386 research outputs found
Perbandingan Hukum Fiqh MTA dengan 4 Madzhab
No full textThis thesis The thesis discusses the study and the comparison between the fiqh laws by MTA and the four religious sects that have been admitted by Islam. The major reason why the author does the study is because the existence of MTA as religious missionary endeavor, educational and social foundation. The influence of MTA with its tafseer (interpretation) method and also its strong fiqh statements in the community.
Some of the fiqh statements by MTA need to be re-analyzed/re-examined, since the statements are not in the right line to the four legal Islamic sects, or, the statements are made based on the weak sect’s statements, or, even more, it is made from really weak of sect’s statement, it is not based on the legalized Istidlal (methodology in making a statement). The author makes the limitations of the study that is only about the fiqh statements by MTA with a faith that the mistaken statements by MTA can be analyzed clearly.
The questions that the author wants to find out are: (1) what are the fiqh statements of MTA that must be re-analyzed? (2) What is relied upon the MTA in getting the statements? (3) And, How are the four sects, Is there any similarity of appropriateness between the fiqh statement by MTA and the four sects?. The answer of those questions is the objective of the author to do the study. The methodology of the research is explorative analytical. The author explores the fiqh statements by MTA and the fiqh laws by the four sects, and analyzes it. The materials are taken from MTA brochures from 1995-2015 editions, the literatures, the recordings of audio and video, books of fiqh, both classic and contemporary, academic discussion that is related to the topic. The author also uses comparative method, that is comparing the fiqh statements by MTA and fiqh statements of four sects to find out whether it is appropriate or not, not only in it law but also its methodology in taking the statement.
The conclusion of the thesis is that the basic law used by the MTA is Al-Quran, sunnah, Ijma, and qiyas. But according to MTA, ijma and qiyas are only used for earth life (custom and social life/human interaction), they are not used in worshipping (to Allah).
Even more, some of the fiqh statements by MTA concerning to the fiqh statement matters seemed peculiar to the four sects, e.g: it is fine to have tayamum even though there is water around, it is an obligation for women to have Friday praying at home, etc. There is also that the statements are taken from a very weak among fiqh experts/ jurists, and its impact is so bad to be implemented in the real life for example: a statement about forbidding any kind of food, but based on the prophecy hadith, it is makhruh. But still, of course, there are still the right statements which still in right away with the fiqh statements of four sects.
Keywords: MTA, Fiqh statemets, legal Islamic four sects
Gerakan Religio-Kultural MTA Dakwah, Mobilisasi dan Tafsir- Tanding
No full textThis article investigates the role of Majelis Tafsir Al-Qur’an (MTA), a dakwah movement operating aminly in Central Java. MTA is known as the Muslim purist movement whose mission focuses on the purification of Islam by utilizing the slogan back to the Qur’an and Sunnah. Using the social movemenet theory, the author analyzes the extent to which MTA uses cultural dakwah or symbolic-cultural mobilization as its dakwah strategy in order to produce counter-interpretation towards the established and hegemonic interpretation of the Javanese culture. Cultural dakwah can mean a bolization process of Javanese symbols by ataching new meaning and interpretation to thos symbols. The author further argues that even though the MTA’s dakwah movement is mainly characterized by confontative attitudes, the MATA has also shown its acomodative character by introducing new new understanding and meaning of the existing cultural symbols. Keywords: Majelis Tafsir Al-Qur’an (MTA), Islamic dakwah movement, symbolic-cultural mobilization
Gerakan Religio-Kultural MTA Dakwah: Mobilisasi dan Tafsir-Tanding
No full textThis article investigates the role of Majelis Tafsir Al-Qur’an (MTA), a dakwah movement operating aminly in Central Java. MTA is known as the Muslim purist movement whose mission focuses on the purification of Islam by utilizing the slogan back to the Qur’an and Sunnah. Using the social movement theory, the author analyzes the extent to which MTA uses cultural dakwah or symbolic-cultural mobilization as its dakwah strategy in order to produce counter-interpretation towards the established and hegemonic interpretation of the Javanese culture. Cultural dakwah can mean mobilization process of Javanese symbols by attaching new meaning and interpretation to those symbols. The author further argues that even though the MTA’s dakwah movement is mainly characterized by confrontative attitudes, the MATA has also shown its accomodative character by introducing new new understanding and meaning of the existing cultural symbols
mRNA adenosine methylase (MTA) deposits m6A on pri-miRNAs to modulate miRNA biogenesis in Arabidopsis thaliana
