30 research outputs found
Synthesis and structural characterization of m-terphenyl Schiff base ligands and their aluminum complexes
No full text2,4,6-Triphenylbenzaldehyde 1 undergoes a condensation reaction with 2-aminophenol to give N-(2′,4′,6′-triphenylbenzylidene)-2-iminophenol (TPIP) 2. The imine 2 can be reduced with NaBH4 in ethanol to form N-(2′,4′,6′-triphenylbenzyl)-2-aminophenol (TPAP) 3. Addition of trimethylaluminum to 2 or 3 results in the formation of the complexes TPIP-AlMe2·AlMe3 (4) or TPAP-AlMe2 (5). Compounds 2, 3, and 4 have been crystallographically characterized. [ABSTRACT FROM AUTHOR]Peer reviewedFinal article publishedSchiff basesN,O ligandsaluminumm-terphenylX-ray crystallograph
Scheduling Strategies for Event-Triggered Control Using Timed Game Automata Over CAN Networks
No full textModern times have seen an increasing use of networked control systems, in which plants and controllers may not necessarily have a direct link but instead be connected through a network, thereby closing control loops over multiple nodes.The system may also be spread out spatially over a large area, and thus the associated network delays could greatly hamper control performance, potentially affecting the closed-loop stability of the system. In such scenarios, event-triggered control approaches could greatly reduce network congestionby allowing a means for the controllers to send control loop computation packets over the network only when required, in an event-driven manner, rather than through periodic transmissions. However, in practice, the number of parallel channels is limited compared to the number of controllers and hence the transmission of packets needs to be scheduled carefully to avoid network conflicts. This thesis explores using a network of timed (game) automata composed of models representing a networked control system’s control loops and its communication network. This reduces the scheduling problem of transmission of control loop computations to one of creating strategies using known algorithms, with the objective being to avoid network conflicts brought about by simultaneous transmissions. Furthermore, the proposed automata models also aim to reduce the conservatism of generated scheduling strategies by allowing the control loops a bounded number of retransmission attempts to send packets over the network in case it is already occupied. The concept is finally demonstrated in practice using simulated plants and controllers distributed over multiple machines connected via a physical CAN network.Electrical Engineering | Embedded System
Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk
No full textInfluence of genetic polymorphisms on frequency of micronucleated buccal epithelial cells in leukoplakia patients
No full textCellular mechanisms promoting cachexia and how they are opposed by sirtuins
No full textMany chronic diseases are associated with unintentional loss of body weight, which is termed as cachexia. Cachexia is a complex multifactorial syndrome associated with the underlying primary disease, and characterized by loss of skeletal muscle with or without loss of fat tissue. Patients with cachexia face dire symptoms like dyspnea, fatigue, edema, exercise-intolerance and low responsiveness to medical therapy, which worsen quality of life. Since cachexia is not a stand-alone disorder, treating primary disease, such as cancer, takes precedence for the physician, and it remains mostly a neglected illness. Existing clinical trials have demonstrated limited success mostly because of their mono-therapeutic approach and late detection of the syndrome. In order to conquer cachexia, it is essential to identify as many molecular targets as possible using the latest technologies we have at our disposal. In this review, we have discussed different aspects of cachexia, which include various disease settings, active molecular pathways and recent novel advances made in this field to understand consequences of this illness. We also discuss roles of the sirtuins, the NAD+-dependent lysine deacetylases, microRNAs, certain dietary options and epigenetic drugs as potential approaches, which can be used to tackle cachexia as early as possible in its course.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
Correlation Review of Classification Algorithm Using Data Mining Tool: WEKA, Rapidminer, Tanagra, Orange and Knime
No full textAbstractThis paper conducts a correlation review of classification algorithm using some free available data mining and knowledge discovery tools such as WEKA, Rapid miner, Tanagra, Orange and Knime. The accuracy of classification algorithm like Decision tree, Decision Stump, K-Nearest Neighbor and Naïve Bayes algorithm have been compared using all five tools. Indian Liver Patient DataSet is used for testing the Classification algorithm in order to classify the people with and without Liver disorder
A rare truncating BRCA2 variant and genetic susceptibility to upper aerodigestive tract cancer
No full text© The Author 2015. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected] Funding This work was supported the National Institutes of Health (R01CA092039 05/05S1) and the National Institute of Dental and Craniofacial Research (1R03DE020116). Notes The authors thank all of the participants who took part in this research and the funders and technical staff who made this study possible. We acknowledge and thank Simone Benhamou (INSERM, France) for sample contributions. We also acknowledge and thank The Cancer Genome Atlas initiative, whose data contributed heavily to this study.Peer reviewe
Computer Support for Successful Project Management Using MS Project 2016 with Information Technology Projects
No full textIn the recent past, computer programs have been used extensively to manage information technology (IT) projects. It has become almost mandatory for software development managers and students of information technology to learn how to use computer software to manage projects using computer software. Computer Support for Successful Project Management: Using MS Project 2016 with Information Technology Projects is a book intended to help IT management professionals and students, in using popular software MS-Project. Although there are many books on MS-Project, there are very few that cover the subject from the IT managers’ perspective. This book uses guided examples from the IT sector. Most of the relevant project management terminology, concepts, and key processes are discussed, based on the standards of the Project Management Institute. This book helps software development project managers to easily relate with the projects they execute in their day-to-day life. The author includes advanced topics like earned value analysis and multiple project management and discusses agile methodology as well as how MS-Project facilitates agile project management. Readers will learn how a tool like MS-Project can be used for processes related to risk and quality, in addition to meeting project objectives like scope, time, and cost. T
Influence of smokeless tobacco exposure on detoxification status and chromosomal damage in male and female habitues
No full textIn India, a large number of tobacco chewers and masheri users are chronically exposed to tobacco genotoxicants. Detoxification processes involving cellular glutathione (GSH) and glutathione S-transferases (GST) determine the outcome of exposure to environmental mutagens including those present in tobacco. Hence, in this study, GSH levels, GST activity, GSTM1 genotype and cytogenetic damage were determined using lymphocytes from 114 smokeless tobacco habitues and controls. The study groups comprised of male tobacco chewers, female masheri users, and age- and sex-matched controls. Irrespective of the tobacco habit, GSH levels and GST activity were higher in females than in males. In both the groups of habitues, GSH levels were similar to those in controls, while a significant reduction in GST activity was observed in tobacco chewers only. The frequency of cytogenetic alterations was significantly elevated in both the groups of habitues with respect to controls. However, break-type aberrations were more frequent in tobacco chewers while gaps were commonly observed in masheri users. Differences in the nature of chromosomal alterations in the two groups of habitues appeared to be related to variation in total tobacco exposure and gender-related differences in the efficacy of the GSH/GST detoxification system
A New, Atypical Case of Cobalamin F Disorder Diagnosed by Whole Exome Sequencing
No full textThe Deciphering Developmental Disorders Study presents independent research commissioned by the Health Innovation Challenge Fund (HICF-1009-003), a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome Trust Sanger Institute (WT098051). The views expressed in this publication are those of the author(s) and not necessarily those of the Wellcome Trust or the Department of Health. The research team acknowledges the support of the National Institute for Health Research, through the Comprehensive Clinical Research Network.Peer reviewe
