544 research outputs found
Corrigendum to “Assessing the capacity of three production efficiency models in simulating gross carbon uptake across multiple biomes in conterminous USA” [Agric. Forest Meterol. 174–175 (2013) 158–169]
No full textThe authors regret that the printed version of the above article missed out the third author's name. The correct and final version follows. The authors would like to apologise for any inconvenience caused.We wish to add: Terence P. Dawson, School of the Environment, University of Dundee, Dundee, DD1 4HN, United Kingdom as a co-author in the article
Harvard's Disappointing DASH: Short Update on the Knoll Case
No full text?p=20051 There are now 123 articles by Professor Knoll. None of the 23 newest articles (at the time of my test there were 100 Knoll articles in DASH) is Open Access in DASH - all are only providing links to the published version: "At the direction of the depositing author this work is not currently accessible through DASH." There is now an field "Other sources" with links to eventually free online versions. But these links are not complete, see e.g. http://dash.harvard.edu/handle/1/3190372 W..
Understanding how food labels impact the dash diet and blood pressure
No full textAbstract
Purpose of Project
This study aims to answer the clinical question of What is the impact of understanding food labels and Dietary Approaches to Stop Hypertension (DASH) diet in relationship with blood pressure?
Methodology
This Quasi-Experimental study will take place in northern New Jersey with male and female patients who are eighteen and older and have a blood pressure that is over 130/80. The method of this study will have the participant take a survey at the first appointment and then watch a YouTube video made by the study team on DASH diet and food label education. The patient will then make a follow up appointment in 2 weeks to take the post-intervention survey. Qualtrics and SPSS program will interpret data on whether the food label and DASH diet education was successful and had a relationship with blood pressure.
Results
There were significant statistics p-value = <0.001 which showed improved patient BP to 129/80 or less (70%) when they understood and used food labels regularly & the DASH diet as well as improved patient weight- by at least 1 lb. (96%) when they understood and used food labels & the DASH diet.
Implications for practice
Patients with hypertension had about two thousand dollars higher annual adjusted expenditure than those without hypertension (Benjamin et al.,2017). Hypertensive patients also had “2.5 times the inpatient cost, almost double the outpatient cost, and nearly triple the prescription medication expenditure” (Benjamin et al., 2017). There are countless complications that come from hypertension like renal disease, cardiac disease, stroke, and or death which can lead to life-threatening situations. Recommendation on Food label and DASH diet education which has a powerful impact on blood pressure and weight should be considered during office visits with patients Keywords: Food labels, DASH diet, Blood Pressure, Hypertension, and Pre-HypertensionD.N.P.Includes bibliographical reference
Metrocoris josephi Jehamalar & Dash 2021, sp. nov.
No full text<i>Metrocoris josephi</i> sp. nov. <p>(Figs. 3A–O)</p> <p> <b>Material examined:</b> <b>Holotype</b> (mac-da ♂): <b>INDIA,</b> MEGHALAYA, <b>West Garo Hills District,</b> Tura Peak, Rongkan River, 653 m, 25.50697° N, 90.23328° E, 12.vi.2016, Coll. E.E. Jehamalar. <b>Paratypes.</b> 1 mac. ♂, 1 apt. ♀, same locality data as for holotype, Coll. E.E. Jehamalar.</p> <p> <b>Repository.</b> The type specimens are deposited in the CEL, ZSI, New Alipore, Kolkata, West Bengal, India. Holotype Reg. No. 11561/H15 and paratypes Reg. No. 11562/H15.</p> <p> <b>Etymology.</b> <i>Metrocoris josephi</i> is named after the first author’s oldest brother Mr. E. Joseph Veera Singh, who accompanied the first author to Garo Hills, Meghalaya, for field work.</p> <p> <b>Diagnosis.</b> The new species can easily be identified by the presence of medium-sized processes clothed with long setae on the coxa and the trochanter of the hind leg of the female (Figs. 3C, J); the coxal process is reached only up to the subbasal region of the trochanter; the subapicodorsal region of the male paramere with a shallow notch and laterally with two short narrow longitudinal depression (Fig. 3N).