57 research outputs found
Red Cell Distribution Width to Albumin Ratio versus Red Cell Distribution Width to Platelet Ratio as Predictors of 28-Day Mortality in Sepsis Patients Admitted to the Intensive Care Unit
No full textBackground: Sepsis is a leading cause of mortality in the Intensive Care Unit (ICU). Early identification of high-risk patients requires simple and accessible prognostic biomarkers. The Red Cell Distribution Width to Albumin Ratio (RAR) and Red Cell Distribution Width to Platelet Ratio (RPR) have been proposed as potential biomarkers.Methods: This prospective cohort study was conducted in the ICU of Dr. Hasan Sadikin General Hospital, Bandung, from July to September 2025, involving 71 subjects who met the Sepsis-3 criteria. RAR and RPR values were calculated from blood tests within the first 24 hours of ICU admission. The primary outcome was 28-day mortality. Statistical analysis used the Receiver Operating Characteristic (ROC) curve to determine the cut-off value, sensitivity, specificity, and Area Under the Curve (AUC). The AUC comparison between RAR and RPR was analyzed using the DeLong test.Results: A total of 41 patients (57.7%) experienced 28-day mortality. The optimal cut-off value for RAR was 5.7404 (Sensitivity 85.4%; Specificity 73.3%) with an AUC of 89.3% (95% CI: 79.8–95.4%). The optimal cut-off value for RPR was 0.0627 (Sensitivity 75.6%; Specificity 76.7%) with an AUC of 74.7% (95% CI: 63.0–84.3%). RAR had a significantly better discriminatory value than RPR (p=0.026).Discussion: The RAR value is a better predictor of 28-day mortality than the RPR value in septic patients treated in the ICU.Conclusion: RAR can be considered a simple and effective prognostic tool for the early risk stratification of septic patients.Background: Sepsis is a leading cause of mortality in the Intensive Care Unit (ICU). Early identification of high-risk patients requires simple and accessible prognostic biomarkers. The Red Cell Distribution Width to Albumin Ratio (RAR) and Red Cell Distribution Width to Platelet Ratio (RPR) have been proposed as potential biomarkers.Methods: This prospective cohort study was conducted in the ICU of Dr. Hasan Sadikin General Hospital, Bandung, from July to August 2025 involving 71 subjects who met the Sepsis-3 criteria. RAR and RPR values were calculated from blood tests within the first 24 hours of ICU admission. The primary outcome was 28-day mortality. Statistical analysis used the Receiver Operating Characteristic (ROC) curve to determine the cut-off value, sensitivity, specificity, and Area Under the Curve (AUC). The comparison of AUC between RAR and RPR was analyzed using the DeLong test.Results: A total of 41 patients (57.7%) experienced 28-day mortality. The optimal cut-off value for RAR was 5.7404 (Sensitivity 85.4%; Specificity 73.3%) with an AUC of 89.3% (95% CI: 79.8–95.4%). The optimal cut-off value for RPR was 0.0627 (Sensitivity 75.6%; Specificity 76.7%) with an AUC of 74.7% (95% CI: 63.0–84.3%). RAR had a significantly better discriminatory value than RPR (p=0.026).Discussion: The RAR value is a better predictor of 28-day mortality than the RPR value in septic patients treated in the ICU.Conclusion: RAR can be considered a simple and effective prognostic tool for the early risk stratification of septic patients
Tatalaksana Pasien Syok Sepsis dengan Peritonitis Diffusa ec. Abses Hepar Post Laparatomi Eksplorasi
