379 research outputs found
Guidelines for diagnosis and management of beta-thalassemia intermedia
No full textBeta-thalassemia intermedia (β-TI) is a genetic variant of beta-thalassemias with a clinical disorder whose severity falls between thalassemia minor and thalassemia major. Different genetic defects are involved in this disorder and, based on severity of disease, clinical complications like skeletal deformities and growth retardation, splenomegaly, extramedullary hematopoiesis, heart failure, and endocrine disorders may be present in untreated patients. Precise diagnosis and management are essential in these patients for prevention of later clinical complications. Diagnosis of TI is based on clinical and laboratory data. There are some treatment strategies like modulation of gamma-globulin chain production with hydroxyurea or other drugs, transfusion, splenectomy, and stem cell transplantation. Iron chelation therapy is also needed in many of these patients even if they are not transfused. The aim of this manuscript is to review the clinical manifestations, complications, genetic defects, and unmet treatments needs in TI.Aessopos A, 2007, ATHEROSCLEROSIS, V191, P427, DOI 10.1016-j.atherosclerosis.2006.04.015; Aessopos A, 2007, TRANSFUSION, V47, P792, DOI 10.1111-j.1537-2995.2007.01192.x; Amoozgar H, 2011, EUR J HAEMATOL, V85, P549; Atichartakarn V, 2003, INT J HEMATOL, V78, P139, DOI 10.1007-BF02983382; Cadili A, 2008, AM J MED, V121, P371, DOI 10.1016-j.amjmed.2008.02.014; CAMASCHELLA C, 1995, HAEMATOLOGICA, V80, P58; Camaschella C, 1997, AM J HEMATOL, V55, P83, DOI 10.1002-(SICI)1096-8652(199706)55:283::AID-AJH63.3.CO;2-M; Cappellini MD, 2005, SEMIN HEMATOL, V42, pS19, DOI 10.1053-j.seminhematol.2005.01.001; Cappellini MD, 2000, BRIT J HAEMATOL, V111, P467, DOI 10.1046-j.1365-2141.2000.02376.x; Derakhshan A, 2008, SAUDI J KIDNEY DIS T, V19, P206; De Sanctis V, 1998, J PEDIATR ENDOCR MET, V11, P965; Dixit A, 2005, ANN HEMATOL, V84, P441, DOI 10.1007-s00277-005-1026-4; Elalfy MS, 2013, EUR J HAEMATOL, V91, P522, DOI 10.1111-ejh.12182; El Rassi F, 2008, PEDIATR ANN, V37, P322; Galanello R, 1998, ANN NY ACAD SCI, V850, P325, DOI 10.1111-j.1749-6632.1998.tb10489.x; Gamberini MR1, 2004, PEDIAT ENDOCRINOL S2, P319; Gladwin MT, 2003, NAT MED, V9, P496, DOI 10.1038-nm0503-496; Gladwin MT, 2008, NEW ENGL J MED, V359, P2254, DOI 10.1056-NEJMra0804411; Haddad A, 2014, TURK J HEMATOL, V31, P5, DOI 10.4274-Tjh.2014.0032; Haghpanah S, 2014, HEMATOLOGY, V19, P187, DOI 10.1179-1607845413Y.0000000121; Harmatz P, 2008, HAEMATOL-HEMATOL J, V93, P1247, DOI 10.3324-haematol.12352; Karimi M, 2012, INT J HEMATOL, V95, P51, DOI 10.1007-s12185-011-0985-6; Karimi M, 2012, ANN HEMATOL, V91, P1833, DOI 10.1007-s00277-012-1527-x; Karimi M, 2009, EUR J HAEMATOL, V82, P213, DOI 10.1111-j.1600-0609.2008.01192.x; Karimi M, 2012, HEMATOLOGY, V17, P122, DOI 10.1179-102453312X13221316477778; Karimi M, 2010, EUR J HAEMATOL, V84, P52, DOI 10.1111-j.1600-0609.2009.01356.x; Karimi M, 2014, HEMATOLOGY; Karimi M, 2007, INT J LAB HEMATOL, V29, P321, DOI 10.1111-j.1365-2257.2006.00856.x; Karimi M, 2010, THROMB HAEMOSTASIS, V103, P989, DOI 10.1160-TH09-09-0661; Karimi M, 2011, EUR J INTERN MED, V22, P607, DOI 10.1016-j.ejim.2011.05.013; Karimi M, 2008, LANCET, V372, P1436, DOI 10.1016-S0140-6736(08)61590-1; Karimi M, 2008, AM J HEMATOL, V83, P77, DOI 10.1002-ajh.20938; Karimi M, 2005, J PEDIAT HEMATOL ONC, V27, P380, DOI 10.1097-01.mph.0000174386.13109.28; Karimi M, 2010, PEDIATR HEMAT ONCOL, V27, P205, DOI 10.3109-08880011003639952; Mancuso A, 2006, HEMOGLOBIN, V30, P119, DOI 10.1080-03630260500455565; Manfre L, 1999, AM J ROENTGENOL, V173, P1477; Matta BN, 2013, J EUR ACAD DERMATOL; Moorchung N, 2006, HAEMA, V9, P505; Musallam KM, 2011, EUR J