1,721,333 research outputs found
TRAN HONG THUAN
No full text학위논문(석사)--아주대학교 일반대학원 :신경과학기술과정,2019. 2I. INTRODUCTION 1
II. MATERIALS AND METHODS 5
A. Generation of mkrn1 mutants and fly strains 5
C. Measurement of developmental speed 7
D. RT-PCR analysis 7
E. Western blot analysis 9
F. Immunostaining 10
III. RESULTS 11
A. Loss of MKRN1 delayed development 11
B. Knockdown of mkrn1 paralogs did not produce developmental delay 18
C. Ecdysone synthesizing enzyme expression was reduced in MKRN1 null larvae. 22
IV. Discussion 29
V. Conclusion 34
VI. References 37MasterCentral mechanism for the coordination of growth and sexual maturation is well conserved among invertebrates and vertebrates. While mutations in the gene encoding makorin RING finger protein 3 (mkrn3) have been reported to associate with central precocious puberty in human, causal relationship has not been elucidated. Here, we examine the role of mkrn1, a Drosophila ortholog of mammalian makorin genes in the regulation of developmental timing. Loss of MKRN1 in the mkrn1exS prolonged 3rd instar stage and delayed pupariation timing resulting in bigger size pupae. MKRN1 was expressed in the prothoracic gland in which steroid hormone ecdysone is produced. In mkrn1exS larvae, phantom, which encodes ecdysone- synthesizing enzyme and E74, which is the downstream target of ecdysone, mRNA levels were reduced. Collectively, these results indicate that MKRN1 functions to fine-tune the developmental timing and sexual maturation via affecting ecdysone synthesis in Drosophila. Moreover, our study supports the notion that malfunction of makorin gene family member, mkrn3 cause the puberty timing dysregulation in mammals
Professor Dr Tran Hong Quan and Dr Don Phillips, 1994
No full textProfessor Dr Quan visited Swinburne to inspect the stormwater detention unit, a device with particular application in Vietnam. Left: Dr Don Phillips, School of Civil Engineering and Building and designer of the On-site Stormwater Detention Unit; Centre: Professor Dr Tran Hong Quan, Vietnam's Minister for Education and Training. Swinburne Staff News 13 October 1994
Faces of Mine Action: Tran Hong Chi Addressing the Legacy of UXO in Vietnam
Get PDFTran Hong Chi grew up amid Vietnam’s unexploded ordnance (UXO) contamination. Now as an adult, Chi works as a program coordinator for Clear Path International, which provides medical and rehabilitative assistance to survivors of UXO incidents
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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