35,476 research outputs found
Color and material for hotel interior / Syed Abdul Malek Syed Ziad Wapha
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1 i l a c s , p u r p l e s , s o m e greys and t u r q u o i s e . T h e s e can h e l p t o c r e a te a s p a c i o u s , e l e g a n t l o o k < i f t h e y a r e n o t t o o d a r k ) i n a r e l a t i v e lys m a l l area. A t h i r d group o-f c o l o u r s a r e o-ften c a l l e d " n e u t r a l".and i n c l u d e g r e y s (those w i t h same c o l o u r c o n t e n t ) , b e i g e s , c r e a ms
and o-f-F w h i t e s , a l t h o u g h s t r i c t l y s p e a k i n g t h e o n l y r e a l n e u t r a ls a r e pure black and w h i t e , o r a m i x t u r e o-F them i n v a r y i ng q u a n t i t i e s to c r e a t e a t r u e g r e y . T h i s range can be used .most s u c c e s s f u l l y to c r e a t e a b a l a n c e between s e v e r a l .strong or contrasting colours , oralon e f o r a s o p h i s t i c a t e d t o n e - o n - t o n e or
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Safety of medical device users: A study of physiotherapists’ practices, procedures and risk perception
No full textThis thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Aims: To study practices and procedures with respect to electrotherapy in physiotherapy departments and to study physiotherapists’ perception of health risk, health consequences and protection of health from different risks including electromagnetic field emissions from electrotherapy devices.
Methods: This cross-sectional study was conducted in three phases from June 2002 to December 2003. The first phase was an audit of the practices and procedures regarding electrotherapy in National Health Service physiotherapy departments (N = 46 including 7 departments in pilot study) located in 12 counties in the southeast and southwest of England including Greater London. The second phase comprised one observational visit to each of the same physiotherapy departments to characterise their occupational environment. The third phase was a questionnaire survey of 584 physiotherapists working in these departments. Variables concerned perception of health risk, health consequences and protection of health associated with different risk factors.
Results: In the first two phases, the recruitment rate of the departments was 80.7% (46 out of 57) and response rate of those recruited was 100% (n=46). The response rate for the last phase of the study was 66.8% (390 out of 584). Results of the practices and procedures audit show that ultrasound was the most common form of electrotherapy while microwave diathermy was neither available nor used in these departments. Pulsed shortwave diathermy was used 4-5 days per week while continuous shortwave diathermy was used rarely. Electrotherapy was provided to up to 50% of patients per week in the departments. The observational visits to the departments revealed that there were metallic objects within close proximity of diathermy equipment and wooden treatment couches for treatment with PSWD and CSWD were rare. The risk perception survey showed that physiotherapists generally perceived a moderate health risk and health consequences (harm) from exposure to EMF emissions from electrotherapy devices. Protection from EMFs in physiotherapy departments was generally perceived as ‘usually’ possible.
