305 research outputs found
Constitutional Validity of Implementation of Mandal Commission Recommendations
No full textThe author argues that the Government action on the Mandal Commission is constitutionally valid. It does not in any way violate any of the Fundamental Rights let alone Articles 14, 15 and 16. However, the author concedes, considering the volatile situation at hand and the instability writ large in the political scenario, it is difficult to be certain as to how the Supreme Court will react. The author maintains that it is possible to uphold the Mandal Commission government action by focusing on the Supreme Court’s interpretation of Articles 14, 15 and 16 as three provisions form part of one code, each embodying a different facet of the guarantee of equality. (Editor’s abstract.
Constitutional Validity of Implementation of Mandal Commission Recommendations
No full textThe author argues that the Government action on the Mandal Commission is constitutionally valid. It does not in any way violate any of the Fundamental Rights let alone Articles 14, 15 and 16. However, the author concedes, considering the volatile situation at hand and the instability writ large in the political scenario, it is difficult to be certain as to how the Supreme Court will react. The author maintains that it is possible to uphold the Mandal Commission government action by focusing on the Supreme Court’s interpretation of Articles 14, 15 and 16 as three provisions form part of one code, each embodying a different facet of the guarantee of equality. (Editor’s abstract.
Nanoparticle-Based Targeted Therapies in Cancer: Opportunities and Challenges
No full textNanoparticle-based targeted therapies have emerged as a promising strategy for the treatment of cancer, offering significant advantages over traditional therapeutic approaches. These therapies leverage the unique properties of nanoparticles, such as their size, surface characteristics, and ability to be functionalized with specific ligands, to deliver drugs directly to tumor cells, minimizing systemic toxicity and enhancing therapeutic efficacy. This paper explores the opportunities provided by nanoparticlebased therapies, including their ability to overcome biological barriers, improve drug solubility, and enable precise targeting of cancer cells. Additionally, we discuss the challenges involved in the development of nanoparticle-based cancer treatments, including issues related to biocompatibility, potential immune responses, and manufacturing scalability. The future of this technology is promising, with ongoing research aimed at overcoming these hurdles and optimizing the clinical translation of nanoparticle-based therapies in oncolog
Topical Delivery of Sulfasalazine via Nanosponges-Loaded Hydrogels: A Novel Approach for Enhanced Psoriasis Management
No full textThe treatment of psoriasis, a chronic skin condition, remains a significant clinical challenge. Traditional therapies often come with limitations such as systemic side effects and inadequate localized treatment. In this study, we propose the development of sulfasalazineloaded nanosponges incorporated into hydrogel matrices to enhance topical psoriasis management. The nanosponges, known for their ability to encapsulate and release drugs in a controlled manner, were synthesized using a simple method to improve the solubility and bioavailability of sulfasalazine. The hydrogel system was optimized for skin compatibility and ease of application. The in vitro release studies demonstrated sustained drug release, while ex vivo permeation studies indicated effective drug delivery across the skin layers. The formulation showed promising anti-inflammatory properties, and its ability to reduce psoriatic symptoms was evaluated through cell culture models. This novel nanosponges-hydrogel combination offers a promising approach to enhance the topical treatment of psoriasis, minimizing systemic exposure and maximizing localized therapeutic efficacy
Mesalamine Microemulsions for Crohn’s Disease: A Review
No full textoai:ojs.ijhse.com:article/1This analysis delves into the promise of mesalamineencapsulated microemulsions in improving bioavailability and therapeutic effectiveness for Crohn\u27s disease. Crohn’s disease, a persistent inflammatory condition of the bowel, frequently necessitates precise medication administration owing to the particular sites of inflammation found in the gastrointestinal system. Mesalamine, a commonly utilised treatment, exhibits restricted efficacy owing to its inadequate absorption in the upper gastrointestinal tract and swift metabolic breakdown. This manuscript explores the obstacles linked to conventional mesalamine formulations and investigates the latest innovations in microemulsion-driven delivery mechanisms aimed at enhancing drug solubility, stability, and precise targeting. Innovative microemulsion methodologies, such as pH-sensitive and enzymeresponsive frameworks, exhibit potential in overcoming the shortcomings of current therapies, creating opportunities for more efficient and patient-centric treatment alternatives
Posaconazole-Loaded Chitosan Transdermal Films: A Microemulsion-Based Strategy for Aspergillosis
