11 research outputs found
Unusual case with venous channels connecting the left and the right brachiocephalic veins
No full textThe S447X variant of lipoprotein lipase gene is inversely associated with severity of coronary artery disease
No full textHyperlipidemia is a major risk factor for coronary artery disease (CAD). Lipoprotein lipase (LPL) is an important enzyme in lipoprotein metabolism. S447X polymorphism of the LPL gene has been implicated in the pathogenesis of CAD. Carriers of X447 allele were reported to have lower triglyceride and higher high-density lipoprotein cholesterol levels as well as a reduced risk of CAD. We hypothesized that S447X gene polymorphism might have a protective effect for CAD. A total of 178 subjects (mean age 42.97 +/- A 6.5 years) who underwent coronary angiography for clinical indications were included in the study. The patients had been referred for evaluation of chest pain and/or abnormal stress tests, and were selected consecutively. Gensini scores were used to assess the severity of CAD; 97 patients were diagnosed with angiographically proven CAD, and 81 subjects did not display significant CAD (a parts per thousand yen70%) angiographically. Genotyping of LPL S447X polymorphism was performed by real-time polymerase chain reaction amplification and fluorescent probe melting point analysis on the light cycler. The minor allele frequencies of LPL 447X allele were 11.1% and 6.2% among subjects without CAD compared with CAD subjects (P = 0.081) and 447X allele had favorable effects on lipid levels among CAD patients; 447X homozygotes and heterozygotes displayed lower total cholesterol (171 +/- A 37 vs 208 +/- A 48 mg/dl, P = 0.02), lower triglycerides (121 +/- A 72 vs 184 +/- A 86 mg/dl, P = 0.02), lower low-density lipoprotein cholesterol (102 +/- A 27 vs 129 +/- A 39 mg/dl, P = 0.03). Gensini scores were significantly lower among the heterozygotes and homozygotes of LPL 447X allele than in the LPL S447 homozygotes (15 +/- A 23 vs 25 +/- A 30, P = 0.048). S447X polymorphism of LPL gene may have a protective role for the severity of CAD. The beneficial effects of S447X polymorphism of the LPL gene may be through its favorable effects on lipid levels
The S447X variant of lipoprotein lipase gene is inversely associated with severity of coronary artery disease
No full textBovine aortic arch and idiopathic pulmonary artery aneurysm associated with bronchial compression
No full textAbstractThe left common carotid artery originating from the brachiocephalic trunk is termed the bovine aortic arch. Although it is the third most-common normal variant found in 9% humans, the origin of this term remains unclear. Until now, It has not been reported in the literature bovine aortic arch togetherness with pulmonary aneurysm and bronchial compression. Herein, we present a case with bovine aorta arch and pulmonary artery aneurysm associated with bronchial compression, which is incidentally detected by X-ray film. A 56-year-old Caucasian female admitted to the cardiology clinic with complaint of chest pain. Physical examination was unremarkable. Blood biochemistry values and cardiac markers were in normal range. Chest radiography revealed a widened mediastinum and prominent pulmonary conus with no active pulmonary disease. A subsequent transthoracic echocardiography revealed left ventricular hypertrophy, left atrial enlargement (diameter: 41mm), mild mitral and tricuspid valve insufficiency, dilatation of main pulmonary artery (parasternal short-axis view diameter: 33mm), normal pulmonary artery pressure and normal left ventricular systolic function. Computed tomography revealed bovine aortic arch associated with pulmonary artery aneurysm (diameter: 53mm). And left main bronch of trachea was critically squeezed by aortic arch. Aortic and pulmonary vascular anomalies should be considered in patients with chest pain. And, identification with imaging modalities is important for prevention of chronic and irreversible complications
Demographics of patients with heart failure who were over 80 years old and were admitted to the cardiology clinics in Turkey
No full textObjective: Heart failure (HF) has a high prevalence and mortality rate in elderly patients; however, there are few studies that have focused on patients older than 80 years. The aim of this study is to describe and compare the age-specific demographics and clinical features of Turkish elderly patients with HF who were admitted to cardiology clinics. Methods: The Epidemiology of Cardiovascular Disease in Elderly Turkish population (ELDER-TURK) study was conducted in 73 centers in Turkey, and it recruited a total of 5694 patients aged 65 years or older. In this study, the clinical profile of the patients who were aged 80 years or older and those between 65 and 79 years with HF were described and compared based on the ejection fraction (EF)-related classification: HFrEF and HFpEF (is considered as EF: >= 50%). Results: A total of 1098 patients (male, 47.5%; mean age, 83.5 +/- 3.1 years) aged 80 years and 4596 patients (male, 50.2 %; mean age, 71.1 +/- 4.31 years) aged 65-79 years were enrolled in this study. The prevalence of HF was 39.8% for patients who were >= 80 years and 27.1% for patients 65-79 years old. For patients aged >= 80 years with HF, the prevalence rate was 67% for hypertension (HT), 25.6% for diabetes mellitus (DM), 54.3% for coronary artery disease (CAD), and 42.3% for atrial fibrilation. Female proportion was lower in the HFrEF group (p=0.019). The prevalence of HT and DM was higher in the HFpEF group (p= 80 years with HFrEF (p<0.01). Conclusion: HF is common in elderly Turkish population, and its frequency increases significantly with age. Females, diabetics, and hypertensives are more likely to have HFpEF, whereas CAD patients are more likely to have HFrEF.Turkish Society of CardiologyThis study was supported by Turkish Society of Cardiology
