45,659 research outputs found
O endomarketing como técnica interveniente no processo de acreditação do HU-UFSC e seus reflexos à cultura organizacional
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Sócio-Econômico. Programa de Pós-Graduação em Administração UniversitáriaA gestão da qualidade nas últimas décadas ultrapassou as fronteiras da indústria, chegando às organizações comerciais e às prestadoras de serviços, dentre elas as organizações prestadoras de serviços de saúde. Dentro deste contexto, o modelo de Acreditação hospitalar emergiu como a ferramenta de gestão da qualidade, preconizando a padronização da assistência ao paciente ou cliente por meio da normatização e classificação dos hospitais em três níveis distintos, quais sejam: Nível 1; Nível 2; e Nível 3. Desta forma, em 1999, foi editado o primeiro Manual Brasileiro da Organização Nacional de Acreditação (ONA, 2010). Razões pelas quais, elaborou-se a presente dissertação no Programa de Mestrado Profissional em Administração Universitária, um estudo de caso realizado no Hospital Universitário Polidoro Ernany de São Thiago da Universidade Federal de Santa Catarina (HU-UFSC) sobre esta problemática. As variáveis analisadas foram: Acreditação Hospitalar, cultura organizacional e endomarketing. A amostra obedeceu a dois momentos distintos: inciamente foi realizada uma entrevista semiestruturada, intensiva e intencional, com o grupo de 14 dirigentes de primeiro escalão do HU-UFSC. Na sequência, aplicou-se um questionário estruturado e tratado de forma probabilística, do Tipo Likert, a 268 servidores que trabalham neste hospital. O período das coletas de dados foi de janeiro a março de 2012. As técnicas de tratamento dos dados foram quanti-qualitativas. Os dados quantitativos foram tabulados em planilha Excel e processados pelo programa SPSS®. Agregaram-se fontes secundárias que valorizassem a pesquisa. Conclui-se que o HU-UFSC é considerado pelos participantes da pesquisa um hospital de boa a muito boa qualidade de atendimento e assistência à saúde, mas requer algumas providências que enderecem à Acreditação Hospitalar Nível 1, tais como: reforçar a comunicação geral e, especialmente, o estreitamento das relações profissionais entre os dirigentes e os servidores. A ferramenta de comunicação mais sinalizada pelos participantes para contribuir no processo de sensibilização à Acreditação hospitalar foi a promoção de palestras sobre o referido programa e reuniões constantes a propósito deste tema. O estudo permitiu concluir ainda que o ambiente para a implantação da Acreditação Hospitalar, Nível 1, parece ser favorável para se iniciar este processo, desde que as técnicas e ferramentas de endomarketing sejam corretamente aplicadas, com o fito de remodelar de forma positiva a cultura organizacional endereçada ao Nível 1, do Manual Brasileiro de Acreditação Hospitalar (ONA, 2010).Quality management in the recent decades has exceeded the industry boundaries, reaching the commercial organizations and service providers, among them, organizations that provide health care services. Within this context, the hospital accreditation model has emerged as a tool for quality management, aiming at the standardization of patient care or client through the standardization and classification of hospitals into three distinct levels, wich are: Level 1, Level 2 and Level 3.Thus in 1999, it was published the first manual of the Brazilian National Accreditation Organizations (ONA, 2010). On these issues this master's dissertation was elaborated to the University of Professional Master of Business Administration, a study case conducted at the University Hospital Polidoro Ernany de São Thiago - Universidade Federal de Santa Catarina (HU-UFSC). The variables analyzed were: Hospital Accreditation, Organizational Culture and Internal Marketing. The sample followed two distinct moments: initially a semi-structured interview was conducted, intensive and intentional, with a group of 14 leaders first step at HU-UFSC. In