1,356,082 research outputs found
How aligned are we? Assessment procedures and practices between early childhood and early intervention
No full textEarly intervention and early childhood share a unique space in our early years education in Aotearoa/New Zealand. The assessment practices of the two are distinctively different and specific to each discipline. As assessment is a powerful agent for change and responsiveness to learners this article will unpack the reasoning behind these differences and consider the possibility of addressing a possible alignment through the early childhood curriculum Te Whariki (Ministry of Education, 1996)
La sicurezza alimentare : strumenti di controllo, informazione dei consumatori e prospettive di sviluppo
No full textSome aspects of the reliability and validity of the Texas Occupational Interest Analyzer (TOIA) when used with secondary school students
No full textA study of the effectiveness of the TOIA in differentiating the interest patterns of male and female students. The TOIA was administered to 890 high school students. Correlation coefficients computed for each sub-scale for each sex at each grade level, were negative and significant (p < .05). Each sub-scale assessed an independent area of occupational interest. Z ratios for each sex at each grade level indicated few significant differences. Students' vocational interests were well defined by the 9th grade and remained relatively stable, although females' interests were somewhat less stable. Male students' dominant interest areas were Mechanical, Science, Business, and People. Females were interested in activities involving People, Business, and Art. Occupations involving Language activities were of little interest to either sex. Correlation coefficients between TOIA sub-scales and students' expressed interests were positive and significant (p < .05). It is concluded that the TOIA effectively differentiates the occupational interests of secondary school students.Psychology, Department o
Plastic and cosmetic surgery of the male breast
No full textThe thorax has a fundamental role in the aesthetic of the male body: Congenital or acquired alterations are experienced as extremely frustrating clinical situations. Most breast surgery texts briefly mention gynecomastia, but no text comprehensively addresses the male breast and thorax, including reconstructive and cosmetic surgery and surgery in transgender patients. This gap is now thoroughly filled by Plastic and Cosmetic Surgery of the Male Breast: After introducing principles of anatomy and aesthetics for the male thorax, the first part focusses on the main congenital malformations and their treatment; the main benign acquired pathologies and their treatment (including an ample section dedicated to gynecomastia), the carcinoma of the male breast, with reference to familiar forms; the treatment of carcinoma and reconstruction of the thorax. The book closes with a chapter dedicated to breast surgery in transgender patients. While female breast surgery is increasingly practiced in specific Breast Units and highly specialized centers, male breast issues are treated in general and plastic surgeries units. This handy volume is a sound reference for the most complex clinical cases, and the latest reconstruction treatments for the male thorax and will be useful for general and thoracic surgeons, plastic surgeons and senologists
How to unshackle innovation from bureaucracy
No full textWe often associate innovation with freedom and creativity, but too often it is managed through heavy structures, rigid steps, bureaucratic control, and lack of empowerment. This approach dates back from the 1980s, when the product innovation cycle was much longer and more linear than today. Gabriele Rosani and Alessandro Toia advocate for a new approach that puts people and purpose, rather than processes and rules, at the heart of innovation
Response to ‘The trap door flap: A reliable, reproducible method of anterior pinna reconstruction’
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Injectable hydrogel formulations to host adipose stem cell spheroids for stemness maintenance and bone and cartilage regeneration
No full textAdipose-derived mesenchymal stem cells (ASCs) represent a great promise for tissue regeneration as fat is a very abundant source of stem cells (1) and owing to their ability to self-renew and differentiate into specific tissue types (2). In general, they are usually cultured as two-dimensional (2D) adherent monolayers, not representative of the in vivo condition, often entailing lower cell viability and, more in general, a lower “cell quality” in terms of regenerative potential (3, 4). When ASCs are cultured in low adhesion flasks and with a suitable culture medium, they aggregate in the form of three-dimensional spheroids (SASCs). The incorporation of these spheroids into injectable, in-situ gelling, polymer solutions can preserve the 3D structure of the cells from extraction to administration, avoid uncontrolled cell spreading, poor interaction and integration with the surrounding tissue. Moreover, in the presence of the right signaling molecules, SASCs are ready to differentiate in osteogenic (5) and chondrogenic (6) tissue, therefore, incorporated in the right scaffold, they can be very useful in the repair of both cartilage and bone defects that are still a challenge for modern medicine (7). As scaffold, hydrogels can meticulously look like the native ECM, due to their interconnected pore architecture, high water content and amenability to incorporate biomolecules or to provide specific biomechanical cues (8, 9). Therefore, hydrogels can be a fundamental element for tissue regeneration, maintenance of stem cell viability and stemess potential, induction of differentiation, support for cell proliferation and spreading with minimally invasive procedures.