Evaluation of Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio in patients with subclinical hypothyroidism
No full textBackground: Prolongation of the peak-to-end interval of the T wave (Tp-e) has been reported as associated with ventricular arrhythmias. The aim of this study was to investigate the ventricular repolarization by using the Tp-e interval, Tp-e/QT ratio and Tp-e/ QTc ratio in patients with subclinical hypothyroidism (SH). Methods: We studied 56 volunteers: These were 28 patients with SH (mean age 45 ± 11 years) and 28 healthy subjects (mean age 34 ± 8 years). All basic biochemical parameters were analyzed and electrocardiograms (ECGs) were recorded. RR and QT intervals, QTc, Tp-e intervals and the Tp-e/QT and Tp-e/QTc ratios were calculated. The categorical and numerical variables were compared using the chi-square test and independent t test, respectively. Correlations were analyzed using the Spearman and Pearson correlation tests. Results: We found no difference between QT and QTc intervals between groups. In the subjects with SH, the Tp-e intervals (87 ± 5 ms, 66 ± 5 ms, p < 0.01), Tp-e/ QT ratio (0.23 ± 0.03, 0.18 ± 0.01, p < 0.01) and Tp-e/QTc ratio (0.21 ± 0.02, 0.16 ± 0.01, p < 0.01) were increased compared with healthy subjects. We also found positive correlations between levels of thyroid stimulating hormone (TSH) and Tp-e ( r = 0.72, p < 0.01), Tp-e/ QT ratio ( r = 0.67 p < 0.01), Tp-e/ QTc ratio ( r = 0.68, p < 0.01). In the subjects with SH, Left Ventricular Myocardial Performance Index (LV-MPI) was increased compared with the healthy subjects (0.64 ± 0.08, 0.59 ± 0.09, p = 0.066) although it was not significant. Conclusions: Compared with healthy subjects, patients with SH demonstrated longer Tp-e intervals, and higher Tp-e/QT and Tp-e/QTc ratios. TSH levels were positively correlated with Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio
Secondary prevention of coronary heart disease in elderly population of Turkey: A subgroup analysis of ELDERTURK study
No full textBackground: Secondary prevention plays an important role after acute coronary event due to high risk of adverse events in elderly. In present study we aimed to evaluate the lifestyle, management of risk factors and medical treatment for secondary protection in elderly patients with known coronary heart disease (CHD). Methods: ELDERTURK is a non-interventional, multi-centered, observational study, which included total of 5694 elderly patients (>65 years) from 50 centers in Turkey. In this study elderly patients from the ELDERTURK population with known CHD were evaluated for cardiovascular risk factors, comorbidities and medication usage. Results: A total of 2976 (52.3% of study) out of 5694 patients included in the ELDERTURK study were evaluated. All had known CHD with a mean age of 73.4 +/- 6.2 years and 60.3% were male. 13.0% of patients were smokers, 42.4% were overweight and 21.1% were obese. Only 23.6% of patients reported to do regular exercise, 73.4% had history of hypertension, 47.4% had dyslipidemia and 33.9% had diabetes mellitus. The rate of patients with systolic blood pressure > 140 mmHg were 31.1% and only 13.9% of patients had a recommended <= 70 mg/dL level of low-density lipoprotein cholesterol. Antiplatelet, statin, beta-blocker and angiotensin-converting enzyme inhibitor/angiotensin receptor blocker usage was limited to 27.3%. Conclusions: The ELDERTURK study shows that many patients with CHD have a high prevalence of modifiable risk factors and unhealthy lifestyle. Apart from this, many patients are not receiving therapeutic intervention and as a consequence most were not achieving the recommended goals.Turkish Society of CardiologyThis trial was supported by Turkish Society of Cardiology
Demographics of patients with heart failure who were over 80 years old and were admitted to the cardiology clinics in Turkey
No full textObjective: Heart failure (HF) has a high prevalence and mortality rate
in elderly patients; however, there are few studies that have focused on
patients older than 80 years. The aim of this study is to describe and
compare the age-specific demographics and clinical features of Turkish
elderly patients with HF who were admitted to cardiology clinics.
Methods: The Epidemiology of Cardiovascular Disease in Elderly Turkish
population (ELDER-TURK) study was conducted in 73 centers in Turkey, and
it recruited a total of 5694 patients aged 65 years or older. In this
study, the clinical profile of the patients who were aged 80 years or
older and those between 65 and 79 years with HF were described and
compared based on the ejection fraction (EF)-related classification:
HFrEF and HFpEF (is considered as EF: >= 50\%).
Results: A total of 1098 patients (male, 47.5\%; mean age, 83.5 +/- 3.1
years) aged 80 years and 4596 patients (male, 50.2 \%; mean age, 71.1
+/- 4.31 years) aged 65-79 years were enrolled in this study. The
prevalence of HF was 39.8\% for patients who were >= 80 years and 27.1\%
for patients 65-79 years old. For patients aged >= 80 years with HF, the
prevalence rate was 67\% for hypertension (HT), 25.6\% for diabetes
mellitus (DM), 54.3\% for coronary artery disease (CAD), and 42.3\% for
atrial fibrilation. Female proportion was lower in the HFrEF group
(p=0.019). The prevalence of HT and DM was higher in the HFpEF group
(p<0.01), whereas CAD had a higher prevalence in the HFrEF group
(p=0.02). Among patients aged 65-79 years, 43.9\% (548) had HFpEF, and
56.1\% (700) had HFrEF. In this group of patients aged 65-79 years with
HFrEF, the prevalence of DM was significantly higher than in patients
aged >= 80 years with HFrEF (p<0.01).
Conclusion: HF is common in elderly Turkish population, and its
frequency increases significantly with age. Females, diabetics, and
hypertensives are more likely to have HFpEF, whereas CAD patients are
more likely to have HFrEF
