83,669 research outputs found
A produção de conhecimentos no Serviço Social: uma análise no HU/UFSC
No full textTCC (graduação) - Universidade Federal de Santa Catarina, Centro Sócio Econômico, Curso de Serviço Social.O presente Trabalho de Conclusão de Curso, tem como objeto de estudo a produção de conhecimento no Serviço Social, utilizados diariamente pelas Assistentes Sociais do HU/UFSC. Pretende-se com este estudo investigar as modificações ocorridas nos conhecimentos no Serviço Social, que estiveram e estão presentes na atuação profissional do Assistente Social, bem como analisar suas influências no atendimento das demandas apresentadas neste espaço ocupacional. Para realização do trabalho, utilizamos a pesquisa bibliográfica, principalmente nas Revistas Serviço Social e Sociedade e Cadernos da ABESS/ABEPSS e ainda pesquisa documental, com intuito de coletar dados e proceder à análise de conteúdo, ambos com vistas a investigar a abordagem e compreensão dos temas usuário, família, saúde, prática profissional, metodologia e teoria. Observamos que além das transformações na própria profissão de Serviço Social, a qual passou a qualificar seu rigor teórico-metodológico a partir da década de 1990, também ocorreram mudanças na abordagem dos termos no interior do HU/UFSC o que auxiliou na inovação dos atendimentos aos usuários, destacando-se o reconhecimento do cidadão como cidadão de direitos
Apecholinus imitator Smetana & Hu 2019
No full textApecholinus imitator Smetana & Hu, 2019 (Figs. 5–6) Material examined. TAIWAN: Pingtung County: 1 spec., Tahanshan (± ÀƜ), 25.IV.2017. leg. B.-X. Guo (TARI); 1 female, Chun-jih, Ta-han shan, ± ÀƜ, 1350m, 2019,V-13 (Night), Y.- T. Chung Leg. CCCC (FSHc); 1 female, Majia Forest Trail (ṞxIJǎ), Majia To., 28-VI-2017, leg. R. H. Liu (FSHc); 1 spec., CCCC, Tahanshan (± ÀƜ), 15.IV.2019. leg. Y.- T. Chung (TARI). Description. For male description see Smetana & Hu (2019). Female. Genital segment. Tergite 10 (Fig. 6) obviously different from male tergite 10. Apical portion of female tergite 10 markedly narrow and elongated, with narrow acute apical portion; setae are relatively concentrated on the apex. Diagnosis. Apecholinus imitator can be distinguished from all other species of Apecholinus in Taiwan by the golden-yellow tomentose setae on the body. An undescribed species of Apecholinus in Taiwan is similar to this species but it currently known only from a single female, so I refrain from describing it until male specimens are found. The patches of golden-yellow tomentose pubescence on the elytra of Ap. imitator are much larger than that of the undescribed species. Bionomics. Based on an import of locality name into Google Earth from collection data (Smetana & Hu 2019 and this study), the species occurs from 800–1700 m. One specimen of Ap. imitator was collected by pitfall trap but nothing known about the habitat the traps were set in; some specimens of Ap. imitator were attracted to an LED flashlight in the evening on a forest trail (Smetana & Hu 2019). Distribution. Apecholinus imitator is at present known from central and southern Taiwan including Nantou County, Taitung County and Pingtung County (Smetana & Hu 2019, this study). Remarks. Up to the present, the morphology of females in Apecholinus is poorly known. So far, only females of Ap. fraternus (see Smetana 2018), Ap. liui (He & Zhou, 2017) (see He & Zhou 2017) and Ap. kaiseri Bernhauer, 1933 (see Smetana 2003) had been described and female tergite 10 of these species is similar to that of the male. However, the apical portion of tergite 10 of Ap. imitator is much narrower and more elongate in females than in males.Published as part of Hu, Fang-Shuo, 2020, New distributional records of Staphylinina in Taiwan, including a new species of Miobdelus Sharp (Coleoptera: Staphylinidae: Staphylininae: Staphylinini), pp. 334-360 in Zootaxa 4768 (3) on page 337, DOI: 10.11646/zootaxa.4768.3.2, http://zenodo.org/record/378403
O endomarketing como técnica interveniente no processo de acreditação do HU-UFSC e seus reflexos à cultura organizacional
