1,720,980 research outputs found
Ruolo della radiomica nella stadiazione, stratificazione del rischio e predizione della prognosi del tumore del colon non metastatico
Full text linkIl cancro del colon è uno dei tumori più comuni al mondo e il percorso decisionale terapeutico dipende dal sistema di stadiazione TNM e dalla presenza di fattori di rischio clinici. Tuttavia, nel caso di pazienti con malattia non metastatica, la valutazione di schemi di trattamento personalizzati rappresenta una sfida clinica.
Negli ultimi anni, la radiomica si è affermata come nuovo strumento per superare i limiti dell'imaging convenzionale, passando da un’analisi soggettiva e qualitativa ad una oggettiva e quantitativa
Nel nostro studio abbiamo indagato e dimostrato le buone capacità dell’analisi radiomica nel distinguere, dalle tc stadiative preoperatorie dei pazienti con neoplasia del colon in Stadio II, i tumori T3 dai T4; distinzione che risulta fondamentale nella stratificazione del rischio dei pazienti, per selezionare i gruppi a maggior rischio che possano beneficiare maggiormente di protocolli di terapia personalizzati.
Abbiamo, dunque, sviluppato un modello radiomico per predire le caratteristiche di malattia ad alto rischio dei tumori del colon non metastatici. Tutti i pazienti sono stati trattati con resezione chirurgica e abbiamo utilizzato i dati clinicopatologici per dividere la popolazione di partenza in pazienti ad alto rischio e senza rischio in base alla presenza di almeno un fattore di rischio clinico (la stadiazione T4, LVI, PNI, tumor budding e metastasi linfonodali) [41, 42]. Abbiamo, quindi, confrontato le caratteristiche radiomiche stabili tra pazienti ad alto rischio e non, e le caratteristiche radiomiche significative sono state utilizzate per costruire un modello predittivo radiomico, validato mediante coorte esterna.
Il modello ha ottenuto buone prestazioni nel predire la malattia ad alto rischio, evidenziando il ruolo promettente della radiomica nella stratificazione del rischio dei pazienti
Abdominal surgical site infection due to Klebsiella pneumoniae carbapenemase-producing K. pneumoniae
No full text.The spread of bacteria extensively resistant to multiple antibiotics is becoming an unprecedented public health concern. Different from multidrug-resistant (MDR) Gram-positive pathogens, for which new antibiotics (such as new glycopeptides
and oxazolidinones) have already been approved in virtue of high efficacy, the situation surrounding MDR Gram-negative
bacteria, such as those belonging to the Enterobacteriaceae family, appears more critical because of the very limited choice
of available antibiotics and the absence of new successful molecules. In particular, Gram-negative K. pneumoniae
carbapenemase (KPC)-producing K. pneumoniae (KPC-Kp) recently emerged as one of the most worrisome germs causing
health care associated infections (HAI) with a poor prognosis in the immediate post-operative period, especially after emergency abdominal surgery
Broncho-hepato-cutaneous fistula of hydatid origin
No full textCystic echinococcosis of the liver is a form of parasitic disease that is endemic world-wide. Generally asymptomatic, on occasion, it can manifest with complications. Rupture and fistulization into the biliary tract, bronchi, or skin are the complications described most frequently. The development of a fistula arising from a liver abscess of hydatid origin communicating with the bronchi as well as the skin is a rare phenomenon, as only one previous case has been reported
Gender stereotypes in the media, online culture and language
No full textThis module intends to offer an overview of the main gender issues in offline and online social contexts as they have developed in recent decades, thanks to the progressive growth of collective
and individual sensitivity towards the relationship between sexual identity and gender identity, with particular attention to the academic world.
Through theoretical insights and interactive activities, academic staff acquire knowledge, skills, strategies and tools to use in their professional role to ensure inclusive learning and egalitarian
opportunities for students and staff of all genders
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Non-operative management for ruptured splenule in haemodynamically stable patients previously splenectomized
No full textStreptococcus intermedius as causative agent of perianal abscess and metastatic brain abscess
No full textPerianal fistula is a common chronic lesion which usually ensues from a close abscess. Local pulsating pain and leakage from a de novo cutaneous orifice are the most common clinical presentations. Brain abscess represents an extremely rare complication of perianal disease (fistula or abscess), as only 4 cases have been reported in the pertinent world literatur
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