324 research outputs found
[archive] Huwelijksaankondiging Gabrielle Thiebaut en Rodolphe De Saegher.
No full textMadame Edouard Thiebaut a l'honneur de vous faire part du mariage de sa fille avec Monsieur Rodolphe De Saegher, Avocat près la Cour d'Appel de GandBijzondere collectiesGenealogische collecti
Monographie du palais de Fontainebleau
No full textFontainebleau, Dungeon (roof detail) Cour Ovale (Plate # 3); Monographie du Palais de Fontainebleau, dessinée Gravée par M. Rodolphe Pfnor, published by Vve. A. Morel et Cie Éditeurs, Paris in 1873, 2 volumes. Source: University of Toronto Libraries; http://main.library.utoronto.ca/ (accessed 2/1/2008
Ressenya de: Christin, Rodolphe (2018). Manual del Anti-turismo. València: Fuera de Ruta
No full textEn paraules del seu autor, autodefinit com “un turista més”, aquest és un llibre dirigit, amb mala intenció, als amants dels viatges i del món. El seu objectiu és analitzar el “drama del turisme”, com ell mateix l’anomena. És el turista un destructor marginal? La pregunta ens trasllada a l’univers on els turistes es converteixen en els principals actius de la “món-fàgia”. Literalment, menjar-se el món. El turisme com a consumidor i principal depredador d’una espècie que resulta el món sencer. Partint del principi de racionalització absoluta introduït per Max Weber a l’era científica i tècnica que significà la industrialització de finals del segle XIX i principis del XX, el sociòleg Rodolphe Christin ens planteja un espai convertit en parc, escenificat i modelitzat per la tecnosfera, on el turista assumeix el paper d’espectador-consumidor, i l’hàbitat el d’actor.In the words of its author, self-described as "another tourist", this is a book intended, with a bad intention, for travel lovers and the world. His goal is to analyze the "tourism drama", as he calls it. Is the tourist a marginal destroyer? The question takes us to the world where tourists become the main assets of the "world-phagia". Literally eating the world. Tourism as the main consumer and predator of a species that is the whole world. Based on the principle of absolute rationalization introduced by Max Weber into the scientific and technical era of industrialization in the late nineteenth and early twentieth centuries, sociologist Rodolphe Christin proposes a park-turned space, staged and modeled by the technosphere, where the tourist assumes the role of spectator-consumer, and the habitat the actor. Book Review. ISBN: 9788494789724.Ressenya de: Christin, Rodolphe (2018). Manual del Anti-turismo. València: Fuera de Rut
Clustering and differential analysis of gene expression data
No full textLes analyses des données d’expression génique issues du séquençage de l’ARN (RNA-seq) en masse (bulk RNA-seq) ou en cellule unique (scRNA-seq) sont devenues courantes dans les études immunologiques. Elles permettent entre autres une meilleure compréhension de l’hétérogénéité présente dans les réponses immunitaires, qu’elles soient en réponse à la vaccination ou face à des maladies. Les analyses de ces données se font souvent selon deux étapes : i) d’abord une classification non supervisée, ou clustering, utilisant l’ensemble des gènes pour regrouper les échantillons en sousgroupes distincts et homogènes ; ensuite ii) l’analyse différentielle se faisant à l’aide de tests d’hypothèse visant à identifier les gènes qui sont différentiellement exprimés entre ces sous-groupes. Cependant, ces deux étapes successives soulèvent un problème méthodologique actuellement souvent ignoré dans la littérature appliquée. En effet, les méthodes traditionnelles d’inférence nécessitent des hypothèses de tests fixées a priori, sans dépendre des données, pour garantir un contrôle effectif de l’erreur de type I. Dans le contexte de ces analyses en deux étapes, les hypothèses de tests sont basées sur les résultats du clustering ce qui compromet le contrôle de l’erreur de type I des méthodes traditionnelles qui peuvent alors conduire à de fausses découvertes. Nous proposons alors de nouvelles méthodes statistiques qui permettent de tenir compte de cette double utilisation des données, garantissant un contrôle effectif du nombre de fausses découvertes.Analyses of gene expression data obtained from bulk RNA sequencing (bulk RNA-seq) or single-cell RNA sequencing (scRNA-seq) have become commonplace in immunological studies. They allow for a better understanding of the heterogeneity present in immune responses, whether in reaction to vaccination or disease. Typically, the analysis of these data is conducted in two steps : i) first, an unsupervised classification, or clustering, is performed using all the genes to group samples into distinct and homogeneous subgroups ; ii) then, differential analysis is conducted using hypothesis tests to identify genes that are differentially expressed between these subgroups. However, these two successive steps lead to methodological challenge that is often overlooked in the applied literature. Traditional inference methods require hypothesis to be fixed a priori and independent of the data to ensure effective control of type I error. In the context of these two-steps analyses, the hypothesis tests are based on the results of the clustering, which compromises the control of type I error by traditional methods and can lead to false discoveries. We propose new statistical methods that account for this double use of the data and ensure an effective control of the number of false discoveries
Comparison of AUC in clinical trials with follow up censoring: Application to HIV therapeutic vaccines
No full textInternational audienc
La nourriture au service de la littérature : le banquet d’inauguration du monument à Karamzine à Simbirsk en 1845
No full textCelebrating Literature with Food : The Inauguration Banquet for Karamzin’s Monument in Simbirsk in 1845.
