187 research outputs found
Chasing targets for EGFR tyrosine kinase inhibitors in non-small-cell lung cancer: Asian perspectives
No full textEGF receptor (EGFR) activation has an important role in various steps of carcinogenesis and progression of non-small-cell lung cancer (NSCLC), implying that EGFR is a potential target for cancer therapy. Therefore, targeted treatments aimed at EGFR have been developed, of which tyrosine kinase inhibitors (TKls), gefitinib and erlotinib have shown activity in NSCLC. The unexpected findings of a lack of association between expression of EGFR, the target and efficacy of EGFR TKls and higher response in selective subgroups of patients were puzzling. Identification of somatic activating mutations in the EGFR tyrosine kinase domain solved the mystery and provided new insight. Several lines of study provided information on various molecular targets for EGFR TKl therapy. A target-based patient-selection strategy is expected to eventually lead to tailored therapy for lung cancer.N
Pengaruh Penerapan Pengkajian Keperawatan Anak Dengan Sistem Head To Toe Terhadap Peningkatan Kinerja Perawat Dalam Pendokumentasian Asuhan Keperawatan 01 Ruang Anak Rumah Sakit Umum Daerah Soe Nusa Tenggara Timur Studi Pra Eksperime.N (One Group Pre Test- Post Test Design)
No full textTo carry out an accurate assessment on children, a nurse should be able to systematically observe and perform physical examination. However, in hospitals, particularly at Pediatric Wards, Regional General Hospital, SoE, East Nusa Tenggara, most of assessment data were found not having orderly content and not in line with what needed in child assessment, so that those data were not optimal, resulting in an impression that the information provided from those sources presents as manipulated data. To create assessment recording appropriate for pediatric clients, a proper and effective standardized format should be established and applied as an instrument for assessment. The aim of this study was to evaluate the influence of completeness and accuracy of child nursing assessment data using Head to Toe system on the improvement of nurse's performance in nursing care documentation after receiving intervention that presented as socialization at Pediatric Wards, Regional General Hospital, SoE, East Nusa Tenggara. This study used one group pretest-posttest design. The independent variable was assessment using Head to Toe system and the dependent variable was nurse's performance in nursing care documentation. Population was all nurses at Pediatric Wards, Regional General Hospital, SoE, East Nusa Tenggara, with total sample comprised 13 respondents. Data were collected using questionnaire before and after intervention and were observed and analyzed using "before after" two sample McNemar statistical test with significance level ofp < 0.05. Results revealed difference in the influence of completeness and accuracy of pediatric nursing care assessment data using Head to Toe system to the improvement of nurse's performance in nursing care documentation after receiving intervention, which was presented as socialization, at Pediatric Wards, Regional General Hospital, SoE, East Nusa Tenggara. The significance level was p = 0.004, indicating the presence of the influence of Head to Toe system assessment on nurse's performance in the aspects of data completeness and accuracy
Morphological tubulointerstitial alterations in renal tissue.
No full textAnalysis of 40 fields in the SO, SOE and TO groups and 60 fields in the TOE group. Total area of each field: 277.000 μm2. Degree of morphological alteration: 0–25%; 26–50% and 51–100%. Data are presented as mean ± standard deviation. * p ≤ 0.05 vs. SO; # p ≤ 0.05 vs. SOE; § p ≤ 0.05 vs. TO. SO, sedentary ovariectomized, SOE, sedentary ovariectomized treated with enalapril, TO, trained ovariectomized; TOE, trained ovariectomized treated with enalapril.</p
國中資優生過度激動特質與創造力之相關研究
No full text[[abstract]]The purposes of this study were to investigate the overexcitabilities (OEs) traits and creativity of gifted students, and to explore the relationship between OEs and creativity.
Subjects include 529 7th and 8th gifted students in Taipei City and Taipei County. Data collected by “The Me Scale” and “New Creativity Test”. The main findings of this research are stated as follows:
1) There are significant differences between academically students and talented students on POE, TOE and EOE (P<.001).
2) The male gifted students show more significant POE (F=18.94，P<.001) and TOE (F=11.73，P<.001) then female gifted students. The female gifted students show more significant SOE (F=15.28，P<.001) and EOE (F=17.03，P<.001) then male gifted students.
3) Most of the gifted students get higher score on five subscales of overexcitabilities.
4) There are significant differences between academically and talented students on verbal fluency, figure fluency, figural originality and figural elaboration (P<.05).
5) Gender differences are at more significant level (P<.01) on creative ability except the elaboration.
6) There are significant positive correlation between POE, SOE, TOE, MOE and most of the creative ability(.21≦r≦.09，P<.05).
7) Gender differences have significant positive correlation between POE, TOE, MOE and most of the creative ability.
8) Academically students and talented students have significant positive correlation between POE, TOE, MOE and most of the creative ability.
9) According to the interview with 5 gifted students, who have strong imaginational overexcitability could be well-adapted in social adjustment, emotional adjustment and easier to creative. On the other hand, strong imaginational overexcitability could make gifted students distraction in the regular class.
[[alternative]]Overexcitabilities and peer relationships of gifted students
No full text[[abstract]]The purposes of this study were to investigate the overexcitabilities (OEs) and peer relationships of 5th and 6th gifted students, and to explore the relationship between OEs and peer relationships.
Subjects include 126 gifted students, 1460 regular students, and 4 teachers in Taipei City. Data were collected by means of “The Me Scale”, sociometric nomination inventory, “The Friendship Perception Scale”, and the interview outline based on the reference.
