17 research outputs found
Transport Properties of Mixed-Matrix Membranes: A Kinetic Monte Carlo Study
No full textKinetic Monte Carlo (KMC) simulations are used to study transport of guest molecules in a two-phase medium in which the minority phase forms closed regions. This type of model system resembles compositions of mixed-matrix membranes (MMMs) made of a matrix and imbedded filler particles with different permeabilities. Based on an ideal filler-matrix composite morphology as defined in [H. Vinh-Thang, S. Kaliaguine, Chem. Rev. 113, 4980, 2013], the effects of the filler-particle volume fraction, particle size, shape (aspect ratio), and the spatial particle distribution on gas transport through MMMs are addressed. The results obtained for nonoverlapping and randomly placed spherical filler particles are found to be in good agreement with the analytical models available in the literature and have proven their good accuracy also for thin membranes where finite-size effects are expected to play an appreciable role. Furthermore, the prominent influence of the aspect ratio for nonspherical particles on the effective permeability is shown and scenarios are discussed where the alignment of the asymmetric filler particles give rise to anisotropic transport properties potentially favorable for the performance of MMMs. The KMC approach developed guides the optimal spatial arrangement and orientation of the filler particles for the different strategies to increase the membrane permeability and separation selectivity by transport enhancement or inhibition.ChemE/Catalysis Engineerin
Choosing the Optimal Method for Measuring Glomerular Filtration Rate in Pediatric Intensive Unit
No full textThe measurement of glomerular filtration rate (GFR) in intensive care unit patients is strategically important and determines the further treatment tactics. The article provides a literature review on choosing the various methods for assessing the glomerular filtration rate in children with kidney injury. We identified the main limitations of creatinine as a marker for measuring GFR; the features of laboratory methods for creatinine determination were detected
Clinical Risk Factors of Thrombosis in Children after Congenial Heart Diseases Management
No full textBackground. Development of thrombotic complications in the postoperative period worsens the course of the disease and increases mortality of children operated for congenital heart diseases (CDC). There is limited data on clinical risk factors of thrombosis after CDCs surgical correction in modern literature. In our opinion, there are several promising factors that have not been studied as predictors of thrombosis in children with CDCs. Aim of the study is to analyze possible effect of patient clinical characteristics on development of thrombotic complications in infants after surgical treatment of CDC. Methods. We have studied data of 156 children aged from birth to 11 months 29 days (median age — 5 months) with CDCs operated under artificial circulation. Following indexes were studied in all patients: age, surgical risk according to RACHS-1 (Risk adjustment for congenital heart surgery), anesthesia duration, surgery duration, aortic cross-clamping time, artificial circulation duration, gestation period, body weight and height at the time of surgery. Results. Thrombosis was diagnosed in 44 patients (28.2%) in the postoperative period. Thromboses of various localizations were found during the patients’ examination: cerebral, intracardiac, limbs vessels, etc. It was revealed that thrombosis detection in patients with RACHS-1 >3 has increased in 2.84 times (95% CI: 1.36-5.92), at anesthesia duration >220 minutes — in 2.64 times (95% CI: 1.15-6.05), at surgery duration >150 minutes — in 3.36 times (95% MD: 1.51-7.5), at aortic cross-clamping time >32 minutes – in 3.23 times (95% CI: 1.45-7.32), at artificial circulation duration >70 minutes — in 3.43 times (95% MD: 1.6-7.34), with gestation period less than 39 weeks — in 2.44 times (95% CI: 1.18-5.03), with child’s weight less than 5.000 grams – in 4.3 times (95% CI: 2.02-9.15), with child’s height less than 60 centimeters — in 4.57 times (95% CI: 2.15-9.73), and at the age less than 3 months old — in 2.31 times (95% CI: 1.08-4.92). Conclusion. RACHS-1 >3, anesthesia duration >220 minutes, surgery duration >150 minutes, aortic cross-clamping time >32 minutes, artificial circulation duration >70 minutes, gestation period less than 39 weeks, weight at the time of surgery less than 5000 grams, height at the time of surgery less than 60 centimeters, and age under 3 months increases the risk of thrombotic complications in postoperative period
Performance of Delta-hedging strategies in interval models - A robustness study
No full texthedging;volatility;option pricing
Определение скорости клубочковой фильтрации у детей: история и современные подходы
No full textThe measurement of glomerular filtration rate (GFR) in intensive care unit patients is strategically important and determines the further treatment tactics. The article provides a literature review on choosing the various methods for assessing the glomerular filtration rate in children with kidney injury. We identified the main limitations of creatinine as a marker for measuring GFR; the features of laboratory methods for creatinine determination were detected.Измерение скорости клубочковой фильтрации у детей необходимо для определения тактики интенсивной терапии. В статье представлен обзор различных методов оценки скорости клубочковой фильтрации у детей при почечном повреждении. Выявлены основные недостатки креатинина как маркера для измерения скорости клубочковой фильтрации, а также особенности лабораторных методов его определения.КОНФЛИКТ ИНТЕРЕСОВАвторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи
Benzocaine-Induced Methemoglobinemia. A Clinical Case
No full textThe article describes a clinical case of the development of a severe, life-threatening methemoglobinemia in a patient with a dystrophic form of congenital epidermolysis bullosa while receiving a drug containing benzocaine. The current data on classification, pathogenesis, clinical course and methods for treating this state has been presented. Many substances and drugs that are methemoglobin formers are widespread and can cause chronic methemoglobinemia. Acute severe methemoglobinemia is accompanied by life-threatening organ disorders. In some cases, it may be difficult to diagnose methemoglobinemia due to the polymorphism of the clinical picture, the need for laboratory confirmation of the diagnosis, which may be underperformed in the absence of adequate alertness. The presented clinical case will be useful for doctors of various specialties
Turkey's relationship with the United States 1960-1975.
