5,444 research outputs found
Soluble TREM2 distinguishes neuromyelitis optica spectrum disorder from MOG antibody disease
No full text[no abstract available
Treatment decisions in multiple sclerosis-insights from real-world observational studies
No full textThe complexity of multiple sclerosis (MS) treatment means that doctors and decision-makers need the best available evidence to make the best decisions for patient care. Randomized controlled trials (RCTs) are accepted as the gold standard for assessing the efficacy and safety of any new drug, but conclusions of these trials do not always aid in daily decision-making processes. Indeed, RCTs are usually conducted in ideal conditions, so can measure efficacy only in restricted and unrepresentative populations. In the past decade, a growing number of MS databases and registries have started to produce long-term outcome data from large cohorts of patients with MS treated with disease-modifying therapies in real-world settings. Such observational studies are addressing issues that are otherwise difficult or impossible to study. In this Review, we focus on the most recently published observational studies designed to identify predictors of poor outcome and treatment response or failure, and to evaluate the relative and long-term effectiveness of currently used MS treatments. We also outline the statistical approaches that are most commonly used to reduce bias and limitations in these studies, and the challenges associated with the use of 'big MS data' to facilitate the implementation of personalized medicine in MS
Experimental and FEM analysis of mar behavior on amorphous polymers
No full textMar is a type of subtle surface damage caused by a sliding object barely visible to human eyes. This minor damage phenomenon has rarely been systematically studied. Significant research efforts for the fundamental understanding of mar behavior in polymers are still needed. In this study, the mar behavior of a series of model amorphous polymers, i.e., polymethylmethacrylate (PMMA), polycarbonate (PC), and polystyrene (PS), were investigated based on a modified ASTM/ISO scratch testing methodology and a corresponding finite element method (FEM) modeling. Furthermore, the mar-induced visibility and material parameter relationships were established through a systematic FEM parametric study. Experimental results show that PMMA has the highest mar visibility resistance, indicated by lower surface roughness variation and low contrast between marred region and the background. The numerical analysis showed that the maximum principal plastic strain (ε1p) and total dissipated plastic energy (Ep) can be considered for evaluating mar visibility resistance. Higher mar visibility resistance corresponds to lower ε1p and Ep values. Based on these two criteria, the parametric analysis shows that mar visibility resistance increases with lower modulus, higher yield stress, higher hardening slope, and lower softening slope. The usefulness of the present study for the preparation of mar resistant polymers is discussed.Structural Integrity & Composite
MSJ877810_supplementary_table_1 – Supplemental material for The long-term outcomes of CIS patients in the Barcelona inception cohort: Looking back to recognize aggressive MS
No full textSupplemental material, MSJ877810_supplementary_table_1 for The long-term outcomes of CIS patients in the Barcelona inception cohort: Looking back to recognize aggressive MS by Mar Tintore, Georgina Arrambide, Susana Otero-Romero, Pere Carbonell-Mirabent, Jordi Río, Carmen Tur, Manuel Comabella, Carlos Nos, María Jesús Arévalo, Elisenda Anglada, Rebeca Menendez, Luciana Midaglia, Ingrid Galán, Angela Vidal-Jordana, Joaquin Castilló, Patricia Mulero, Ana Zabalza, Breogan Rodríguez-Acevedo, Marta Rodriguez, Carmen Espejo, Joao Sequeira, Raquel Mitjana, Andrea de Barros, Deborah Pareto, Cristina Auger, Santiago Pérez-Hoyos, Jaume Sastre-Garriga, Alex Rovira and Xavier Montalban in Multiple Sclerosis Journal</p
Efficient implementation of the domain-integrated field relations method for quasi-static magnetic fields
No full textAuthor accepted manuscript of the 17th Annual Review of Progress in Applied Computational Electromagnetics, Monterey, pp. 337-344, 19 Mar 2001 → 23 Mar 2001Electrical Engineering, Mathematics and Computer Scienc
MSJ877810_supplementary_table_2 – Supplemental material for The long-term outcomes of CIS patients in the Barcelona inception cohort: Looking back to recognize aggressive MS
No full textSupplemental material, MSJ877810_supplementary_table_2 for The long-term outcomes of CIS patients in the Barcelona inception cohort: Looking back to recognize aggressive MS by Mar Tintore, Georgina Arrambide, Susana Otero-Romero, Pere Carbonell-Mirabent, Jordi Río, Carmen Tur, Manuel Comabella, Carlos Nos, María Jesús Arévalo, Elisenda Anglada, Rebeca Menendez, Luciana Midaglia, Ingrid Galán, Angela Vidal-Jordana, Joaquin Castilló, Patricia Mulero, Ana Zabalza, Breogan Rodríguez-Acevedo, Marta Rodriguez, Carmen Espejo, Joao Sequeira, Raquel Mitjana, Andrea de Barros, Deborah Pareto, Cristina Auger, Santiago Pérez-Hoyos, Jaume Sastre-Garriga, Alex Rovira and Xavier Montalban in Multiple Sclerosis Journal</p
"En el mar", 1899 Diciembre 3
No full textabstract: Handwritten poem composed by Rubén Darío.The original Rubén Darío Papers 1882-1945 (MSS-339) are located at ASU Libraries Archives & Special Collections. For more information about visiting the collection see http://hdl.handle.net/2286/L.A.0.The first page has the title "En el mar" and Ruben Dario's name. Likewise the odd numbers pages have the written words "En el mar..." as well as Ruben Dario's name.On the first page of this piece, beside the composition date, is written the word "Madrid".Most pages show transfer ink from the reverse opposing page.All pages are numerated in roman numerals
Mortality of marine planktonic copepods : global rates and patterns
No full textUsing life history theory we make predictions of mortality rates in marine epi-pelagic copepods from field estimates of adult fecundity, development times and adult sex ratios. Predicted mortality increases with temperature in both broadcast and sac spawning copepods, and declines with body weight in broadcast spawners, while mortality in sac spawners is invariant with body size. Although the magnitude of copepod mortality does lie close to the overall general pattern for pelagic animals, copepod mortality scaling is much weaker, implying that small copepods are avoiding some mortality agent/s that other pelagic animals of a similar size do not, We compile direct in situ estimates of copepod mortality and compare these with our indirect predictions; we find the predictions generally match the field measurements well with respect to average rates and patterns. Finally, by comparing in situ adult copepod longevity with predation-free laboratory longevity, we are able to make the first global approximations of the natural rates of predation mortality. Predation and total mortality both increase with increasing temperature; however, the proportion that predation makes of total adult mortality is independent of ambient temperature, on average accounting for around 2/3 to 3/4 of the total
Geschichte Josefs von Mar Narses
No full textThis volume contains Grabowski’s inaugural dissertation: an edition, with annotated translation, of one of Narsai’s poems on the Joseph story from Genesis. The Syriac text was edited from a Berlin manuscript, and Grabowski, in the introduction, discusses Narsai’s possible sources and the meter, and gives a description of the manuscript itself. The notes to the translation highlight biblical, lexicographical, textual, and literary details.Annotated translation from the Syriac to German
- …
