23 research outputs found
MENDORONG LITERASI DIGITAL GURU MELALUI MANAJEMEN PENDIDIKAN: TINJAUAN LITERATUR
No full textThe development of digital technology has had a significant impact on the world of education, particularly in how teachers structure, implement, and assess the learning process. This condition requires teachers to have digital literacy skills that not only focus on technical skills, but also include critical thinking, ethical awareness, and creativity in information management. This article aims to analyze the role of educational management in improving teachers' digital literacy through a literature study with a qualitative descriptive approach. The analysis was conducted using content analysis of various relevant academic sources for the period 2021–2025. The results of the study indicate that educational management plays a strategic role in three main dimensions: (1) the formulation of adaptive digital policies and curricula, (2) the provision and optimal utilization of technological infrastructure, and (3) the implementation of teacher training and professional development. These three aspects complement each other and emphasize that improving digital literacy is not only the responsibility of individual teachers, but also the result of a synergy of policies, support facilities, and structured managerial programs. Of this research lies in the integration of the three dimensions of educational management into a holistic conceptual framework, which has not been widely explored in studies of teacher digital literacy
PENDAMPINGAN DIGITAL MARKETING UNTUK MENINGKATKAN PENJUALAN USAHA RUMAH HAWWA
No full textRumah Hawwa merupakan salah satu UMKM yang bergerak dalam produksi busana muslimah serta berbagai kerajinan tangan. Meskipun memiliki potensi produk yang kompetitif, usaha ini masih menghadapi tantangan dalam memanfaatkan peluang pemasaran digital secara optimal. Untuk menjawab permasalahan tersebut, program pengabdian ini dirancang dengan tujuan meningkatkan kemampuan dan pengetahuan pelaku usaha Rumah Hawwa dalam menerapkan strategi pemasaran digital, khususnya melalui pemanfaatan media sosial dan platform e-commerce secara lebih efektif, efisien, dan berkelanjutan. Metode pelaksanaan meliputi kegiatan pelatihan dasar, pendampingan intensif, praktik pembuatan foto dan video konten, serta evaluasi perkembangan yang dilakukan secara bertahap dengan melibatkan partisipasi aktif peserta pelatihan. Berdasarkan hasil kegiatan, terjadi peningkatan pemahaman peserta sebesar 33,3% mengenai konsep pemasaran digital, disertai peningkatan kemampuan dalam merancang konten promosi, mengelola akun bisnis, serta menganalisis perilaku pasar digital sebagai dasar pengambilan keputusan pemasaran. Secara keseluruhan, program ini memberikan dampak positif terhadap peningkatan kompetensi pelaku UMKM dan berkontribusi pada penguatan daya saing Rumah Hawwa di tengah dinamika transformasi digital yang semakin berkembang pesat
Alternative activation of macrophages by IL-4 requires SHIP degradation
No full textAlternatively activated macrophages are critical in host defense against parasites and are protective in inflammatory bowel disease, but contribute to pathology in asthma and solid tumors. The mechanisms underlying alternative activation of macrophages are only partially understood and little is known about their amenability to manipulation in pathophysiological conditions. Herein, we demonstrate that Src homology 2-domain-containing inositol-5'-phosphatase (SHIP)-deficient murine macrophages are more sensitive to IL-4-mediated skewing to an alternatively activated phenotype. Moreover, SHIP levels are decreased in macrophages treated with IL-4 and in murine GM-CSF-derived and tumor-associated macrophages. Loss of SHIP and induction of alternatively activated macrophage markers, Ym1 and arginase I (argI), were dependent on phosphatidylinositol 3-kinase (PI3K) activity and argI induction was dependent on the class IA PI3Kp110δ isoform. STAT6 was required to reduce SHIP protein levels, but reduced SHIP levels did not increase STAT6 phosphorylation. STAT6 transcription was inhibited by PI3K inhibitors and enhanced when SHIP was reduced using siRNA. Importantly, reducing SHIP levels enhanced, whereas SHIP overexpression or blocking SHIP degradation reduced, IL-4-induced argI activity. These findings identify SHIP and the PI3K pathway as critical regulators of alternative macrophage activation and SHIP as a target for manipulation in diseases where macrophage phenotype contributes to pathology.Peer reviewedfinal article publishedAlternatively activated macrophagesSHIPIL‐
Self-Pity: Exploring the Links to Personality, Control Beliefs, and Anger