</p> <p> <b>Description. Macropterous dealated male</b> (holotype): (Figs. 3E–H, K–O). Body length 5.07 (4.74–5.07, up to tip of hemelytra 6.26), body width at mesoacetabula 2.30 (2.18–2.30).</p> <p> <i>Colour</i>. Dorsum of body black with yellowish-brown marks; broad black mark on head slightly wider posteriorly and not bifid posteriorly (in macropterous male and apterous female with three black spots (Figs. 3A, C), differ from holotype), posterosublaterally indistinctly connected with black mark near eyes; antenna and legs dark-brown to black; antennal tubercle black; base of first antennal segment yellowish-brown (Fig. 3E); rostrum dark-brown to black, except lateral region of first to third segments yellowish-brown; proacetabulum black; pronotum with Tshaped black mark, sublateral mark broad curved downwards, extended laterally and connected to lateral mark of posterior pronotal lobe (Fig. 3E); small area near anterolateral region of pronotum below eye yellowish-brown; fore femur dorsally and ventrally with broad black stripe connected to apical black ring, extensor region yellowish-brown; sublateral black marks of posterior lobe of pronotum connected to median black mark anteriorly (not or indistinctly connected in macropterous male, Fig. 3A); mesopleural black mark not connected anteriorly and posteriorly with transverse black marks (Fig. 3E); mesopleural yellowish-brown mark reaches up to sublateral region of mesosternum medially, apex extended anteriorly and posteriorly; yellowish-brown mark on metacetabulum uninterrupted (Fig. 3F); pro-, meso- and metaacetabular regions with a stripe of silvery-white setae; area above base of metacetabular region with a small yellowish-brown mark; thoracic venter black, except mesosternal yellowish-brown mark on mediolateral region and yellow mark on omphalium surrounding area of metanotum; coxa and trochanter of all legs yellowish-brown; mid femur with long thin brown stripe; lateral and posterior margins of tergum VIII yellowishbrown (Fig. 3F); venter of abdomen black, except from apical half of sternum VI to apex yellowish-brown, except sternum VII basally and posterior region of pygophore dark-brown to black.</p> <p> <i>Structural characteristics.</i> Eyes covering anterior 1/3 of propleura (Fig. 3E); antenna without any characteristic setae; sixth abdominal sternum to abdominal tip clothed with yellowish-brown setae (Fig. 3G); pygophore laterally with long yellowish-brown setae (Fig. 3M); head laterally with two long black setae in front of eyes; eye width less than posterior eye width. Pleural region of prothorax posteriorly with some long black setae; fore femur slender, basally with four long setae, almost medially with shallow notch; mid femur longer than hind femur; sternum VII distinctly longer than combined length of sterna V and VI; posterior margin of sternum VII concave (Fig. 3G). <b>Terminalia:</b> Tergum VIII large, slightly concaved posteriorly, fringed with small setae laterally and posteriorly with medium-sized brown setae and pronounced posterolaterally; basomedian region of sternum VIII smoothly raised and slightly depressed sublaterally; lateral margin of sternum VIII parallel-sided; sternum VIII distinctly longer than sternum VII; proctiger subovate (Fig. 3L), slightly visible from above (Fig. 3F); pygophore posteriorly convex with fringe of medium-sized setae, posterolaterally fringed with long setae (Fig. 3M); paramere falciform, apicodorsally with a shallow notch and laterally with two short narrow longitudinal depression, nearly middle slightly raised with few long and short setae, (Fig. 3N), slightly visible from outside of genital segments (Fig. 3H). Endosoma in lateral aspect: proximal region of dorsal sclerite inwardly curved, with short reflex angled process; dorsal sclerite concaved medially; accessory apical sclerite indistinct; accessory dorsal sclerite thin; lateral sclerite proximally slightly bend upwards, with blunt tip; ventral sclerite very long (Fig. 3O).</p> <p> <b>Measurements.