No full textAbses hepar didefinisikan sebagai benjolan yang berisi pus pada hepar yang dapat berkembang dari cedera pada hepar atau infeksi intra-abdominal yang menyebar dari sirkulasi portal. Tingkat kejadian tahunan abses hepar adalah sekitar 2,3 kasus per 100.000 orang. Abses hepar dapat pecah yang menyebar sehingga menyebabkan peritonitis dan syok. Komplikasi penularan ke organ lain termasuk endoftalmitis atau emboli septik sistem saraf pusat yang berakibat fatal pada pasien yang dapat menyebabkan kematian. Laporan kasus ini menjelaskan pasien laki-laki 18 tahun dengan syok sepsis dan abses hepar. Prinsip tata laksana pasien abses hepar adalah insisi dan debridement. Pada kasus ini pasien sudah mengalami syok septik tata laksananya meliputi resusitasi cairan, optimalisasi penggunaan vasopresor-inotropik, pengendalian sumber infeksi (source control), dan pemberian antibiotik intravena dini, sebaiknya dalam waktu satu jam setelah diagnosis sepsis dan syok septik ditegakkan. Selain itu, perawatan pasien kritis di ICU juga merupakan tantangan tersendiri terutama pasien dengan syok septik. Manajemen cairan, nutrisi, serta pemberian analgesia dan sedasi sesuai dengan kebutuhan. Penatalaksanaan tepat pasien dengan syok sepsis karena abses hepar, luaran pasien yang baik dengan length of stay (LOS) yang singkat di ruangan ICU merupakan target dokter anestesi dan intensivis. Penatalaksanaan yang tepat akan memberikan prognosis pasien yang lebih baik; pada kasus ini pasien ditatalaksana dengan baik sehingga pasien mendapatkan perbaikan keadaan umum dan kesadaran pasien kompos mentis setelah diterapi.Abses hepar didefinisikan sebagai benjolan yang berisi pus pada hepar yang dapat berkembang dari cedera pada hepar atau infeksi intra abdominal yang menyebar dari sirkulasi portal. Tingkat kejadian tahunan abses hepar adalah sekitar 2,3 kasus per 100.000 orang. Abses hepar dapat pecah yang menyebar sehingga menyebabkan peritonitis dan syok. Komplikasi penularan ke organ lain termasuk endoftalmitis atau emboli septik sistem saraf pusat yang berakibat fatal pada pasien yang dapat menyebabkan kematian. Laporan kasus ini menjelaskan pasien laki-laki 18 tahun dengan syok sepsis dengan Abses Hepar. Penatalaksanaan tepat pasien dengan syok sepsis karena abses hepar, luaran pasien yang baik dengan Length Of Stay (LOS) yang singkat di ruangan ICU merupakan target dokter anestesi dan intensivis. Penatalaksanaan yang tepat akan memberikan prognosis yang lebih baik terhadap pasien
IFNG polymorphism (+874 T>A) is not a risk factor for cervical cancer
No full textIntroduction
Cervical cancer cases are rising and many women are infected with human papillomavirus (HPV). Interferon gamma (IFN-ã) is one of the key regulatory cytokines that influence the HPV clearance. The production and the function of IFN-ã may impaired by the defect of the IFNG gene leading to the cervical malignant progression. This study aimed to examine the association between IFNG+874 T>A polymorphism and cervical cancer in women
Methods
In a case-control study design, consecutive untreated women with cervical cancer who showed for the first time in Hasan Sadikin Hospital Bandung were enrolled (n=98) and for controls women who came for PAP smear (n = 81). Controls were not matched in ages and ethnicities. DNA extracted from blood was amplified by amplification refractory mutation system - polymerase chain reaction method (ARMS – PCR) to detect IFNG+874 T>A polymorphism.
Results
The distribution of IFNG genotypes TT, TA and AA for women with cervical cancer who met the inclusion criteria (n= 64) and with negative intraepithelial lesion or malignancy (n=42) were 14.1%, 50.0%, 35.9% and 7.1%, 52.4%, 40.5%, respectively. No significant differences could be observed between both groups (p=0.64). Stratifying the cervical cancer women into a group of squamous cell carcinoma (n = 54) revealed no statistical different.