Full text linkSelf-pity is a frequent response to stressful events. So far, however, empirical research has paid only scant attention to this subject. The present article aims at exploring personality characteristics associated with individual differences in feeling sorry for oneself. Two studies with N = 141 and N = 161 university students were conducted, employing multidimensional measures of personality, control beliefs, anger, loneliness, and adult attachment. With respect to personality, results showed strong associations of self-pity with neuroticism, particularly with the depression facet. With respect to control beliefs, individuals high in self-pity showed generalized externality beliefs, seeing themselves as controlled by both chance and powerful others. With respect to anger expression, self-pity was primarily related to anger-in. Strong connections with anger rumination were also found. Furthermore, individuals high in self-pity reported emotional loneliness and ambivalent-worrisome attachments. Finally, in both studies, a strong correlation with gender was found, with women reporting more self-pity reactions to stress than men. Findings are discussed with respect to how they support, extend, and qualify the previous literature on self-pity, and directions for future empirical research are pointed out
HUKUM TUKAR GULING TANAH STUDI KOMPARASI HUKUM ISLAM DAN HUKUM POSITIF
Full text linkThe exchange of land according to the laws and regulations in force in Indonesia is as follows, KUH.Per as regulated in Article 1541, the word exchange of land has the meaning of an agreement, whereby both parties bind themselves to give each other goods in reciprocity, as exchange for an item. Meanwhile, land is a gift from God Almighty to the people, nation and State of Indonesia, which must be cultivated, exploited and utilized for the greatest prosperity of the people. if it is appropriate and the same then justice can be applied otherwise if not this will cause, problems then the instrument will appear without justice. The concept of swapping is one way of transaction. In the big Indonesian dictionary, swapping means exchanging goods without adding money. The rise in cases of land swapping in Indonesia is for nothing other than expediency. In Islamic Law and Positive Law, there is no need for land swaps that are outside of laws or statutes and also Islamic law. Departing from this background, the author is interested in researching how land swaps are carried out according to Islamic law and positive law and pondered this in alegal research entitled "Land Exchange Law Comparative Study of Islamic Law and Positive Law". The aim of this research is to find out what the laws and regulations are according to Islamic law and positive law regarding land swaps.
The type of researcher used in this research is library research, which is a series of activities related to data collection methods or materials sourced from books, scientific journals, or internet websites that have relevance to the title. The nature of this research is descriptive-analytic, namely an orderly breakdown of all concepts that are relevant to the research being discussed. Next, the data that has been collected is compiled and analyzed. So that later we will analyze the law of land exchange according to Islamic law and positive law using the theory of Good Governance.
The results of this thesis research show that there are two conclusions. Firstly, in Islamic Law and Positive Law, Imam Malik allows land swaps in emergency situations, but it is also based on the principle of the land, namely the existence of benefits in the future. Secondly, according to positive law, it is permissible to exchange land provided that it refers to the principles of Good Governance which include Accountability, Rule of law, Transparency
Actual State of the Tokharian Studies
Full text linkAs a continuation of his article: The Designation-problem of the so-called Tokharian Language (1935), the author tries to give a brief survey of the progress in the Tokharian studies since 1935. (1) Designation-problem. The author distinguishes between the established results (: A=Agnean, B=Kuchean) and various pending problems (: uig. Twγry=tuγr- (Henning) or toγar- (Bailey), Āryacandra’s birthplace=Agnideśa (Henning), uig. yaratmiš and tokh. A raritw “translate” or “compose”? tokh. A ārśi=Tokh. A (Sieg) or skt. ārya (Bailey)? Henning’s Argi and Agni, etc.). (2) Position of Tokharian among the Indo-European family of languages (Benveniste, Pedersen, etc.). (3) Texts and translations enumerated so far as known to the author. (4) Grammatical, etymological and lexical studies with special reference to comprehensive works by Pedersen, van Windekens, Krause, etc. (5) Lexicon and glossaries.journal articl
Edukasi Keselamatan dan Kesehatan Kerja (K3) sebagai Upaya Peningkatan Keselamatan Kerja di PT. Binangkit Baja Mulya
