1,084 research outputs found
Redox-Responsive Nanocapsules for the Spatiotemporal Release of Miltefosine in Lysosome: Protection against Leishmania
No full textLeishmaniasis, a vector-borne disease, is caused by intracellular parasite Leishmania donovani. Unlike most intracellular pathogens, Leishmania donovani are lodged in parasitophorous vacuoles and replicate within the phagolysosomes in macrophages. Effective vaccines against this disease are still under development, while the efficacy of the available drugs is being questioned owing to the toxicity for nonspecific distribution in human physiology and the reported drug-resistance developed by Leishmania donovani. Thus, a stimuli-responsive nanocarrier that allows specific localization and release of the drug in the lysosome has been highly sought after for addressing two crucial issues, lower drug toxicity and a higher drug efficacy. We report here a unique lysosome targeting polymeric nanocapsules, formed via inverse mini-emulsion technique, for stimuli-responsive release of the drug miltefosine in the lysosome of macrophage RAW 264.7 cell line. A benign polymeric backbone, with a disulfide bonding susceptible to an oxidative cleavage, is utilized for the organelle-specific release of miltefosine. Oxidative rupture of the disulfide bond is induced by intracellular glutathione (GSH) as an endogenous stimulus. Such a stimuli-responsive release of the drug miltefosine in the lysosome of macrophage RAW 264.7 cell line over a few hours helped in achieving an improved drug efficacy by 200 times as compared to pure miltefosine. Such a drug formulation could contribute to a new line of treatment for leishmaniasis.A. Das acknowledges SERB (India) Grants (CRG/2020/000492 and JCB/2017/000004) and DBT Grant (BT/PR22251/NNT/28/1274/2017) for supporting this research. N. Mukherjee acknowledges SERB (India) Grant PDF/2016/001437 and K. Das acknowledges the grant EMR/2015/001674 for supporting this research. Financial support from DST (DST/INSPIRE/03/2017/002477) is acknowledged by R.T. This manuscript bears CSMCRI registration no 7/2021.Pramanik, SK (corresponding author), CSIR Cent Salt & Marine Chem Res Inst, Bhavnagar 364002, Gujarat, India.
Mukherjee, N (corresponding author), CSIR Indian Inst Chem Biol, Canc Biol & Inflammatory Disorder Div, Kolkata 700032, India.
Chattopadhy, S (corresponding author), BITS Pilani, Pilani 403726, Goa, India.
Das, A (corresponding author), Indian Inst Sci Educ & Res Kolkata, Mohanpur 741246, W Bengal, India.
[email protected]; [email protected]; [email protected]
RTA 2012 Proceedings Frontmatter
No full textFrontmatter, Table of Contents, Conference Organization, External Reviewers, Author Index
Socio-Psychological Profile of Olympic Bronze Medallist Hockey Player Mr Sumit Valmiki: A Case Study
No full textPurpose: -Games and Sports play a significant role in society, to promote physical fitness, to give them entertainment, and to develop a sense of community. They have the power to inspire and unite people across cultures and contribute to personal and societal well-being. Games and Sport is considered one of the foundational pillars of the holistic advancement of civilized societies. The aim of the Researchers was to explore the Socio-Psychological Factors and experiences that have influenced Mr. Sumit Valmiki\u27s performance and success as an Olympic Bronze Medalist Methodology: - The original information was collected from the subject as a primary source. Researchers used the “Frustration Test” by Dr N. S Chauhan and Dr. Govind Tiwari, the “Self-Confidence Inventory” Developed by Rekha Gupta, “Sports Achievement Motivation Questionnaire” by M.L. Kamlesh, and the “Aggression Questionnaire by Km. Roma Pal is a tool for the collection of the data in this study. Result: -By applying the above-mentioned tools and analyzing the collected data, it was found that Mr. Sumit Valmiki possesses unique characteristics, outstanding abilities, extraordinary potential, and excellent Hockey-playing qualities. Further, it has been found that he is having an optimal level of Frustration and an average level of Self-Confidence and the ability to be confident in difficult situations and to solve problems. Conclusion It has also been found that he is having High levels of Sports Achievement Motivation. He has the ability to develop competence for success within his chosen field. He is also having a low level of Aggression and the ability to remain cool and calm
Impact of the Photovoltaic Integration on the Hydrothermal Dispatch on Power Systems
No full textThe amount of electricity generated by traditional power plants accompanied by the non-conventional renewable resources has increased significantly in the latest years in Honduras. This is leading to a different dispatch operation that guarantees the lowest cost, optimizing the water resource installed and operated in the Honduran power system. The purpose of this paper is to study the effect on the operation of the Honduran power system with the incorporation of photovoltaic (PV) generation and to compare the operation prior to the installation of such generation. Finally, it is proposed that the optimal hydrothermal dispatch of the system allows us to reduce the marginal costs of operation in a medium-term study horizon. To achieve this objective, in this study the operation of the electric system will be simulated using the Stochastic Dual Dynamic Programming (SDDP) software that allows us in a study horizon to estimate the function of future costs with optimal hydrothermal dispatch optimizatio
Professional NoSQL
No full textA hands-on guide to leveraging NoSQL databases NoSQL databases are an efficient and powerful tool for storing and manipulating vast quantities of data. Most NoSQL databases scale well as data grows. In addition, they are often malleable and flexible enough to accommodate semi-structured and sparse data sets. This comprehensive hands-on guide presents fundamental concepts and practical solutions for getting you ready to use NoSQL databases. Expert author Shashank Tiwari begins with a helpful introduction on the subject of NoSQL, explains its characteristics and typical uses, and looks at wher
Context-Driven Engineering Learning Model (CDELM): Companion Teaching Resource and Applied Decision Framework
No full textThis Open Science Framework (OSF) project documents the Context-Driven Engineering Learning Model (CDELM), a structured pedagogical framework integrating engineering education with applied decision-making, managerial reasoning, and real-world contextual triggers.
