114 research outputs found
Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma?
No full textTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. We aimed to compare the performance of SUVmax reduction (ΔSUVmax%) and the PET ratio (rPET) versus the Deauville score (DS) for assessing the chemotherapy response in pediatric HL patients undergoing 18F-FDG PET-CT. Fifty-two patients with biopsy-proven HL (aged 8–16 years) were enrolled at baseline, interim (after the second or third chemotherapy round) and post-therapy (on completion of first-line chemotherapy). Interim and post-therapy DS, ΔSUVmax% and rPET were compared as response predictors. Patients were classified as responders or non-responders based on a 24-month clinical follow-up. Interim DS showed a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of 100%, 80.4%, 100%, 40% and 82.7%, respectively, in predicting the therapy response. Post-therapy DS showed a sensitivity, specificity, PPV, NPV and accuracy of 66.7%, 97.8%, 95.7%, 80% and 94.2%, repsectively. Interim ΔSUVmax% showed a sensitivity, specificity, PPV, NPV and accuracy of 83.3%, 82.6%, 97.4%, 38.5% and 82.7%, respectively, with a 56.3% cutoff. Post-therapy ΔSUVmax% showed a sensitivity, specificity, PPV, NPV and accuracy of 83.3%, 84.8%, 97.5%, 41.7% and 84.6%, respectively, with a 76.8% cutoff. Compared to ΔSUVmax%, DS showed a significantly higher sensitivity, specificity (p < 0.05) and NPV (p < 0.01). The sensitivity, specificity, PPV, NPV and accuracy of rPET in predicting the therapy response at 24 months were 76.1%, 100%, 100%, 35.3% and 78.8%, respectively, with a cut-off of 1.31. DS and rPET showed comparable predictive performance (p > 0.58). In conclusion, DS is an easier method with better performance than ΔSUVmax% and rPET in predicting the chemotherapy response in pediatric HL patients
Filosofi Canang Sari Sebagai Simbol Padma Astadala
Get PDF"Canang Sari," a distinctive flower offering in Balinese culture, holds profound significance as a symbol of Padma Asta Dala. Within the concept of Padma Asta Dala, each petal of the lotus represents essential aspects in the pursuit of spiritual balance. This article elaborates on the close relationship between Canang Sari and this concept, revealing how the arrangement and elements of Canang Sari reflect the symbolism of Dharma (duty), Adharma (disobedience), Lobha (greed), and Parama (perfection). Canang Sari serves as a potent visual reflection of life philosophy and spiritual quest in Balinese culture. This study employs qualitative observation and document analysis, with the author immersing themselves in the field. Through Canang Sari, the Balinese community immortalizes and celebrates harmony between humans, nature, and the divine. This article provides insights into the symbolic and practical significance of Canang Sari as a representation of the Padma Asta Dala concept in daily Balinese life. Despite the passage of time, Canang Sari remains a robust cultural symbol. As a manifestation of Padma Asta Dala, Canang Sari guides the Balinese people in seeking life harmony, conquering emotional challenges, and attaining inner peace. In every carefully arranged flower and leaf, a deeper spiritual message is unveiled, uniting nature, spirit, and the divine. Canang Sari not only adorns the corners of sacred places but also radiates symbolic meaning, teaching that balance is the key to achieving perfection in the spiritual journey
Jarcho-Levin syndrome with association of unilateral pulmonary hypoplasia and diastometamyelia: A case illustration
No full textPET/CT in paediatric malignancies - An update
No full text18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a well-established imaging modality in adult oncological practice. Its role in childhood malignancies needs to be discussed as paediatric malignancies differ from adults in tumor subtypes and they have different tumor biology and FDG uptake patterns. This is also compounded by smaller body mass, dosimetric restrictions, and physiological factors that can affect the FDG uptake. It calls for careful planning of the PET study, preparing the child, the parents, and expertise of nuclear physicians in reporting pediatric positron emission tomography/computed tomography (PET/CT) studies. In a broad perspective, FDG-PET/CT has been used in staging, assessment of therapy response, identifying metastases and as a follow-up tool in a wide variety of pediatric malignancies. This review outlines the role of PET/CT in childhood malignancies other than hematological malignancies such as lymphoma and leukemia
PENGARUH KEPEMIMPINAN, BUDAYA ORGANISASI DAN DISIPLIN TERHADAP KINERJA KARYAWAN PADA PT. PADMA SOODE INDONESIA
Get PDFAbstract: The purpose of this study was to examine the Effect of Leadership, Organizational Culture and Work Discipline on Performance on Employees of PT. Padma Soode Indonesia with 99 respondents as permanent employees who work at PT. Padma Soode Indonesia. Data is processed with Partial Least Square (smartPLS) version 3.0. The research design used by the author in this study was conclusive research, a type of causal research using a descriptive method with a quantitative approach. The results of this study indicate that leadership has a positive and significant effect on work discipline, organizational culture has a positive and significant effect on work discipline, leadership has a positive and significant effect on performance, organizational culture has a positive effect on performance, work discipline has a positive and significant effect on performance, leadership through Work discipline as an intervening variable has a positive and significant effect on performance, and organizational culture through work discipline as an intervening variable has an effect on performance
Pengaruh Kepemimpinan, Budaya Organisasi dan Disiplin terhadap Kinerja Karyawan pada PT. Padma Soode Indonesia
No full textThe purpose of this study was to examine the Effect of Leadership, Organizational Culture and Work Discipline on Performance on Employees of PT. Padma Soode Indonesia with 99 respondents as permanent employees who work at PT. Padma Soode Indonesia. Data is processed with Partial Least Square (smartPLS) version 3.0. The research design used by the author in this study was conclusive research, a type of causal research using a descriptive method with a quantitative approach. The results of this study indicate that leadership has a positive and significant effect on work discipline, organizational culture has a positive and significant effect on work discipline, leadership has a positive and significant effect on performance, organizational culture has a positive effect on performance, work discipline has a positive and significant effect on performance, leadership through Work discipline as an intervening variable has a positive and significant effect on performance, and organizational culture through work discipline as an intervening variable has an effect on performance
Myocardial viability evaluation using a novel 99mTc SestaMIBI and low dose Dobutamine infusion technique in high risk Ischemic cardiomyopathy patients – A pilot study
No full textCongenital lymphatic hypoplasia in unilateral lower limb with abnormal technetium-99m sulphur colloid uptake in both breasts
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