3,283 research outputs found
Comparison of the Effectiveness of Percutaneous Intervention of the Left-Main Coronary Artery With Everolimus-Eluting Stents in Women -Vs- Men
No full textEverolimus-eluting stents are largely used for left main (LM) percutaneous coronary interventions (PCI) . Long-term follow-up of patients undergoing LM PCI in a real world clinical setting, in particular women, have been scarcely reported. Consecutive patients undergoing unprotected LM PCI with EES at a single Institution from December 2006 to April 2016 were included. Main outcome assessed was the occurrence of major adverse cardiovascular events (MACE) as a composite of death, myocardial infarction or target lesion revascularization at follow-up. Overall, 589 patients (20.8% women), were included in the present analysis. Women were older, had lower BMI and more frequently hypertensive compared to men. Main clinical presentation was stable CAD; unstable angina was more frequently observed in women compared to men, whereas STEMI was less frequent. After 69.7 ± 28.3 months of follow-up, 47 patients overall experienced MACE (1.43 per 100*patients/year). MACE rate was higher in female compared to male patients, with a rate of 2.49 and 1.17 per 100*patients/year, respectively (P=0.015). The difference was driven mainly by higher mortality in women (0.89 vs. 0.15 per 100*patients/years, P=0.002). At multivariable Cox regression, female gender was independently associated with an increased risk of MACE at follow-up (HR 2.21, 95% CI 1.20 – 4.08, P=0.011). In conclusion, EES can be safely and effectively adopted for LM PC
Xience stent single-center registry
No full textABSTRACT
Background: Safety and effectiveness of the everolimus-eluting stent (EES) have been previously demonstrated.
Aims: To assess very long-term performance and outcomes of the EES in a real-world population. Methods: This single-center registry prospectively enrolled 6,893 patients (mean age 66±9.7 years, 81.4% men) undergoing elective coronary intervention with the EES over a decade. Clinical follow-up (FU) was performed at 1 year and then yearly.
Results: Multiple risk factors were present in 34%. Stable angina was the main stenting indication (78.1%), followed by unstable angina (5.3%) and positive stress test (16.6%) for 1- (44%) or 2/3-VD (56%). Multiple stents (stent/patient ratio: 2.1±0.8) in >1vessel were implanted in 36.9% (mean stent length=43±31.3 mm). At 1 year, 80% of patients were on dual antiplatelet therapy, while 3% only at 2 years. A low (5%) 1-year MACE rate was observed; ST occurred in 19 (0.3%) patients with a prevalence of early (9) over late (4) and very late (6) (0.08%) events. Clinically driven TLR/TVR occurred in 3.3% at 1-year follow-up. Long-term FU (3 years) completed in 6210 (90%) patients showed a 5.9% MACE rate, while very long-term (>5 years and up to 10 years) follow-up, available in 3550 out of 4635 exposed patients (72%), showed an 8.6% MACE rate. Independent MACE predictors were stented segment length (OR: 2.1; 95% CI:1.57-2.82), small vessel stenting (OR: 1.34;95% CI: 1.08-1.68) and multivessel disease (2VD, OR:1.59; 95% CI: 1.21-2.08; 3VD, OR: 2.26; 95% CI: 1.72-2.97).
Conclusions: This large prospective registry confirms the very long-term safety and efficacy of the EES in unselected real world and complex coronary lesions
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Is the Sirolimus encapsulated balloon a reliable tool for treating the in-stent restenosis?-insights from the SABRE trial
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Imparare le lingue per abbracciare il mondo
No full textL’autrice che si colloca, come Daniela Zorzi, tra i fautori di una linguistica “impegnata”, propone in ricordo della studiosa amica, una riflessione sul ruolo cruciale del multilinguismo e delle lingue- culture, per il successo professionale e il benessere sociale, nella società contemporanea. Il multilinguismo appare come un’urgenza educativa che interpella studiosi e formatori a tutti i livelli al fine di promuovere nei giovani un apprendimento consapevole efficace ed autonomo.Multilingualism constitutes an urgent objective for education, which needs to involve teachers and researchers at all levels if we are to promote effective and autonomous learning in the young. Like Daniela Zorzi, the author considers herself a socially engaged linguist, and in memory of her friend’s work, offers a reflection on the key roles of languages and cultures and of multilingualism for professional success and social welfare today
Reclamações ambientais em Aveiro, Portugal: atores, preocupações, padrão territorial e resoluções
No full textThis paper presents an environmental diagnosis based on public complaints on environmental
issues submitted to the Environmental Department of the Aveiro City Council, Portugal, between
2000 and 2005. It discusses the potential influences of these in local environmental planning
and governance. The paper has been organised into five sections. The first of these introduces
the study. The second section focuses on the conceptual approaches relating to environmental
grassroots movements, the main actors involved in these movements and the role played by
local government. It also contains a brief review of the most recent urban environmental
quality challenges in the European context together with a description of the main features of
the associated political and legal framework in Portugal. The third section describes the case
study and the methodology used. The results of the empirical study are detailed in the fourth
section. The final section critically analyses these results with emphases on the temporal
evolution of the submission of complaints, the actors involved, the local environmental problems
and their associated spatial pattern as well as the responses given by the City Council. This
information may then be used to provide a useful indicator for the perception of environmental
quality as well as a credible instrument for the visualisation and evaluation of local performance
in terms of environmental planning and management.AlBan Programme - n. E05M053040B
Jak rozumieć „historyczność” biblijnego Daniela? Różne kierunki wyjaśniania orędzia Księgi Daniela
No full textThe subject of this article is the issue of the historicity of the figure of Daniel, who is the main character of the biblical book bearing his name. The question of whether Daniel is a historical or just a literary figure is important because it influences the exegesis of the text of the Book of Daniel. First, the author will indicate the reasons for questioning the historicity of Daniel, and then he will present different approaches to interpreting the content of the Book of Daniel.Przedmiotem artykułu jest kwestia historyczności postaci Daniela, który jest głównym bohaterem księgi biblijnej noszącej jego imię. Pytanie o to, czy Daniel jest postacią historyczną, czy tylko literacką, jest ważne z tego powodu, że ma wpływ na egzegezę tekstu Księgi Daniela. Najpierw autor wskaże powody, na podstawie których podważa się historyczność Daniela, a następnie przedstawi różne podejścia w interpretacji treści Księgi Daniela
Selected Works of Daniela Krolupperová in Leisure Education for Reading
No full textThis thesis is concerned with usage of selected works of contemporary Czech author Daniela Krolupperová in leisure time education to reading. The thesis is divided into two parts - theoretical and practical. In theoretical part the curriculum vitae and literary creation of the crucial author of publishing houses Albatros, Mladá fronta and Portál Daniela Kroulupperová is presented. Further, literary genre preferred by the author, target groups and selected methods of her work incl. texts used in practical parts, are described. There are also working sheets, their verification in practice and reflection in practical part
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