361 research outputs found
From the 'Rescue of the Nation State' to the Emergence of European Spaces. EUIJ-Kansai Workshop on "New Research Horizons of the History of European Integration", May 10, 2008, Toyonaka (Osaka)
No full textThe aim of this paper is to make some contribution to the discussion on the future direction of the historical research on the European integration processes. What I intend to do here is, broadly, to link the contemporary European studies to the Historical studies, and concretely, to emphasise the transnational dimension of European integration. This exercise should be read as presenting my "wish list" to the Integration Historians
高校生の英語スピーキングに対する学習意欲を踏まえた指導実践 : 効果的なリテリング活動の開発
No full textThe purpose of this study is to show how retelling activities can be used to enhance Japanese high school students’ English proficiency. As a graduate student. the author participated in a ２-year teaching practicum at a public high school in Shimane Prefecture. The first-year research showed that retelling activities can provide students with valuable opportunities to practice speaking in their own words. Therefore, in the following year, experimental instruction was designed and given to two classes, and its effects were evaluated relative to a control group in terms of the amount of students’ utterances in retelling tasks. The results show that a) retelling activities increased the number of words students speak for １ min (but n. s.), and b) interactive instruction can be used to teach implicit retelling skills
SimpleBounce: A simple package for the false vacuum decay
No full textWe present SimpleBounce, a C++ package for finding the bounce solution for the false vacuum decay. This package is based on a flow equation which is proposed by the author R. Sato (2020) and solves Coleman–Glaser–Martin’s reduced problem (S. R. Coleman et al. 1978): the minimization problem of the kinetic energy while fixing the potential energy. The bounce configuration is obtained by a scale transformation of the solution of this problem. For models with 1–8 scalar field(s), the bounce action can be calculated with O(0.1) % accuracy in O(0.1) s. This package is available at http://github.com/rsato64/SimpleBounce
APPLICATION OF A MARKOV PROCESS TO A MECHANICAL MODEL OF GRANULAR MATERIALS (2)
No full textIn the previous paper the author proposed a mechanical model of particulate materials as aMarkov process and explained the concepts of the potential barrier and the potential slip planewhich are introduced in the proposed model. Furthermore, the strain of particulate materialswas defined by using the change of contact angles at the contact points of particles and the dis-continuous motion of particles.In this paper the results of shearing tests obtained by the modified triaxial apparatus whichis designed and constructed, and can generate three different principal stresses are presented.The results of numerical experiments which are carried out by using the proposed model arealso presented. From both results it is shown that the proposed model can versatilely follow themechanical behaviours of particulate materials such as sands with complicated stress paths include-ing the stress reverse and repeated loading.In the previous paper the author proposed a mechanical model of particulate materials as aMarkov process and explained the concepts of the potential barrier and the potential slip planewhich are introduced in the proposed model. Furthermore, the strain of particulate materialswas defined by using the change of contact angles at the contact points of particles and the dis-continuous motion of particles.In this paper the results of shearing tests obtained by the modified triaxial apparatus whichis designed and constructed, and can generate three different principal stresses are presented.The results of numerical experiments which are carried out by using the proposed model arealso presented. From both results it is shown that the proposed model can versatilely follow themechanical behaviours of particulate materials such as sands with complicated stress paths include-ing the stress reverse and repeated loading
Rescue of Metabolic Alterations in AR113Q Skeletal Muscle by Peripheral Androgen Receptor Gene Silencing
No full textSummarySpinal and bulbar muscular atrophy (SBMA), a progressive degenerative disorder, is caused by a CAG/glutamine expansion in the androgen receptor (polyQ AR). Recent studies demonstrate that skeletal muscle is an important site of toxicity that contributes to the SBMA phenotype. Here, we sought to identify critical pathways altered in muscle that underlie disease manifestations in AR113Q mice. This led to the unanticipated identification of gene expression changes affecting regulators of carbohydrate metabolism, similar to those triggered by denervation. AR113Q muscle exhibits diminished glycolysis, altered mitochondria, and an impaired response to exercise. Strikingly, the expression of genes regulating muscle energy metabolism is rescued following peripheral polyQ AR gene silencing by antisense oligonucleotides (ASO), a therapeutic strategy that alleviates disease. Our data establish the occurrence of a metabolic imbalance in SBMA muscle triggered by peripheral expression of the polyQ AR and indicate that alterations in energy utilization contribute to non-neuronal disease manifestations
Multiplicative Characters and Gaussian Fluctuation Limits