Conclusion
IFNG +874 T>A polymorphismseems not to contribute in susceptibility to cervical cancer. Identification of other variants in IFNG gene signaling and its role in the development of cervical cancer diseases need to be further examined
IFNG Polymorphism (+874 T>A) is not a risk factor for cervical cancer
No full textINTRODUCTION Cervical cancer cases are rising and many women are infected with human papillomavirus (HPV). Interferon gamma (IFN-ã) is one of the key regulatory cytokines that influence the HPV clearance. The production and the function of IFN-ã may impaired by the defect of the IFNG gene leading to the cervical malignant progression. This study aimed to examine the association between IFNG+874 T>A polymorphism and cervical cancer in women METHODS In a case-control study design, consecutive untreated women with cervical cancer who showed for the first time in Hasan Sadikin Hospital Bandung were enrolled (n=98) and for controls women who came for PAP smear (n = 81). Controls were not matched in ages and ethnicities. DNA extracted from blood was amplified by amplification refractory mutation system - polymerase chain reaction method (ARMS – PCR) to detect IFNG+874 T>A polymorphism. RESULTS The distribution of IFNG genotypes TT, TA and AA for women with cervical cancer who met the inclusion criteria (n= 64) and with negative intraepithelial lesion or malignancy (n=42) were 14.1%, 50.0%, 35.9% and 7.1%, 52.4%, 40.5%, respectively. No significant differences could be observed between both groups (p=0.64). Stratifying the cervical cancer women into a group of squamous cell carcinoma (n = 54) revealed no statistical different. CONCLUSION IFNG +874 T>A polymorphismseems not to contribute in susceptibility to cervical cancer. Identification of other variants in IFNG gene signaling and its role in the development of cervical cancer diseases need to be further examined
Perbandingan Efek Pemberian Cairan Kristaloid Sebelum Tindakan Anestesi Spinal (Preload) dan Sesaat Setelah Anestesi Spinal (Coload) terhadap Kejadian Hipotensi Maternal pada Seksio Sesarea
No full textProphylactic fluid as a preload before spinal anesthesia has been a routine procedure to prevent maternal hypotension during cesarean delivery. Unlike colloid, timing of infusion of crystalloid may be important because it has short linger time in the intravascular space. This study aimed to compare the effect of the timing of administration of crystalloid, especially Ringerfundin, which is more effective between preload and co-load in preventing maternal hypotension during spinal anesthesia for cesarean section. This study was performed at the Central Operating Theatre (COT) of Dr. Hasan Sadikin General Hospital Bandung in June−July 2015 using the single blind randomized controlled trial method on 36 patients who underwent caesarean section with American Society of Anesthesiologist (ASA) II physical status. The incidence of hypotension was observed starting from the time the spinal anesthesia was performed to the time when the baby was born. Data were analyzed statistically using t-test, Mann Whitney test, and chi-square test where a p value of <0.05 considered significant. The incidence of hypotension was lower in the co-load group when compared to the preload group (44.4% vs. 77.8%, p value=0.040). In conclusion, the use of crystalloids for cesarean delivery in co-loading manner is more effective than preloading for the prevention of maternal hypotension after spinal anesthesia