HAEMATOL, V87, P73, DOI 10.1111-j.1600-0609.2011.01623.x; Musallam KM, 2011, HAEMATOL-HEMATOL J, V96, P1605, DOI 10.3324-haematol.2011.047852; Musallam KM, 2012, THROMB RES, V130, P695, DOI 10.1016-j.thromres.2012.07.013; Olivieri NF, 1999, NEW ENGL J MED, V341, P99, DOI 10.1056-NEJM199907083410207; Pakbaz Z, 2005, ANN NY ACAD SCI, V1054, P457, DOI 10.1196-annals.1345.059; Pierre T.G., 2005, BLOOD, V105, P855; Rachid H, 2010, EUR SPINE J, V19, P871; Rachmilewitz A, 2011, BLOOD, V118, P3479; Rachmilewitz EA, 1998, ANN NY ACAD SCI, V850, P129, DOI 10.1111-j.1749-6632.1998.tb10470.x; Pantalone GR, 2010, BRIT J HAEMATOL, V150, P245, DOI 10.1111-j.1365-2141.2010.08180.x; Rund D, 2005, NEW ENGL J MED, V353, P1135, DOI 10.1056-NEJMra050436; SPANOS T, 1990, VOX SANG, V58, P50; Taher A, 2006, THROMB HAEMOSTASIS, V96, P488, DOI 10.1160-TH06-05-0267; Taher A, 2006, BLOOD CELL MOL DIS, V37, P12, DOI 10.1016-j.bcmd.2006.04.005; Taher AT, 2013, ANN HEMATOL, V92, P1485, DOI 10.1007-s00277-013-1808-z; Taher AT, 2011, BRIT J HAEMATOL, V152, P512, DOI 10.1111-j.1365-2141.2010.08486.x; Taher AT, 2010, J THROMB HAEMOST, V8, P2152, DOI 10.1111-j.1538-7836.2010.03940.x; Taher AT, 2010, J THROMB HAEMOST, V8, P54, DOI 10.1111-j.1538-7836.2009.03651.x; Taher AT, 2010, BLOOD, V115, P1886, DOI 10.1182-blood-2009-09-243154; Taher AT, 2012, BLOOD REV, V26, pS24, DOI 10.1016-S0268-960X(12)70008-5; Thein SL, 2004, BRIT J HAEMATOL, V124, P264, DOI 10.1046-j.1365-2141.2003.04769.x; Voskaridou E, 2010, BRIT J HAEMATOL, V148, P332, DOI 10.1111-j.1365-2141.2009.07930.x; WEATHERALL D, 1995, MOL MED TODAY, V1, P15, DOI 10.1016-1357-4310(95)80014-X; Weatherall DJ, 2001, J HEMATOL S1, V86, P186; Weatherall DJ, 2001, NAT REV GENET, V2, P245, DOI 10.1038-35066048; Wood JC, 2005, BLOOD, V106, P1460, DOI 10.1182-blood-2004-10-39821
Return Migration After 30 September 2009 Earthquake in West Sumatra, Indonesia
No full textThis article analyzed return migrants associated with the West Sumatra Large-Scale Earthquake on 30 September 2009. A survey of 400 households traced the number of return migrants. Any respondent migrated due to the earthquake belongs to return migrant. This study found the return migrants accounting for almost 37% because of the disaster. Both men and women migrated because of the earthquake, but more men migrated than women. Married couple migrated more than unmarried. Pekanbaru, the capital of Riau province, is the most famous destination for migration. The education level of return migrants is higher than the stayers. More than 88% are living from trade, public services, and fishing. Above 50% is living from trading alone. The return migrants shared a similar employment status with the stayers. Entrepreneurial status is more important for return migrants than for the stayers. Income distribution shows a different pattern between return migrants and the stayers. The return migrants have a more significant part of the maximum income group. The return migrants at the highest income group account for 27%, which is obviously greater than the stayers.</jats:p
Inequality, Economic Growth, and Redistribution; Literature Review
No full textEconomists have long believed that economic growth will solve the problem of inequality and poverty. For decades, the question of whether and how inequality affects growth has been the subject of open debate in the academic world. In the same section, the redistribution which is considered part of the equalization step also has positive and negative impacts on economic growth. This paper presents a literature review consisting of several sections including: 1) literature review on the relationship between inequality and growth; 2) the relationship between redistribution and growth; 3) even distribution of infrastructure is part of the form of redistribution