the present paper analyzes the reference to food in Mikhail Pogodin’s depiction of the banquet given by the nobility of Simbirsk on the occasion of the inauguration of the monument to nikolay Karamzin in 1845. After reminding how the different genres of classical poetry deal with the depiction of food, particularly with fish, the author shows how Pogodin used the specific features of the odic tradition, from the hyperbole to the enthusiastic tone, in his depiction of the Simbirsk banquet.Sapchenko Lioubov, Baudin Rodolphe. La nourriture au service de la littérature : le banquet d’inauguration du monument à Karamzine à Simbirsk en 1845. In: Revue Russe n°44, 2015. Manger russe. pp. 65-73
Evaluating the Use of Generalized Dynamic Weighted Ordinary Least Squares for Individualized HIV Treatment Strategies
No full textDynamic treatment regimes (DTR) are a statistical paradigm in personalized medicine which aims to optimize the outcome of long-term treatments. At its simplest, a DTR can optimize for a decision rule which consists of a single treatment; such DTRs are called individualized treatment rules (ITR) and they are often used in optimizing short-term rather than long-term rewards. DTR estimation methods such as dynamic weighted ordinary least squares (dWOLS) offer desirable theoretical advantages such as double robustness of parameter estimates in the decision rules. A recent extension of dWOLS called generalized dWOLS can now accommodate categorical treatments in the estimation of optimal treatment strategies. An application of this novel method will be demonstrated on HIV-infected individuals called low immunological responders (LIR), who are characterized by their low CD4+ T cell counts despite receiving antiretroviral treatment. The administration of Interleukin 7 (IL-7) injections has been shown to increase the concentration of CD4 cells in LIRs, but the optimal number of injections has yet to be determined. In this project, an ITR will be devised to maximize the duration where the CD4+ load is above a healthy threshold (500 cells/µL) while preventing the administration of unnecessary injections
When it is better to estimate a slope with only one point.
No full textInternational audienceWhen investigating the change in a biomarker, it is often believed that at least two measurements are needed from each participant, and that those with only one measurement should be excluded. In this short note, we explain why this could lead to imprecise and biased estimates. Furthermore, we discuss a standard statistical method that handles such issues
Yearb Med Inform
No full textOBJECTIVES: To introduce and summarize current research in the field of Public Health and Epidemiology Informatics. METHODS: The 2018 literature concerning public health and epidemiology informatics was searched in PubMed and Web of Science, and the returned references were reviewed by the two section editors to select 15 candidate best papers. These papers were then peer-reviewed by external reviewers to give the editorial team an enlightened selection of the best papers. RESULTS: Among the 805 references retrieved from PubMed and Web of Science, three were finally selected as best papers. All three papers are about surveillance using digital tools. One study is about the surveillance of flu, another about emerging animal infectious diseases and the last one is about foodborne illness. The sources of information are Google news, Twitter, and Yelp restaurant reviews. Machine learning approaches are most often used to detect signals. CONCLUSIONS: Surveillance is a central topic in public health informatics with the growing use of machine learning approaches in regards of the size and complexity of data. The evaluation of the approaches developed remains a serious challenge
Inférence dans les modèles dynamiques de population (applications au VIH et au VHC)
No full textL'étude des modèles explicatifs du VIH basés sur des systèmes d'équations différentielles ordinaires non-linéaires a consiférablement amélioré les connaissances sur la dynamique de l'infection. En raison des difficultés d'inférence dans ces modèles, les principaux résultats ont été obtenus en faisant des estimations patient-par-patient sur des modèles simplifiés. Toutefois, ces modèles ne permettent pas de considérer la dynamique de l'infection dans son ensemble. C'est pourquoi nous développons ici une méthode d'inférence par maximisation directe de la vraisemblance sur des modèles non simplifiés, en utilisant la structure particulière de ces modèles ainsi que les variabilités inter-patients. En prenant en compte la censure de la charge virale, nous appliquons notre méthode sur des données réelles et montrons son intérêt, en particulier pour définir des critères alternatifs d'analyse des essais cliniques. Efin, nous étudions l'identifiabilité pratique de ces modèles.The study of the dynamical models of HIV, based on non- linear systems of Ordinary Differential Equations has considerably improved the knowledge on its pathogenicity. This modelling leads to complex issues for identifiability and parameter estimation. To overcome these difficulties, the first models used simplified ODE systems and analyzed each patient separately. However, these models prevent from considering the course of the infection as a whole. We propose here an alternative way based on a full likelihood inference, using the particular structure of the non-simplified models and borrowing strength from the whole sample. We apply it to real data, taking into account the viral load left-censoring, and we illustrate the interest of this approach to provide an alternative tool for analyzing clinical trials. Last, we study the practical identifiability of these models.BORDEAUX2-BU Santé (330632101) / SudocSudocFranceF
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