No full textCopyright © 2020 the Author(s). Published by PNAS. In Arabidopsis thaliana, the METTL3 homolog, mRNA adenosine methylase (MTA) introduces N6-methyladenosine (m6A) into various coding and noncoding RNAs of the plant transcriptome. Here, we show that an MTA-deficient mutant (mta) has decreased levels of microRNAs (miRNAs) but accumulates primary miRNA transcripts (pri-miRNAs). Moreover, pri-miRNAs are methylated by MTA, and RNA structure probing analysis reveals a decrease in secondary structure within stem-loop regions of these transcripts in mta mutant plants. We demonstrate interaction between MTA and both RNA Polymerase II and TOUGH (TGH), a plant protein needed for early steps of miRNA biogenesis. Both MTA and TGH are necessary for efficient colocalization of the Microprocessor components Dicer-like 1 (DCL1) and Hyponastic Leaves 1 (HYL1) with RNA Polymerase II. We propose that secondary structure of miRNA precursors induced by their MTA-dependent m6A methylation status, together with direct interactions between MTA and TGH, influence the recruitment of Microprocessor to plant pri-miRNAs. Therefore, the lack of MTA in mta mutant plants disturbs pri-miRNA processing and leads to the decrease in miRNA accumulation. Furthermore, our findings reveal that reduced miR393b levels likely contributes to the impaired auxin response phenotypes of mta mutant plants
Religio-cultural dakwah movement of MTA (Majelis Tafsir Al-Quran):mobilisation and counter-interpretation
No full textThis article investigates the role of Majelis Tafsir Al-Qur’an (MTA), a dakwah movement operating aminly in Central Java. MTA is known as the Muslim puristmovement whose mission focuses on the purification of Islam by utilizing the slogan back to the Qur’an and Sunnah. Using the social movement theory, the author analyzes the extent to which MTA uses cultural dakwah or symbolic-cultural mobilization as its dakwah strategy in order to produce counter-interpretation towards the established and hegemonic interpretation of the Javanese culture. Cultural dakwah can mean mobilization process of Javanese symbols by attaching new meaning and interpretation to those symbols. The author further argues that even though the MTA’s dakwah movementis mainly characterized by confrontative attitudes, the MATA has also shown itsaccomodative character by introducing new new understanding and meaning ofthe existing cultural symbols
Implementasi Kompetensi Inti Kurikulum 2013 dalam Pembelajaran Sejarah (Studi Kasus di SMA Mta Surakarta)
No full textThe objectives of research were: 1) to find out the historical teachers' understanding in SMA MTA Surakarta about the main competency of 2013 Curriculum, 2) to find out the implementation plan of main competency of the 2013 curriculum in historical learning in SMA MTA Surakarta, 3) to find out the application of main competency of 2013 curriculum in historical learning in SMA MTA Surakarta, and 4) to find out the evaluation the history teachers took in SMA MTA Surakarta in the implementation of main competency of 2013 curriculum.This study was a descriptive qualitative research. Techniques of collecting data used were interview, observation, and data analysis. To validate the data, the author employed data and method triangulations. Technique of analyzing data used by the author was an interactive model of analysis. The research procedure employed included pre research, field research, data analysis, and report writing stages.The results of research were as follows: 1) History teacher in SMA MTA Surakarta understood the main competency as the foundation on which a teacher realized the objective to be achieved in learning and the objective wanted by curriculum. 2) The plan the teachers made in historical learning implementation with the main competency of 2013 curriculum corresponding to the Learning Implementation Plan (RPP) of 2013 curriculum. 3) The historical learning implementation based on the main competency of 2013 curriculum in SMA MTA Surakarta had run well, because in historical learning process, the teachers always generated spiritual, social attitude competencies, knowledge competency, and skill competency of students. The student had also been able to demonstrate well every main competency. 4) During historical learning process, evaluation on any competency had also been carried out well by the teacher.The conclusion of research was that the application of main competency of 2013 curriculum through scientific approach with 5M (observing, questioning, collecting information, associating, and communicating) stages and student-centered approach could improve the competency of students comprehensively in historical learning in SMA MTA Surakarta
Salt dependence of MTA and MSK binding constants at 25°C (Record's plot ())
No full text<p><b>Copyright information:</b></p><p>Taken from "Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences"</p><p></p><p>Nucleic Acids Research 2007;35(7):2215-2226.</p><p>Published online 16 Mar 2007</p><p>PMCID:PMC1874653.</p><p>© 2007 The Author(s)</p> The linear least-squares fit of the data yields slopes of 0.37 (MTA) and 0.40 (MSK), which are equivalent to the number of ions released upon binding of MTA or MSK to DNA
Design, synthesis and evaluation of potential MTA prodrugs for the treatment of MTAP-deficient tumors in combination with 5-FU/6-TG/antifolates