Contemporary approaches to treatment of beta-thalassemia intermedia
No full textBeta-thalassemia intermedia (TI) is associated with a variety of serious clinical complications that require proactive and comprehensive management. These include skeletal deformities and osteopenia, compensatory extramedullary hematopoiesis and tumor formation, progressive splenomegaly, a hypercoagulable state resulting in thromboembolic events and pulmonary hypertension, and increased gastrointestinal iron absorption that often results in nontransfusional iron overload and liver damage. Although TI is generally considered a non-transfusion-dependent thalassemia, transfusion therapy may be an important part of the comprehensive management of this disease. This review describes the current state of the art for medical management of TI, with particular focus on the roles of splenectomy, transfusion, and iron chelation therapy. © 2012 Elsevier Ltd.Aessopos A, 2005, ANN NY ACAD SCI, V1054, P342, DOI 10.1196-annals.1345.041; Aessopos A, 2007, HAEMATOL-HEMATOL J, V92, P658, DOI 10.3324-haematol.10915; Aessopos A, 2001, BLOOD, V97, P3411, DOI 10.1182-blood.V97.11.3411; Amoozgar H, 2011, EUR J HAEMATOL, V87, P61, DOI 10.1111-j.1600-0609.2011.01620.x; [Anonymous], FERR SUMM PROD CHAR; [Anonymous], 2010, EXJADE PACK INS; [Anonymous], EXJADE SUMM PROD CHA; Ataga KI, 2007, BRIT J HAEMATOL, V139, P3, DOI 10.1111-j.1365-2141.2007.06740.x; Atichartakarn V, 2003, INT J HEMATOL, V78, P139, DOI 10.1007-BF02983382; Bisharat N, 2001, J INFECTION, V43, P182, DOI 10.1053-jinf.2001.0904; Borgna-Pignatti C, 2010, ANN NY ACAD SCI, V1202, P214, DOI 10.1111-j.1749-6632.2010.05550.x; Borgna-Pignatti C, 2007, BRIT J HAEMATOL, V138, P291, DOI 10.1111-j.1365-2141.2007.06654.x; Cappellini MD, 2005, SEMIN HEMATOL, V42, pS19, DOI 10.1053-j.seminhematol.2005.01.001; Cappellini MD, 2000, BRIT J HAEMATOL, V111, P467, DOI 10.1046-j.1365-2141.2000.02376.x; COSSU P, 1981, EUR J PEDIATR, V137, P267, DOI 10.1007-BF00443255; Davies JM, 2011, BRIT J HAEMATOL, V155, P308, DOI 10.1111-j.1365-2141.2011.08843.x; Eder AF, 2007, ARCH PATHOL LAB MED, V131, P708; Gardenghi S, 2010, J CLIN INVEST, V120, P4466, DOI 10.1172-JCI41717; Haidar R, 2010, EUR SPINE J, V19, P871, DOI 10.1007-s00586-010-1357-2; Karimi M, 2010, EUR J HAEMATOL, V84, P52, DOI 10.1111-j.1600-0609.2009.01356.x; Karimi M, 2011, EUR J INTERN MED, V22, P607, DOI 10.1016-j.ejim.2011.05.013; Karimi M, 2010, PEDIATR HEMAT ONCOL, V27, P205, DOI 10.3109-08880011003639952; Kontoghiorghes GJ, 2010, HEMOGLOBIN, V34, P251, DOI 10.3109-03630269.2010.486335; Ladis V, 2010, BRIT J HAEMATOL, V151, P504, DOI 10.1111-j.1365-2141.2010.08346.x; Li HH, 2010, NAT MED, V16, P177, DOI 10.1038-nm.2073; Musallam KM, 2011, EUR J HAEMATOL, V87, P73, DOI 10.1111-j.1600-0609.2011.01623.x; Musallam KM, 2011, HAEMATOL-HEMATOL J, V96, P1605, DOI 10.3324-haematol.2011.047852; Novartis Pharmaceutical Corporation, 2010, DESF PACK INS; Porter J, 2011, 16 C EUR HEM ASS JUN; Porter JB, 2001, SEMIN HEMATOL, V38, P63, DOI 10.1053-shem.2001.20145; Rigano P, 2010, BRIT J HAEMATOL, V151, P509, DOI 10.1111-j.1365-2141.2010.08397.x; Sankaran VG, 2010, NEW ENGL J MED, V363, P2258, DOI 10.1056-NEJMcibr1010767; STURGEON P, 1955, BRIT J HAEMATOL, V1, P264, DOI 10.1111-j.1365-2141.1955.tb05509.x; Taher A, 2008, HAEMATOL-HEMATOL J, V93, P1584, DOI 10.3324-haematol.13098; Taher A, 2006, THROMB HAEMOSTASIS, V96, P488, DOI 10.1160-TH06-05-0267; Taher A, 2006, BLOOD CELL MOL DIS, V37, P12, DOI 10.1016-j.bcmd.2006.04.005; Taher A, 2009, BRIT J HAEMATOL, V147, P634, DOI 10.1111-j.1365-2141.2009.07848.x; Taher A, 2002, HEMOGLOBIN, V26, P107, DOI 10.1081-HEM-120005447; Taher AT, 2008, BLOOD REV, V22, P283, DOI 10.1016-j.blre.2008.04.001; Taher AT, 2010, BRIT J HAEMATOL, V150, P486, DOI 10.1111-j.1365-2141.2010.08220.x; Taher AT, 2011, BRIT J HAEMATOL, V152, P512, DOI 10.1111-j.1365-2141.2010.08486.x; Taher AT, 2010, J THROMB HAEMOST, V8, P54, DOI 10.1111-j.1538-7836.2009.03651.x; Taher AT, 2010, BLOOD, V115, P1886, DOI 10.1182-blood-2009-09-243154; Taher ATPJ, 2011, 53 AM SOC HEM ANN M; Treadwell MJ, 2001, SEMIN HEMATOL S1, V38, P77; Voskaridou E, 2010, BRIT J HAEMATOL, V148, P332, DOI 10.1111-j.1365-2141.2009.07930.x9151