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Sócio-Econômico. Programa de Pós-Graduação em Administração UniversitáriaA gestão da qualidade nas últimas décadas ultrapassou as fronteiras da indústria, chegando às organizações comerciais e às prestadoras de serviços, dentre elas as organizações prestadoras de serviços de saúde. Dentro deste contexto, o modelo de Acreditação hospitalar emergiu como a ferramenta de gestão da qualidade, preconizando a padronização da assistência ao paciente ou cliente por meio da normatização e classificação dos hospitais em três níveis distintos, quais sejam: Nível 1; Nível 2; e Nível 3. Desta forma, em 1999, foi editado o primeiro Manual Brasileiro da Organização Nacional de Acreditação (ONA, 2010). Razões pelas quais, elaborou-se a presente dissertação no Programa de Mestrado Profissional em Administração Universitária, um estudo de caso realizado no Hospital Universitário Polidoro Ernany de São Thiago da Universidade Federal de Santa Catarina (HU-UFSC) sobre esta problemática. As variáveis analisadas foram: Acreditação Hospitalar, cultura organizacional e endomarketing. A amostra obedeceu a dois momentos distintos: inciamente foi realizada uma entrevista semiestruturada, intensiva e intencional, com o grupo de 14 dirigentes de primeiro escalão do HU-UFSC. Na sequência, aplicou-se um questionário estruturado e tratado de forma probabilística, do Tipo Likert, a 268 servidores que trabalham neste hospital. O período das coletas de dados foi de janeiro a março de 2012. As técnicas de tratamento dos dados foram quanti-qualitativas. Os dados quantitativos foram tabulados em planilha Excel e processados pelo programa SPSS®. Agregaram-se fontes secundárias que valorizassem a pesquisa. Conclui-se que o HU-UFSC é considerado pelos participantes da pesquisa um hospital de boa a muito boa qualidade de atendimento e assistência à saúde, mas requer algumas providências que enderecem à Acreditação Hospitalar Nível 1, tais como: reforçar a comunicação geral e, especialmente, o estreitamento das relações profissionais entre os dirigentes e os servidores. A ferramenta de comunicação mais sinalizada pelos participantes para contribuir no processo de sensibilização à Acreditação hospitalar foi a promoção de palestras sobre o referido programa e reuniões constantes a propósito deste tema. O estudo permitiu concluir ainda que o ambiente para a implantação da Acreditação Hospitalar, Nível 1, parece ser favorável para se iniciar este processo, desde que as técnicas e ferramentas de endomarketing sejam corretamente aplicadas, com o fito de remodelar de forma positiva a cultura organizacional endereçada ao Nível 1, do Manual Brasileiro de Acreditação Hospitalar (ONA, 2010).Quality management in the recent decades has exceeded the industry boundaries, reaching the commercial organizations and service providers, among them, organizations that provide health care services. Within this context, the hospital accreditation model has emerged as a tool for quality management, aiming at the standardization of patient care or client through the standardization and classification of hospitals into three distinct levels, wich are: Level 1, Level 2 and Level 3.Thus in 1999, it was published the first manual of the Brazilian National Accreditation Organizations (ONA, 2010). On these issues this master's dissertation was elaborated to the University of Professional Master of Business Administration, a study case conducted at the University Hospital Polidoro Ernany de São Thiago - Universidade Federal de Santa Catarina (HU-UFSC). The variables analyzed were: Hospital Accreditation, Organizational Culture and Internal Marketing. The sample followed two distinct moments: initially a semi-structured interview was conducted, intensive and intentional, with a group of 14 leaders first step at HU-UFSC. In the sequency, we applied a structured questionnaire and treated in a probabilistic manner, the Ukert Type, to 268 servers working in this hospital. The period of data collection was from January through March, 2012. The treatment techniques of quantitative and qualitative data were: Quantitative data formulated in an Excel spreadsheet and processed by SPSS®. And added to secondary sources that value the search. It is concluded that the UFSC-HU hospital is considered to have a good to a very good quality of health care and assistance by the research participants and requires some steps that addresses the Hospital Accreditation Level 1, such as strengthening the general communication and especially the strengthening of professional relationships between managers and servers, the communication tool most marked by the participants to contribute in the process of sensltl7atlon to Hospital Accreditation. Also it was mentioned the promotion of lectures on the program and constant meetings on the topic. It is thought that the environment for the implementation of the Hospital Accreditation, Level 1, seems to be favorable to stan this process, since the internal marketing techniques and tools are correctly applied, aiming on reshaping a positive culture addressed to an organizational level, the Brazilian Manual of Hospital Accreditation (ONA, 2010)
