8,874 research outputs found
Widefield and Ultra-Widefield Retinal Imaging: A Geometrical Analysis
No full textDiabetic retinopathy (DR) often causes a wide range of lesions in the peripheral retina, which can be undetected when using a traditional fundus camera. Widefield (WF) and Ultra-Widefield (UWF) technologies aim to significantly expand the photographable retinal field. We conducted a geometrical analysis to assess the field of view (FOV) of WF and UWF imaging, comparing it to the angular extension of the retina. For this task, we shot WF images using the Zeiss Clarus 500 fundus camera (Carl Zeiss Meditec, Jena, Germany). Approximating the ocular bulb to an ideal sphere, the angular extension of the theoretically photographable retinal surface was 242 degrees. Performing one shot, centered on the macula, it was possible to photograph a retinal surface of ~570 mm2, with a FOV of 133 degrees. Performing four shots with automatic montage, we obtained a retinal surface area of ~1100 mm2 and an FOV of 200 degrees. Finally, performing six shots with semi-automatic montage, we obtained a retinal surface area of ~1400 mm2 and an FOV of 236.27 degrees, which is close to the entire surface of the retina. WF and UWF imaging allow the detailed visualization of the peripheral retina, with significant impact on the diagnosis and management of DR
Follow-up Extension Up to 43 Years of Modified Osteo-Odonto-Keratoprosthesis
No full textThe osteo-odonto-keratoprosthesis is a biological corneal prosthesis (KPro), introduced by Strampelli in 1964. It uses an osteodental lamina as a biological haptic derived from an autologous
mono-radicular tooth. An acrylic optical cylinder at the center of the lamina replaces the cornea, and the resulting osteo-dentalacrylic lamina is preferably covered by autologous buccal mucosa
or, if not available, by skin. In 2005, Falcinelli et al2 proposed several advances to the original surgical technique, the so-called modified osteo-odonto-keratoprosthesis (MOOKP), reporting
favorable results in a large cohort of patients who underwent surgery between 1973 and 1999 and followed up to 25 years.2 This study aimed at extending the follow-up of the same cohort
of patients, providing further evidence about long-term anatomic and functional outcomes of the MOOKP technique
Andrea Bacová
No full textAndrea Bacová focuses on research and teaching in the field of residential architecture. Her work includes systematic research on residential buildings and their urban context. She actively participates in promoting Slovak architecture and is the author of several publications and exhibitions
Recent Advances in Nanotechnology for the Treatment of Dry Eye Disease
No full textDry eye disease (DED) incidence is continuously growing, positioning it to become an emergent health issue over the next few years. Several topical treatments are commonly used to treat DED; however, reports indicate that only a minor proportion of drug bioavailability is achieved by the majority of eye drops available on the market. In this context, enhancing drug ability to overcome ocular barriers and prolonging its residence time on the ocular surface represent a new challenge in the field of ocular carrier systems. Therefore, research has focused on the development of multi-functional nanosystems, such as nanoemulsions, liposomes, dendrimers, hydrogels, and other nanosized carriers. These systems are designed to improve topical drug bioavailability and efficacy and, at the same time, require fewer daily administrations, with potentially reduced side effects. This review summarizes the different nanotechnologies developed, their role in DED, and the nanotechnology-based eyedrops currently approved for DED treatment
Efficacy of perfluorohexyloctane for the treatment of patients with dry eye disease: a meta-analysis
No full textIntroduction: To systematically review the evidence from randomized controlled trials that evaluate the efficacy and safety of perfluorohexyloctane in the treatment of dry eye disease. Methods: Literature search was conducted on PubMed and Scopus in April 2024 with the search strategy ("perfluorohexyloctane" or "NOV03" or "semifluorinated alkane") and "dry eye". Extension and paired-eyes study were excluded. The risk of bias was assessed using the Cochrane Risk of Bias Tool. Forest plots and a summary of findings were prepared for total corneal fluorescein staining (tCFS), tear film break-up time (TFBUT), eye dryness score (EDS), and Ocular Surface Disease Index (OSDI). Results: The pooled standardized mean difference (SMD) for tCFS after 8 weeks of treatment was -0.53 (95% CI, -0.68 to -0.38; P<0.001), indicating a significant improvement in patients treated with perfluorohexyloctane. The between-study heterogeneity was moderately high (I2=52.0%). No significant differences in TFBUT were observed (SMD=0.05; 95% CI, -0.16 to 0.25; P=0.654). Regarding symptoms, patients treated with NOV03 had significantly lower EDS compared to controls (SMD=-0.49; 95% CI, -0.66 to -0.32; P<0.001), with moderately high heterogeneity (I2=71.1%). Conversely, the pooled SMD of OSDI was -0.13 (95% CI, -0.43 to 0.17; P=0.412), indicating no significant difference. Conclusion: Perfluorohexyloctane is an effective and safe alternative for the treatment of evaporative dry eye disease due to MGD that can significantly reduce tCFS and eye dryness symptoms. More well-designed non-sponsored randomized clinical trials are required to investigate the impact on other ocular surface parameters
Viewer-, Author-, and Ownership in the Work of Andrea Zittel
No full textAndrea Zittel invites others to collapse the distinctions between artist, viewer, and collaborator by interacting with her usable works. This thesis explores the process of interacting with Zittel\u27s works, and how it affects viewer-, author- and ownership
The Lettere of Andrea Calmo: authorial artifices and historical reality
No full textopenNonostante l’edizione di Vittorio Rossi del 1888, la raccolta di "ingegnosi cheribizzi" e di "fantastiche fantasie" di Andrea Calmo è ancora avvolta da un certo mistero. L’autore, dissimulando la propria identità dietro alla “maschera” dell’umile pescatore veneziano, è stato in grado di offrire uno spaccato della cultura e della società nella Venezia cinquecentesca.
