1,720,957 research outputs found
GTF2I mutations are common in thymic epithelial tumors but not in hematological malignancies
No full textBackground: Mutation of general transcription factor IIi (GTF2I) (chromosome 7 c.74146970T>A) is common in thymic epithelial tumors and is a candidate driver aberration for cancer growth. To our knowledge, this mutation has not been described in other diseases. We evaluated the presence of GTF2I mutation in hematological malignancies. Materials and Methods: We sequenced samples from 31 patients with acute leukemia, 29 with chronic leukemia and 12 with myelodysplastic syndrome. The genomic fragment of exon 15 containing the hotspot of mutation was amplified using polymerase chain reaction (PCR) and sequenced. Results: We did not identify any GTF2I mutation in patients with hematological malignancies. Conclusion: Even though our sample size was limited, our data and reports from the literature suggest that GTF2I mutation is not present or is uncommon in these diseases
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Suscettibilita genetica al carcinoma papillare tiroideo: analisi del polimorfismo rs3764340 sul gene oncosoppressore WWOX
No full textI carcinomi differenziati della tiroide rappresentano una delle neoplasie endocrine più comuni. Il principale e più diffuso tra di essi è rappresentato dal carcinoma papillare (PTC). Questa tesi si propone di indagare, tramite uno studio caso-controllo, la diversa suscettibilità genetica al tumore papillare tiroideo conferita dalla presenza del polimorfismo a singolo nucleotide (SNP) rs 3764340 nel gene oncosoppressore WWOX. Questo polimorfismo consiste in una sostituzione citosina>guanina (NM_016373.1:c.844C>G) che causa il cambiamento aminoacidico Prolina > Alanina al codone 282
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Tecnologie di Next-Generation Sequencing: nuove prospettive per la caratterizzazione molecolare dei tumori timici
No full textI tumori timici sono le più frequenti neoplasie del mediastino nella popolazione adulta, rappresentano circa il 50% delle masse mediastiniche anteriori; hanno un’incidenza di 0.05 per 100.000 persone l’anno. I tumori timici sono un gruppo molto eterogeneo di neoplasie, hanno origine dalle cellule epiteliali del timo, anche se la nella maggioranza dei casi, sono costituiti da percentuali variabili di cellule epiteliali e linfociti.
I tumori del timo sono comunemente classificati dal punto di vista anatomopatologico in timomi e carcinomi del timo. La classificazione più recente è quella proposta dall’Organizzazione Mondiale della Sanità che raggruppa i tumori epiteliali timici (TETs) in carcinomi e timomi; quest’ultimi ulteriormente suddivisi in 5 sottogruppi (A, AB, B1, B2, B3 e C). Il più frequente sottotipo istologico è il timoma, mentre il carcinoma timico (rappresentato dal sottotipo C nella classificazione OMS) è molto più raro. Il timoma rappresenta, infatti, quantitativamente il 90% dei tumori del timo. L’età media di presentazione dei timomi è 53 anni, anche se possono presentarsi a qualunque età con una uguale distribuzione in entrambi i sessi.
Ad oggi le conoscenze riguardo alle alterazioni molecolari dei TETs sono ancora scarse; limitando di conseguenza anche lo sviluppo di farmici specifici per il trattamento.
Lo screening delle mutazioni con il convenzionale metodo Sanger è considerato il “gold standard” riguardo alla qualità delle sequenze ottenute. Tuttavia, questo metodo permette l’analisi di un solo gene per volta, esone per esone.
Le tecnologie Next Generation Sequencing (NGS) permettendo il sequenziamento contemporaneo dell’intera porzione codificante di geni candidati, o, se necessario, dell’intero esoma offrono importanti prospettive per lo studio molecolare di tumori come i TETs, ad oggi ancora poco conosciuti
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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