13 research outputs found
The Clinical Importance of Herb-Drug Interactions and Toxicological Risks of Plants and Herbal Products
No full textNatural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases
No full textPsychiatric disorders are frequently encountered in many neurological disorders, such as Alzheimer's and Parkinson diseases along with epilepsy, migraine, essential tremors, and stroke. The most common comorbid diagnoses in neurological diseases are depression and anxiety disorders along with cognitive impairment. Whether the underlying reason is due to common neurochemical mechanisms or loss of previous functioning level, comorbidities are often overlooked. Various treatment options are available, such as pharmacological treatments, cognitive-behavioral therapy, somatic interventions, or electroconvulsive therapy. However oral antidepressant therapy may have some disadvantages, such as interaction with other medications, low tolerability due to side effects, and low efficiency. Natural compounds of plant origin are extensively researched to find a better and safer alternative treatment. Experimental studies have shown that phytochemicals such as alkaloids, terpenes, flavonoids, phenolic acids as well as lipids have significant potential in in vitro and in vivo models of psychiatric disorders. In this review, various efficacy of natural products in in vitro and in vivo studies on neuroprotective and their roles in psychiatric disorders are examined and their neuro-therapeutic potentials are shed light
Evaluation of Cucurbita pepo L. seeds used in folk medicine for their anti-inflammatory and wound healing activity
No full textSince Cucurbita pepo L. seeds have been reported to have beneficial effects in folk medicine for many years, in this study, in vivo wound healing activities of diethyl ether, chloroform and ethyl acetate extracts prepared from C. pepo seeds were evaluated by linear incision wound model, and hydroxyproline content. Furthermore, the extracts were screened for anti-inflammatory activity based on the inhibition of acetic acid-induced capillary permeability. The ethyl acetate extract had the highest inhibitory effect on acetic acid-induced capillary permeability, but the rest of the extracts didnt display significant anti-inflammatory activity. On the other hand, according to the activity using linear incision wound model as well as hydroxyproline content of the treated tissue, all three extracts did not indicate wound healing activity. [Med-Science 2020; 9(2.000): 381-4
The evaluation of sterile solutions of Ilwensisaponin A and C from Verbascum pterocalycinum var. mutense Hub.-Mor. on antiviral, antinociceptive and anti-inflammatory activities
No full textAntiviral, antinociceptive and anti-inflammatory activities of the 1% sterile solutions of Ilwensisaponin A and C isolated from the methanolic extract of the flowers of Verbascum pterocalycinum var. mutense Hub.-Mor. were investigated. Antiviral activities of sterile solutions were evaluated against Bovine Herpes Virus Type-1 (BHV-1) (Cooper strain). Both solutions showed cytotoxic effects. However, none of the sterile solutions showed antiviral activity with CPE values. Anti-inflammatory and antinociceptive response were obtained at doses of 100 mg/kg. The results of the evaluation of the anti-inflammatory activities induced by carrageenan showed that these sterile solutions possess active constituents and diminish cyclooxygenase activitiy. In addition, antinociceptive activities using p-benzoquinone-induced writhing model in mice of tested solutions were found to show notable activity in statistical analysis without inducing any apparent acute toxicity as well as gastric damage. To the best of our knowledge, this study is the first investigation of antiviral, anti-inflammatory and antinociceptive activities of sterile solutions of Ilwensisaponin A and C isolated from Verbascum pterocalycinum var. mutense Hub.-Mor. growing in Turkey. Keywords: Ilwensisaponin A, Ilwensisaponin C, Verbascum, Antiviral activity, Anti-inflammatory activity, Sterile solutio
The potential anticonvulsant activity of the ethanolic extracts of Achillea nobilis and Momordica charantia in rats
No full text© 2016 Journal of Pharmacy & Pharmacognosy Research.Context: Currently available antiepileptic drugs have debilitating adverse effects. Natural products and plants already used in traditional medicine can be a good place to start in the search for safer and more effective options. Aims: To investigate the anticonvulsant potential of Achillea nobilis and Momordica charantia extracts in maximal electroshock (MES), as well as pentylenetetrazole (PTZ)- And strychnine nitrate (STN)- induced seizure models in rats. Methods: For each model, eight groups of 21-day-old male Albino rats were used. The 1st group was kept as control, 2nd as standard (diazepam, 7.5 mg/kg); 3rd - 5th treated with A. nobilis (100, 200 and 300 mg/kg); and 6th - 8th administered M. charantia (100, 200 and 300 mg/kg). After 30 min, rats were exposed to a shock of 150 mA by a convulsiometer, via ear electrodes for 2 s (in MES test) or sc injection of PTZ (85 mg/kg) or STN (2.5 mg/kg). Results: A. nobilis and M. charantia extracts (200 and 300 mg/kg) demonstrated dose-dependent anticonvulsant effect against MES-induced seizures. In the PTZ induced convulsion, A. nobilis and M. charantia (200 and 300 mg/kg) significantly slowed the commencement of convulsions and minimized the duration of seizures. A. nobilis (300 mg/kg) showed 60% protection in rats against STN induced seizures. In contrast, A. nobilis (100 and 200 mg/kg) and M. charantia (100, 200 and 300 mg/kg) showed no significant protection against STN-induced seizures in rats. Conclusions: The results of the present study suggest that both extracts exhibited marked anticonvulsant activities
Non-targeted metabolomic profiling of Cistus species and association with anticholinesterase efficacy for Alzheimer's disease: In vitro and in silico evaluation
