393 research outputs found
Exploring hidden narratives: Conscript graffiti at the former military base of Kummersdorf
No full textThis article explores the cultural significance and interpretative potential of graffiti left by Soviet conscripts at Kummersdorf, a former military base in the German federal state of Brandenburg. The graffiti is framed as war art and its typology, distribution and content is studied in detail. In this way opportunities for further research are highlighted, as well as the potential for the graffiti to contribute to interpretative and conservation strategies. We demonstrate how the graffiti embodies multi-level interpretative narratives which can help to reveal hidden aspects of Soviet conscript life and cultural practices whilst alluding to global events and Soviet and Russian military policy. More generally, the article aims to promote the potential of graffiti and other forms of what is traditionally considered vandalism to contribute to the cultural significance and interpretation of heritage sites
Justice in the Fields
No full textIn this piece, Nick Hack talks about the agricultural labor in California. The paper explores the ebb and flow of the shifting tides of ethnicity in the state: What ethnic groups have been the major contributors to labor in Californian agriculture and what roles have they played? The author challenges the reader to consider the parallelism between land and labor exploitation and further explores local organizations that have been created to bring alternatives both in the management of the land as well as in the creation of opportunities for agricultural laborers
Characterizing the mechanism of differential pharmacokinetic disposition of two structurally similar nucleoside reverse transcriptase inhibitors, zidovudine and didanosine
No full textThe differential contributions of efflux transporters and metabolizing enzymes to the disposition of zidovudine (azidothymidine, AZT) and didanosine (dideoxyinosine, ddI) were investigated using murine and human cells, mouse kidney slices, and mice. Cellular transport, transport in mouse kidney slices, brain uptake, and urinary excretion of AZT and ddI were investigated.
Fumitremorgin C (FTC), a breast cancer resistance protein (BCRP) specific inhibitor), increased AZT accumulation, but had little or no effect on ddI accumulation in either HEK-R482 or in J774. Involvement of BCRP was investigated by comparing results in Mock- and BCRP- transfected cells, and confirmed by repeating the studies after silencing BCRP using siRNA. MK-571, a MRP family inhibitor, blocked the efflux of AZT and ddI in murine and human cells. Silencing MRP3 and MRP4 attenuated the efflux of AZT while silencing MRP1 attenuated ddI efflux. The effect of blocking efflux transporters was found to be minor as compared to inhibition of metabolizing enzymes. The major form of AZT deposited inside murine cells was AZT-MP, while the major form found inside human cells was AZT-TP. MK-571 abolished the efflux of AZT-MP in both murine and human cells. However, the efflux of AZT, ddI and their metabolites was not affected by FTC. Application of MK-571 also decreased the efflux of GAZT and ddI in kidney slices. The urinary excretion of AZT and ddI with MK-571 in mice was measured. MK-571 did not cause any significant changes in the urinary excretion of AZT, ddI, or their metabolites between the MK-571 untreated and treated groups.
Collectively, the results of these studies indicate that AZT and ddI are substrates of BCRP and MRPs, however since their effects are limited in in situ and in vivo situation they appear to be relatively minor players in the overall disposition of these drugs.Ph.D.Includes bibliographical references (p. 98-107)
Evaluating the development potential for intermodal transportation centers using the Miami Intermodal Center (MIC)
No full textThesis (M.S.)--Massachusetts Institute of Technology, Dept. of Architecture, 1996 [first author]; and, (M.S.)--Massachusetts Institute of Technology, Dept. of Urban Studies, 1996 [second author].Includes bibliographical references (leaves 143-151).by Omar F. del Rio and Donald R. Hackstaff.M.S
Laten we meer gebruikmaken van internationale praktijken in gebiedsontwikkeling
No full textIn zijn bespreking van ‘Site Planning: International Practice’ van Gary Hack ziet Tom Daamen wederom de noodzaak bevestigd om te leren van de internationale praktijk in gebiedsontwikkeling. En Nederland heeft ook veel te bieden, zo blijkt uit het boek van Hack dat de belangrijkste internationale trends op het gebied van gebiedsontwikkeling samenbrengt: “Nederlandse ontwerp- en ingenieursbureaus draaien internationaal mee in de top en drukken op plekken ver buiten Europa een enorme stempel.”Urban Development Managemen
Appropriation and the Hack: New Forms of Production
No full text‘Transitoriness vs. permanence: creative practices in the era of hyper-mobility’.
My art practice is hybrid, involving the production of works that are immaterial/online and material/physical. This hybridity necessitates testing the notion of ‘mobilised sites’ where work is shown (sometimes simultaneously) in both online and material spaces. This process for the dissemination of the work also interrogates how the work might be received, read or used and the difference in audiences for each site.