the sequency, we applied a structured questionnaire and treated in a probabilistic manner, the Ukert Type, to 268 servers working in this hospital. The period of data collection was from January through March, 2012. The treatment techniques of quantitative and qualitative data were: Quantitative data formulated in an Excel spreadsheet and processed by SPSS®. And added to secondary sources that value the search. It is concluded that the UFSC-HU hospital is considered to have a good to a very good quality of health care and assistance by the research participants and requires some steps that addresses the Hospital Accreditation Level 1, such as strengthening the general communication and especially the strengthening of professional relationships between managers and servers, the communication tool most marked by the participants to contribute in the process of sensltl7atlon to Hospital Accreditation. Also it was mentioned the promotion of lectures on the program and constant meetings on the topic. It is thought that the environment for the implementation of the Hospital Accreditation, Level 1, seems to be favorable to stan this process, since the internal marketing techniques and tools are correctly applied, aiming on reshaping a positive culture addressed to an organizational level, the Brazilian Manual of Hospital Accreditation (ONA, 2010)
Apecholinus imitator Smetana & Hu 2019
No full textApecholinus imitator Smetana & Hu, 2019 (Figs. 5–6) Material examined. TAIWAN: Pingtung County: 1 spec., Tahanshan (± ÀƜ), 25.IV.2017. leg. B.-X. Guo (TARI); 1 female, Chun-jih, Ta-han shan, ± ÀƜ, 1350m, 2019,V-13 (Night), Y.- T. Chung Leg. CCCC (FSHc); 1 female, Majia Forest Trail (ṞxIJǎ), Majia To., 28-VI-2017, leg. R. H. Liu (FSHc); 1 spec., CCCC, Tahanshan (± ÀƜ), 15.IV.2019. leg. Y.- T. Chung (TARI). Description. For male description see Smetana & Hu (2019). Female. Genital segment. Tergite 10 (Fig. 6) obviously different from male tergite 10. Apical portion of female tergite 10 markedly narrow and elongated, with narrow acute apical portion; setae are relatively concentrated on the apex. Diagnosis. Apecholinus imitator can be distinguished from all other species of Apecholinus in Taiwan by the golden-yellow tomentose setae on the body. An undescribed species of Apecholinus in Taiwan is similar to this species but it currently known only from a single female, so I refrain from describing it until male specimens are found. The patches of golden-yellow tomentose pubescence on the elytra of Ap. imitator are much larger than that of the undescribed species. Bionomics. Based on an import of locality name into Google Earth from collection data (Smetana & Hu 2019 and this study), the species occurs from 800–1700 m. One specimen of Ap. imitator was collected by pitfall trap but nothing known about the habitat the traps were set in; some specimens of Ap. imitator were attracted to an LED flashlight in the evening on a forest trail (Smetana & Hu 2019). Distribution. Apecholinus imitator is at present known from central and southern Taiwan including Nantou County, Taitung County and Pingtung County (Smetana & Hu 2019, this study). Remarks. Up to the present, the morphology of females in Apecholinus is poorly known. So far, only females of Ap. fraternus (see Smetana 2018), Ap. liui (He & Zhou, 2017) (see He & Zhou 2017) and Ap. kaiseri Bernhauer, 1933 (see Smetana 2003) had been described and female tergite 10 of these species is similar to that of the male. However, the apical portion of tergite 10 of Ap. imitator is much narrower and more elongate in females than in males.Published as part of Hu, Fang-Shuo, 2020, New distributional records of Staphylinina in Taiwan, including a new species of Miobdelus Sharp (Coleoptera: Staphylinidae: Staphylininae: Staphylinini), pp. 334-360 in Zootaxa 4768 (3) on page 337, DOI: 10.11646/zootaxa.4768.3.2, http://zenodo.org/record/378403
Correlation between neutralising antibody titres against vaccine (Wuhan-hu-1) and VOCs.