Full text linkKeselamatan dan kesehatan kerja merupakan hal penting yang harus diperhatikan untuk menghindari terjadinya risiko dan kecelakaan kerja. Penyebab utama kecelakaan kerja terjadi karena faktor manusia dan lingkungan kerja. Faktor manusia lebih banyak ditemukan, hal ini disebabkan ketidakdisplinan dan kurangnya pemahaman penerapan K3 sesuai SOP yang berlaku selama melakukan aktifitas kerja. Tingginya angka kecelakaan kerja akibat kelalaian penggunaan atribut keselamatan juga menjadi faktor penyebab. Oleh sebab itu, perlu adanya edukasi dan pemahaman penerapan kedisiplinan terhadap K3 sesuai SOP yang baik dan benar. Pelatihan pemahaman penerapan K3 sesuai SOP memberikan dampat positif bagi peserta. Hal ini dapat dibuktikan dari hasil nilai soal Pre-Test dan Post-Test, dimana sebelumnya hanya 1 dari 7 peserta mendapat nilai 80 dan setelah mendapat materi pelatihan menjadi 5 peserta dengan nilai 90. Hal ini tentu saja akan memberikan dampak positif dari peserta pelatihan akan pentingnya arti dari keselamatan kerja, sehingga dapat meningkatkan image perusahaan, peningkatan sense of belonging, efisiensi dan mengurangi waste sebagai tujuan abdimas ini
Alternatively activated macrophages protect mice during induced intestinal inflammation
No full textInflammatory bowel disease (IBD) is an idiopathic disease characterized by chronic intestinal
inflammation and ulceration. Canada has the highest incidence of IBD in the world with 1 in
150 people affected. While treatment options target symptoms and attempt to dampen down
inflammation, an increasing population of patients is refractory to current therapeutic
options. Macrophages are heterogeneous in their functions and while it is clear that
inflammatory macrophages contribute to inflammation in IBD, multiple lines of evidence
suggest that alternatively activated macrophages may offer protection during intestinal
inflammation. In vivo SHIP deficient mouse macrophages are alternatively activated so
SHIP deficient mice provide a unique genetic model of alternative macrophage activation.
Using the dextran sodium sulfate (DSS)-induced model of colitis, I found that SHIP-/- mice
are protected during induced intestinal inflammation, the protection is macrophage mediated,
and can be conferred to a susceptible host. To determine how SHIP contributes to alternative
activation of macrophages, I demonstrate that SHIP-deficient murine macrophages are more
sensitive to IL-4-mediated skewing to an alternatively activated phenotype. Moreover, SHIP
levels are reduced in alternatively activated macrophages and this is required for alternative
activation because it is dependent on PI3K activity. Arginase (ArgI) induction is specifically
dependent on the PI3Kp110δ isoform of class IA PI3K. As such, mice deficient in
PI3Kp110δ catalytic subunit activity have increased clinical disease activity and histological
damage during DSS-induced colitis. Colitis severity correlates with reduced numbers of
ArgI+ M2 macrophages in the colon, increased nitric oxide production, and is macrophagedependent. Importantly, adoptive transfer of IL-4-treated macrophages from wild type mice,
but not from PI3Kp110δ deficient mice, protects mice during DSS-induced colitis. Protection is lost when mice are treated with inhibitors that block arginase activity showing that ArgI
activity is required for M2 macrophage-mediated protection from intestinal inflammation.
These findings identify SHIP and the PI3K pathway as critical regulators of alternative
macrophage activation and as potential targets for manipulation in IBD. In addition,
adoptive transfer of alternatively activated macrophages to patients with IBD also offers a
promising, new strategy for treatment that may be particularly useful in patients who are
refractory to conventional therapies
Análisis crítico de los desarrollos etimológicos de Uhlenbeck y Michelena para el vasco ilargi “luna”
Full text linkIn this article the author proposes the possible etymologisation for the basque word ilargi (moon). In his opinion this term is in relation to old basque’s customs, believes and religion. He reviews Uhlenbeck’s proposal and comments Michelena’s work over the same subject.El autor propone en este artículo la posible etimologización del término vasco ilargi “luna”. A su juicio, esta palabra del antiguo léxico vasco está unida claramente a la religión, a las creencias y costumbres de los antiguos vascos. Critica la propuesta de Uhlenbeck y comenta la aportación de Mitxelena.Artikulu honetan autoreak ilargi hitzaren etimologizazio posiblea proposatzen du. Bere ustez, euskararen lexiko zaharreko hitz hau argi lotzen da antzinako euskaldunen erlijio, sinismen eta ohiturekin. Uhlenbeck-en proposamena kritikatzen du eta Mitxelenaren ekarpena ere komentatzen du.