Hybridity is also present in the methods of production where a symbiotic co-authorship exists between (myself as) author and search engines as ‘co-authors’. The process of digital appropriation from the Internet and also the digital presentation of the work references McKenzie Wark’s theories of the ‘hack’: "In art, in science, in philosophy and culture, in any production of knowledge where data can be gathered, where information can be extracted from it, and where in that information new possibilities for the world produced, there are hackers, hacking the new out of the old". (Wark, 2004, s.004
台灣中海拔地區芒草之遺傳結構研究
No full text[[abstract]]Miscanthus sinensis var. formosanus Hack is a grass species growing in 1200-2000 M elevation mountain areas in Taiwan, where the species grows is between the distribution of M. sincesis var. glaber (Naki) J. Lee and M. sincesis var. transmorrisonensis Hayata.
In this study, isozyme electrophoresis was applied to detect the (1) genetic strusture of natural populations; (2) genetic variation of spike's offspring and (3) the genetic differentiation among these three varieties in species of Miscanthus sinensis in Taiwan. 16 loci from nine stains was used to analyze the isozymic variation of adult individuals, 6 loci from six stains for spike offspring. The results shown the average of expected heterozygosity (HE) is 0.202 and the coefficient of gene differentiation (GST) is 0.09, both demonstrated the similar parameter to mix-mating wind-pollinated species. The FST values from 6 populations of M. sinensis var. formosanus Hack are 0.093, which is higher than the genetic differentiation (FST=0.056) among the populations of the three varieties in Nantou. The higher FST is showing the gene flow among these three varieties is greater than other different populations of M. sinensis var. formosanus Hack. The estimation of multilocus outcrossing rate, tm=0.89, suggests an outcrossing mating strategy in M. sinensis var. formosanus Hack. In addition, the study of genetic variation from spike offspring indicated that genetic composition from a single spike is indistinguishable from its natural population, the genetic similarity is as high as 0.998. The genetic homogeneity implies a high gene flow within M. sinensis var. formosanus Hack population.
O parlamento das técnicas e dos homens: um estudo sobre as redefinições do trabalho numa indústria da Zona Franca de Manaus
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro tecnológico. Programa de Pós-Graduação em Engenharia de ProduçãoA tese intitulada "O Parlamento das Técnicas e dos Homens. Um estudo sobre as redefinições do trabalho numa indústria da Zona Franca de Manaus" investiga as redefinições do trabalho e os novos espaços de conhecimento emergentes no contexto do atual avanço científico e tecnológico através da conceituação, organização e desenvolvimento cognitivo do agente humano na planta produtiva enquanto mediada por novos atores tecnológicos como a tecnologia digital. Adota-se como horizonte de análise a identificação dos novos espaços teórico-práticos de formação do homem como perspectiva de alargamento da compreensão e prática dos processos cognitivos humanos no trabalho
Three-dimensional dynamic modelling of earthquake tremors: Memoirs of the Centre of Engineering Geology in the Netherlands, No. 200
No full textIn this research a three-dimensional dynamic elasto-plastic finite element model is developed to simulate earthquake response for a three-dimensional irregular topography in the city of Armenia, Colombia. Topographical and geomorphologic effects may be the cause for high local accelerations during the earthquake of January 1999. This effect has been studied for a simple geometrical model. In this study, the Brasilia Nueva area has been chosen as a test site for this purpose. The Brasilia Nueva area, situated on a narrow ridge, shows more damage than the surrounding area. Three-dimensional modelling is necessary because one- and two-dimensional simulations cannot model Site effects, since these effects incorporate geometry and different waves travelling in three directions. The three-dimensional modelling of earthquake response has resulted in amplifications for different locations and directions in a small area (250m x 750m). Ratios of maximum acceleration at the surface, and the input signal, are displayed, irrespective of the frequency and dependent on the frequency. The selection of an appropriate constitutive model is very important. This model should correctly represent the main features of (dynamic) behaviour while behaving mathematically accurate, using soil parameters that can easily be obtained in field and through laboratory tests. The parameters used for modelling are derived from investigations described in INGEOMINAS reports. The results show that with finite element modelling it is possible to simulate strong ground motion for a small area. The actual damage pattern in the Brasilia Nueva area, caused by the January 1999 earthquake, does show great similarities with the results of the analysis. The presence of high accelerations in the Brasilia area, in the dangerous frequency ranges for local structures, has also been found in the model near the top and close to the edges.Engineering GeologyApplied Earth SciencesCivil Engineering and Geoscience
- …
