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    Impact de l'identification précoce de la porte d'entrée du choc septique sur les défaillances d'organes

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    Introduction: Septic shock accounts for 10 to 15% of ICU admissions and is a major cause of morbidity and mortality. Early identification of the source of septic shock is essential for optimizing management and improving prognosis. However, the actual impact of this rapid identification on organ failures remains to be demonstrated. The objective of the study was to determine whether knowledge of the source upon admission influenced the SOFA score and other morbidity and mortality criteria, particularly in cirrhotic patients. Material and method: This retrospective monocentric study, conducted at the CHU of Amiens, included 144 patients admitted to the ICU in 2022 for suspected septic shock. Patients were divided into two groups: those with a confirmed source and those with an uncertain source at admission. The primary outcome was an increase of at least 2 points in the SOFA score between ICU admission and the third day of treatment. Results: Of the 144 patients, 113 had a confirmed source, while 31 had an uncertain source. No significant difference was observed regarding the worsening of the SOFA score at 72 hours (p > 0.05). However, advanced age (>80 years), COPD, and a high SOFA score at admission were associated with worsening organ failures. Among cirrhotic patients, the SOFA score increased more often when the source was unknown. Discussion: The lack of a significant association between an unknown source and the worsening of organ failures may be explained by standardized management or by the limitations of the SOFA score. However, in cirrhotic patients, an unknown source seems to be associated with a worse prognosis, suggesting a need for more diagnostic investigations in this population. Conclusion: The lack of knowledge of the source of septic shock at admission does not worsen the SOFA score on day 3.Introduction : le choc septique représente 10 à 15 % des admissions en réanimation et constitue une cause majeure de morbi-mortalité. L'identification précoce de la porte d'entrée du choc septique est essentielle pour optimiser la prise en charge et améliorer le pronostic. Cependant, l'impact réel de cette identification rapide sur les défaillances d'organes reste à démontrer. L'objectif de l'étude était de déterminer si la connaissance de la porte d'entrée dès l'admission influençait le score SOFA et d'autres critères de morbi-mortalité, notamment chez les cirrhotiques. Matériel et méthode : cette étude rétrospective monocentrique, réalisée au CHU d'Amiens, a inclus 144 patients admis en réanimation en 2022 pour suspicion de choc septique. Les patients ont été répartis en deux groupes : ceux avec une porte d'entrée certaine et ceux avec une porte d'entrée incertaine à l'admission. Le critère de jugement principal était l'augmentation du score SOFA d'au moins 2 points entre l'admission en réanimation et le troisième jour de prise en charge. Résultats : sur les 144 patients, 113 avaient une porte d'entrée certaine et 31 avaient une porte d'entrée incertaine. Aucune différence significative n'a été observée quant à l'aggravation du score SOFA à 72 heures (p > 0,05). Toutefois, un âge avancé (>80 ans), la BPCO et un score SOFA élevé à l'admission étaient associés à une aggravation des défaillances. Chez les cirrhotiques, le score SOFA augmentait plus souvent en cas de porte d'entrée inconnue. Discussion : l'absence d'association significative entre la méconnaissance de la porte d'entrée et l'aggravation des défaillances d'organes peut s'expliquer par la prise en charge standardisée ou bien par les limites relatives au score SOFA. Cependant, chez les cirrhotiques, la méconnaissance de la porte d'entrée semble associée à un pronostic plus défavorable suggérant un besoin d'investigations diagnostiques plus poussées dans cette population. Conclusion : la méconnaissance de la porte d'entrée du choc septique à l'admission n'aggrave pas le score SOFA à J3

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Author Index

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    koamabayili/VECTRON-author-checklist: VECTRON author checklist

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    We have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used

    Author Under Sail The Imagination of Jack London, 1893-1902

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    In Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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