85 research outputs found
The Need for a Concert of Cytogenomic Methods in Chromosomic Research and Diagnostics
No full textThis review focuses on the experimental methods and technologies of cytogenomics and how they can be combined in the process of chromosomic diagnostics and research. It is stressed that no cytogenomic methods can be comprehensive on their own. The strengths and weaknesses of each method have to be considered. This is especially important in a time where the main stream of human genetics diagnostics is actively proclaiming that high throughput methods are able to replace all other established tests
Spectroscopic (FT-IR, Raman, NMR and UV-vis.) and quantum chemical investigations of (E)-3-[4-(pentyloxy)phenyl]-1-phenylprop-2-en-1-one
No full textGokce, Halil/0000-0003-2258-859X; Naseer, Muhammad Moazzam/0000-0003-2788-2958WOS: 000342254500042In this study, the molecular structure and vibrational and electronic transition spectra and H-1 and C-13 NMR chemical shift values (gas phase and in chloroform solvent), HOMO-LUMO analysis, molecular electrostatic potential (MEP), thermodynamic properties and Mulliken atomic charges of (E)-344-(pentyloxy)phenyl]-1-phenylprop-2-en-1-one molecule, C20H22O2, which has many biological activities have been calculated using the DFT/B3LYP method with 6-311++G(d,p) basis set in the ground state. The obtained results indicate a good harmony among the calculated and the experimental FT-IR, Raman, UV vis. (in methanol solvent) and H-1 and C-13 NMR (in chloroform-d solvent) spectra of the mentioned compound. (C) 2014 Elsevier B.V. All rights reserved.Higher Education Commission of PakistanHigher Education Commission of PakistanThe author AA is grateful to Higher Education Commission of Pakistan for financial support
Giving money to the poor: the political payoffs of allocating conditional cash transfers in Turkey
No full textThis dissertation analyzes the political consequences of the Conditional Cash Transfer program (CCT) in Turkey, The purpose is three-fold: first, to investigate the political incentives and payoffs that motivate policymakers to adopt CCTs; second, to test whether political or technocratic criteria explain the allocation of CCTs in Turkey, and third, to examine whether conditionally transferring cash to the poor empowers poor citizens, or produces/reproduces pressure on the poor to reciprocate by supporting the political party that made the cash transfer. My research draws on six months of fieldwork conducted in Malkara, Tekirdağ (with Roma beneficiaries) and Diyarbakır (with Kurdish beneficiaries), and on regression analysis of original district level data on the allocation of CCTs. I reach three primary conclusions. First, the adoption of CCTs under the coalition government, influenced and pushed by the World Bank, led to a relatively strict formulation of the social assistance scheme in Turkey, which provides a promising attempt to make a transition to programmatic social policy. Second, although on balance, social and economic indicators guide the distribution of funds, Kurdish districts appear to receive favorable treatment. Third, due to the lack of CCTs requirements for increased social participation and active social engagement on the part of beneficiaries, the CCT program does not have a transformative impact on the enhancement of citizenship and the empowerment of women for both the Kurdish and Roma communities. Rather, more politicized groups, such as the Kurdish people, view the benefit as their social right due to state’s inefficiency in creating jobs in the eastern part of Turkey and their uneasy relations with the state. Among less politicized groups, such as the Roma people, the program triggers feelings of gratitude and appreciation to the politicians providing this program, especially Prime Minister Erdoğan.Ph. D.Includes bibliographical referencesby Ozgen Gokce Bayka
Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes
No full textImmunological characterization and transcription profiling of peripheral blood (PB) monocytes in children with autism spectrum disorders (ASD) and specific polysaccharide antibody deficiency (SPAD): case study
No full textAbstract Introduction There exists a small subset of children with autism spectrum disorders (ASD) characterized by fluctuating behavioral symptoms and cognitive skills following immune insults. Some of these children also exhibit specific polysaccharide antibody deficiency (SPAD), resulting in frequent infection caused by encapsulated organisms, and they often require supplemental intravenous immunoglobulin (IVIG) (ASD/SPAD). This study assessed whether these ASD/SPAD children have distinct immunological findings in comparison with ASD/non-SPAD or non-ASD/SPAD children. Case description We describe 8 ASD/SPAD children with worsening behavioral symptoms/cognitive skills that are triggered by immune insults. These ASD/SPAD children exhibited delayed type food allergy (5/8), treatment-resistant seizure disorders (4/8), and chronic gastrointestinal (GI) symptoms (5/8) at high frequencies. Control subjects included ASD children without SPAD (N = 39), normal controls (N = 37), and non-ASD children with SPAD (N = 12). Discussion and Evaluation We assessed their innate and adaptive immune responses, by measuring the production of pro-inflammatory and counter-regulatory cytokines by peripheral blood mononuclear cells (PBMCs) in responses to agonists of toll like