 
Generation and characterization of murine alternatively activated macrophages
No full textThe chapter, "Generation and characterization of murine alternatively activated macrophages" was written by the listed authors including Shelley B. Weisser (Douglas College Faculty). Part of the "Methods in Molecular Biology (Methods and Protocols)" book series (MIMB, volume 946): For over 35 years, biological scientists have come to rely on the research protocols and methodologies in the critically acclaimed Methods in Molecular Biology series. The series was the first to introduce the step-by-step protocols approach that has become the standard in all biomedical protocol publishing. Each protocol is provided in readily-reproducible step-by step fashion, opening with an introductory overview, a list of the materials and reagents needed to complete the experiment, and followed by a detailed procedure that is supported with a helpful notes section offering tips and tricks of the trade as well as troubleshooting advice. These hallmark features were introduced by series editor Dr. John Walker and constitute the key ingredient in each and every volume of the Methods in Molecular Biology series. Tested and trusted, comprehensive and reliable, all protocols from the series are indexed in PubMed.
Book "Basic Cell Culture Protocols": At some point in their careers, virtually every scientist and technician, as well as many medical professionals, regardless of their area of specialization have a need to utilize cell culture systems. Updating and significantly expanding upon the previous editions, Basic Cell Culture Protocols, Fourth Edition provides the novice cell culturist with sufficient information to perform the basic techniques, to ensure the health and identity of their cell lines, and to be able to isolate and culture specialized primary cell types. The intent of this extensive volume is to generate a valuable resource containing clear methodologies pertinent to current areas of investigation, rather than attempting to educate cell culturists on specific cell types or organ systems. Written in the highly successful Methods in Molecular Biology™, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and up-to-date, Basic Cell Culture Protocols, Fourth Edition compiles the essential techniques needed to approach this vital laboratory activity with full success.
Book Chapter: Macrophages play a key role in the innate immune response and help to direct the acquired immune response. Early in the innate immune response, they produce reactive oxygen species and pro-inflammatory cytokines and chemokines to drive inflammation and are referred to as “classically activated” or “killer” macrophages (M1). During the resolution phase of inflammation, they switch to what is known as an “alternatively activated” phenotype or “healer” macrophage (M2) and contribute to debris scavenging, angiogenesis, and wound healing. M1 macrophages are activated by treatment with IFNγ or LPS and M2 macrophages are activated by treatment with Th2 cytokines IL-4 or IL-13 and the M2 phenotype switch can be enhanced by IL-10. Macrophages can also be skewed during differentiation in vitro, and the resultant phenotype depends upon the cytokine provided to support their differentiation. In murine macrophages, MCSF promotes differentiation to an M1 phenotype, GM-CSF promotes differentiation to an M2 phenotype and IL-3 promotes differentiation into a profoundly M2 skewed phenotype. A defining feature of the phenotype of murine M1 versus M2 macrophages is how they metabolize L-arginine. In response to an inflammatory stimulus like LPS, M1 macrophages produce inducible nitric oxide synthase (iNOS) which uses L-arginine as a substrate to produce nitric oxide (NO). M2 macrophages constitutively produce the enzyme arginase I (argI), which sequesters L-arginine from iNOS and results in the production of ornithine and downstream polyamines and L-proline. M1 macrophages also produce relatively higher levels of pro-inflammatory IL-12 and lower levels of anti-inflammatory IL-10 relative to M2 macrophages. In this chapter, we describe in vitro derivation of polarized bone marrow macrophages and methods to analyze the resulting phenotype including Q-PCR, Western blotting, and enzyme assays to determine argI and iNOS expression and activity, as well as production of IL-12p40 and IL-10 and determination of IL-12/IL-10 ratios. Production of iNOS, NO, IL-12p40, and IL-10 are measured after treatment with LPS.book chapterPublished.IL-10IL-12p40Arginase INitric oxideInducible nitric oxide synthesisIL-4IL-3Granulocyte macrophage colony stimulating factorMacrophage colony stimulating factorBone marrow derived macrophagesMacrophage phenotypeMacrophage polarizationAlternative activatio