In particolare, è il quarto libro delle Lettere ad aver suscitato maggiore interesse tra gli studiosi ed i lettori: pubblicato nel 1566, a diversi anni di distanza dai primi tre, questo libro si distingue per il fatto che tutte le epistole sono indirizzate a delle donne immaginarie o realmente esistite.
In questa sede si propone, in primo luogo, uno studio della biografia del Calmo accompagnata da un’analisi del contesto storico-culturale della Venezia cinquecentesca; in secondo luogo, invece, viene proposto un commento di alcune lettere dell’ultimo libro dell’opera calmiana, che cerchi di far luce principalmente sull’aspetto linguistico e contenutistico del testo.Despite Vittorio Rossi's 1888 edition, Andrea Calmo's collection of "ingegnosi cheribizzi" and "fantastiche fantasie" is still shrouded in a certain mystery. The author, dissimulating his own identity behind the "mask" of the humble Venetian fisherman, was able to offer a cross-section of culture and society in sixteenth-century Venice.
In particular, it is the fourth book of the Letters that has aroused greater interest among scholars and readers: published in 1566, several years after the first three, this book stands out for the fact that all the epistles are addressed to women imaginary or actually existed.
Here we propose, first of all, a study of Calmo's biography accompanied by an analysis of the historical-cultural context of sixteenth-century Venice; secondly, however, a commentary on some letters from the last book of Calmo's work is proposed, which seeks to shed light mainly on the linguistic and content aspect of the text
I collaboratori della rivista. Schede bio-bibliografiche
No full textQuesta sezione contiene le schede bio-bibliografiche dei 108 autori che
dal 1866 al 1868 alimentarono con i loro contributi i 60 fascicoli del “Politecnico” di Brioschi, la cui pubblicazione sui due versanti della rivista fu
tutt’altro che uniforme. Mentre infatti la Parte letterario-scientifica uscì
ogni mese nel corso del triennio, la Parte tecnica cominciò a trovarsi in
difficoltà dal febbraio del secondo anno e riuscì a completare l’annata
1867 solo alla fine del ’68, un anno dopo la prima parte.
A fronte di questa disparità nelle uscite delle due parti (36 furono i
fascicoli della prima alla fine del triennio, e solo 24 quelli della seconda),
i collaboratori della Parte letteraria hanno originato 78 schede bio-bibliografiche, più del doppio delle 35 originate dai collaboratori della Parte
tecnica. Il che rinvia direttamente al diverso rapporto che esisteva fra
l’attività scrittoria come mezzo di espressione comunicativa e le “due culture” tradizionali: l’umanistico-letteraria e la scientifico-tecnica. Mentre i
cultori della prima scrivevano per mestiere e trattavano argomenti che
assorbivano molte pagine, i cultori della seconda usavano la penna il minimo indispensabile, esercitando professioni tecnico-pratiche in cui molti discorsi potevano riassumersi in poche formule matematiche e in disegni di per sé eloquent
Ocular-Surface Regeneration Therapies for Eye Disorders: The State of the Art
No full textThe ocular surface is a complex structure that includes cornea, conjunctiva, limbus, and tear film, and is critical for maintaining visual function. When the ocular-surface integrity is altered by a disease, conventional therapies usually rely on topical drops or tissue replacement with more invasive procedures, such as corneal transplants. However, in the last years, regeneration therapies have emerged as a promising approach to repair the damaged ocular surface by stimulating cell proliferation and restoring the eye homeostasis and function. This article reviews the different strategies employed in ocular-surface regeneration, including cell-based therapies, growth-factor-based therapies, and tissue-engineering approaches. Dry eye and neurotrophic keratopathy diseases can be treated with nerve-growth factors to stimulate the limbal stem-cell proliferation and the corneal nerve regeneration, whereas conjunctival autograft or amniotic membrane are used in subjects with corneal limbus dysfunction, such as limbal stem-cell deficiency or pterygium. Further, new therapies are available for patients with corneal endothelium diseases to promote the expansion and migration of cells without the need of corneal keratoplasty. Finally, gene therapy is a promising new frontier of regeneration medicine that can modify the gene expression and, potentially, restore the corneal transparency by reducing fibrosis and neovascularization, as well as by stimulating stem-cell proliferation and tissue regeneration
- …
