1,721,166 research outputs found

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Enamel matrix derivative stabilizes blood clot and improves clinical healing in deep pockets after flapless periodontal therapy: A Randomized Clinical Trial

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    AIM: An acute phase response is induced after non-surgical periodontal treatment (SRP). The main aim of this study was to compare acute phase (24-hr) and medium-term (3-months) inflammation and clinical outcomes after SRP with or without application of enamel matrix derivative (EMD) in sites with probing pocket depth (PPD) ≥ 6 mm. METHODS: Thirty-eight periodontitis-affected subjects were randomized to SRP or SRP + EMD. Periodontal parameters were recorded at baseline and 3 months. Serum samples were collected at baseline, 1 and 90 days after treatment. RESULTS: Both treatments triggered an intense acute inflammation on day 1, which regressed to baseline values at 3 months. D-dimer and cystatin C levels did not show sharp increases in SRP + EMD group 24 hr after treatment, compared to SRP. Significant difference between groups was observed for D-dimer (p < 0.001). EMD application was also associated with better periodontal healing as shown by greater PPD reduction and clinical attachment level gain in sites with PPD ≥ 6 mm, and higher number of cases with no residual PPD ≥ 6 mm (p < 0.05) at 3 months. CONCLUSIONS: EMD application after non-SRP resulted in lower fibrinolysis, and better periodontal healing of deep pockets. These initial observations warrant further investigations on the potential to modulate both local and systemic outcomes of non-SRP. NCT03544931

    The structure of Periodontal tissues formed following guided tissue regeneration therapy of intrabony defect in ther monkey

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    OBJECTIVE: To describe the periodontal tissues formed following guided tissue regeneration (GTR) therapy of intra-bony defects (IBD). METHODS: Eight adult Macaca fascicularis monkeys were used. Proximal IBD were created at the mandibular second pre-molars and second molars. After 3 months, GTR surgery was performed. The animals were euthanized at 6 months and 2 years after surgery. Block biopsies were harvested, and prepared for histological analysis. RESULTS: At 6 months the defect had healed with new cementum (NC), periodontal ligament (PDL) and bone. The NC seemed to be firmly anchored to the dentin. Supra-crestally, the NC consisted of a 10 microm thick layer of acellular extrinsic fibre cementum (AEFC). Sub-crestally, the NC was considerably thicker and consisted of an inner layer of AEFC and an outer thicker layer of cellular mixed fibre cementum (CMFC). The extrinsic fibre density amounted to about 10 fibres per 100 microm. The PDL was wider than the pristine PDL and widened in coronal direction. After 2 years of healing, the thickness of the NC in the sub-crestal compartment had increased by about 20 microm and the fibre density had increased by about 50%. CONCLUSION: After 2 years of healing the structure of the regenerated tissues resembled that of pristine periodontal tissues

    A real-time model of a small turbocharged Multijet Diesel engine: application and validation

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    Theoretical models are useful tools in the design of engine control systems, with applications that range from the definition of optimised management systems, to hardware-in-the-loop testing (HIL) and to model-based control strategies. To define theoretical models for control-oriented applications, an original library has been built up in Matlab®/Simulink® environment for the simulation of the intake and exhaust systems of automotive turbocharged engines. Starting from this library, a Mean Value Model (MVM) of a Diesel engine, with variable-geometry turbocharger (VGT), EGR and throttle valve, has been defined and fitted on a small automotive application. The model allowed to simulate in “real-time” engine behaviour: calculated and experimental data are reported and compared in the paper showing a good agreement both in steady and transient operating conditions

    Periodontal wound healing following GTR therapy of dehiscence-type defects in the monkey: short-, medium- and long-term healing.

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    OBJECTIVE: To describe periodontal wound healing in dehiscence-type defects following guided tissue re-generation (GTR) therapy. METHODS: Ten adult Macaca fascicularis monkeys were used. Buccal dehiscence-type defects were created at the maxillary second pre-molars and second molars. After 3 months, GTR surgery was performed. The animals were euthanized at 6 weeks, 6 months and 2 years after surgery. Block biopsies were harvested, and prepared for histological analysis. RESULTS: A new attachment apparatus was structured already after 6 weeks of healing. A 10-20 microm thin layer of acellular extrinsic fibre cementum (AEFC) had formed along the instrumented root surface. At 6 months, the thickness of the supracrestal cementum was comparable with that at 6 weeks, while the thickness of the subcrestal cementum had increased to 40-60 microm. In this zone, the cementum consisted of an inner layer of AEFC attached to the circum-pulpal dentin and an outer layer of cellular mixed fibre cementum (CMFC). The numerical extrinsic fibre density was twice that at 6 weeks. At 2 years, the periodontal tissues resembled the pristine periodontium. CONCLUSION: Periodontal healing following GTR therapy of recession-type defects will result in a restitutio ad integrum, i.e. healing by re-generation. A continuous maturation process occurs over at least 2 years

    A comparison of particle number and mass collection efficiency of a close-coupled DOC-DPF system under different engine operating conditions

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    PM effects on health are believed to be more related to particle total number rather than to particle total mass. This gave rise in Europe to the forthcoming introduction of an emission standard on total particle number, that will take place for passenger cars from EURO5 (stage b) on. The behavior of the DPF is therefore under investigation, to better understand its effectiveness toward particle number reduction. Moving from that background, a study on the effect of a close coupled DOC-CDPF (Diesel Oxidation Catalyst + Catalyzed Diesel Particulate Filter) on PM emissions is proposed in this paper, with special focus on the comparison between mass and number collection efficiency. Experimental data have been gathered at the engine laboratory of the University of Rome Tor Vergata, equipped with a FIAT 2.0l EURO 5 passenger car engine. Data have been acquired with a TSI 3090 EEPS to measure particle distribution and total number, and an AVL-415 S to measure PM mass emissions. A numerical code has been also developed to represent the DPF behavior, in terms of soot load (g/l) trend, under forced regenerating operating conditions and better understand regeneration potential as a function of time. Results, acquired for three non regenerating and one forced regenerating modes, prove that mass and number efficiencies are close to 100%, with a slight decrease during the forced regeneration mod
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