No full textAntibody responses measured by pseudotype-based neutralisation assay against Wuhan-hu-1 were compared with those against B.1.617.1, B.1.617.2 and B.1.351. Responses were compared for A) BNT162b2 1 dose, B) BNT162b2 2 doses, C) ChAdOx1 1 dose and D) ChAdOx1 2 doses. Correlations between groups were evaluated and non-parametric Spearman correlation coefficients calculated using GraphPad Prism version 8. (DOCX)</p
Correlation between neutralising antibody titre against Wuhan-hu-1 and variants of concern.
No full textAntibody responses measured by pseudotype-based neutralisation assay against Wuhan-hu-1 were compared with those against B.1.617.1, B.1.617.2 and B.1.351. Responses were compared for A) BNT162b2 1 dose, B) BNT162b2 2 doses, C) ChAdOx1 1 dose and D) ChAdOx1 2 doses. Correlations between groups were evaluated and non-parametric Spearman correlation coefficients calculated. (DOCX)</p
HIV-1 infection and CD4 T cell depletion in the humanized Rag2<sup>-/-</sup>γc<sup>-/- </sup>(RAG-hu) mouse model
No full textAbstract Background The currently well-established humanized mouse models, namely the hu-PBL-SCID and SCID-hu systems played an important role in HIV pathogenesis studies. However, despite many notable successes, several limitations still exist. They lack multi-lineage human hematopoiesis and a functional human immune system. These models primarily reflect an acute HIV infection with rapid CD4 T cell loss thus limiting pathogenesis studies to a short-term period. The new humanized Rag2-/-γc-/- mouse model (RAG-hu) created by intrahepatic injection of CD34 hematopoietic stem cells sustains long-term multi-lineage human hematopoiesis and is capable of mounting immune responses. Thus, this model shows considerable promise to study long-term in vivo HIV infection and pathogenesis. Results Here we demonstrate that RAG-hu mice produce human cell types permissive to HIV-1 infection and that they can be productively infected by HIV-1 ex vivo. To assess the capacity of these mice to sustain long-term infection in vivo, they were infected by either X4-tropic or R5-tropic HIV-1. Viral infection was assessed by PCR, co-culture, and in situ hybridization. Our results show that both X4 and R5 viruses are capable of infecting RAG-hu mice and that viremia lasts for at least 30 weeks. Moreover, HIV-1 infection leads to CD4 T cell depletion in peripheral blood and thymus, thus mimicking key aspects of HIV-1 pathogenesis. Additionally, a chimeric HIV-1 NL4-3 virus expressing a GFP reporter, although capable of causing viremia, failed to show CD4 T cell depletion possibly due to attenuation. Conclusion The humanized RAG-hu mouse model, characterized by its capacity for sustained multi-lineage human hematopoiesis and immune response, can support productive HIV-1 infection. Both T cell and macrophage tropic HIV-1 strains can cause persistent infection of RAG-hu mice resulting in CD4 T cell loss. Prolonged viremia in the context of CD4 T cell depletion seen in this model mirrors the main features of HIV infection in the human. Thus, the RAG-hu mouse model of HIV-1 infection shows great promise for future in vivo pathogenesis studies, evaluation of new drug treatments, vaccines and novel gene therapy strategies.</p
Phylogenetic tree of 44 novel SARS-CoV-2 genomes from Colorado and Wuhan-Hu-1.
No full textGenomes were aligned with Mugsy and the consensus tree was generated under the Jukes-Cantor model using IQTree. Tip labels indicate the sample names as identifiable in GISAID. Red branch labels indicate the major phylogroups described in this paper. Blue asterisk indicates the Wuhan-Hu-1 genome outgroup, NC_045512.2. (TIF)</p
Tax PBM sustains the proliferation of T-cells from HTLV-1 infected hu-mice.