Pengaruh Penambahan Klonidin 75 mcg pada 12,5 mg Levobupivakain 0,5% Secara Intratekal terhadap Lama Kerja Blokade Sensorik dan Motorik untuk Bedah Ortopedi Ekstremitas Bawah
No full textSpinal anesthesia has some limitations that limits its use, such as limited duration of action in motoric and sensoric. This research aimed to provide an overview on the effect of adding clonidine 75 mcg to 12.5 mg 0.5% levobupivacaine on the motoric and sensoric blockade action duration in lower extremity orthopedic surgery spinal anesthesia. This experimental prospective research used double blind randomized controlled trial approach on 36 patients with ASA I-II physical status who underwent lower extremity orthopedic surgery using spinal anesthesia in Dr. Hasan Sadikin General Hospital during the period of June to August 2014. LC group, clonidine 75 mcg was added to 12.5 mg 0.5% levobupivacaine. On LS group, 12.5 mg 0.5% mg levobupivacaine mixed with 0.5 mL 0.9% NaCl. The data were then statistically tested using t-test, Mann-Whitney, and chi-square. The result showed that the duration of action of sensoric blockade in LK group was significantly longer, i.e. 224.44 (37.84) minutes compared to LS group, i.e. 107.89 (17.63) minutes (p=0.000). Duration of action of motoric blockade in LK group was significantly longer, i.e. 278,72 (41,75) minutes, compared to LS group, i.e. 128.39 (18.26) minutes (p=0.000). It is concluded that the additiona of clonidine 75 mcg to 12,5 mg 0,5% levobupivacaine significantly prolongs the duration of action of the motoric and sensoric blockade if given intrathecally
Perbandingan Kedalaman Sedasi antara Deksmedetomidin dan Kombinasi Fentanil-Propofol Menggunakan Bispectral Index Score pada Pasien yang Dilakukan Kuretase
No full textKuretase tergolong bedah minor yang menyebabkan nyeri dan ketidaknyamanan pasien sehingga memerlukan tindakan sedasi-analgesi. Tujuan penelitian adalah membandingkan kedalaman sedasi antara deksmedetomidin dan kombinasi fentanil-propofol menggunakan bispectral index score (BIS) pada pasien yang dilakukan kuretase. Penelitian ini merupakan penelitian randomized controlled trial dengan teknik double blind pada 36 pasien dengan status fisik American Society of Anesthesiologists (ASA) I−II yang menjalani kuretase di ruangan Obstetri dan Ginekologi RSUP Dr. Hasan Sadikin Bandung periode Juli sampai Oktober 2017. Kelompok deksmedetomidin mendapatkan loading dose deksmedetomidin 1 mcg/kgBB dalam waktu 10 menit dilanjutkan dosis pemeliharaan 0,5 mcg/kgBB/jam. Kelompol fentanil-propofol mendapatkan loading dose propofol 1 mg/kgBB dalam 10 menit diikuti dosis pemeliharaan 50 mcg/kgBB/jam ditambah fentanil 1 mcg/kgBB dalam 5 menit, lalu dicatat nilai BIS. Data dianalisis dengan uji-t dan Uji Mann-Whitney dengan p<0,05 dianggap bermakna. Analisis data statistik nilai BIS kelompok deksmedetomidin 79,50±2,121 dan fentanil-propofol 85,22±0,732 dengan perbedaan bermakna (p<0,05). Simpulan, penelitian ini menunjukkan kedalaman sedasi pada kelompok deksmedetomidin menghasilkan nilai BIS lebih rendah dibanding dengan fentanil-propofol pada pasien yang dilakukan kuretase.