</b> Head length 0.70, width 1.38; eye length 0.59, width 0.33, posterior eye width 0.35; synthlipsis 0.57; lengths of antennomeres I–IV 2.03, 0.82, 0.76, 0.60. Pronotal lobe length 3.18, width at humeral angle 2.19; mesosternal length 2.00; metasternal length 0.13. Lengths of leg segments: foreleg: femur 2.06, tibia 1.77, tarsomeres I–II 0.12, 0.64; mid leg: femur 5.48, tibia 3.81, tarsomeres I–II 1.89, 0.36; hind leg: femur 5.44, tibia 2.57, tarsomeres I–II 0.27, 0.39; widths of fore, mid, hind femora 0.34, 0.26, 0.16. Length from pronotal lobe tip to abdominal tip 1.18; length of abdominal sternum 1.66; lengths of abdominal sterna II–VIII 0.09, 0.08, 0.09, 0.09, 0.10, 0.31, 0.48; pygophore length 0.43; combined length of abdominal sterna V–VI 0.18; width of abdominal tergum VIII 0.65.</p> <p> <b>Apterous female</b> (paratype): (Figs. 3C, D, I, J). Body length 4.22, body width at mesoacetabula 2.19.</p> <p> <i>Colour</i>. Appendages and venter of body similar to macropterous male. Dorsum of body yellowish-brown with black marks; interocular region with three black marks, anteromedian mark long and two small and circular lateral posterior marks (Fig. 3C), lateral marks indistinctly connected to black mark near eyes (Fig. 3D); proacetabulum black; pronotum with T-shaped black mark, sublateral mark medium-sized and not or indistinctly connected to lateral mark of mesonotum (Fig. 3D); small area near anterolateral region of pronotum below eye yellowish-brown; mesonotal longitudinal black marks narrower than adjacent yellowish-brown marks (Fig. 3C), lateral black marks thin, medial and lateral dark marks connected to horizontal black marks anteriorly and posteriorly, sublateral black mark of mesonotum not connected posteriorly to black mark between meso- and metanota, sublateral black mark anterior half narrow and abruptly widened posteriorly; mesopleural black mark anteriorly connected with transverse black mark between propleura and mesopleura, posteriorly not connected with black mark of mesoacetabulum (Fig. 3D); mesopleural yellowish-brown mark reaches up to sublateral region of mesosternum medially, apex extended anteriorly and posteriorly; yellowish-brown mark on metacetabulum uninterrupted; area above base of metacetabular region with a small yellowish-brown mark; dorsum of abdomen black, except two stripes on tergum I, connexival segment VII, posteromedian region of tergum VII and whole tergum VIII yellowish-brown.</p> <p> <i>Structural characteristics.</i> Similar to macropterous male, except for the following characteristics: body clothed with small black adpressed setae; eyes covering anterior almost 1/2 of propleura (Fig. 3D); eye width less than posterior eye width; hind coxa and trochanter with medium-sized processes clothed with long setae, coxal process longer than process of trochanter; coxal process reached only up to subbasal region of trochanter (Figs. 3C, J); setae of coxal process curved; flexor region of hind femur basally with short setal fringe (Fig. 3J); genital segments completely concealed under sternum VII (Figs. 3I, J); sternum VII laterally constricted and posteriorly narrow (Fig. 3I); abdomen short, not surpassing apex of hind coxa (Figs. 3C, I, J).</p> <p> <b>Measurements.</b> Head length 0.61, width 1.34; eye length 0.57, width 0.28, posterior eye width 0.33; synthlipsis 0.54; lengths of antennomeres I–IV 1.69, 0.78, 0.81, 0.65. Pronotal length 0.42, width 1.41; combined length of meso- and metanota 1.88; mesosternal length 1.85; metasternal length 0.12. Lengths of leg segments: foreleg: femur 1.89, tibia 1.62, tarsomeres I–II 0.15, 0.59; mid leg: femur 5.31, tibia 3.73, tarsomeres I–II 1.98, 0.30; hind leg: femur 5.29, tibia 2.76, tarsomeres I–II 0.29, 0.39; widths of fore, mid, hind femora 0.29, 0.23, 0.16; lateral length of hind coxal process 0.17; lateral length of hind trochanter process 0.09. Length of abdominal tergum 1.21; length of abdominal sternum 0.91; lengths of abdominal sterna II–VII 0.09, 0.07, 0.05, 0.05, 0.11, 0.54; combined length of abdominal sterna II–VI 0.37; combined length of abdominal sterna V–VI 0.16; length of tergum VII 0.11.</p> <p> <b>Distribution.</b> Presently known only from West Garo Hills, Meghalaya, India.</p> <p> <b>Comparative notes.</b> See the comparative notes under <i>M. issaci</i> <b>sp. nov.</b></p>Published as part of <i>Jehamalar, E. Eyarin & Dash, Swetapadma, 2021, Three new species of Metrocoris Mayr, 1865 (Heteroptera: Gerridae) from India and establishment of species groups, pp. 341-356 in Zootaxa 5082 (4)</i> on pages 349-351, DOI: 10.11646/zootaxa.5082.4.3, <a href="http://zenodo.org/record/5792709">http://zenodo.org/record/5792709</a>
