649 research outputs found
Human amnion mesenchyme harbors cells with allogeneic T-cell suppression and stimulation capabilities
No full textCells derived from the amniotic membrane of human placenta have been receiving particular attention because of their stem cell potentiality and immunomodulatory properties, which make them an attractive candidate source for cell therapy approaches. In this study, we isolated cells from the mesenchymal region of amnion and identified two subpopulations discordant for expression of the HLA-DR, CD45, CD14, and CD86 cellular markers. We therefore refer to the unfractionated cell population derived from this region as amniotic mesenchymal tissue cells (AMTC). We studied the suppressive and stimulatory characteristics of the unfractionated, HLA-DR-positive, and HLA-DR-negative AMTC populations and demonstrated that all three fail to induce an allogeneic T-cell response. However, unfractionated AMTC, which could inhibit T-cell allogeneic proliferation responses, induced proliferation of T cells stimulated via the T-cell receptor (TcR), in a cell-cell contact setting. We have shown that this stimulatory capacity can be attributed to the HLA-DR-positive AMTC subpopulation. Indeed, even though the HLA-DR-positive AMTC fraction surprisingly failed to induce proliferation of resting allogeneic T cells, they could cause strong proliferation of anti-CD3-primed allogeneic T cells. This stimulatory effect was not observed using the HLA-DR-negative AMTC fraction. The revelation that human amniotic mesenchyme possesses cell populations with both suppressive and stimulatory properties sheds additional light on the immunomodulatory functions of this tissue and may contribute to the clarification of some ongoing controversies associated with mesenchymal stromal cells of other sources, such as the presence of HLA-DR-positive cells and the suppressive versus stimulatory properties of these cells
First responder CBRN - 9-liner pocket response card
No full textThe nine lines or points related to Chemical, Biological, Radiological and Nuclear agents (CBRN) pocket response card represents a quick form that the operator can entirely fill with critical information of his investigation during the 5-10 first minutes after his arrival on the scene. The idea is, that, in a very short time, all the necessary information will be shared directly with other emergency services or emergency management services, so that everybody is aware of what they are dealing with, and what kind of equipment and personnel needs to be deployed or dispatched. This card is intended to implement a harmonized model of information flow between first responders, being able to act more quickly in prevention, first aid, and managing the incident at the scene, whether it is an act of terrorism, traffic accident or standard industrial incident. The card will be available for different emergency services, such as police, fire department, civil protection units and emergency first responders. This will help to integrate the different missions that every single emergency management system (EMS) unit has to cover. © Science & Technology Research Institute for Defence (STRIDE), 2018
Forward pi0 meson production at HERA
No full textThe production of high transverse momentum piz^0-mesons has been measured in deep-inelastic e-p scattering events at low Bjorken- taken with the H1 detector at HERA. The production of high p_T particles is strongly correlated to the emission of hard partons in QCD and is therefore sensitive to the dynamics of the strong interaction. For the first time the measurement of single particles has been extended to the region of small angles w.r.t. the proton remnant (forward region) and down to very low values of x ~ 5x10^-5. This region is expected to be particularly sensitive to QCD evolution effects in final states. Differential cross sections of inclusive pi^0-meson production have been measured as a function of Bjorken-x and the four-momentum transfer Q^2, and also as a function of the transverse momentum and the polar angle of the pi^0-mesons. A recent BFKL calculation and QCD models based on the DGLAP splitting functions are compared to the data. The best description of the data is achieved by the BFKL calculation
Jet production in two-photon collisions at LEP
No full textJet and di-jet production are studied in collisions of quasi-real photons collected during the LEP2 program at e+e- center-of-mass energies from 189 to 209 GeV. OPAL reports good agreement of NLO perturbative QCD with the measured differential di-jet cross sections, which reach a mean transverse energy of the di-jet system of 25 GeV. L3, on the other hand, finds drastic disagreement of the same calculation with single jet production for transverse jet momenta larger than about 25 GeV
In addition to the individually listed research outputs in which I have direct involvement, I am also the co-author of a significant number of publications as a member of the H1, OPAL, and ATLAS collaborations. A complete list (including the items listed here individually) can be obtained at the link given in this entry.
No full textIn addition to the individually listed research outputs in which I have direct involvement, I am also the co-author of a significant number of publications as a member of the H1, OPAL, and ATLAS collaborations. A complete list (including the items listed here individually) can be obtained at the link given in this entry.
No full textThe Hadronic Picture of the Photon
No full textThe hadronic interactions of the photon are studied in terms of new measurements of the total hadronic cross section and di-jet production in photon-photon collisions at LEP2.The hadronic interactions of the photon are studied in terms of new measurements of the total hadronic cross section and di-jet production in photon-photon collisions at LEP2
Di-Jet Production in Photon-Photon Collisions at = 189 to 209 GeV
No full textDi-jet production is studied in collisions of quasi-real photons at e+e- centre-of-mass energies from 189 to 209 GeV at LEP. The data were collected with the OPAL detector. The structure of jets is investigated and differential cross sections are measured and compared to QCD calculations.Di-jet production is studied in collisions of quasi-real photons at e+e- centre-of-mass energies from 189 to 209 GeV at LEP. The data were collected with the OPAL detector. The structure of jets is investigated and differential cross sections are measured and compared to QCD calculations
The Parton Content of the Photon
No full textThe structure of the photon is studied in photon-photon collisions at LEP. New measurements have become available exploring the structure function F2g of the photon to the lowest values of x yet, where the hadronic component of the photon is most important. Inclusive cross sections for charged D* have been measured as a function of their transverse momenta and are used to test the validity of perturbative QCD in NLO in this region. The total charm quark production cross section is extracted. For the first time the inclusive production of D* mesons in deep inelastic electron-photon scattering has been used to extract the charm structure function of the photon. A first sign of beauty production in photon-photon collisions is reported
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