No full textEthnopharmacological relevance: Alzheimer's disease (AD) is characterized by decreased glucose utilization, and insulin therapy has been associated with improved memory. Therefore, AD is suggested to be classified as Type 3 diabetes. Cistus L. species are traditionally used to treat diabetes, which is highly associated with AD, and the potential of this genus for treating AD has not been sufficiently investigated. Aim: This study focused on the untargeted metabolomic profiling of methanolic extracts from five Cistus species to investigate the correlation between the metabolites and bioactivity. Materials and methods: Gas chromatography-mass spectrometry and liquid chromatography quadrupole time-offlight mass spectrometry were employed for metabolomics analysis. The inhibitory activity of the extracts on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), as well as their antioxidant capacity, were assessed. Additionally, molecular modeling techniques were utilized to corroborate the correlation between the metabolites and their cholinesterase inhibitory potency. Results: The plant extracts demonstrated inhibitory effects on BChE with IC50 values ranging from 1.80 to 9.83 mu g/mL, which were notably lower than those observed for AChE. Correlation analysis revealed that chlorogenic acid demonstrated strong correlations with AChE inhibitory activity, while sinapyl alcohol was closely associated with BChE inhibitory activity. Additionally, molecular modeling studies supported the inhibitory potential of these metabolites. Conclusion: This study highlights the substantial cholinesterase inhibitory capabilities of Cistus species, with C. creticus demonstrating particularly strong activity against both AChE and BChE. The results indicate that extracts from these species could be valuable natural sources of active metabolites with potent cholinesterase inhibitory effects, presenting promising new options for AD therapy
<i>In Vitro</i> Anthelmintic Activity of Five Different <i>Artemisia </i>L. Species Growing in Türkiye
No full textThis study aims to determinate in vitro anthelmintic activity of the plant extracts from the aerial part of five different Artemisia L. species (A. absinthium L., A. abrotanum L., A. annua L., A. incana (L.) Druce, A. tournefortiana Rchb.) growing in Turkiye. Depending on the ethnobotanical usage, the aqueous plant extracts were prepared by decoction and maceration methods. The anthelmintic activity of the plant extracts on Haemonchus (H.) contortus eggs and larvae was assessed using in vitro test methods. The extracts were prepared in five concentrations (50; 25; 12.5; 6,25; 3.125 and 1.5625 mg/mL) by using PBS for egg hatch and larval motility inhibition assay. In comparison to the negative control group, the extracts had significant anthelmintic effect on H. contortus eggs and larvae (p<0.05). In the egg hatch assay, all plants were found to be fully effective in the concentration range studied. In the analysis of larval motility, the activity was correlated with the quantities of the plant extracts. When the concentration-activity values of the plants were examined for both extraction methods, the highest activity was in A. annua and the lowest activity was observed in A. tournefortiana. Due to the development of resistance to anthelmintic drugs, natural sources such as Artemisia species can be considered as an alternative for the treatment of nematodes
The in vivo anthelmintic efficacy of some Verbascum species growing in Turkey
No full textVerbascum L (Scrophulariaceae) species are used for desiccating wounds and as a fish poison in Anatolia as well as for diarrhea and dysentery of animals in several countries. To further evaluate their activity, methanolic extracts obtained from 13 Verbascum species growing in Turkey, including V. chionophyllum Hub.-Mor., V. cilicicum Boiss., V. dudleyanum (Hub.-Mor.) Hub.-Mor., V. lasianthum Boiss., V. latisepalum Hub.-Mor., V: mucronatum Lam., V. olympicum Boiss., V. pterocalycinum var. mutense Hub.-Mor., V. pycnostachyum Boiss. & Heldr., V. salviifolium Boiss.. V. splendidum Boiss., V. stachydifolium Boiss. & Heldr. and V. uschackense (Murb.) Hub.-Mor. were evaluated for their in vivo anthelmintic activity. The extracts from V. lasianthum, V. latisepalum, V. mucronatum and V. salviifolum showed the highest inhibitory rates against Aspiculuris tetraptera at 100 mg/kg in mice. Additionally, extracts from V. dudleyanum and V. pterocalycinum var. mutense were found generally highly effective. The remaining species did not show any activity. Results of the present study support the utilization of these plant species employed in Turkish folk medicine. (C) 2011 Elsevier Inc. All rights reserved
Potential Anticonvulsant Activity of Ethanol Extracts of Cichorium Intybus and Taraxacum Serotinum in Rats
No full textPurpose: To evaluate the acticonvulsant activity of Cichorium intybus (C. intybus) and Taraxacum serotinum (T. serotinum) in maximal electroshock (MES), as well as pentylenetetrazole (PTZ)- and strychnine nitrate (STN) - induced seizure models in rats. Methods: For each model, 8 groups of Swiss albino rats (n=10) were used. The 1st group was kept as control, 2nd as standard (diazepam, 7.5 mg/kg); 3rd - 5th were treated with C. intybus ethanol extract (125, 250 and 500 mg/kg); and 6th - 8th treated with T. serotinum extract (125, 250 and 500 mg/kg). After 30 min of administration, the rats were exposed to a shock of 150 mA by a convulsiometer, via ear electrodes for 2 s (in MES test) or sc injection of PTZ (85 mg/kg) or STN (2.5 mg/kg). Anticonvulsant activity was confirmed by abolition of hind limb tonic extension (HLTE) in MES test and by measuring the latency to PTZ or STN-induced threshold seizures, and the duration of seizures in the rats. Results: In MES model, 500 mg/kg of C. intybus and T. serotinum resulted in complete abolition of HLTE in 70 and 50 % of the rats, respectively, compared to 80 % in diazepam-medicated animals. Both extracts at 500 mg/kg prolonged latency to seizure onset in PTZ model to 144.7 and 114.7 s, respectively (vs 55.2 s in control group; p < 0.05). Both extracts failed to protect rats against STN-induced seizures. Conclusion: C. intybus and T. serotinum possess anticonvulsant effect as they both abolish HLTE induced by MES and delay the latency of seizures produced by PTZ.WoSScopu