From global goals to local gains—a framework for crop water productivity
No full textCrop water productivity (CWP) has become a recognised indicator in assessing the state of Sustainable Development Goals (SDG) 6.4—to substantially increase water use efficiency. This indicator, while useful at a global scale, is not comprehensive at a local scale. To fill this gap, this research proposes a CWP framework, that takes advantage of the spatio-temporal availability of remote sensing, that identifies CWP goals and sub-indicators specific to the needs of the targeted domain. Three sub-indicators are considered; (i) a global water productivity score (GWPS), (ii) a local water productivity score (LWPS) and (iii) a land and water use productivity score (YWPS). The GWPS places local CWP in the global context and focuses on maximised CWP. The LWPS differentiates yield zones, normalising for potential product, and focuses on minimising water consumption. The YWPS focuses simultaneously on improving land and water productivity equally. The CWP framework was applied to potato in the West Bank, Palestine. Three management practices were compared under each sub-indicator. The case study showed that fields with high and low performance were different under each sub-indicator. The performance associated with different management practices was also different under each sub-indicator. For example, a winter rotation had a higher performance under the YWPS, the fall rotation had a higher performance under the LWPS and under the GWPS there was little difference. The results showed, that depending on the basin goal, not only do the sub-indicators required change, but also the management practices or approach required to reach those basin goals. This highlights the importance of providing a CWP framework with multiple sub-indicators, suitable to basin needs, to ensure that meeting the SDG 6.4 goal does not jeopardise local objectives.Water Resource
ANALISIS PEREKONOMIAN MASYARAKAT DI DAERAH RAWAN BENCANA (Studi Kasus Kecamatan Batang Anai Kabupaten Padang Pariaman)
No full textANALISIS PEREKONOMIAN MASYARAKAT DI DAERAH RAWAN BENCANA
(STUDI KASUS ; KECAMATAN BATANG ANAI KABUPATEN PADANG PARIAMAN)
Oleh : ENDI KURNIA (1320511015)
(Dibawah bimbingan : Prof. Dr. Syafruddin Karimi, SE, MA dan Dr. Indrawari, SE, MA, PhD)
Abstrak
Penelitian ini bertujuan untuk menganalisa kerentanan ekonomi dan ketahanan ekonomi masyarakat Kecamatan Batang Anai Kabupaten Padang Pariaman dan merumuskan kebijakan pemerintah dalam menghadapi bencana. Bencana merupakan kejadian sosial akibat kolektif atas kerentanan (vulnerability) pada di satu pihak dengan komponen bahaya (hazard) yang berupa fenomena alam/buatan di pihak lain. Kerentanan adalah suatu kondisi dari suatu komunitas atau masyarakat yang mengarah atau menyebabkan ketidakmampuan dalam menghadapi bencana. Ketahanan adalah kemampuan masyarakat dalam menghadapi bencana pada semua tahapannya melalui berbagai sistem yang dikembangkannya. Penelitian ini menggunakan Analytic Hierarchy Process (AHP). Tingkat kerentanan ekonomi yang paling tinggi adalah persentase rumah tangga miskin sebesar 0,41 dan tingkat ketahanan ekonomi adalah 4,6 dengan skor interval 3,66 – 5 yang artinya tingkat ketahanan ekonomi tinggi.