Monomeric and dimeric oxidomolybdenum(V and VI) complexes, cytotoxicity, and DNA interaction studies: molybdenum assisted C═N bond cleavage of salophen ligands
No full textFour novel dimeric bis-μ-imido bridged metal–metal bonded oxidomolybdenum(V) complexes [MoV2O2L′21–4] (1–4) (where L′1–4 are rearranged ligands formed in situ from H2L1–4) and a new mononuclear dioxidomolybdenum(VI) complex [MoVIO2L5] (5) synthesized from salen type N2O2 ligands are reported. This rare series of imido- bridged complexes (1–4) have been furnished from rearranged H3L′1–4 ligands, containing an aromatic diimine (o-phenylenediamine) “linker”, where Mo assisted hydrolysis followed by −C═N bond cleavage of one of the arms of the ligand H2L1–4 took place. A monomeric molybdenum(V) intermediate species [MoVO(HL′1–4)(OEt)] (Id1–4) was generated in situ. The concomitant deprotonation and dimerization of two molybdenum(V) intermediate species (Id1–4) ultimately resulted in the formation of a bis-μ-imido bridge between the two molybdenum centers of [MoV2O2L′21–4] (1–4). The mechanism of formation of 1–4 has been discussed, and one of the rare intermediate monomeric molybdenum(V) species Id4 has been isolated in the solid state and characterized. The monomeric dioxidomolybdenum(VI) complex [MoVIO2L5] (5) was prepared from the ligand H2L5 where the aromatic “linker” was replaced by an aliphatic diimine (1,2-diaminopropane). All the ligands and complexes have been characterized by elemental analysis, IR, UV–vis spectroscopy, NMR, ESI- MS, and cyclic voltammetry, and the structural features of 1, 2, 4, and 5 have been solved by X-ray crystallography. The DNA binding and cleavage activity of 1–5 have been explored. The complexes interact with CT-DNA by the groove binding mode, and the binding constants range between 103 and 104 M–1. Fairly good photoinduced cleavage of pUC19 supercoiled plasmid DNA was exhibited by all the complexes, with 4 showing the most promising photoinduced DNA cleavage activity of ∼93%. Moreover, in vitro cytotoxic activity of all the complexes was evaluated by MTT assay, which reveals that the complexes induce cell death in MCF-7 (human breast adenocarcinoma) and HCT-15 (colon cancer) cell lines
Dietary Approaches to Stop Hypertension (DASH) Diet and Blood Pressure Reduction in Adults with and without Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
No full textThe Dietary Approaches to Stop Hypertension (DASH) diet is recognized as an effective dietary intervention to reduce blood pressure (BP). However, among randomized controlled trials (RCTs) investigating the DASH diet-mediated BP reduction, there are significant methodological and clinical differences. The purpose of this study was to comprehensively assess the DASH diet effect on BP in adults with and without hypertension, accounting for underlying methodological and clinical confounders. We systematically searched Medline and the Cochrane Collaboration Library databases and identified 30 RCTs (n = 5545 participants) that investigated the BP effects of the DASH diet compared with a control diet in hypertensive and nonhypertensive adults. Both random-effects and fixed-effect models were used to calculate the mean attained systolic BP (SBP) and diastolic BP (DBP) differences during follow-up. Subgroup and meta-regression analyses were also conducted. Compared with a control diet, the DASH diet reduced both SBP and DBP (difference in means: -3.2 mm Hg; 95% CI: -4.2, -2.3 mm Hg; P < 0.001, and -2.5 mm Hg; 95% CI: -3.5, -1.5 mm Hg; P < 0.001, respectively). Hypertension status did not modify the effect on BP reduction. The DASH diet compared with a control diet reduced SBP levels to a higher extent in trials with sodium intake >2400 mg/d than in trials with sodium intake ≤2400 mg/d, whereas both SBP and DBP were reduced more in trials with mean age <50 y than in trials of older participants. The quality of evidence was rated as moderate for both outcomes according to the Grading of Recommendations, Assessment, Development, and Evaluation approach. The adoption of the DASH diet was accompanied by significant BP reduction in adults with and without hypertension, although higher daily sodium intake and younger age enhanced the BP-lowering effect of the intervention. This meta-analysis was registered at www.crd.york.ac.uk/prospero as CRD42019128120. Copyright © 2020 The Author(s) on behalf of the American Society for Nutrition