Our work explores the suitability of hydrogels obtained by temperature-triggered self-assembly of partially degalactosylated xyloglucan aqueous dispersions (dXGaq) as SASCs niches for stemness considtions maintenance or for their differentiation in either osteogenic or chondrogenic lineages. The influence of the different culture media mixed with dXGaq and the presence of cell spheroids in the mixtures on the flow properties before gelation of all the above and the extrusion process with a syringe on the formed physical networks were investigated by shear viscosity and small amplitude oscillatory rheological analyses.
(1) Cheng, N. C., Wang, S., & Young, T. H. (2012). The influence of spheroid formation of human adipose-derived stem cells on chitosan films on stemness and differentiation capabilities. Biomaterials, 33(6), 1748-1758.
(2) Nii, M., Lai, J. H., Keeney, M., Han, L. H., Behn, A., Imanbayev, G., & Yang, F. (2013). The effects of interactive mechanical and biochemical niche signaling on osteogenic differentiation of adipose-derived stem cells using combinatorial hydrogels. Acta Biomaterialia, 9(3), 5475-5483.
(3) Di Stefano, A. B., Montesano, L., Belmonte, B., Gulino, A., Gagliardo, C., Florena, A. M., ... & Toia, F. (2020). Human Spheroids from Adipose-Derived Stem Cells Induce Calvarial Bone Production in a Xenogeneic Rabbit Model. Annals of Plastic Surgery.
(4)Di Stefano, A. B., Grisafi, F., Perez-Alea, M., Castiglia, M., Di Simone, M., Meraviglia, S., ... & Toia, F. (2020). Cell quality evaluation with gene expression analysis of spheroids (3D) and adherent (2D) adipose stem cells. Gene, 145269.
(5) Li, W., Liu, Y., Zhang, P., Tang, Y., Zhou, M., Jiang, W., ... & Zhou, Y. (2018). Tissue-engineered bone immobilized with human adipose stem cells-derived exosomes promotes bone regeneration. ACS applied materials & interfaces, 10(6), 5240-5254.
(6) Ansari, S., Diniz, I. M., Chen, C., Aghaloo, T., Wu, B. M., Shi, S., & Moshaverinia, A. (2017). Alginate/hyaluronic acid hydrogel delivery system characteristics regulate the differentiation of periodontal ligament stem cells toward chondrogenic lineage. Journal of Materials Science: Materials in Medicine, 28(10), 162.
(7) Kwon, H., Brown, W. E., Lee, C. A., Wang, D., Paschos, N., Hu, J. C., & Athanasiou, K. A. (2019). Surgical and tissue engineering strategies for articular cartilage and meniscus repair. Nature Reviews Rheumatology, 15(9), 550-570.
(8) Geckil, H., Xu, F., Zhang, X., Moon, S., & Demirci, U. (2010). Engineering hydrogels as extracellular matrix mimics. Nanomedicine, 5(3), 469-484.
(9) Hong, K. H., Kim, Y. M., & Song, S. C. (2019). Fine‐Tunable and Injectable 3D Hydrogel for On‐Demand Stem Cell Niche. Advanced Science, 6(17), 1900597
Axial propeller flaps: A proposal for update of the "Tokyo consensus on propeller flaps"
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