Kata kunci: Bispectral index score(BIS), dexmedetomidine, fentanil, kuretase, propofo
Pengaruh Penambahan Klonidin 75 mcg pada 12,5 mg Levobupivakain 0,5% Secara Intratekal terhadap Lama Kerja Blokade Sensorik dan Motorik untuk Bedah Ortopedi Ekstremitas Bawah
No full textKeterbatasan anestesi spinal antara lain ialah lama kerja blokade sensorik dan motorik terbatas. Penelitian ini bertujuan melihat pengaruh penambahan 75 mcg klonidin pada 12,5 mg levobupivakain 0,5% terhadap lama kerja blokade sensorik dan motorik pada anestesi spinal untuk bedah ortopedi ekstremitas bawah. Penelitian bersifat eksperimental prospektif dengan metode acak terkontrol tersamar ganda pada 36 sampel dengan kriteria American Society of Anesthesiologist (ASA) I-II yang menjalani operasi ortopedi ekstremitas bawah dengan anestesi spinal di Rumah Sakit Dr. Hasan Sadikin Bandung pada bulan Juni–Agustus 2014. Kelompok levobupivakain dan klonidin (LK) mendapatkan 12,5 mg levobupivakain 0,5% ditambah klonidin 75 mcg. Kelompok levobupivakain dan salin (LS) mendapatkan 12,5 mg levobupivakain 0,5% ditambah NaCl 0,9% 0,5 mL. Data hasil penelitian diuji secara statistik menggunakan uji-t, Mann-Whitney, dan chi-kuadrat. Hasil penelitian menunjukkan lama kerja blokade sensorik kelompok LK lebih lama secara bermakna yaitu 244,44 (37,84) menit dibandingkan dengan kelompok LS, yaitu 107,89 (17,63) menit (p=0,000). Lama kerja blokade motorik kelompok LK lebih lama secara bermakna yaitu 278,72 (41,75) menit dibandingkan dengan kelompok LS, yaitu 128,39 (18,26) menit (p=0,000). Simpulan, penambahan klonidin 75 mcg pada 12,5 mg levobupivakain 0,5% secara intratekal memerpanjang lama kerja blokade sensorik dan motorik.Kata kunci: Anestesi spinal, klonidin, levobupivakain, lama kerja blokade sensorik, lama kerja blokade motorikEffect of Clonidine 75 mcg Addition to Intrathecal 12.5 mg 0.5% Levobupivacaine on Sensoric and Motoric Blockade Duration in Lower Extremity Orthopedic SurgeryAbstractSpinal anesthesia has some limitations that limits its use, such as limited duration of action in motoric and sensoric. This research aimed to provide an overview on the effect of adding clonidine 75 mcg to 12.5 mg 0.5% levobupivacaine on the motoric and sensoric blockade action duration in lower extremity orthopedic surgery spinal anesthesia. This experimental prospective research used double blind randomized controlled trial approach on 36 patients with ASA I-II physical status who underwent lower extremity orthopedic surgery using spinal anesthesia in Dr. Hasan Sadikin General Hospital during the period of June to August 2014. LC group, clonidine 75 mcg was added to 12.5 mg 0.5% levobupivacaine. On LS group, 12.5 mg 0.5% mg levobupivacaine mixed with 0.5 mL 0.9% NaCl. The data were then statistically tested using t-test, Mann-Whitney, and chi-square. The result showed that the duration of action of sensoric blockade in LK group was significantly longer, i.e. 224.44 (37.84) minutes compared to LS group, i.e. 107.89 (17.63) minutes (p=0.000). Duration of action of motoric blockade in LK group was significantly longer, i.e. 278,72 (41,75) minutes, compared to LS group, i.e. 128.39 (18.26) minutes (p=0.000). It is concluded that the additiona of clonidine 75 mcg to 12,5 mg 0,5% levobupivacaine significantly prolongs the duration of action of the motoric and sensoric blockade if given intrathecally.Key words: Clonidine, duration of action, duration of action of motoric blockade, levobupivacaine, spinal anesthesia DOI: 10.15851/jap.v3n1.374
Area Under the Curve dan Akurasi Cystatin C untuk Diagnosis Acute Kidney Injury pada Pasien Politrauma
No full textPasien yang mengalami cedera dengan Injury Severity Score (ISS) >16 didefinisikan sebagai politrauma. Pada politrauma terjadi hipoksia jaringan, autoregulasi terganggu, mikrosirkulasi glomerulus, cedera sel tubular serta proses inflamasi yang apabila tidak diatasi secara adekuat dapat menyebabkan acute kidney injury (AKI). Saat ini diagnosis AKI berdasar atas kenaikan kreatinin serum yang terdeteksi setelah terjadi kerusakan ginjal. Cystatin C merupakan penanda biologis yang dapat mendeteksi AKI. Tujuan penelitian ini adalah mengetahui nilai area under the curve (AUC) dan akurasi cystatin C untuk diagnosis AKI pada pasien politrauma di Instalasi Gawat Darurat (IGD) RSUP Dr. Hasan Sadikin Bandung. Penelitian uji diagnostik ini dengan analisis data sekunder pada sebagian data penelitian Academic Leadership Grant (ALG) pasien politrauma di IGD RSUP Dr. Hasan Sadikin Bandung dari Januari–Juni 2017. Analisis data menggunakan kurva receiver operating characteristic (ROC) dengan program statistical product and service solution (SPSS)versi 24.0 for windows. Hasil penelitian dari 23 sampel menunjukkan pada cut-off point 354,97 ng/mL cystatin C plasma memiliki sensitivitas 100%, spesifisitas 88,9%, nilai duga positif 71,4%; nilai duga negatif 100%; nilai AUC 0,967; dan akurasi 91,3%. Simpulan penelitian ini adalah nilai AUC dan akurasi cystatin C memberikan hasil yang baik dalam diagnosis AKI pada pasien politrauma.
