14,147 research outputs found
Rede uitgesproken op 17 september 1956 ter gelegenheid van de erepromotie van Dr. Th. von Karman door de promotor Dr. C.B. Biezeno
No full textRede uitgesproken door prof. C.B. Biezeno ter gelegenheid van de erepromotie aan de TH Delft van dr. Theodore von Karman.Precision and Microsystems EngineeringMechanical, Maritime and Materials Engineerin
Prof. Th. W. Adorno and the author Hans Erich Nossack.
No full textProf. Th. W. Adorno and the author Hans Erich Nossack at a reception of Insel Verlag, Buchmesse Frankfurt 1966LB
Author, publisher and bookseller : a tripartite synergy in Nigerian book industry
No full textThis work is about the roles of Author, Publisher and Bookseller in Book development in
Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after
which it proceeded by defining who an author, a publisher, and a bookseller is and
expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in
the emerging Information Society. Furthermore, the various constraints to book
development were identified while the paper advised on how the Book Industry can be
further promoted in Nigeria. However, the paper concluded and made recommendations
on how the Book sector can help in enhancing scholarship in the country
Yersinia pestis DNA from Skeletal Remains from the 6(th) Century AD Reveals Insights into Justinianic Plague.
No full textYersinia pestis, the etiologic agent of the disease plague, has been implicated in three historical pandemics. These include the third pandemic of the 19(th) and 20(th) centuries, during which plague was spread around the world, and the second pandemic of the 14(th)-17(th) centuries, which included the infamous epidemic known as the Black Death. Previous studies have confirmed that Y. pestis caused these two more recent pandemics. However, a highly spirited debate still continues as to whether Y. pestis caused the so-called Justinianic Plague of the 6(th)-8(th) centuries AD. By analyzing ancient DNA in two independent ancient DNA laboratories, we confirmed unambiguously the presence of Y. pestis DNA in human skeletal remains from an Early Medieval cemetery. In addition, we narrowed the phylogenetic position of the responsible strain down to major branch 0 on the Y. pestis phylogeny, specifically between nodes N03 and N05. Our findings confirm that Y. pestis was responsible for the Justinianic Plague, which should end the controversy regarding the etiology of this pandemic. The first genotype of a Y. pestis strain that caused the Late Antique plague provides important information about the history of the plague bacillus and suggests that the first pandemic also originated in Asia, similar to the other two plague pandemics
Clinical and experimental implementation of standardized hypothermic treatment for neonatal asphyxia in low-income settings
No full textBackground: Hypoxic ischemic encephalopathy (HIE) is a potentially devastating condition caused by birth asphyxia. The standard of care for infants with moderate and severe HIE is therapeutic hypothermia (TH), initiated within six hours after delivery. This intervention improves survival rates and reduces long- term neurological disabilities. Despite its efficacy in high-income countries, the implementation of TH faces significant challenges in low- and middle-income settings, including a lack of evidence supporting its benefits, inadequate high- cost cooling equipment, and insufficient long-term outcome predictive markers and evaluations.Aims: The overall aim of this thesis was to develop and evaluate novel equipment for counteracting hypoxic-ischemic brain injuries in newborns in low- and middle-income countries. The specific aims included: To evaluate the application of phase changing material (PCM) for induction of TH in infants with moderate- severe HIE in a tertiary setting and during inter-hospital transportation, in order to enhance the therapeutic effects of TH (Studies I & II) and to determine neurological and neurodevelopmental outcomes for infants treated with TH in low- and middle-income settings (Study III). An additional aim was to evaluate early predictors of outcome of asphyxiated newborns transported for TH, by measuring levels of blood lactated dehydrogenase (LDH) activity and monitoring brain function with amplitude-integrated EEG (aEEG) (Study IV).Materials and methods: One pilot observational study (Study I) and one clinical trial (Studies II-IV) were conducted in Hanoi, Vietnam, between 2014 and 2019. The studies involved neonates born in the northern regions of Vietnam with HIE and requiring TH. The primary outcomes were short-term outcomes of HIE and medium-term outcomes. In study IV, the predictive values of high LDH (>1000 U/L) and severely depressed aEEG were evaluated.Results: Studies I and II showed that, despite not being a servo-controlled device, the PCM mattress effectively cooled and maintained infantsŐ body temperatures at more than 80% of the 72-hour treatment period with little nursing intervention, a significant advantage in resource-limited settings. When used during inter- hospital transportation, PCM as compared to passive cooling did not improve short-term outcomes. However, PCM was a safe and effective piece of equipment for transport of babies eligible for TH and reduced the time to achieve the target temperature for TH. Follow-up at 18 months showed that infants who received TH 67% survived, and, among the survivors, 60% demonstrated normal development or only mild delays in movement and cognition. The remaining survivors exhibited severe neurological disorders, such as cerebral palsy or epilepsy. Study III showed that these serious sequelae can be identified early in the post-natal period using simple screening tools like the Ages and Stages Questionnaires and the Hammersmith Infant Neurological Examination with high sensitivity and specificity. In Study IV, we also found that biological and