receptors (TLR), stimuli of innate immunity, and T cell stimulants. Transcription profiling of PB monocytes was also assessed. ASD/SPAD PBMCs produced less proinflammatory cytokines with agonists of TLR7/8 (IL-6, IL-23), TLR2/6 (IL-6), TLR4 (IL-12p40), and without stimuli (IL-1ß, IL-6, and TNF-α) than normal controls. In addition, cytokine production of ASD/SPAD PBMCs in response to T cell mitogens (IFN-γ, IL-17, and IL-12p40) and candida antigen (Ag) (IL-10, IL-12p40) were less than normal controls. ASD/non-SPAD PBMDs revealed similar results as normal controls, while non-ASD/SPAD PBMCs revealed lower production of IL-6, IL-10 and IL-23 with a TLR4 agonist. Only common features observed between ASD/SPAD and non-ASD/SPAD children is lower IL-10 production in the absence of stimuli. Transcription profiling of PB monocytes revealed over a 2-fold up (830 and 1250) and down (653 and 1235) regulation of genes in ASD/SPAD children, as compared to normal (N = 26) and ASD/non-SPAD (N = 29) controls, respectively. Enriched gene expression of TGFBR (p Conclusions The Immunological findings in the ASD/SPAD children who exhibit fluctuating behavioral symptoms and cognitive skills cannot be solely attributed to SPAD. Instead, these findings may be more specific for ASD/SPAD children with the above-described clinical characteristics, indicating a possible role of these immune abnormalities in their neuropsychiatric symptoms.</p
Postwar negotiations:: the first generation of Turkish "guest workers" in West Germany, 1961-1973
No full textThis dissertation explores the immigration of Turkish "guest workers" to West Germany in the 1960s and 1970s and focuses on the decision making of workers who actively shaped new lives in West Germany, as they dealt with the emerging permanence of their situation. The frequently mismatched interests of the German employers, Employment Bureau Officials, dorm managers, and employers, and of the Turkish workers themselves, highlight the personal as well as institutional negotiations inherent in the guest worker process. Significantly, the immigration of Turkish guest workers to West Germany during the years 1961-1973 now stands at the center of several topical discussions about Germany's postwar ethnic relations, on citizenship in the new Europe, and of Muslim communities' integration in Europe. Turkish guest workers are necessarily a part of the central issues of German and European social, political, and cultural history after 1945, especially in the context of debates concerning "who are Europeans?" and "what makes Europe?"
The sources for this dissertation include Turkish-language sources, including oral history interviews, as well as German sources in addition to an alltag or everyday-life approach to consider the individuals involved. I explore the entire process, examining, for example, interactions between low-ranking German officials and average Turkish workers during the pre-departure application process in Turkey; in a workers' dormitory, as captured in the surveillance records of the dorm manager; and in the workers' own labor organizing. I reveal a breakdown of the streamlined, orderly process that published workers' instructional manuals, the media, and politicians portrayed. Comparing these published accounts with workers' own versions and with memos and records not meant for the public eye demonstrates that there was no standardized guest-worker application, housing, or experience. Additionally, at every step workers achieved modifications and negotiations that reveal ways in which male and female workers were able to maintain a sense of self within a highly controlled and regulated process. In sum, the thesis gives an entirely new picture of the textured and variegated spaces of the lives of individual Turkish guest workers within West Germany's specific postwar history.Ph.D.Includes bibliographical references (p. 201-215)
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Infrastructures of Entrepreneurship: State Reform and Development in Oman
No full textTitled “Infrastructures of Entrepreneurship: State Reform and Development in Oman,” this dissertation explores how under pressure from low oil prices, enormous budget deficits, and a faltering economic model the Omani state has been renegotiating its relationship with global capitalism in a dawning post-oil era. To apprehend this development, I ethnographically explore how the Omani government has embarked on a multi-sited program of economic reform, in which the promotion of entrepreneurship plays an important role. Based on 12 months of archival and field research in London and Muscat, I demonstrate how the state reform project, meant to revitalize the engines of capital accumulation in one country, transcends the “economic.” It explores how emotions, bureaucratic complaints, new ideas about productivity and creativity, foreign experts, and local entrepreneurs are reworking the contours of capitalism in Oman, while seeking to transform the state, society, and the individual. This dissertation provides a glimpse into this complex and contradictory reform process and the exigencies of post-oil development under late capitalism.Originally embargoed upon deposit through 05/19/2028; contacted by Graduate College to apply permanent restriction per author request, 06-July-2021, Kimberly; contacted by author to release dissertation 31-Oct-2023, Kimberly
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