1,436 research outputs found
Sponge-associated fungi and their bioactive compounds - the Suberites case
No full textSpecimens of Suberites domuncula that had been cultured in aquaria for 4 weeks were analyzed for their associated fungi. A total of 81 fungal strains belonging to 20 different genera was isolated and identified by morphological and molecular methods. The most frequently isolated taxa were Cladosporium spp., Penicillium spp., Petriella sp., Phialophora spp. and Engyodontium album. Based on chromatographic and mass spectrometric analysis of fungal extracts, as well as on bioassay results, Aspergillus ustus, Penicillium sp., Petriella sp. and Scopulariopsis sp. were selected for in-depth analysis of their natural products. A total of 19 different fungal metabolites, including three new natural products, was isolated and structurally identified. A. ustus yielded two sesquiterpenes, a drimane derivative and deoxyuvidin, as well as a sesterterpene ophiobolin H. The drimane derivative had an ED50 value against L5178Y cells of 1.9 mu g ml(-1) in vitro. The crude extract of Petriella sp. was also strongly cytotoxic against the L5178Y cell line. The cyclic tetrapeptide WF-3161 was primarily responsible for the activity; the ED50 value was <0.1 mu g ml(-1). It was identical to the known compound WF-3161 and had been previously isolated from Petriella guttulata. In addition to WF-3161, three further natural products were obtained and unequivocally identified as new derivatives of infectopyrone by one-and two-dimensional NMR spectroscopy and by mass spectroscopy. Of the new compounds, only dihydroinfectopyrone was active against L5178Y cells; the ED50 value was 0.2 mu g ml(-1). Penicillium sp. yielded the largest number of metabolites. Viridicatin, viridicatol, cyclopenin and cyclopenol suppressed larval growth of the polyphagous pest insect Spodoptera littoralis when incorporated into an artificial diet at an arbitrarily chosen concentration of 237 ppm. Viridicatol was the most active compound and had an ED50 value of ca. 50 ppm. Scopulariopsis sp. yielded three metabolites, including the known acetylcholinesterase inhibitors quinolactacin A1 and A2
Giftedness and talent
No full textOne of the most contentious debates in psychology, education, biology, and other related disciplines centres on the source of exceptional ability. This chapter addresses fundamental issues surrounding the nature/nurture debate in music and, in doing so, scrutinises much of the folklore that typically accompanies remarkable musical abilities. Specifically, it outlines a broad framework that distinguishes between 'giftedness' and 'talent' and discusses, in turn, six core components of this framework: giftedness, the developmental process, intrapersonal factors, environmental catalysts, chance, and talent. It then explores the scope and potential for identifying musically gifted children. Throughout, it draws on the early experiences of Wolfgang Amadeus Mozart, commonly evoked as the paradigmatic example of childhood accomplishment, to elucidate these components
MULTIPHOTON DISSOCIATION AND IONIZATION OF Ni(CO), AND VARIOUS COBALT COMPLEXES IN A JET-COOLED MOLECULAR BEAM: COMPARISON WITH MPI OF WF.
No full textAuthor Institution: Department of Chemistry, University of Illinois at ChicagoMutiphoton ionization spectroscopy of Ni(CO), and various cobalt complexes have been investigated. Their MPI spectra exhibited relatively sharp and narrow peaks, namely atomic lines, in the 410-510nm region. Two-photon resonance ionization spectra of metal atoms have been observed in Ni(CO), and cobalt complexes. The multiphoton process for dissociation and ionization in these complexes will be discussed. However, MPI spectra of WF, have exhibited broad bands over the 450-500nm region. The MPI spectra of WF, are quite different than those of Ni(CO), and cobalt complexes: no atomic bands have been observed. The spectra can be instead assigned to three-photon molecular resonance ionization of WF,. All the MPI spectra observed have been assigned and predicted pathways of the MPD/MPI mechanism have been postulated based on energertic thresholds and a power study. Comparison between molecular MPI and atomic MPI in the supersonic jet expansion will be discussed
Thielen, Clara (Birth, 1886-04-15)
No full textAddress: 17 Rice2467/Pg 134/1886/WF/Ger./Ger./Cath.Kessen,Mid.Original record filed in drawer labeled 'THIE- THOMPSON'
Tieferman (Birth, 1887-06-03)
No full textAddress: 317 Wade3665/Pg 90/1887/WF/Germ./Germ./Mrs Buetker, Mid.Original record filed in drawer labeled 'THOMPSON-TIMMERN'
Tieman, Goldie (Birth, 1887-06-17)
No full textAddress: 263 W. 6th St.3205/Pg. 79/1887/WF/Am./Am./J. P. WalkerOriginal record filed in drawer labeled 'THOMPSON-TIMMERN'
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