3,308 research outputs found
Gate-to-grave assessment of plastic from recycling to manufacturing of TENG: a comparison between India and Singapore
No full text\ua9 The Author(s) 2024. This study assesses the viability of recycled plastic-based triboelectric nanogenerators (TENGs) for sustainable energy harvesting in India and Singapore, concurrently examining plastic waste management. Using material flow analysis and life cycle assessment, the findings revealed that in Singapore, waste-to-energy incineration has a lower environmental impact than landfilling and mechanical recycling, attributed to natural gas usage. In India, recycling offsets impacts from incineration and landfilling, contributing to a lower net environmental impact. Economic performance of a TENG module from PET recyclates showed a 20% carbon footprint reduction when scaling up from lab to industrial “freeze-drying” processes. Key challenges in TENG manufacturing processes are also assessed for future development. This research highlights the potential of recycled plastic-based TENGs in sustainable energy and waste management
Impacts of Spinal Cord Injury and Formulation on Riluzole Pharmacokinetics and Pharmacokinetics/Pharmacodynamics (PK/PD) Correlation
No full textAcute Spinal Cord injury (SCI) is a complex disorder involving a sudden traumatic insult to the cord resulting in deficits to ambulatory, sensory and autonomic function. At present, no effective acute treatment or rehabilitative therapy exists. Recently, several studies show that Riluzole has neuroprotective effect and promotes functional and neurological recoveries in animal models of brain and spinal cord ischemic and traumatic injuries; however, hepatotoxicity is a significant side effect concern for this therapy. Therefore, pharmacokinetic (PK) and pharmacodynamic (PD) study of Riluzole is of great importance for us to understand its toxicity and efficacy in acute SCI patients.
We hypothesize that spinal cord injury and formulation/administration alteration would affect the pharmacokinetics of Riluzole, and PK/PD studies would enable us to establish the correlation of Riluzole concentration/exposure with its toxicity and efficacy outcomes. Our project has three specific aims: 1) To investigate whether the change of formulation/administration would alter the PK of Riluzole. The rat model was used and different formulations of Riluzole were administrated (oral: crushed tablet, crushed paste, crushed paste with glycerin, suspension and solution; i.v.: solution). The PK of Riluzole in different treatment groups would be characterized and compared. 2) To explore the impact of SCI on Riluzole PK. Spinal cord injured and non-injured control rats were used to establish the impacts of acute SCI on Riluzole PK by monitoring PK profiles of Riluzole in plasma, brain and spinal cord after single and multiple doses. 3) To characterize individual and population PK of Riluzole and establish PK/PD correlation of Riluzole in terms of concentration/exposure with its toxicity and efficacy in acute SCI patients. Thirty-five individuals with acute SCI, American Spinal Injury Association (ASIA) Impairment Scale (AIS) Grades A-C, neurological levels from C-4 to T-12, who were enrolled in the Phase 1 clinical trial sponsored by the North American Clinical Trial Network (NACTN) for the treatment of SCI, received 50 mg Riluzole twice daily for 28 doses. The first dose was administered at a mean of 8.7 ± 2.2 hours post-injury. Trough plasma samples were collected within 1 hour pre-dose, and peak plasma samples were collected 2 hours post-dose on Day 3 and 14 of treatment. The data were analyzed for individual and population PK using basic structural and covariate models. The PK measures studied were the peak concentration (Cmax), trough concentration (Cmin), systemic exposure (AUC0-12), clearance (CL/F), and volume of distribution (V/F) normalized by the bioavailability (F). Linear and logistic regressions were used to establish the PK/PD correlations of Riluzole in acute SCI patients. Riluzole concentrations were quantified by a validated high-performance liquid chromatographic with UV detection assay.
In animal models, the alteration of formulation from crushed tablet to liquid increased the bioavailability of Riluzole, but did not affect its intrinsic PK characteristics; Acute SCI resulted in higher plasma, brain and spinal cord concentrations in acute phase of SCI after multiple I.P. doses, which was due to a slower elimination caused by an impaired hepatic clearance.