Performance Evaluation of Distributed-Antenna Communications Systems Using Beam-Hopping
No full textDigital beamforming (DBF) techniques are capable of improving the performance of communications systems significantly. However, if the transmitted signals are conflicted with strong interference, especially, in the direction of the transmitted beams , these directional jamming signals will severely degrade the system performance. In order to efficiently mitigate the interference of the directional jammers, in this contribution a beam-hopping (BH) communications scheme is proposed. In the proposed BH communications scheme, only one pair of the beams is used for transmission and it hops from one to the next according to an assigned BH pattern. In this contribution a range of expressions in terms of the average SINR performance have been derived, when both the uplink and downlink are considered. The average SINR performance of the proposed BH scheme and that of the conventional single-beam (SB) as well as multiple-beam (MB) assisted beam-processing schemes have been investigated. Our analysis and results show that the proposed BH scheme is capable of efficiently combating the directional jamming, with the aid of utilizing the directional gain of the beams generated by both the transmitter and the receiver. Furthermore, the BH scheme is capable of reducing the intercept probability of the communications. Therefore, the proposed BH scheme is suitable for communications, when several distributed antenna arrays are available around a mobile
Paraneoplastic Neurological Syndromes associated with anti-Hu antibodies: are T lymphocytes involved or not?
No full textIn paraneoplastic neurological syndromes (PNS), ectopic expression of onconeural antigens by the tumor triggers an immune response that not only reacts with the tumor but also with the same antigens expressed in the nervous system. This immune response inhibits tumor growth. However, the price of tumor control is high, as PNS are devastating neurological syndromes leaving most of the patients severely disabled within a few months. One of the most frequently involved tumors is small cell lung cancer (SCLC), and approximately 50% of patients with PNS and SCLC have high-titer antibodies against the onconeural Hu-antigens (anti-Hu). Previous studies have clearly demonstrated that anti-Hu antibodies do not play a pathogenic role in Hu-PNS and tumor control, but rather are a useful diagnostic marker. Therefore, a role for the cellular immune system in the pathogenesis of PNS is hypothesized. In this thesis the role of T cells in PNS was investigated by studying CSF and blood of Hu-PNS patients. This role of T cells was confirmed by (i) 4-fold higher T lymphocyte numbers in CSF of Hu-PNS patients compared to controls; (ii) association of Hu-PNS with HLA-DQ2 and HLA-DR3; and (iii) neurological improvement or stabilization upon treatment with hCG. However, the presence of HuD-specific CD8+ T cells in CSF could not be demonstrated. Therefore, more research is required to either confirm or reject a role for T lymphocytes in Hu-PNS
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
B and T cell imbalances in CSF of patients with Hu-antibody associated PNS
No full textIn paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS) an important role for cellular immunity is hypothesized. We characterized the cerebrospinal fluid (CSF) pleocytosis in Hu-PNS patients by assessing the major lymphocyte subsets by flow cytometry. The B cell subset in the CSF of Hu-PNS patients showed a significant absolute (similar to 20x) and relative (similar to 3x) expansion, while the numbers of CD4+ T cells, CD8+ T cells and NK cells only showed an absolute expansion (similar to 4-7x) compared to the controls. On the other hand, the NKT cell subset showed a significant relative reduction in CSF and in blood of Hu-PNS patients. The relative B cell expansion is consistent with the intrathecal synthesis of Hu-antibodies, while the increased number of T and NK cells supports an additional role for cellular immunity in the pathogenesis of Hu-PNS. In addition, the autoimmune hypothesis of Hu-PNS is supported by the relative NKT cell deficiency. (C) 2008 Elsevier B.V. All rights reserved
No evidence for circulating HuD-specific CD8+ T cells in patients with paraneoplastic neurological syndromes and Hu antibodies
