresseur).Une des observations surprenantes de la dernière décennie est que les réponses immunitaires dans des sites éloignés de l'intestin peuvent également être régulées par le microbiote intestinal. L'absence de microbiote ou une dysbiose affecte l'expression des maladies auto-immunes dans les sites distaux dans des modèles animaux. Ainsi, certaines maladies nécessitent la présence du microbiote pour se développer. Elles sont améliorées chez les patients traités par antibiotiques ou les souris sans germes.Le syndrome des abcès aseptiques peut survenir de manière isolée mais aussi associée à de nombreuses maladies notamment les colites inflammatoires (maladie de Crohn ou rectocolite hémorragique), la maladie de Behçet, la polyarthrite rhumatoïde ou les dermatoses neutrophiliques. Comprendre sa physiopathologie permettrait de mieux appréhender certains phénotypes de ces maladies.La physiopathologie des abcès aseptiques est pour le moment peu connue et par le biais de cette étude, nous cherchons à montrer une potentielle participation du microbiote intestinal et salivaire par son impact sur le système immunitaire.Cette hypothèse de « l'inflammation à distance » pourrait être appliquée à d'autres pathologies
Aseptic abscess syndrome. Host-microbiota relationship
No full textLe syndrome des abcès aseptiques est une entité anatomo-clinique bien individualisée et caractérisée par des collections profondes et circonscrites de polynucléaires neutrophiles (PNN). Cette maladie inflammatoire se manifeste le plus souvent par une fièvre accompagnée d'une symptomatologie douloureuse variable selon la localisation des abcès qui sont volontiers intra-abdominaux. L'antibiothérapie est inefficace. Par définition, aucun germe n'est retrouvé et ils sont sensibles au traitement anti inflammatoire par corticoïdes. Les patients rechutent majoritairement et leur qualité de vie est impactée (multiples hospitalisations, traitement immunosuppresseur).Une des observations surprenantes de la dernière décennie est que les réponses immunitaires dans des sites éloignés de l'intestin peuvent également être régulées par le microbiote intestinal. L'absence de microbiote ou une dysbiose affecte l'expression des maladies auto-immunes dans les sites distaux dans des modèles animaux. Ainsi, certaines maladies nécessitent la présence du microbiote pour se développer. Elles sont améliorées chez les patients traités par antibiotiques ou les souris sans germes.Le syndrome des abcès aseptiques peut survenir de manière isolée mais aussi associée à de nombreuses maladies notamment les colites inflammatoires (maladie de Crohn ou rectocolite hémorragique), la maladie de Behçet, la polyarthrite rhumatoïde ou les dermatoses neutrophiliques. Comprendre sa physiopathologie permettrait de mieux appréhender certains phénotypes de ces maladies.La physiopathologie des abcès aseptiques est pour le moment peu connue et par le biais de cette étude, nous cherchons à montrer une potentielle participation du microbiote intestinal et salivaire par son impact sur le système immunitaire.Cette hypothèse de « l'inflammation à distance » pourrait être appliquée à d'autres pathologies.Aseptic Abscess Syndrome is a well-defined anatomo-clinical entity characterized by deep and localized collections of neutrophil polymorphonuclear cells (PMNs). This inflammatory disease typically presents with fever and varying degrees of pain, depending on the location of the abscesses, which are often intra-abdominal. Antibiotic therapy is ineffective in treating this condition. By definition, no microorganisms are found, and the condition responds to anti-inflammatory treatment with corticosteroids. Most patients experience relapses, which significantly impact their quality of life, leading to multiple hospitalizations and immunosuppressive treatment.One of the surprising observations of the past decade is that immune responses in distant sites from the intestines can also be influenced by the intestinal microbiota. The absence of microbiota or dysbiosis affects the expression of autoimmune diseases in remote sites in animal models. As a result, certain diseases require the presence of the microbiota to develop and are improved in patients treated with antibiotics or in germ-free mice.Aseptic Abscess Syndrome can occur in isolation or be associated with numerous diseases, including inflammatory bowel diseases (Crohn's disease or ulcerative colitis), Behçet's disease, rheumatoid arthritis, or neutrophilic dermatoses. Understanding its pathophysiology may shed light on certain phenotypes of these diseases.The pathophysiology of aseptic abscesses is currently poorly understood, and through this study, we aim to demonstrate a potential role of the intestinal and salivary microbiota in modulating the immune system. This concept of 'remote inflammation' could have implications for other pathologies as well
Le syndrome des abcès aseptiques : mises à jour et nouvelles données de 2025
No full textInternational audienceAseptic abscess syndrome (AAS) is a rare systemic disorder characterized by sterile abscesses rich in neutrophils. It occurs isolated or associated with inflammatory bowel diseases (IBD). Clinically, AAS presents with fever, abdominal pain, and elevated inflammatory markers. Diagnosis is based on a combination of clinical, laboratory, and imaging findings (CT scan, PET scan), along with the exclusion of infectious and malignant causes. The French national registry currently includes 100 patients, with 44% women and a mean age at diagnosis of 33.7 f 16.5 years. The average diagnostic delay is 9.1 f 18.3 months, reflecting limited awareness of this entity. Abscesses most commonly affect the spleen (62%), lymph nodes (41%), liver (33%), skin (24%), and lungs (21%). An associated IBD is reported in 39% of cases. The clinical course is marked by a high relapse rate (57%), especially in patients with hepatic or cutaneous involvement at presentation. Conversely, colchicine treatment and coexisting IBD appear to be protective against relapse. Management relies primarily on corticosteroids and colchicine, often combined with immunosuppressants or biologic agents. Over recent years, there has been a trend toward fewer IBD associations and increased use of biologics. The ongoing multicenter translational study ABSCESSBIOT aims to further elucidate the pathophysiology of AAS and improve therapeutic strategies
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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