Kata kunci: Kerentanan, Ketahanan, Analytic Hierarchy Proces
VOLATILITAS NILAI TUKAR DAN PERTUMBUHAN EKONOMI : STUDI KASUS INDONESIA
No full textVOLATILITAS NILAI TUKAR DAN PERTUMBUHAN EKONOMI : STUDI KASUS INDONESIA
Oleh
Agung Pramudio
1510512047
Diajukan ke jurusan Ilmu Ekonomi pada tanggal 25 Juni 2020, untuk memenuhi sebagian syarat dalam mencapai derajat
Sarjana Ekonomi
Abstrak
Skripsi ini mengkaji tentang pengaruh volatilitas nilai tukar terhadap pertumbuhan ekonomi di indonesia. Data yang digunakan yaitu data time series tahun 1997 sampai dengan 2018. Model yang digunakan yaitu model ARDL dengan aplikasi STATA. Variabel yang digunakan yaitu PDB rill, volatillitas nilai tukar rill, external balance on goods and services, gross capital formation, Financial Development index, inflasi rill serta ekspor dan impor (net ekspor).
Hasil menunjukan bahwa terdapat hubungan yang positif antara volatilitas nilai tukar dan pertumbuhan ekonomi di indonesia. Hubungan positif tersebut hanya berpengaruh pada waktu jangka pendek.
Kata Kunci : Volatilitas nilai tukar, pertumbuhan ekonomi, ARDL
Pembimbing : Prof. Dr. Syafruddin Karimi, SE., MA
The girl who wanted to stand-up in class and speak to her classmates
No full textThere are several factors that can lead to social anxiety disorder (fear of being judged or rejected), such as genetics, environmental factors, learned experiences, deficits in social skills, cognitive factors and/or culture. Considering all these factors, there are many people prone to develop social anxiety disorder in Afghanistan. In a recent study conducted at Herat University, it was shown that many students suffer from social anxiety disorder. The case described in this personal reflection concerns a student, who, upon assessment of her symptoms, the author diagnosed as having social anxiety disorder and provided several counselling sessions. After some time, positive results were achieved and the client recovered significantly from her disorder by the conclusion of the sessions
Structural capital and Business Perfomance of Pharmaceutical Firms in Kenya
No full textA Journal article by Dr. James Mark Ngari Karimi an assistant Professor of Management in the Chandaria School of Business in USIU-AThis book revisits what in the two decades preceding the end of the Cold
War was popularly known as ‘the African development crisis’. Nigeria, one of
Africa’s largest economies, is used as case study. The core aim of the book
is ‘to interrogate the central role of modernization in Africa’s development
trajectory’ (p. 5). Based on a searching critique of the modernization literature,
the author assembles a plethora of theoretical and empirical evidence to prove
that, as opposed to enhancing development, the modernization paradigm is
responsible for Africa’s development crisis and has reinforced the peripheral
role of African countries in the global capitalist system. This argument is not
entirely novel. It is indeed a core argument of many dependency-school and
Marxist political economy scholars that dominated the discourse of African
development crisis throughout the 1980s and 1990s. The collapse of the
communist bloc and the end of the Cold War has not only had a significant
effect on the African left – once the champion of the anti-modernization debate
in the continent – but has also seen many stalwarts gravitate to the ‘centre
ground’ and ‘right’ of the ideological spectrum. Dibua adopts ‘a radical political
economy approach’ in his analysis (p. 6).
The author makes a spirited argument in Chapter 2 that the dominant neoliberal
solutions to Africa’s development crisis promoted by the Internati
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