No full textAim: In paraneoplastic neurological syndromes (PNS) associated with small cell lung cancer (SCLC) and Hu antibodies (Hu-PNS), Hu antigens expressed by the tumour hypothetically trigger an immune response that also reacts with Hu antigens in the nervous system, resulting in tumour suppression and neuronal damage. To gain more insight into the hypothesized CD8+T cell-mediated immune pathogenesis of these syndromes, we searched for circulating HuD-specific CD8+T cells in a large cohort of Hu-PNS patients and controls. Patients and methods: Blood was tested from 43 Hu-PNS patients, 31 Hu antibody negative SCLC patients without PNS and 54 healthy controls. Peripheral blood mononuclear cells (PBMC) were stimulated with HuD protein-spanning peptide pools (15-mers) and individual HuD-derived peptides (9-mers) and analysed by cytokine flow cytometry and interferon-γ ELISPOT-assays. Additionally, HuD-based Class I HLA multimers were used to visualize HuD-specific CD8+T cells. Results: No HuD-specific CD8+T cells could be detected in the blood of Hu-PNS patients or controls. Conclusions: Our results do not support a role for HuD-specific CD8+T cells in Hu-PNS. Further studies should focus on the detection of circulating HuD-specific CD4+T cells and examine the antigen specificity of T cells in affected tissues
O Projeto ético-político na produção de conhecimentos do serviço social: uma análise no hospital universitário - HU
No full textTCC (graduação) - Universidade Federal de Santa Catarina, Centro Sócio Econômico, Curso de Serviço Social.O presente Trabalho de Conclusão de Curso tem como objeto de estudo investigar se as produções dos TCCs do Serviço Social do HU estão em conformidade com o projeto éticopolítico profissional e os fundamentos do SUS. Para a realização do trabalho utilizou-se a pesquisa bibliográfica, com o objetivo de coletar dados e analisar o conteúdo, visando conhecer o que a produção dos acadêmicos/pesquisadores reflete em relação ao projeto éticopolítico profissional e ao SUS. Foi feito um levantamento de todos os TCCs em Serviço Social realizados no HU, posteriormente estes trabalhos foram sistematizados por período, setor de atuação do Serviço Social no HU e por temas. Definiu-se como amostra de pesquisa os TCCs elaborados na Maternidade do HU. Estes abordavam os temas: Auxílio Natalidade, gravidez de alto risco, aborto por anencefalia, planejamento familiar, projeto de extensão # organizações da sociedade civil e prematuridade, descritos no presente trabalho. Por fim, fezse uma análise destes temas em relação a quais elementos do projeto ético-político estavam presentes nos TCC
Antigen-specific cytotoxic T cells mediate human fetal pancreas allograft rejection in SCID-hu mice
No full textHuman allograft rejection was studied in SCID mice transplanted with human fetal liver and thymus tissue (SCID-hu mice), These SCID-hu mice have functional, mature T cells with a polyclonal TCR repertoire. Within 12 to 36 wk after construction, SCID-hu mice were transplanted with an HLA-mismatched human fetal pancreas, In contrast to control SCID mice transplanted with pancreas alone, cellular infiltration, induction of HLA-DR on pancreatic epithelial cells, and tissue destruction of the allogenic pancreata were observed in SCID-hu mice, In addition, human insulin was not detected in the serum of SCID-hu mice in which pancreas rejection occurred. The infiltrating cells were mainly human CD3(+) T lymphocytes of thymic origin, expressing the CD45RO isoform, T cell lines and CD4(+) T cell clones obtained from the rejected tissues proliferated vigorously when stimulated with EBV-transformed B cell lines of pancreas donor origin. Furthermore, the majority of these CD4(+) T cell clones displayed strong allospecific cytotoxicity, In addition, CD8(+) T cell clones cytotoxic for EBV-transformed B tell lines of pancreas donors were isolated. Blocking experiments with anti-HLA mAbs and panel studies with HLA-matched cell lines showed that these CD4(+) and CD8(+) T cell clones were specific for the HLA class II and class I molecules, respectively, expressed by the pancreas donor, These data indicate that human T lymphocytes developing in SCID-hu mice are able to mount in vivo responses against allogenic organs, resulting in tissue infiltration and rejection, In addition, they show that both CD4(+)- and CD8(+)-allospecific CTL can be isolated from rejected allogenic pancreata
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