No full textMany solid tumors and hematologic malignancies are characterized by a deficiency of the enzyme methylthioadenosine phosphorylase (MTAP). MTAP cleaves its natural substrate MTA which is generated during polyamine biosynthesis to adenine via a salvage pathway for AMP production. MTAP deficient cells are unable to salvage adenine from MTA. The difference in the lack of expression of MTAP in tumor cells compared to normal healthy cells has been explored in a therapeutic strategy for selectively killing tumor cells. Antimetabolites such as 5-FU, 6-TG or antifolates disrupt DNA replication and inhibit de-novo purine synthesis through the release of cytotoxic nucleotides generated via phosphorylation using phosphoribosyl-1-pyrophosphate (PRPP). Unfortunately, one major drawback of these cytotoxic nucleotides is that they produce harmful effects on the growth and proliferation of normal cells. To eliminate or reduce the cytotoxicity of these chemotherapeutic drugs and thus increase their therapeutic index, administration of MTA or MTA analogs in conjugation with antimetabolites could prevent damage to healthy MTAP competent cells. This is because adenine generated in this process by MTAP in healthy cells will block the conversion of 5-FU/6-TG to their cytotoxic nucleotides by competing for the rate-limiting pools of PRPP. Since no adenine is produced in tumor cells due to lack of MTAP, PRPP is present in sufficient levels and the co-administered drug can be readily converted to its toxic metabolite. Thus, a high degree of selectivity can be achieved. There are several MTA prodrugs discussed in the literature for delivering MTA to protect MTAP competent cells and proof of concept exists through in vitro studies emphasizing the protective effects of MTA in the presence of antimetabolites. However, there is still no successful clinical trial reported to have co-administered MTA or its analog with an antimetabolite. Also, the optimum dose of MTA that can rescue normal MTAP competent cells without compromising the ability of antimetabolites to selectively kill MTAP deficient tumor cells remains to be identified. In this thesis work, prodrugs of MTA were designed to be activated by the carboxylesterases to release MTA. We explored two types of prodrugs, namely the N-(alkyloxy)carbonyl-MTA derivatives and N-[(acyloxy)alkyloxy]carbonyl-MTA derivatives. The N-(alkyloxy)carbonyl-MTA prodrugs were stable at physiological pH and showed longer activation half-lives when tested in mouse liver microsomes but failed to be activated in human liver microsomes. Conversely, the N-[(acyloxy)alkyloxy]carbonyl-MTA prodrugs showed shorter half-lives ranging from a few minutes to a few hours in the presence of mouse and human liver microsomes but suffered from an inherent instability at physiological pH. As expected, the hydrolytic susceptibility of the ester group in N-[(acyloxy)alkyloxy]carbonyl-MTA prodrugs decreased with increasing steric hindrance around the ester bond by replacement with bulkier alkyl groups. Therefore, the N-[(acyloxy)alkyloxy]carbonyl-MTA prodrugs show promise and further modifications can be made to increase stability at physiological pH.M.S.Includes bibliographical referencesby Ashwini Ranad
Kontribusi Program Keagamaan Dalam Peningkatan Kualitas Pendidikan Di SMA MTA Surakarta Tahun Pelajaran 2017/2018
No full textMoral formation is a very important thing done as the importance of morals for human life. One means of fostering morals in schools through religious programs. In addition, continuous improvement of quality is also important, especially in education. Because the future of a nation depends on how the education is organized. SMA MTA Surakarta is a private Islamic school that has a vision to form a person who 'morals, knowledgeable and achievement'. SMA MTA in overall execution of morals than anything else. This principle becomes the foundation and way to realize one vision of SMA MTA.
The purpose of this research is to know and describe religious program that exist in SMA MTA Surakarta, and contribution of religious program in improving education quality in SMA MTA Surakarta. This research is a field research, where the author down directly to the field to be in carefully to find out the problems and factors that influence it, with the method of analysis in the form of descriptive method, that is by describing the data as it is through the exposure of words, and the deductive method is with linking data with research theory to then analyzed.
The conclusion of this research is that the program conducted in SMA MTA Surakarta is divided into two, namely in schools such as, studying lajo students, additional tahsin tahfidz and Arabic, Islamic spirituality, praying together, and qiraah; and in dormitories such as, routine study, congregational prayer, tahfidz, qiraah, as well as conditioning sunnah and fasting. The contribution of religious programs in improving the quality of education is as a means in realizing the vision of SMA MTA itself, that is morals, knowledge and achievement
Differential scanning calorimetry analysis of MTA and MSK complexes with salmon testes DNA
No full text<p><b>Copyright information:</b></p><p>Taken from "Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences"</p><p></p><p>Nucleic Acids Research 2007;35(7):2215-2226.</p><p>Published online 16 Mar 2007</p><p>PMCID:PMC1874653.</p><p>© 2007 The Author(s)</p> Melting curves for DNA alone and identical DNA solution in the presence of saturating amounts of MTA or MSK (0.2 mol antibiotic/mol DNA (bp)). The plots show the excess of heat capacity (kcal mol K) as a function of temperature. The area under the peaks provides direct estimates of the enthalpy for DNA melting and the MTA–DNA and MSK–DNA complexes
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