For data analysis, descriptive statistics were used to investigate the OEs and the peer relationships, chi-square test, t-test, and ANOVA were to test the differences of independent variables in OEs and peer relationships. Besides Pearson correlation and the statistical methods mentioned above, qualitative data were recorded as detailed dialogue to explore the relationship between OEs and peer relationships.
The main findings of this research are as follows:
1.The number of gifted students exhibiting more TOE, MOE and EOE is more than regular students.
2.The male gifted students show more significant POE (F＝6.119, p<.05) and TOE (F＝4.210, p<.05) than female gifted students.
3.The male gifted students are more popular than regular male students (χ²=10.977，p<.05), and the difference of popularity between female gifted students and regular female students is not significant.
4.The percentage of the gifted students nominating the same-sex friends mutually is .78, and the proportion of gifted students regarding other gifted as friends is not low (.45).
5.There is no gender difference in the friendship reciprocity of the gifted students (χ²=2.346, p>.05).
6.The average amount of the gifted students’ friends is 2.82 (SD＝1.7).
7.There is no gender difference in the number of the gifted students’ friends (t＝-1.781, p>.05).
8.Gifted students have good friendship qualities in terms of ‘association’, ‘admiration’, ‘affection’, ‘prosocial’, and ‘intimacy’.
9.The friendship qualities of female gifted students are better than male gifted students in ‘association’ (F＝5.52, p<.05), ‘prosocial’ (F＝12.882, p<.001), and ‘intimacy’ (F＝9.659, p<.01). Besides, in ‘association’, gifted students with mutual nomination score higher than those with unilateral nomination (F＝7.851, p<.01).
10.Those traits of TOE and MOE, such as intelligent, charming wit and humor, and a few characteristics of EOE can be factors contributing to the sociometric status of gifted students.
11.Those traits of TOE and EOE, such as busybody and irascible, and a few characteristics of POE are reasons that classmates don’t like gifted students.
12.Gifted students with medium SOE (χ²=11.942，p<.05), MOE (χ²=6.801，p<.05), and EOE (χ²=10.864，p<.05) tend to have regular or good popularity, and those with higher SOE, MOE and EOE are likely to be neglected and rejected.
13.There are no differences among levels of OEs in the friendship reciprocity of the gifted students (p>.05).
14.Gifted students with medium TOE have more friends, and those with higher TOE have less friends (χ²=5.217，p<.05).
15.In terms of the correlation between OEs and friendship qualities, there is low positive correlation between SOE and ‘extracharacteristic’ (r＝.205), and low negative correlation between SOE and ‘admiration’ (r＝-.266).
16.According to the interview with 4 gifted students, the differences of the demonstration of EOE, in aspects of feelings of guilt, concern with death, complex emotions, strong affective memory, identification with others’ feelings, and sensitivity in relationships, between the popular and rejected gifted students show the unfavorable impact of EOE on peer relationship.
Preparation and Characterization of Magnesium Ferrite (MgFe2O4) Nanoparticles
No full textThe materials with porous structure and high surface area are very popular for several applications in nanotechnology in the current years. The present research deals with a study on the synthesis and characterization of (spinels) nanoparticles (MgFe2O4). Two types of MgFe2O4 nanoparticles were synthesized by sol-gel method using two different acids such as acetic acid and formic acid. The metal nitrates such as magnesium nitrate and ferric nitrate were used as oxidizers. The gels were dried in the oven at temperature of 105°C to obtain constant weights. The resulting samples were thermally treated in the muffle furnace at temperature of 400 ºC for four hours to get required MgFe2O4 nanoparticles. The prepared samples were characterized by X-ray powder diffraction (XRD), Fourier transform Infrared spectroscopy (FTIR) and Energy Dispersive X-ray fluorescence (EDXRF)
Representative renal histological sections from the studied groups stained with Masson’s trichrome at a 20x objective lens magnification.
No full textCollagen deposition represented by blue color. (A) sedentary ovariectomized (SO), (B) sedentary ovariectomized treated with enalapril (SOE), (C) trained ovariectomized (TO) and (D) trained ovariectomized treated with enalapril (TOE) groups. * Glomeruli; † Tubular atrophy; ‡ Severe tubular injury.</p
Renal function parameters.
No full text(A) Serum urea, (B) serum creatinine, (C) creatinine clearance and (D) protein levels in the urine in sedentary ovariectomized (SO), sedentary ovariectomized treated with enalapril (SOE), trained ovariectomized (TO) and trained ovariectomized treated with enalapril (TOE) groups. Data are presented as mean ± standard deviation. * p≤ 0.05 vs. SO.</p
Blood pressure and blood pressure variability.
No full text(A) Systolic blood pressure, (B) standard deviation of systolic blood pressure, (C) variance of systolic blood pressure, (D) low frequency band of systolic blood pressure and (E) alpha index in sedentary ovariectomized (SO), sedentary ovariectomized treated with enalapril (SOE), trained ovariectomized (TO) and trained ovariectomized treated with enalapril (TOE) groups. Data are presented as mean ± standard deviation. * p ≤ 0.05 vs. SO; # p ≤ 0.05 vs. SOE; § p ≤ 0.05 vs. TO. SBP, systolic blood pressure; SD-SBP, standard deviation of systolic blood pressure; VAR-SBP, variance of systolic blood pressure; LF-SBP, low frequency band of systolic blood pressure; α, alpha index.</p
Jehovah's Witnesses and Ethics
No full textThe Jehovah's Witnesses is a Christian sect that was founded in the late 1870 by Charles Russel in Pittsburgh, Pennsylvania. What began as a small Bible study group evolved into a religious sect that currently includes over 2.6 million members worldwide
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