No full textPosaconazole, a broad-spectrum antifungal agent, has gained prominence in the treatment of Aspergillosis. However, its clinical efficacy is often limited due to poor bioavailability and the need for frequent administration. To overcome these limitations, this study proposes the development of Posaconazole-loaded chitosan transdermal films using a microemulsion-based strategy. The microemulsion system serves as a potential carrier for enhanced drug penetration, facilitating controlled release and increasing the bioavailability of Posaconazole. Chitosan, a biocompatible and biodegradable polymer, was utilized to prepare transdermal films that exhibit favorable mechanical properties and skin permeability. The films were optimized for their drug-loading capacity, in vitro release behavior, and skin permeation profile, with the goal of improving the therapeutic efficacy of Posaconazole in the treatment of Aspergillosis. The results demonstrate that the microemulsion-based strategy significantly enhances the transdermal delivery of Posaconazole, providing a promising alternative to conventional oral or intravenous formulations. This approach holds potential for improving patient compliance and treatment outcomes for Aspergillosis
Phytochemicals in Traditional Medicine: A Modern Approach to Evidence-Based Herbal Therapies
No full textPhytochemicals, bioactive compounds found in plants, have been integral to traditional medicine systems worldwide, including Ayurveda, Traditional Chinese Medicine (TCM), and Indigenous healing practices. With the rise of modern scientific methodologies, there is an increasing emphasis on validating the therapeutic potential of these plant-derived compounds through evidence-based approaches. This paper explores the role of phytochemicals in traditional medicine, highlighting their pharmacological properties, mechanisms of action, and clinical applications. A comparative analysis of conventional herbal therapies and their integration into modern medicine is presented, emphasizing advancements in analytical techniques, clinical trials, and regulatory frameworks. The study also addresses challenges such as standardization, bioavailability, and potential toxicity, underscoring the need for rigorous scientific validation. By bridging the gap between traditional knowledge and modern research, this paper aims to promote the safe and effective use of phytochemicals in contemporary healthcare
Cryptocurrency and the Future of Financial Markets: A Mini Review
No full textThe rapid evolution of cryptocurrency has significantly influenced global financial markets, raising questions about its potential role in the future financial landscape. This review explores the fundamental aspects of cryptocurrency, its impact on traditional financial institutions, regulatory challenges, and prospects for widespread adoption. The discussion covers the role of blockchain technology, decentralization, and financial inclusivity. While cryptocurrencies promise enhanced security, transparency, and efficiency, concerns regarding volatility, regulatory frameworks, and security threats remain. The paper concludes by highlighting future research directions and policy recommendations to navigate the evolving financial ecosystem shaped by digital assets
Correlations between meteorological parameters and prostate cancer
No full textAbstract Background There exists a north-south pattern to the distribution of prostate cancer in the U.S., with the north having higher rates than the south. The current hypothesis for the spatial pattern of this disease is low vitamin D levels in individuals living at northerly latitudes; however, this explanation only partially explains the spatial distribution in the incidence of this cancer. Using a U.S. county-level ecological study design, we provide evidence that other meteorological parameters further explain the variation in prostate cancer across the U.S. Results In general, the colder the temperature and the drier the climate in a county, the higher the incidence of prostate cancer, even after controlling for shortwave radiation, age, race, snowfall, premature mortality from heart disease, unemployment rate, and pesticide use. Further, in counties with high average annual snowfall (>75 cm/yr) the amount of land used to grow crops (a proxy for pesticide use) was positively correlated with the incidence of prostate cancer. Conclusion The trends found in this USA study suggest prostate cancer may be partially correlated with meteorological factors. The patterns observed were consistent with what we would expect given the effects of climate on the deposition, absorption, and degradation of persistent organic pollutants including pesticides. Some of these pollutants are known endocrine disruptors and have been associated with prostate cancer.</p
Jane Austen and the popular novel: the determined author
No full textJane Austen and the Popular Novel: The Determined Author offers a provocative reinterpretation of one of the most cherished authors in the English literary canon. Austen criticism has traditionally fixed her oeuvre within the ideological locus of the 1790s, ignoring the more topical elements displayed by her novels. Such accounts have consequently neglected the complex interactions that took place between Austen's works and newer forms of popular fiction, such as the Evangelical tale, the national romance, and historical novel. By situating Austen in the 1810s - the immediate literary period within which she published - this book argues for the inherently intertextual nature of her novels, positing that her 'innovation' lies not in her uniqueness, but in her polyvalent negotiations with other literary models. Jane Austen and the Popular Novel demonstrates the extent to which Austen was not only a determined author, but also an author determined by the literary marketplace itself
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