No full textSIGLEAvailable from British Library Document Supply Centre-DSC:DX189187 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Метгемоглобинемия, ассоциированная с приемом бензокаина. Клинический случай
No full textThe article describes a clinical case of the development of a severe, life-threatening methemoglobinemia in a patient with a dystrophic form of congenital epidermolysis bullosa while receiving a drug containing benzocaine. The current data on classification, pathogenesis, clinical course and methods for treating this state has been presented. Many substances and drugs that are methemoglobin formers are widespread and can cause chronic methemoglobinemia. Acute severe methemoglobinemia is accompanied by life-threatening organ disorders. In some cases, it may be difficult to diagnose methemoglobinemia due to the polymorphism of the clinical picture, the need for laboratory confirmation of the diagnosis, which may be underperformed in the absence of adequate alertness. The presented clinical case will be useful for doctors of various specialties.В статье представлено описание клинического случая развития тяжелой, угрожающей жизни метгемоглобинемии у пациента с дистрофической формой врожденного буллезного эпидермолиза на фоне приема препарата, содержащего бензокаин. Приведены современные данные о классификации, патогенезе, клиническом течении и способах терапии указанного состояния. Многие вещества и лекарства, являющиеся метгемоглобинобразователями, широко распространены и могут вызывать хроническую метгемоглобинемию. Острая тяжелая метгемоглобинемия сопровождается угрожающими жизни органными нарушениями. Диагностика метгемоглобинемии в ряде случаев может быть затруднена в силу полиморфизма клинической картины, необходимости лабораторного подтверждения диагноза, которое может быть не выполнено в случае отсутствия должной настороженности. Представленный клинический случай будет полезен для врачей различных специальностей
Efeitos da inulina nas propriedades físicas, químicas, de textura e aceitabilidade no desenvolvimento de muffin destinado a consumidores em idade escolar
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-graduação em Ciência dos alimentos, Florianópolis, 2013A obesidade infantil já é epidemia; o problema é global e se estende por todo o mundo, inclusive no Brasil. A prevalência crescente de excesso de peso deriva de fatores que determinam as escolhas alimentares, dentre eles, palatabilidade e disponibilidade, principalmente para crianças que costumam comer somente aquilo que gostam. O objetivo deste estudo foi investigar as preferências alimentares de escolares com idade de 7 a 10 anos e suas percepções sobre alimentos saudáveis e saborosos para que fosse desenvolvido um lanche saudável e sensorialmente bem aceito por essa população. Foram realizados 26 grupos focais e, após análise de conteúdo, o lanche desejado pela população estudada foi um muffin. A fórmula-base dos muffins foi retirada da literatura e, uma vez definida, foi investigado em que concentrações (2%, 5% e 8%) a inulina influenciou as características físico-químicas, a cor, as propriedades de textura, características de poros da massa e aceitabilidade global do produto. As diferenças entre as amostras foram avaliadas por meio de análise de variância seguida de teste de Tukey. O coeficiente de correlação de Pearson também foi aplicado, com nível de significância de 5% (p < 0,05). Diferenças significativas (p <0,05) foram encontradas entre as amostras para o teor de gordura, fibra alimentar, umidade e valor energético. A adição de inulina reduziu aproximadamente 70% o conteúdo de gordura dos muffins, contribuindo com a diminuição de seu valor calórico. Nas análises de coloração de crosta, a amostra contendo a maior quantidade de inulina (8%) apresentou os maiores valores de L*. Para os valores de a* e b*, não foram significativas as diferenças entre o muffin-controle e as demais amostras. Na avaliação da cor do miolo, a amostra contendo 8% de inulina também obteve maior luminosidade. Em relação a valores de a*, o muffin contendo 8% de inulina foi significativamente diferente de todos os outros, apresentando valores mais elevados que a amostra-padrão. Diferenças significativas foram observadas na dureza, elasticidade, coesividade e mastigabilidade entre todas as amostras. Dentre elas, a amostra com 8% de inulina foi a que apresentou mais semelhança nos parâmetros de perfil de textura, quando comparada à amostra-controle. A imagem do muffin com 2% de inulina foi a mais heterogênea quanto ao número de poros da massa, apresentando pequenos, médios e grandes poros. A amostra com 8% de inulina foi a que apresentou a maior quantidade de poros em tamanhos mais homogêneos. Quanto à aceitabilidade, as amostras contendo inulina não diferiram significativamente (p <0,05) do controle. . A quantidade máxima de inulina testada (8%) foi a que manteve as características físicas, de perfil de textura, cor e aceitabilidade global do muffin mais semelhantes àquelas do controle. Uma das maiores diferenças apresentadas foi a quantidade de gordura; sua diminuição deixou o produto significativamente menos calórico. A modificação na quantidade de fibra também foi bastante expressiva. Além das características apontadas, o tamanho e a quantidade dos poros da massa também foram alterados com as diferentes quantidades de inulina. Os resultados demonstram que a substituição de gordura por 8% de inulina não apresentou diferença significativa na maioria das análises, quando comparada a amostra controle <br