In acute SCI patients, the Cmax and AUC0-12 of Riluzole were lower than those in ALS patients on the same dose basis, due to a higher CL and a larger V. The PK of Riluzole (Cmax, Cmin, AUC0-12, CL/F, and V/F) changed during the acute and subacute phases of SCI in the 14 days of therapy. It was consistently observed in patients at all clinical sites that Cmax, Cmin, and AUC0-12 (128.9 ng/ml, 45.6 ng/ml, and 982.0 ng*hr/ml, respectively) were significantly higher on Day 3 than on Day 14 (76.5 ng/ml, 19.1 ng/ml, and 521.0 ng*hr/ml, respectively). These changes resulted from a lower CL (49.5 vs 106.2 L/hour) and a smaller V (557.1 vs 1297.9 L) on Day 3. Neither fluid imbalance nor cytochrome P 1A2 induction due to concomitant medications was identified during the treatment course to account for such increases in V and CL on Day 14, respectively. Possible mechanisms underlying these changes are discussed. The changes of motor and sensory scores at 3-month follow-up had good correlation with Day 3 AUC/kg. The establishments of PK-PD correlation could be used to predict the PD outcomes in the future clinical trial.Pharmacological and Pharmaceutical Sciences, Department o
Computing many faces in arrangements of lines and segments
No full textWe present randomized algorithms for computing many faces in an arrangement of lines or of segments in the plane, which are considerably simpler and slightly faster than the previously known ones. pn The main new idea is a simple randomized O(n log n) expected time algorithm for computing root n cells in an arrangement of n lines.A part of this work was done while the first and third authors were visiting Charles University and while the first author was visiting Utrecht University. The first author has been supported by National Science Foundation Grant CCR-93-01259 and an NYI aword. The second author has been supported by Charles University grant No. 351 and Czech Republic Grant GACR 201/93/2167. The third author has been supported by the Netherlands' Organization for Scientific Research (NWO) and partially supported by ESPRIT Basic Research Action No. 7141 (project ALCOM 2:Algorithms and Complexity)
Search for CP violation using triple product asymmetries in Λ b 0 → pK−π+π−, Λ b 0 → pK−K+K− and Ξ b 0 → pK−K−π+ decays
No full text© 2018, The Author(s). A search for CP and P violation using triple-product asymmetries is performed with Λb0 → pK−π+π−, Λb0 → pK−K+K− and Ξb0 → pK−K−π+ decays. The data sample corresponds to integrated luminosities of 1.0 fb−1 and 2.0 fb−1, recorded with the LHCb detector at centre-of-mass energies of 7 TeV and 8 TeV, respectively. The CP - and P - violating asymmetries are measured both integrating over all phase space and in specific phase-space regions. No significant deviation from CP or P symmetry is found. The first observation of Λb0 → pK−χc0(1P)(→π+π−, K+K−) decay is also reported
Test of lepton universality with Λb0→ pK-ℓ+ℓ- decays
No full text© 2020, The Author(s). The ratio of branching fractions of the decays Λb0 → pK−e+e− and Λb0 → pK−μ+μ−,RpK−1, is measured for the first time using proton-proton collision data corresponding to an integrated luminosity of 4.7 fb−1 recorded with the LHCb experiment at center-of-mass energies of 7, 8 and 13 TeV. In the dilepton mass-squared range 0.1 < q2< 6.0 GeV2/c4 and the pK− mass range m(pK−) < 2600 MeV/c2, the ratio of branching fractions is measured to be RpK−1=1.17−0.16+0.18±0.07, where the first uncertainty is statistical and the second systematic. This is the first test of lepton universality with b baryons and the first observation of the decay Λb0 → pK−e+e−. [Figure not available: see fulltext.]
Test of lepton universality with Λb0→ pK-ℓ+ℓ- decays
No full text© 2020, The Author(s). The ratio of branching fractions of the decays Λb0 → pK−e+e− and Λb0 → pK−μ+μ−,RpK−1, is measured for the first time using proton-proton collision data corresponding to an integrated luminosity of 4.7 fb−1 recorded with the LHCb experiment at center-of-mass energies of 7, 8 and 13 TeV. In the dilepton mass-squared range 0.1 < q2< 6.0 GeV2/c4 and the pK− mass range m(pK−) < 2600 MeV/c2, the ratio of branching fractions is measured to be RpK−1=1.17−0.16+0.18±0.07, where the first uncertainty is statistical and the second systematic. This is the first test of lepton universality with b baryons and the first observation of the decay Λb0 → pK−e+e−. [Figure not available: see fulltext.]
NALURI KEMASYARAKATAN DALAM PENCIPTAAN KUMPULAN CERPEN SONG OF SEPTEMBER KARYA MALIM GHOZALI PK.
No full textPengarang kreatif, Malim Ghozali Pk terkenal dalam genre cerpen dan novel yang kebanyakan ideanya terhasil semasa mengembara di luar negara. Sumbangannya diiktiraf hingga pernah menerima Anugerah SEA Write Award dari kerajaan Thailand. Bagaimanapun, karya kreatif Malim Ghozali Pk tidak diberi perhatian oleh mana-mana pengkaji untuk dianalisis secara ilmiah. Justeru, situasi ini menjadi permasalahan yang mendorong kepada kajian ini dibuat dan menggunakan Teori Sastera Perjalanan atau Pengembaraan dan Model Proses Kreatif Teksnaluri. Kajian ini bertujuan mengkaji naluri kemasyarakatan disebabkan pengembaraan yang mendorong pengarang Malim Ghozali PK menghasilkan cerpen dalam Kumpulan Cerpen Songs of September. Kumpulan cerpen ini mengandungi 20 buah cerpen, namun hanya enam sahaja cerpen dianalisis. Kajian ini menggunakan kaedah kualitatif, iaitu kajian kepustakaan dan analisis teks melalui Teori Sastera Perjalanan atau Pengembaraan dan naluri kemasyarakatan berdasarkan Model Proses Kreatif Teksnaluri. Hasil dapatan kajian menunjukkan bahawa Malim Ghozali Pk adalah seorang pengarang kreatif yang memaparkan naluri kemasyarakatan dalam menghasilkan cerpen melalui pengalaman yang diperolehnya ketika melakukan pengembaraan. Cerpen yang bertajuk “Aku diSini, Sayang”, “ꓕ!”, “Tika Hujan di Bogor”, “Di Kantor Suryadi”, “Nyet” dan “Song Of September” menjadi fokus utama pengkaji untuk mencungkil naluri kemasyarakatan pengarang Malim Ghozali PK. Secara keseluruhannya, boleh dikatakan bahawa cerpen Malim Ghozali PK ini mencerminkan kehidupan yang pernah dilalui ketika pengarang melakukan pengembaraan di luar negara.