No full text(A) Expression of Tax in the cultured T-cell lines isolated from WT and ΔPBM infected hu-mice. Western blot analysis was performed using anti-Tax and anti-actin antibodies. (B) Phenotypic characterization of the cultured T-cell lines isolated from WT and ΔPBM infected hu-mice by FACS analysis of the CD25, CCR4, GITR and CADM-1 markers. (C) Growth curves. Human T-cells (2x105) isolated from the spleen of a WT (black line) or a ΔPBM (grey line) infected hu-mice were cultured in growth medium supplemented with IL2 in 24-well plates. Cells were split as indicated and counted. The mean and sem of each time point was determined from triplicate counts from one of three representative experiments performed at 2-, 5- and 8-months of in vitro culture. (D) Clumps of WT and ΔPBM T-cells and the actin cytoskeleton shown by IF staining. (E) Quantification of the ratio long/short length of the nuclei (Mann-Whitney one-paired: P = 0.0267) (left panel), and the length of the protrusions (Mann-Whitney one-paired: P = 0.0001) (right panel).</p
O Projeto ético-político na produção de conhecimentos do serviço social: uma análise no hospital universitário - HU
No full textTCC (graduação) - Universidade Federal de Santa Catarina, Centro Sócio Econômico, Curso de Serviço Social.O presente Trabalho de Conclusão de Curso tem como objeto de estudo investigar se as produções dos TCCs do Serviço Social do HU estão em conformidade com o projeto éticopolítico profissional e os fundamentos do SUS. Para a realização do trabalho utilizou-se a pesquisa bibliográfica, com o objetivo de coletar dados e analisar o conteúdo, visando conhecer o que a produção dos acadêmicos/pesquisadores reflete em relação ao projeto éticopolítico profissional e ao SUS. Foi feito um levantamento de todos os TCCs em Serviço Social realizados no HU, posteriormente estes trabalhos foram sistematizados por período, setor de atuação do Serviço Social no HU e por temas. Definiu-se como amostra de pesquisa os TCCs elaborados na Maternidade do HU. Estes abordavam os temas: Auxílio Natalidade, gravidez de alto risco, aborto por anencefalia, planejamento familiar, projeto de extensão # organizações da sociedade civil e prematuridade, descritos no presente trabalho. Por fim, fezse uma análise destes temas em relação a quais elementos do projeto ético-político estavam presentes nos TCC
Performance Evaluation of Distributed-Antenna Communications Systems Using Beam-Hopping
No full textDigital beamforming (DBF) techniques are capable of improving the performance of communications systems significantly. However, if the transmitted signals are conflicted with strong interference, especially, in the direction of the transmitted beams , these directional jamming signals will severely degrade the system performance. In order to efficiently mitigate the interference of the directional jammers, in this contribution a beam-hopping (BH) communications scheme is proposed. In the proposed BH communications scheme, only one pair of the beams is used for transmission and it hops from one to the next according to an assigned BH pattern. In this contribution a range of expressions in terms of the average SINR performance have been derived, when both the uplink and downlink are considered. The average SINR performance of the proposed BH scheme and that of the conventional single-beam (SB) as well as multiple-beam (MB) assisted beam-processing schemes have been investigated. Our analysis and results show that the proposed BH scheme is capable of efficiently combating the directional jamming, with the aid of utilizing the directional gain of the beams generated by both the transmitter and the receiver. Furthermore, the BH scheme is capable of reducing the intercept probability of the communications. Therefore, the proposed BH scheme is suitable for communications, when several distributed antenna arrays are available around a mobile
Plasma-escape scores for sera or antibodies mapped against the Wuhan-Hu-1, Beta, or Delta RBD single-mutant libraries.
No full textThe serum-escape scores for sera/plasmas mapped against the Delta RBD libraries are new to this study. The data for antibodies or sera/plasmas mapped against the Wuhan-Hu-1 or Beta RBD libraries were previously published [12,22–24,29,42–44]. This table is also available at https://github.com/jbloomlab/SARS-CoV-2-RBD_Delta/blob/main/results/supp_data/aggregate_raw_data.csv. (CSV)</p
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