1,660 research outputs found

    Adenine phosphoribosyltransferase deficiency: its inheritance and occurrence in a female with gout and renal disease

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    Summary: Adenine phosphoribosyltransferase deficiency: its inheritance and occurrence in a female with gout and renal disease. B. T. Emmerson, R. B. Gordon and L Thompson, Aust. NX. J. Med., 1975,5, pp. 440–446

    The IPHAS catalogue of H alpha emission-line sources in the northern Galactic plane

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    We present a catalogue of point-source H alpha emission-line objects selected from the INT/WFC Photometric Ha Survey (IPHAS) of the northern Galactic plane. The catalogue covers the magnitude range 13 <= r' <= 19.5 and includes Northern hemisphere sources in the Galactic latitude range -5 degrees < b < 5 degrees. It is derived from similar to 1500 deg(2) worth of imaging data, which represents 80 per cent of the final IPHAS survey area. The electronic version of the catalogue will be updated once the full survey data become available. In total, the present catalogue contains 4853 point sources that exhibit strong photometric evidence for Ha emission. We have so far analysed spectra for similar to 300 of these sources, confirming more than 95 per cent of them as genuine emission-line stars. A wide range of stellar populations are represented in the catalogue, including early-type emission-line stars, active late-type stars, interacting binaries, young stellar objects and compact nebulae. The spatial distribution of catalogue objects shows overdensities near sites of recent or current star formation, as well as possible evidence for the warp of the Galactic plane. Photometrically, the incidence of Ha emission is bimodally distributed in (r' - i'). The blue peak is made up mostly of early-type emission-line stars, whereas the red peak may signal an increasing contribution from other objects, such as young/active low-mass stars. We have cross-matched our H alpha-excess catalogue against the emission-line star catalogue of Kohoutek & Wehmeyer, as well as against sources in SIMBAD. We find that fewer than 10 per cent of our sources can be matched to known objects of any type. Thus IPHAS is uncovering an order of magnitude more faint (r' > 13) emission-line objects than were previously known in the Milky Way

    Isotopic palaeodiet studies of Ancient Egyptian fauna and humans

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    We report here stable carbon and nitrogen isotope results from human and faunal bone collagen from samples taken from sites in the Egyptian Nile Valley and surrounding region, dating from the Predynastic (c. 5500 BC) through to the Dynastic (c. 343 BC) periods. Isotopic values for the human population cluster together across this broad time range, with high ?15N ratios, and ?13C values indicating a largely C3 based diet. The human data is not easily explained through comparison with our associated faunal data, and so may be explained by the consumption of protein from an ecosystem we did not adequately sample, such as freshwater fish or plants and fauna with unusually high ?15N values due to the extreme aridity of this region. The faunal isotopic data we did produce shows a great range in values between and within species, especially in cattle, and reflects the close proximity of three ecozones across a relatively narrow geographical area; the river, the immediate flood-plain area around the Nile and the desert surroundings. <br/

    Energetic Ions at Earth's Quasi-Parallel Bow Shock

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    Zugl.: München, Univ., Diss., 200

    Introduction to special issue on high speed solar wind streams and geospace interactions (HSS-GI)

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    This special issue of the Journal of Atmospheric and Solar-Terrestrial Physics is devoted to research into high speed solar wind streams (HSSs) and their effects on the region of near-Earth space commonly known as ‘geospace’. Interest in the effects of HSSs has increased during the last solar cycle and, following the successful meeting focusing on corotating solar wind streams in Manaus, Brazil (Tsurutani et al., 2006), we recognised the need for further work on the topic, with particular focus on HSSs and their effects in the inner magnetosphere, ionosphere, and neutral atmosphere. As a result the High Speed Solar Wind Streams and Geospace Interactions (HSS–GI) Workshop was held at Hilltop, St. Martin's College in Ambleside, UK, from 2 to 7 September, 2007 (Kavanagh and Denton, 2007; Denton et al., 2008 M.H. Denton, J.E. Borovsky, R.B. Horne, R.L. McPherron, S.K. Morley and B.T. Tsurutani, High speed solar wind streams: a call for key research, EOS Trans. AGU 89 (7) (2008), pp. 62–63. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (7)Denton et al., 2009), sponsored by the Department of Communication Systems at Lancaster University. The majority of the work presented in this special issue was prompted by discussion and interaction at the workshop. It is indeed an indication of the importance of HSSs that the papers in this issue cover the entire region from the Sun and solar wind, through the magnetosphere, and into the ionosphere, thermosphere, and down to the stratosphere. It is hoped that this research will stimulate more understanding, appreciation, and research, into these important drivers of physical phenomena within geospace

    An updated meta-analysis to understand the variable efficacy of drotrecogin alfa (activated) in severe sepsis and septic shock

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    Background. Significant debate continues over the efficacy of drotrecogin alpha activated (DAA) in sepsis. This updated meta-analysis provides an updated summary effect estimate and explores the reasons for outcome heterogeneity in placebo-controlled randomized clinical trials of DAA on 28-day all-cause mortality in patients with severe sepsis or septic shock. Methods. Computer searches of MEDLINE, EMBASE, the Cochrane Library, ClinicalTrials.gov, published abstracts from major intensive care meetings and examination of reference lists were used to identify five placebo-controlled randomized clinical trials with 7260 patients. The primary endpoint was 28-day all-cause mortality. Secondary outcomes were 28-day incidence of severe bleeding and intracranial hemorrhage. Results. DAA was not associated with improved 28-day all-cause mortality in patients with severe sepsis or septic shock (pooled relative risk (RR) of 0.97 [95% CI 0.83-1.14]), and is associated with an increase in serious bleeding. The significant heterogeneity in the pooled RR for 28-day mortality (I2 value of 59.4%, χ2 P-value 0.043) is no longer present with exclusion of the post-study amendment portion of PROWESS (I2 value of 0%, χ2 P-value 0.44 without PROWESS post-amendment). Using meta-regression, the best ranked predictor of outcome heterogeneity was baseline mortality in the placebo arm, which was among the highest in PROWESS. Conclusion. DAA is not associated with improved survival in patients with severe sepsis or septic shock. Further studies should be done to determine whether changes in supportive therapy for sepsis explain the variable efficacy of DAA in randomized controlled clinical trials observed over time
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