Conclusions: Physiotherapy departments report safe electrotherapy practices. Use of diathermy devices that use RF EMFs is declining. The key predictors of physiotherapists’ perception of health risk were perception of health consequences and vice versa. Gender was a significant predictor of the perception of health risks and health consequences. The main predictor of perception of protection against risk was the knowledge of environmental and health issues. Latent dimensions of perceptions of health risk, health consequences and protection from risk were identified and confirmed and their predictors were determined.Brunel Universit
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
The maternal immune system during pregnancy and its influence on fetal development
No full textThe maternal immune system plays a critical role in the establishment, maintenance, and completion of a healthy pregnancy. However, the specific mechanisms utilized to achieve these goals are not well understood. Various cells and molecules of the immune system are key players in the development and function of the placenta and the fetus. Effector cells of the immune system act to promote and yet limit placental development. The T helper 1 (Th1)/T helper 2 (Th2) immune shift during pregnancy is well established. A fine balance between proinflammatory and anti-inflammatory influences is required. We herein review the evidence regarding maternal tolerance of fetal tissues and the underlying cell-mediated immune and humoral (hormones and cytokines) mechanisms. We also note the many unanswered questions in our understanding of these mechanisms. In addition, we summarize the clinical manifestations of an altered maternal immune system during pregnancy related to susceptibility to common viral, bacterial, and parasitic infections, as well as to autoimmune diseases.Peer reviewe
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Letter from X. N. Steeves to Carl Hayden
No full textLetter from X. N. Steeves to Carl T. Hayden describing road conditions around the Grand Canyon National Par
Letter from Carl Hayden to X. N. Steeves
No full textLetter with red pencil corrections from Carl T. Hayden to X. N. Steeves about the construction of an approach road to the canyo
Enhancing Autonomous Orchard Navigation: A Real-Time Convolutional Neural Network-Based Obstacle Classification System for Distinguishing ‘Real’ and ‘Fake’ Obstacles in Agricultural Robotics
No full textAutonomous navigation in agricultural environments requires precise obstacle classification to ensure collision-free movement. This study proposes a convolutional neural network (CNN)-based model designed to enhance obstacle classification for agricultural robots, particularly in orchards. Building upon a previously developed YOLOv8n-based real-time detection system, the model incorporates Ghost Modules and Squeeze-and-Excitation (SE) blocks to enhance feature extraction while maintaining computational efficiency. Obstacles are categorized as “Real”—those that physically impact navigation, such as tree trunks and persons—and “Fake”—those that do not, such as tall weeds and tree branches—allowing for precise navigation decisions. The model was trained on separate orchard and campus datasets and fine-tuned using Hyperband optimization and evaluated on an external test set to assess generalization to unseen obstacles. The model’s robustness was tested under varied lighting conditions, including low-light scenarios, to ensure real-world applicability. Computational efficiency was analyzed based on inference speed, memory consumption, and hardware requirements. Comparative analysis against state-of-the-art classification models (VGG16, ResNet50, MobileNetV3, DenseNet121, EfficientNetB0, and InceptionV3) confirmed the proposed model’s superior precision (p), recall (r), and F1-score, particularly in complex orchard scenarios. The model maintained strong generalization across diverse environmental conditions, including varying illumination and previously unseen obstacles. Furthermore, computational analysis revealed that the orchard-combined model achieved the highest inference speed at 2.31 FPS while maintaining a strong balance between accuracy and efficiency. When deployed in real-time, the model achieved 95.0% classification accuracy in orchards and 92.0% in campus environments. The real-time system demonstrated a false positive rate of 8.0% in the campus environment and 2.0% in the orchard, with a consistent false negative rate of 8.0% across both environments. These results validate the model’s effectiveness for real-time obstacle differentiation in agricultural settings. Its strong generalization, robustness to unseen obstacles, and computational efficiency make it well-suited for deployment in precision agriculture. Future work will focus on enhancing inference speed, improving performance under occlusion, and expanding dataset diversity to further strengthen real-world applicability
Table_S3-Detailed_Prevalence_Revised_191219 – Supplemental material for Analgesic Use in Patients With Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis
No full textSupplemental material, Table_S3-Detailed_Prevalence_Revised_191219 for Analgesic Use in Patients With Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis by Sara N. Davison, Sarah Rathwell, Chelsy George, Syed T. Hussain, Kate Grundy and Liz Dennett in Canadian Journal of Kidney Health and Disease</p
TableS1_Search_Strategy_211019 – Supplemental material for Analgesic Use in Patients With Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis
No full textSupplemental material, TableS1_Search_Strategy_211019 for Analgesic Use in Patients With Advanced Chronic Kidney Disease: A Systematic Review and Meta-Analysis by Sara N. Davison, Sarah Rathwell, Chelsy George, Syed T. Hussain, Kate Grundy and Liz Dennett in Canadian Journal of Kidney Health and Disease</p
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