95 research outputs found
The Need for a Concert of Cytogenomic Methods in Chromosomic Research and Diagnostics
No full textThis review focuses on the experimental methods and technologies of cytogenomics and how they can be combined in the process of chromosomic diagnostics and research. It is stressed that no cytogenomic methods can be comprehensive on their own. The strengths and weaknesses of each method have to be considered. This is especially important in a time where the main stream of human genetics diagnostics is actively proclaiming that high throughput methods are able to replace all other established tests
Metallurgical Assessment of Novel Mg-Sn-La Alloys Produced by High-Pressure Die Casting
No full textSakarya University Scientific Research Project Council [2017-0908-014]; Turkish National Scientific Council (Tubitak) via 2219 - International Postdoctoral Research Fellowship ProgramTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1059B191800747]This work was supported by the Sakarya University Scientific Research Project Council under Grant [number 2017-0908-014]. The author also would like to acknowledge funding assistance provided by the Turkish National Scientific Council (Tubitak) via 2219 - International Postdoctoral Research Fellowship Program Grant no 1059B191800747. The help of Ipek GOKCE, Murat GOKCE, Paramjot SINGH and Arulselvan ARUMUGHAM AKILAN in the experimental work are gratefully acknowledged.Mg alloys containing Al are widely used for industrial applications, but the use of these alloys as an automotive part is limited due to the low melting temperature of the Mg17Al12 intermetallic phase. Therefore, magnesium alloys without aluminum that can withstand higher operating temperatures are of interest to the automotive industry. The objective of this work is to develop Al-free Mg alloys for industrial applications. In the current work, four types of alloys were produced with varying La contents. The high-pressure die casting method was selected to overcome the problems inherent in the gravity casting method with respect to the production of parts with complex shapes and thin walls. X-ray diffraction analysis revealed that the base alloy (Mg-5Sn wt%) comprises of alpha-Mg and Mg2Sn phases whereas La containing alloys included intermetallic phases such as LaMg3, Mg17La2, and La5Sn3. Corresponding grain sizes of the alloys with La are lower than those of the Mg5Sn alloy. Due to this lower grain size and emerging dispersoids, the tensile strength of the Mg5Sn4La alloy (205 MPa) is roughly double that of Mg5Sn. Moreover, the addition of the 4% wt. La to the Mg5Sn alloys led to an increase in yield strength and ductility by 25% and 50%, respectively
Spectroscopic (FT-IR, Raman, NMR and UV-vis.) and quantum chemical investigations of (E)-3-[4-(pentyloxy)phenyl]-1-phenylprop-2-en-1-one
No full textGokce, Halil/0000-0003-2258-859X; Naseer, Muhammad Moazzam/0000-0003-2788-2958WOS: 000342254500042In this study, the molecular structure and vibrational and electronic transition spectra and H-1 and C-13 NMR chemical shift values (gas phase and in chloroform solvent), HOMO-LUMO analysis, molecular electrostatic potential (MEP), thermodynamic properties and Mulliken atomic charges of (E)-344-(pentyloxy)phenyl]-1-phenylprop-2-en-1-one molecule, C20H22O2, which has many biological activities have been calculated using the DFT/B3LYP method with 6-311++G(d,p) basis set in the ground state. The obtained results indicate a good harmony among the calculated and the experimental FT-IR, Raman, UV vis. (in methanol solvent) and H-1 and C-13 NMR (in chloroform-d solvent) spectra of the mentioned compound. (C) 2014 Elsevier B.V. All rights reserved.Higher Education Commission of PakistanHigher Education Commission of PakistanThe author AA is grateful to Higher Education Commission of Pakistan for financial support
Giving money to the poor: the political payoffs of allocating conditional cash transfers in Turkey
No full textThis dissertation analyzes the political consequences of the Conditional Cash Transfer program (CCT) in Turkey, The purpose is three-fold: first, to investigate the political incentives and payoffs that motivate policymakers to adopt CCTs; second, to test whether political or technocratic criteria explain the allocation of CCTs in Turkey, and third, to examine whether conditionally transferring cash to the poor empowers poor citizens, or produces/reproduces pressure on the poor to reciprocate by supporting the political party that made the cash transfer. My research draws on six months of fieldwork conducted in Malkara, Tekirdağ (with Roma beneficiaries) and Diyarbakır (with Kurdish beneficiaries), and on regression analysis