The creative author, Malim Ghozali Pk which is well known in genre of short stories and novels created during his journey to other countries. The contribution has been recognized as he received the SEA Write Award from the government of Thailand. However, the creative writing of Malim Ghozali Pk are not catching any attention to any researcher for academic purpose. Thus, this situation become a problems that driven to the author Malim Ghozali PK to create a short stories in "Songs of September". These short stories contained 20 short stories, however there are only six has been analyzed. This research will use the qualitative type of method, which is the library research and analyzing texts through the Theory Journey or Adventure of Literature and society instinct based on the Model of Process Creative Instinctive Text. The findings of this study indicates that Malim Ghozali Pk is the creative author that shows his society instinct in creating the short stories based on his past experience that he gain during his journey. The short story entitled "Aku di Sini Sayang", ''Tika Hujan di Bogor'', Di Kantor Suryadi”, “Nyet” dan “Song Of September” become the main focus for the researcher to find the society instinct in Malim Ghozali Pk himself. All in all, it can be said that the short stories of Malim Ghozali PK reflecting his life during the journey to other countries. 
Amplitude analysis of the Λb0→pK−γ decay
No full textThe resonant structure of the radiative decay Λb0→pK−γ in the region of proton-kaon invariant-mass up to 2.5 GeV/c2 is studied using proton-proton collision data recorded at centre-of-mass energies of 7, 8, and 13 TeV collected with the LHCb detector, corresponding to a total integrated luminosity of 9 fb−1. Results are given in terms of fit and interference fractions between the different components contributing to this final state. Only Λ resonances decaying to pK− are found to be relevant, where the largest contributions stem from the Λ(1520), Λ(1600), Λ(1800), and Λ(1890) states. © The Author(s) 2024
Measurement of the Absolute Branching Fraction of Lambda(+)(C) -> Pk(S)(0)Eta Decays
No full textBased on 586 pb(-1) of e(+) e(-) annihilation data collected at a center-of-mass energy of root s = 4.6 GeV with the BESIII detector at the BEPCII collider, the absolute branching fraction of Lambda(+)(c) -> pK(S)(0)eta decays is measured for the first time to be B(Lambda(+)(c) -> pK(S)(0)eta) = (0.414 +/- 0.084 +/- 0.028)%, where the first uncertainty is statistical and the second is systematic. The result is compatible with a previous CLEO result on the relative branching fraction B(Lambda(+)(c) -> pK(S)(eta)(0))/B(Lambda(+)(c) -> pK(-)pi(+)), and consistent with theoretical predictions of SU(3) flavor symmetry. (C) 2021 The Author. Published by Elsevier B.V
Presentation_1_Long-Read Sequencing Annotation of the Transcriptome in DNA-PK Inactivated Cells.pdf
No full textThe DNA-dependent protein kinase catalytic subunit (DNA-PKcs) with a Ku70/Ku80 heterodimer constitutes the intact DNA-PK kinase, which is an upstream component of the DNA repair machinery that signals the DNA damage, orchestrates the DNA repair, and serves to maintain genome integrity. Beyond its role in DNA damage repair, the DNA-PK kinase is also implicated in transcriptional regulation and RNA metabolism, with an illuminated impact on tumor progression and therapeutic responses. However, the efforts to identify DNA-PK regulated transcriptomes are limited by short-read sequencing to resolve the full complexity of the transcriptome. Therefore, we leveraged the PacBio Single Molecule, Real-Time (SMRT) Sequencing platform to study the transcriptome after DNA-PK inactivation to further underscore the importance of its role in diseases. Our analysis revealed additional novel transcriptome and complex gene structures in the DNA-PK inactivated cells, identifying 8,355 high-confidence new isoforms from 3,197 annotated genes and 523 novel genes. Among them, 380 lncRNAs were identified. We validated these findings using computational approaches and confirmatory transcript quantification with short-read sequencing. Several novel isoforms representing distinct splicing events have been validated through PCR experiments. Our analyses provide novel insights into DNA-PK function in transcriptome regulation and RNA metabolism.</p
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