605 research outputs found
Directive speech acts in the New Testament
No full textDanuta Pytel-Pandey, WrocławThis article discusses the directive speech acts in the New Testament. The
author presents examples of such acts from the New Testament Scriptures, and
then carries out their pragmalinguistic [email protected]
Lung Mucosal Response to Repeated Inhalational Insults with Immunomodulatory Agents in a Murine Model of Fungal Asthma: Airway Epithelium Takes the Center Stage
No full textAsthma is a debilitating disease of the lungs affecting 235 million people worldwide. Fungus-associated asthma leads to a particularly severe type of disease, and exposure to environmental fungi and their products is unavoidable due to the ubiquitous nature of fungal species. Besides being allergenic, fungi are opportunistic pathogens, and anti-fungal and/or allergic pathways may be modified through repeated inhalation of immunomodulatory agents, affecting the outcome of fungus-induced asthma. Our aim in this project was to investigate the extent to which repeated inhalation of immunomodulatory agents influence the lung mucosal responses in a na?ve murine host or in one that had been sensitized to fungal proteins (allergic). The immunomodulatory substances chosen hold relevance to human inhalational exposure, and included live or irradiation-killed Aspergillus fumigatus (a fungi) spores, deoxyxnivalenol (a mycotoxin), and fluticasone propionate (an inhalationally administered corticosteroid, commonly prescribed for allergic asthma). In a na?ve host, inhalation of live A. fumigatus spores showed pathological features of fungal asthma. However, in an allergen-sensitized lung, both dead and live A. fumigatus spores established fungal airway disease, albeit to different extents. Next, we tested the effect of deoxynivalenol in an allergic host and found that its repeated inhalation did not affect pulmonary disease pathology, but did lead to a dose- and time- dependent increase in mucosal and systemic total IgA. Finally, we tested the effect of fluticasone propionate, and found that it did not influence the development of fungal airway disease, but did induce dynamic changes in lung physiology and antibody titers. Besides mimicking human inhalational exposures, inhalation ensures direct interaction of the inhaled substances with airway epithelium, which plays an important role in defense against inhaled substances and in asthma pathophysiology. By analyzing various mechanisms involved in murine lung-mucosal response to the inhaled substances, a critical involvement of airway epithelium as an orchestrator of immune responses is highlighted, and this would inform mechanism-based future studies. In conclusion, this project is likely to aid in establishing evidence based standards for fungus-related exposures and in making informed therapeutic decisions for fungus-associated diseases.North Dakota State University. Microbiological Sciences DepartmentConcordia College (Moorhead, MN). Biology Departmen
Similarities between 2D and 3D convection for large Prandtl number
No full textUsing direct numerical simulations of Rayleigh-B\'enard convection (RBC), we perform a comparative study of the spectra and fluxes of energy and entropy for large and infinite Prandtl numbers in two (2D) and three (3D) dimensions. We observe close similarities between the 2D and 3D RBC, in particular the kinetic energy spectrum , and the entropy spectrum exhibits a dual branch with a dominant spectrum. We showed that the dominant Fourier modes in the 2D and 3D flows are very close
Evaluation and analysis of impact of subsidies on small scale renewable energy technologies dissemination: a case study of Nepal
No full textThe report has analysed the status of rural electrification using renewable energy technologies (RETs) and the current subsidy delivery modality of RETs in Nepal. As the Government of Nepal is subsidizing small scale renewable energy projects, it is important to evaluate and analyse the programme to make sure that a programme is running in an effective and efficient way while reaching the target group.
During the course of the research, primary information collected from the field has been compiled using appropriate tools/software (such as MS Office) and analyzed. Different sets of questionnaires were prepared, targeting different personnel ranging from the users’ level to the government policy level. The field survey methods include field observations of RETs installations and operations along with interviews with selected users on a random sampling basis to identify barriers to subsidy delivery and possible measures to overcome these barriers; to determine user satisfaction level and time period for subsidy delivery mechanisms.
The report started with the country background information and the rationale behind the study. This is followed by the literature review and information on the current status of small scale RETs in the country. Next it deals with the organizational structure and current subsidy delivery modality of RETs in the country. The evaluation of the effectiveness of the subsidy with the current subsidy delivery modality has been analyzed based on six parameters; Targets and Achievements, Impact of RETs, Subsidy Delivery System Efficiency, Transparency, Sustainability and Effectiveness.
The research shows that the subsidized government program has been successful in achieving its goal to provide basic energy services in rural areas through RETs in terms of its quantitative target. Although the subsidized program is successful in electrifying the rural communities via RETs, the poorest of the poor families are still excluded from the subsidy. The program seems to benefit more the rich and upper middle class families rather than the poor families for which the subsidy was intended. The high capital cost and long subsidy delivery process are the main important reasons for this failure. The author has proposed a new modality which might overcome the time barriers and bureaucratic process in the subsidy delivery mechanism and will decrease the lead time. This will in turn help to reduce the operational cost of the private companies and will encourage more players to enter the market, increase competition and result in lower system costs.
After identifying gaps in the current subsidy delivery modality, the project report ends with the recommendation of a new modality improving the current modality and filling the gaps identified. As this study has some limitations, as described in chapter one, the scope of further works has been listed at the end
this paper is the real work of the author
No full textthe author is the renouned economist and have an experience of 25 years as a reader and as a guest professor .unemployemnt
this paper is the real work of the author
No full textthe author is the renouned economist and have an experience of 25 years as a reader and as a guest professor .unemployemnt
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No full textNot AvailableSearch; Personalize: Your alerts; Your baskets; Your searches. Your alerts; Your baskets; Your searches. login. login. Home > Management of early blight disease of tomato cv 'Kashi Amrit' through fungicides, bioagents and cultural practices in India. World Vegetable Center. Information; Usage statistics; Files; Holdings. Record Details. Title: Management of early blight disease of tomato cv 'Kashi Amrit' through fungicides, bioagents and cultural practices in India. Author(s): Kumar, V. Gupta, RC Singh, PC Pandey, KK Kumar, R. Rai, AB Rai, M. Publication date: 2007. Subject(s): TOMATOES EARLY BLIGHT PLANT DISEASES FUNGICIDES PLANT DISEASE CONTROL DISEASE RESISTANCE ALTERNARIA SOLANI ALTERNARIA ALTERNATA GROWTH India IN …Not Availabl
Retracted: C4d deposition in native kidney disease and its correlation with proteinuria and serum urea/creatinine
No full textThe article titled, "C4d deposition in native kidney disease and its correlation with proteinuria and serum urea/creatinine", published in the International Journal of Research in Medical Sciences, Volume 6, Issue 12, 2018, Pages 3935-3941, DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20184886 is being retracted. We received complaint from one of the co-authors, after publication of the article that corresponding author, Dr. Sant Pandey had submitted the manuscript without informing other co-authors and it was not his original work. We contacted the corresponding author who could not satisfactorily respond to our queries. Since the author could not satisfactorily defend his paper and contravened the declaration he made while submitting his manuscript, it was decided to retract the article from International Journal of Research in Medical Sciences and not to consider any manuscript submitted by him in future
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