of original district level data on the allocation of CCTs. I reach three primary conclusions. First, the adoption of CCTs under the coalition government, influenced and pushed by the World Bank, led to a relatively strict formulation of the social assistance scheme in Turkey, which provides a promising attempt to make a transition to programmatic social policy. Second, although on balance, social and economic indicators guide the distribution of funds, Kurdish districts appear to receive favorable treatment. Third, due to the lack of CCTs requirements for increased social participation and active social engagement on the part of beneficiaries, the CCT program does not have a transformative impact on the enhancement of citizenship and the empowerment of women for both the Kurdish and Roma communities. Rather, more politicized groups, such as the Kurdish people, view the benefit as their social right due to state’s inefficiency in creating jobs in the eastern part of Turkey and their uneasy relations with the state. Among less politicized groups, such as the Roma people, the program triggers feelings of gratitude and appreciation to the politicians providing this program, especially Prime Minister Erdoğan.Ph. D.Includes bibliographical referencesby Ozgen Gokce Bayka
Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes
No full textExpression profiling reveals MSX1 and EphB2 expression correlates with the invasion capacity of Wilms tumors
No full textBackground. Wilms tumor is the most common pediatric renal malignancy, but the parameters that are important to its invasion capacity are poorly understood. The aim of this study was to identify new proteins associated with the invasion capacity of Wilms tumor. Procedure. Gene expression profiles for 15 primary Wilms tumor samples were determined by Affymetrix Genechip (R) Human Genome Ul33A microarray analysis. The gene expression profiles for selected genes was further confirmed by quantitative RTPCR analysis. Immunohistochemical analysis was performed on 25 Wilms tumor cases to confirm expression for Bcl2A1, EphB2, MSX1, and RIN1. Results. Using microarray analysis 14 genes showed differential expression (P < 0.05) comparing stage 1 non-invasive Wilms tumor to stages 2-4 invasive Wilms tumor. The differential expression for Bcl2A1, EphB2, MSX1, and RIN1 was confirmed by quantitative RT-PCR. MSX1 protein was statistically significantly lower in stages 2-4 invasive Wilms tumor cases compared to stage 1 non-invasive cases (P = 0.013). EphB2 protein was higher in stages 2-4 Wilms tumor cases compared to stage 1 cases (P = 0.006). There was no statistically significant difference between stages 1 and 2-4 Wilms tumor for Bcl2A1 (P = 0.230) or RIN1 (P = 0.969) at the protein level. Conclusion. Our results indicate that MSX1 may be associated with the invasion capacity of Wilms tumors. RIN1 is a downstream effector of RAS and Bcl2A1 functions as an anti-apoptotic protein. EphB2 is an ephrin receptor and is up-regulated in invasive tumors but its role needs to be confirmed in further cases of Wilms tumors. Pediatr Blood Cancer 2011; 57: 950-957. (C) 2011 Wiley-Liss, Inc
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Infrastructures of Entrepreneurship: State Reform and Development in Oman
No full textTitled “Infrastructures of Entrepreneurship: State Reform and Development in Oman,” this dissertation explores how under pressure from low oil prices, enormous budget deficits, and a faltering economic model the Omani state has been renegotiating its relationship with global capitalism in a dawning post-oil era. To apprehend this development, I ethnographically explore how the Omani government has embarked on a multi-sited program of economic reform, in which the promotion of entrepreneurship plays an important role. Based on 12 months of archival and field research in London and Muscat, I demonstrate how the state reform project, meant to revitalize the engines of capital accumulation in one country, transcends the “economic.” It explores how emotions, bureaucratic complaints, new ideas about productivity and creativity, foreign experts, and local entrepreneurs are reworking the contours of capitalism in Oman, while seeking to transform the state, society, and the individual. This dissertation provides a glimpse into this complex and contradictory reform process and the exigencies of post-oil development under late capitalism.Originally embargoed upon deposit through 05/19/2028; contacted by Graduate College to apply permanent restriction per author request, 06-July-2021, Kimberly; contacted by author to release dissertation 31-Oct-2023, Kimberly
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