Kata kunci: Acute kidney injury, akurasi, cystatin C, nilai AUC, politrauma
Area Under the Curve and Cystatin C Accuracy for Acute Kidney Injury Diagnosis in Polytrauma Patients
Patients experiencing injuries with an Injury Severity Score (ISS) of >16 are defined as polytrauma patients. Polytrauma can cause hypoxia, disruption of autoregulation, glomerular microcirculation, tubular cell injury, and inflammation processes that, without adequate treatment, may lead to acute kidney injury (AKI). The current diagnosis of AKI is based on the elevated serum creatinine that can be detected after kidney damage. Cystatin C is a biomarker that can detect AKI. The aim of this study was to determine the value of area under the curve (AUC) and accuracy of cystatin C for diagnosing AKI in polytrauma patients in the Emergency Room (ER) of Dr. Hasan Sadikin Bandung. A diagnostic test study using secondary data from theAcademic Leadership Grant (ALG) study onpolytrauma patients in the ER of Dr. Hasan Sadikin General Hospital Bandung, from January 2017−June 2017 was performed. Data was analyzed using the receiver operating characteristic (ROC) curve with statistical product and service solution (SPSS) version 24.0 for windows. Results from 23 samples showed that the cut off point of plasma cystatin C was 354.97ng/mL with a sensitivity of 100.0%, specificity of 88.9%, positive predictive value of 71.4%, negative value of 100.0%, AUC value of 0.967 and accuracy of 91.3%. Hence, the AUC values and cystatin C accuracy present good results for diagnosing AKI in polytrauma patients.
Key words: Accuracy, acute kidney injury, cystatin C, the value of AUC, polytraum
Perbandingan Efek Pemberian Norepinefrin Bolus Intravena dengan Norepinefrin Infus Kontinu dalam Tatalaksana Hipotensi, Laju Nadi, dan Nilai APGAR pada Seksio Sesarea dengan Anestesi Spinal
No full textVasopresors are commonly used for the treatment of hypotension in spinal anesthesia for cesarean section. This research aimed to compare intravenous bolus of norepinephrine to continuous infusion of norepinephrine effectiveness in hypotension management in caesarean section patient under spinal anesthesia and their effect on heart rate and APGAR Score, The experimental study was conducted in a double-blind randomized manner to 44 American Society of Anesthesiologist (ASA) physical status II pregnant women undergoing cesarean section with spinal anesthesia in Dr. Hasan Sadikin General Hospital Bandung within the period of September to -November 2013. The Study subjects were grouped into two groups, the first group received 4 µg intravenous bolus of norepinephrine group (NB) and and the second received 8 µg/minute continuous infusion of norepinephrine group (NK). Data were analyzed by t-test, Mann-Whitney test, chi-square and analysis of variance (ANOVA) t-test with p0.05). Conclusion from this study is the administration of norepinephrine in both ways can be used for the treatment of hypotension of spinal anesthesia without affecting the heart rate and APGAR scor
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