Modified Chinese disabilities of arm, shoulder and hand tool : validity and reliability for upper extremity injuries
No full textDesign: Clinimetric evaluation study. Introduction: The Chinese Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire has necessitated the development of a revised version to the specific needs of individuals with upper extremity injuries with the progress of times and lifestyle changes. Purpose of the study: This research aimed to evaluate the reliability and validity of Modified Chinese Disability of Arm, Shoulder and Hand (MC-DASH) questionnaire in individuals with upper extremity injuries. Methods: One hundred and one individuals with upper extremity injuries (UEI) were recruited. The function of upper extremity was measured using the electronic version of MC-DASH, and compared against the Chinese Disability of Arm, Shoulder and Hand. The MC-DASH was reassessed within three days in all individuals. We investigated the internal consistency, test-retest reliability, content validity, criterion validity, and construct validity of MC-DASH. Results: The internal consistency was deemed sufficient, as indicated by a Cronbach's alpha of 0.986 and an intraclass correlation coefficient of 0.957. Moreover, the mean total scores of MC-DASH on the first-test and retest were 37.86 and 38.19, respectively (ICC: 0.957, 95 %CI: 0.937–0.971, p < 0.001). Furthermore, the MC-DASH version exhibited satisfactory content validity evidenced by its strong correlation (R= 0.903, p < 0.001) with the Chinese DASH. Three major influencing factors were identified from 37 items. The cumulative variance contribution rate of the MC-DASH questionnaire was 75.76 %, confirming its construct validity. Conclusion: The Modified Chinese Disability of Arm, Shoulder and Hand questionnaire has been shown to be a valid, reliable, and practical tool for use in patients with upper extremity injuries. © 2024 The Author(s
The molecular diagnosis of Pneumocystis pneumonia in children using nasopharyngeal aspirate samples
No full textPneumocystis pneumonia (PCP) is an important opportunistic infection caused by thefungus Pneumocystis jirovecii. The incidence of PCP in sub-Saharan Africa is on theincrease. This is due to the progression of the HIV-pandemic and limited access to healthcare facilities, specific highly active anti-retroviral therapy and chemoprophylaxis. It is a major cause of hospitalization and mortality in HIV-infected children with in-hospital case-fatality rates ranging from 20-63%
Modification of Loop 1 Affects the Nucleotide Binding Properties of Myo1c, the Adaptation Motor in the Inner Ear
No full textMyo1c is one of eight members of the mammalian myosin I family of actin-associated molecular motors. In stereocilia of the hair cells in the inner ear, Myo1c presumably serves as the adaptation motor, which regulates the opening and closing of transduction channels. Although there is conservation of sequence and structure among all myosins in the N-terminal motor domain, which contains the nucleotide- and actin-binding sites, some differences include the length and composition of surface loops, including loop 1, which lies near the nucleotide-binding domain. To investigate the role of loop 1, we expressed in insect cells mutants of a truncated form of Myo1c, Myo1c1IQ, as well as chimeras of Myo1c1IQ with the analogous loop from other myosins. We found that replacement of the charged residues in loop 1 with alanines or the whole loop with a series of alanines did not alter the ATPase activity, transient kinetics properties, or Ca2+ sensitivity of Myo1c1IQ. Substitution of loop 1 with that of the corresponding region from tonic smooth muscle myosin II (Myo1c1IQ-tonic) or replacement with a single glycine (Myo1c1IQ-G) accelerated the release of ADP from A.M 2?3-fold in Ca2+, whereas substitution with loop 1 from phasic muscle myosin II (Myo1c1IQ-phasic) accelerated the release of ADP 35-fold. Motility assays with chimeras containing a single ?-helix, or SAH, domain showed that Myo1cSAH-tonic translocated actin in vitro twice as fast as Myo1cSAH-WT and 3-fold faster than Myo1cSAH-G. The studies show that changes induced in Myo1c via modification of loop 1 showed no resemblance to the behavior of the loop donor myosins or to the changes previously observed with similar Myo1b chimeras
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