No full textIt is known that extreme characters of several inductive limits of compact groups exhibit multiplicativity in a certain sense. In the paper, we formulate such multiplicativity for inductive limit quantum groups and provide explicit examples of multiplicative characters in the case of quantum unitary groups. Furthermore, we show a Gaussian fluctuation limit theorem using this concept of multiplicativity.The author gratefully acknowledges comments from Professor Makoto Katori at the early stage of this work. The author is grateful to Professor Yoshimichi Ueda for the useful discussion and his comments on the draft of this paper. Finally, the author gratefully thanks the referees for their kind reading and comments. This work was supported by JSPS Research Fellowship for Young Scientists PD (KAKENHI Grand Number 22J00573)
Dataset: An empirical study on self-admitted technical debt in modern code review
No full textThis data was used in the IST paper "An Empirical Study on Self-Admitted Technical Debt in Modern Code Review". The program to use this data is published in GitHub (https://github.com/Yutaro-Kashiwa/ReviewSATD_RP)
When you use this data in your research, please cite the following papers:
```
@article{Kashiwa:IST:2022:SATD_Review,
author = {Yutaro Kashiwa and
Ryoma Nishikawa and
Yasutaka Kamei and
Masanari Kondo and
Emad Shihab and
Ryosuke Sato and
Naoyasu Ubayashi},
title = {An empirical study on self-admitted technical debt in modern code
review},
journal = {Information and Software Technology},
volume = {146},
pages = {106855},
year = {2022},
url = {https://doi.org/10.1016/j.infsof.2022.106855},
doi = {10.1016/j.infsof.2022.106855}
}
``
Anharmonic vibrational computations with a quartic force field for curvilinear coordinates
No full textThe direct vibrational self-consistent field (VSCF) method, which combines anharmonic vibrational theory with electronic structure calculations, is a sophisticated theoretical approach to calculate the vibrational spectra of molecules from first principles. Combining the VSCF approach with the quartic force field (QFF) is a good alternative to direct VSCF, with a lower computational cost. QFF is a 4th-order Taylor expansion of the potential energy surface near an equilibrium geometry. In this study, a new strategy is proposed to derive the QFF in terms of normal coordinates; the QFF coefficients are determined through numerical differentiations of the energy by representing the normal coordinates in internal rather than Cartesian coordinates. The VSCF/QFF-internal method was implemented in the General Atomic and Molecular Electronic Structure System electronic structure program and applied to the evaluations of the fundamental vibrational frequencies of HNO2, HNO3, H2O dimer, and H2O trimer, using Møller-Plesset second order perturbation theory and the aug-cc-pVDZ and aug-cc-pVTZ basis sets. The results are much improved, especially for the intermolecular vibrational modes, compared with the Cartesian coordinate representation of the normal coordinates in the VSCF/QFF approach.This article is published as Harabuchi, Yu, Ryosuke Tani, Nuwan De Silva, Bosiljka Njegic, Mark S. Gordon, and Tetsuya Taketsugu. "Anharmonic vibrational computations with a quartic force field for curvilinear coordinates." The Journal of Chemical Physics 151, no. 6 (2019): 064104. DOI: 10.1063/1.5096167. Copyright 2019 Author(s). Posted with permission
Rapid Deterioration of Latent HBV Hepatitis during Cushing Disease and Posttraumatic Stress Disorder after Earthquake
No full textAbstractReactivation of the hepatitis B virus (HBV) is a risk in the 350 million HBV carriers worldwide. HBV reactivation may cause hepatocellular carcinoma, cirrhosis, and fulminant hepatitis, and HBV reactivation accompanied with malignant tumor and/or chemotherapy is a critical problem for patients with chronic HBV infection. Multiple risk factors causing an immunosuppressive state can also induce HBV reactivation.We present a case of HBV reactivation during an immunosuppressive state caused by Cushing disease and physical and psychological stress after a disaster. A 47-year-old Japanese woman was an inactive HBV carrier until the Great East Japan Earthquake occurred and follow-up was discontinued. One year after the earthquake she had intractable hypertension, and her visual acuity gradually worsened. Head magnetic resonance imaging showed a sellar tumor compressing the optic chiasm, and hepatic dysfunction with HBV reactivation was identified. Endocrinologic examination established the diagnosis as Cushing disease. After normalization of hepatic dysfunction with antiviral therapy, transsphenoidal tumor removal was performed that resulted in subtotal removal except the right cavernous portion. Steroid hormone supplementation was discontinued after 3 days of administration, and gamma knife therapy was performed for the residual tumor. Eighteen months after the operation, adrenocorticotropic hormone and cortisol values returned to normal. The patient has been free from tumor regrowth and HBV reactivation throughout the postoperative course.Accomplishment of normalization with intrinsic steroid value with minimization of steroid supplementation should be established. Precise operative procedures and careful treatment planning are essential to avoid HBV reactivation in patients with this threatening condition.</jats:p
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