imaging markers can predict outcomes early, including lactate dehydrogenase (LDH) and early aEEG.Conclusion: The studies presented in this PhD thesis demonstrate the effectiveness of a mattress made of PCM as a low-cost cooling method for TH of infants with moderate to severe HIE in low- and middle-income countries. A majority of the infants treated with TH had favorable outcomes, with many surviving and developing normally or with only mild delays. Early identification of neurological sequelae through simple screening tools and early biomarkers aids clinicians in improving prognosis and treatment decisions for HIE babies.List of scientific papersI. HANG T T TRAN, Ha T. T. Le, Hanh T. P. Tran, Dung T. K. Khu, Hugo Lagercrantz, Dien M. Tran, Birger Winbladh, Lena Hellstršm-Westas, Tobias AlfvŽn*, Linus Olson*. Hypothermic treatment for neonatal asphyxia in low-resource settings using phase-changing material- An easy to use and low-cost method. Acta Paediatrica. 2021;110:85Đ93. *Shared last authorship.https://doi.org/10.1111/apa.15331II. HANG T T TRAN, Dien M Tran, Ha T Le, Lena Hellstršm-Westas, Tobias AlfvŽn*, Linus Olson*. Cooling during transportation of asphyxiated newborns using phase change material mattresses in low-resource settings: a randomized controlled trial in Hanoi, Vietnam. *Shared last authorship.https://doi.org/10.1186/s12887-024-04987-6III. HANG T T TRAN, Ha Thi Le, Dien Minh Tran, Giang Thi Huong Nguyen, Lena Hellstršm-Westas, Tobias AlfvŽn*, Linus Olson*. Therapeutic hypothermia after perinatal asphyxia in Vietnam - medium-term outcomes at 18 months: a prospective cohort study. BMJ Paediatr Open. 2024; 8(1): e002208. *Shared last authorship.https://doi.org/10.1136/bmjpo-2023-002208IV. HANG T T TRAN, Ha T Le, Dien M Tran, Tobias AlfvŽn, Lena Hellstršm-Westas, Linus Olson. Phase-change material, lactate dehydrogenase and amplitude-integrated EEG (aEEG), and for management of out-born hypothermia-treated newborns in Hanoi, Vietnam. [Manuscript]</p
Hadron yields in Au + Au / Pb + Pb at RHIC and LHC from thermalized minijets
No full textWe calculate the yields of a variety of hadrons for RHIC and LHC energies assuming thermodynamical equilibration of the produced minijets, and using as input results from pQCD for the energy densities at midrapidity. In the calculation of the production of partons and of transverse energy one has to account for nuclear shadowing. By using two parametrizations for the gluon shadowing one derives energy densities di ering strongly in magnitude. In this publication we link those perturbatively calculated energy densities of partons via entropy conservation in an ideal fluid to the hadron multiplicities at chemical freeze-out
Anatomic response of occult choroidal neovascularization to intravitreal ranibizumab: a study by indocyanine green angiography.
No full textAbstract
BACKGROUND:
To investigate changes in indocyanine green angiography (ICGA) features of occult choroidal neovascularization (CNV) after intravitreal ranibizumab injections.
METHODS:
We reviewed the charts of all consecutive patients with newly diagnosed occult CNV secondary to age-related macular degeneration (AMD) treated by intravitreal ranibizumab. In all patients, optical coherence tomography (OCT) and ICGA were performed at baseline, after 3 months and 12 months.
RESULTS:
Fifty-one eyes of 44 patients (ten males, 34 females, mean age 77.8 ± 7.3 years) were included. Mean follow-up was 20.3 ± 6.2 months. During the first 12 months, patients received 5.5 ± 2.7 intravitreal ranibizumab injections. When compared with baseline, best-corrected visual acuity (BCVA) significantly improved at the 3-month follow-up visit (60.5 ±22.0 vs 50.9 ±20.7 letters, p = 0.04), and stabilized at 12-month visit (55.7 ±18.2 letters; p = 0.05). Central macular thickness (CMT) significantly improved during follow-up (229.0 ±54.7 μm vs 281.0 ±61.3 μm at baseline, p = 0.003). An overall stabilization was observed on ICGA in both the lesion area (5.27 ± 3.9 mm(2) at baseline vs 4.60 ± 3.5 mm(2) at month 12, p = 0.4), and greatest linear dimension (GLD 2.66 ± 1.2 mm at baseline vs 2.55 ± 1.0 mm at month 12, p = 0.3). Eight eyes (15.7%) showed CNV growth on ICGA (lesion area 3.98 ± 3.2 mm2 at baseline vs 4.3 ± 2.7 mm2 at month-12, p = 0.6; GLD 2.11 ± 1.0 mm at baseline vs 2.70 ± 0.8 mm at month-12, p = 0.05).
CONCLUSION:
ICGA suggests that functional outcomes after intravitreal ranibizumab is related to CMT reduction rather than CNV regression
Dissipative Range Scaling of Higher Order Structure Functions for Velocity and Passive Scalars
No full textDifferently to Kolmogorov's second similarity hypothesis, we find that the 2n-th order velocity and scalar structure functions scale with n-th order moment of the energy dissipation and the scalar dissipation, respectively. The origins of this scaling are analyzed by the transport equations of the fourth order velocity and scalar increment moments and by direct numerical simulations
Also By The Same Author: AKTiveAuthor, a Citation Graph Approach to Name Disambiguation
No full textThe desire for definitive data and the semantic web drive for inference over heterogeneous data sources requires co-reference resolution to be performed on those data. In particular, name disambiguation is required to allow accurate publication lists, citation counts and impact measures to be determined. This paper describes a graph-based approach to author disambiguation on large-scale citation networks. Using self-citation, co-authorship and document source analyses, AKTiveAuthor clusters papers, achieving precision of 0.997 and recall of 0.818 over a test group of eight surname clusters
Adaptation to flood and salinity environments in the Vietnamese Mekong Delta: Empirical analysis of farmer-led innovations
No full text10.1016/j.agwat.2019.01.020Agricultural Water Management21689-9
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