The project serves as a companion academic resource aligned with the Zenodo DOI publication and associated implementation materials. It includes conceptual structure, applied classroom scenarios, framework architecture, and decision-context mapping methodology designed for engineering and management education.
This repository supports transparent dissemination, academic reproducibility, and open scholarly visibility.
Associated DOI:
https://doi.org/10.5281/zenodo.18604436
Author:
Mohit Tiwari
Assistant Professor, Department of Computer Science & Engineering
Bharati Vidyapeeth's College of Engineering, Delhi, Indi
Alpheid shrimps (Crustacea: Decapoda: Alpheidae) of Vietnam
No full textThe present paper deals with a collection of alpheid shrimps from Vietnam received by Mr R. Serene, formerly Director the Institute of Oceanography, Nhatrang (Vietnam). Though small in size the material has proved to be fairly rich. It contains 23 species belonging to the genera Alpheopsis Coutiere, Synalpheus Bate and Alpheus Fabricius, the last named genus accounting for all but three species. Two new species, one each belonging to Alpheopsis and Alpheus, have been briefly described by the author (Tiwari, 1962) in an earlier paper. The remaining species are already known and some of them have an extensive distribution in the Indo-West-Pacific
An exploration of pharmacological and psychological interventions in patients with treatment-resistant affective disorders
No full textPreface:The Mood and Anxiety Disorder Service in Southampton is a regional specialistservice for patients with complex and usually treatment-resistant affective disorders, which accepts referrals mainly from secondary care mental health services. Professor David Baldwin is the lead consultant for this service. He has clinical and research expertise in the identification, assessment and treatment of depressive illness and anxiety disorders, and is the lead author of evidence-based treatment guidelines for anxiety disorders.I have worked with Professor David Baldwin since 2008. Through his encouragement and support, I have undertaken a series of pharmacological and psychological interventions in patients with treatment-resistant affective disorders. My dual aims were to examine treatment recommendations within the Service, and to investigate the potential feasibility, effectiveness, and acceptability of non-pharmacological treatment options for groups of patients with severe treatment-resistant depression or generalised anxiety disorder (GAD): partly in the hope that this might inform the development of additional treatment interventions within the local services.Inspection of the medical records of patients referred to the tertiary services inSouthampton allowed an examination of currently offered pharmacological and psychological treatments. I realized that for most patients, and often over long periods of treatment in secondary care mental health services, there had been a lack of non-pharmacological treatments options apart from cognitive behaviour therapy (CBT). This thesis includes a description of patients referred to the Service, including their demographic and clinical characteristics, and current and recommended treatments: and an account of the effectiveness and acceptability of two non-pharmacological group interventions, namely mindfulness-based CBT in patients with highly recurrent unipolar depressive disorder, and Yogic breathing in patients with treatment resistant GA
A hierarchical spectral clustering and nonlinear dimensionality reduction scheme for detection of prostate cancer from magnetic resonance spectroscopy (MRS)
No full textIn this article the authors present a novel CAD scheme that integrates nonlinear dimensionality reduction (NLDR) with an unsupervised hierarchical clustering algorithm to automatically identify suspicious regions on the prostate using MRS and hence avoids the need to explicitly identify metabolite peaks.The published version of this article is available at: http://scitation.aip.org/getpdf/servlet/GetPDFServlet?filetype=pdf&id=MPHYA6000036000009003927000001&idtype=cvips&prog=normalThis work was made possible via grants from the Wallace H. Coulter Foundation, New Jersey Commission on Cancer Research, National Cancer Institute (Grant Nos. R01CA136535-01, ARRA-NCl-3 R21CA127186–02S1, R21CA127186–01, and R03CA128081-01), the Society for Imaging Informatics in Medicine (SIIM), The Cancer Institute of New Jersey, and the Life Science Commercialization Award from Rutgers University
Alpheid shrimps (Crustacea: Decapoda: Alpheidae) of Vietnam
No full textThe present paper deals with a collection of alpheid shrimps from Vietnam received by Mr R. Serene, formerly Director the Institute of Oceanography, Nhatrang (Vietnam). Though small in size the material has proved to be fairly rich. It contains 23 species belonging to the genera Alpheopsis Coutiere, Synalpheus Bate and Alpheus Fabricius, the last named genus accounting for all but three species. Two new species, one each belonging to Alpheopsis and Alpheus, have been briefly described by the author (Tiwari, 1962) in an earlier paper. The remaining species are already known and some of them have an extensive distribution in the Indo-West-Pacific.Reprinted as: Institut Océanographique de Nha Trang Vietnam, Contribution, nr 83(III
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