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HUBUNGAN KADAR HORMON TRIIODOTHYRONINE DAN THYROID STIMULATING HORMONE SERUM DENGAN DERAJAT KEPARAHAN MELASMA DI RSUP DR.M.DJAMIL PADANG
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Melasma adalah hipermelanosis kronis didapat, merupakan gangguan kulit yang umum terjadi pada perempuan terutama pada area paparan sinar matahari. Etiologi melasma belum dipahami dengan baik, salah satu faktornya adalah hormon tiroid. Terdapat beberapa penelitian yang dilakukan untuk mengetahui hubungan melasma dengan gangguan tiroid namun memiliki hasil yang bervariasi. Penelitian ini mencari hubungan antara parameter hormon tiroid (triiodothyronine dan thyroid stimulating hormone) dengan derajat keparahan melasma.
Tujuan penelitian:
Untuk mengetahui hubungan kadar hormon triiodothyronine (T3) dan thyroid stimulating hormone (TSH) serum dengan derajat keparahan melasma.
Subyek dan metode penelitian:
Tiga puluh enam perempuan dengan melasma berusia >18 tahun sebagai subyek penelitian memiliki pekerjaan dalam ruang di RSUP Dr.M.Djamil Padang. Kriteria eksklusi: hamil/menyusui, menggunakan kontrasepsi oral, menggunakan terapi hormonal, mendapat pengobatan antijamur sistemik dan antikonvulsan yang bersifat photosensitizer, dan sedang dalam pengobatan melasma topikal/sistemik. Didapat riwayat perlindungan terhadap matahari. Skor MASI dicatat. Kadar hormon T3 dan TSH serum diukur dengan metode electrochemiluminescence-immunoassay (ECLIA).
Hasil penelitian:
Usia rerata pasien melasma dalam penelitian ini: 45,52±8,11 tahun, paling banyak usia >50 tahun (50%). Tipe malar lebih banyak dibandingkan sentrofasial (61,1%), tidak ditemukan tipe mandibular. Melasma derajat ringan paling banyak ditemukan (19 orang) dari total 36 subyek penelitian. Rerata skor MASI: 21,46±10,40. Rerata kadar hormon T3 dan TSH serum: 1,578±0,282 nmol/l dan 1,773±1,457 µIU/L (p>0,05).
Kesimpulan:
Ditemukan rerata kadar hormon T3 dan TSH serum tidak berhubungan dengan derajat keparahan melasma, namun peningkatan kadar TSH sesuai dengan peningkatan derajat melasma, tetapi secara statistik tidak bermakna. Diperlukan penelitian lebih lanjut dengan cara memasukkan kriteria inklusi pasien hipotiroidisme yang memiliki melasma dibandingkan dengan pasien kontrol menggunakan metode cross-sectional comparative sampling dengan jumlah sampel masing-masing derajat keparahan melasma sama besar.
Kata kunci: hormon triiodothyronine, thyroid stimulating hormone, derajat keparahan melasm
BASAL CELL CARCINOMA IN XERODERMA PIGMENTOSUM IN AN 18.YEAR.OLD MALE
Get PDFXeroderma pigmentosum (XP) is a rare autosomalrecessiye disorder that occurs becauseof inactivation of the xeroderma pigmentosum protein, which is an important DNA damagerecognition protein involved in DNA nucleotide excision repair (NER). This defect, whichprevents removal of a wide array of direct and indirect DNA /esions, is assocrafe d with adecrease in catalase activity. This photosensifive disarder resulfs in multipte face, neck andhead basal cell carcinomas (BCCs), squamous cell carcinomas (SCCsJ and melanomas whichis characterized by cellular hypersensitivity to ultraviolet radiation, development of cancers at anearly age, severe actinic cancer, and photophobia. As a common sfressor of skin, uttraviotet-B(UVB) induces a biphasic HIF-Iq variation through ROS generation in keratinocytes. Wereported a case of an 18-year-old-male with XP presented with BCC on the teft cheek. Thcpatient had hypo- and hyperpigmented macules since early childhood, throughout the body,more on sun exposed areas.AbstrakXeroderma pigmentosum (XP) adalah kelainan autosomal resesif yang jarang terjadidisebabkan oleh inaktivasi protein xeroderma pigmentosum yang merupakan protein pentingpengenal kerusakan DNA yang terlibat dalam nucleotide excision repair (NER) DNA. Defekini mencegah penghapusan beragam lesi DNA langsung dan tidak langsung, terkait denganpenurunan aktivitas katalase. Kelainan fotosensitivitas ini menyebabkan terjadinya basalkarsinoma sel (BCC), karsinoma sel skuamosa (SCC) dan melanoma pada wajah, leher dankepala yang ditandaidengan hipersensitivitas seluler radiasi ultraviolet, perkembangan kankerpada usia dini, kanker actinic yang berat, dan fot'ofobia. Ultraviolet-B (UVB) merupakan stressorpada kuit yang menginduksi variasi HIF-1q bifasik melalui generasi ROS dalam keratinosit.Kami melaporkan kasus XP dengan BCC di pipi kiri pada laki-laki berusia 18 tahun. Pasienmemiliki makula hipo- dan hiperpigmentasisejak masa kanak-kanak awal, seluruh tubuh, lebihpada daerah yang terpapar sinar matahari
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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