International Journal of Multidisciplinary Science and Innovation
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16 research outputs found
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Topical Delivery of Sulfasalazine via Nanosponges-Loaded Hydrogels: A Novel Approach for Enhanced Psoriasis Management
No full textThe treatment of psoriasis, a chronic skin condition, remains a significant clinical challenge. Traditional therapies often come with limitations such as systemic side effects and inadequate localized treatment. In this study, we propose the development of sulfasalazineloaded nanosponges incorporated into hydrogel matrices to enhance topical psoriasis management. The nanosponges, known for their ability to encapsulate and release drugs in a controlled manner, were synthesized using a simple method to improve the solubility and bioavailability of sulfasalazine. The hydrogel system was optimized for skin compatibility and ease of application. The in vitro release studies demonstrated sustained drug release, while ex vivo permeation studies indicated effective drug delivery across the skin layers. The formulation showed promising anti-inflammatory properties, and its ability to reduce psoriatic symptoms was evaluated through cell culture models. This novel nanosponges-hydrogel combination offers a promising approach to enhance the topical treatment of psoriasis, minimizing systemic exposure and maximizing localized therapeutic efficacy
Posaconazole-Loaded Chitosan Transdermal Films: A Microemulsion-Based Strategy for Aspergillosis
No full textPosaconazole, a broad-spectrum antifungal agent, has gained prominence in the treatment of Aspergillosis. However, its clinical efficacy is often limited due to poor bioavailability and the need for frequent administration. To overcome these limitations, this study proposes the development of Posaconazole-loaded chitosan transdermal films using a microemulsion-based strategy. The microemulsion system serves as a potential carrier for enhanced drug penetration, facilitating controlled release and increasing the bioavailability of Posaconazole. Chitosan, a biocompatible and biodegradable polymer, was utilized to prepare transdermal films that exhibit favorable mechanical properties and skin permeability. The films were optimized for their drug-loading capacity, in vitro release behavior, and skin permeation profile, with the goal of improving the therapeutic efficacy of Posaconazole in the treatment of Aspergillosis. The results demonstrate that the microemulsion-based strategy significantly enhances the transdermal delivery of Posaconazole, providing a promising alternative to conventional oral or intravenous formulations. This approach holds potential for improving patient compliance and treatment outcomes for Aspergillosis
Phytochemicals as Epigenetic Modulators in Cancer Therapy
No full textPhytochemicals, the bioactive compounds found in plants, have garnered significant attention for their potential role in cancer prevention and therapy. Emerging evidence suggests that these natural compounds can modulate epigenetic mechanisms, which play a critical role in gene expression regulation, chromatin remodeling, and cell differentiation. By influencing epigenetic modifications such as DNA methylation, histone modification, and non-coding RNA expression, phytochemicals can potentially reverse aberrant epigenetic changes that drive cancer initiation and progression. This paper explores the diverse classes of phytochemicals, including flavonoids, polyphenols, terpenoids, and alkaloids, and their mechanisms of action as epigenetic modulators in cancer cells. Additionally, we discuss the challenges and opportunities for integrating phytochemicals into current cancer therapy regimens, highlighting the need for further research to understand their therapeutic potential and clinical applicability. Ultimately, the incorporation of epigenetic-modulating phytochemicals could offer a novel, non-toxic adjunct to conventional cancer treatments, with the promise of improved patient outcomes and reduced side effects
Mobile Solar Photovoltaic Water Pumping System
No full textSolar photovoltaic (PV) water pumping systems are a good alternative to traditional water pumps powered by electricity or diesel because of their low cost and environmental friendliness. These gadgets are suitable for remote places where there is no access to the power grid. Sun PV system output varies with environmental factors such as solar irradiation and temperature. This paper presents a low-cost photovoltaic water pumping system with maximum power point tracking for water harvesting in distant areas. To extract the greatest available power from PV panels, the MPPT P & O algorithm is employed. MPPT charge controller technology boosts efficiency. To increase the PV module voltages for the needed load, an MPPT DC-DC boost converter is used
Ion-Sensitive Gellan Gum–Arabinogalactan Hydrogels for Ocular Delivery in Dry Eye Disease
No full textDry eye disease (DED) is a multifactorial disorder that affects a significant portion of the population, leading to discomfort, visual disturbances, and potential damage to the ocular surface. The need for effective drug delivery systems to treat DED has driven the development of novel formulations that can enhance therapeutic efficacy while minimizing side effects. In this study, we explore the potential of ionsensitive gellan gum (GG) and arabinogalactan (AG) hydrogels as a promising ocular delivery system for dry eye disease. The combination of GG and AG forms a biocompatible, biodegradable hydrogel that responds to changes in ionic strength, allowing for controlled drug release at the ocular site. The hydrogel formulation was evaluated for its physical properties, including gelation time, viscosity, and swelling behavior, as well as its drug release kinetics using model drugs commonly used in DED therapy. In vitro cytotoxicity studies confirmed the non-toxic nature of the hydrogels to human corneal epithelial cells. In vivo studies demonstrated enhanced ocular retention time and improved therapeutic outcomes in DED models compared to conventional eye drops. The results of this study suggest that ionsensitive GG-AG hydrogels may offer a novel, effective, and patientfriendly approach for the treatment of dry eye disease, providing prolonged drug delivery and improved ocular comfort
Assessment of Leachate Impact on Ground Water and Soil Quality Near Kasabe Digraj Dumping Site, Sangli, Maharashtra, India
No full textBased on population Maharashtra ranks first in urbanization among the all-major states in the country. Sangli city ranks in top 20 major cities in Maharashtra in urbanization. As compare to rural population the requirement of urban population is also a wide range of needs like clean water supply, sewerage and solid waste management etc. In most urban areas, the strong waste is dumped in open dumps without appropriate coating which influences the ecological media, for example, air, water and land. Along these lines, the present examination was centered around the effect of leachate permeation on ground water quality and soil quality. Leachate, soil and ground water samples were collected from Kasabe Digraj site and the surrounding areas of within 1.5 Km radius. The concentration of pH, EC, TDS, TH, Cl- , SO42-, NO3- and heavy metals is high in the sampling site near to the dumping yard. The high concentration of these chemical parameters and heavy metals reveals that there is a ground water and soil contamination from leachate percolation in the study area
Probiotic–Nanocurcumin Combination Therapy: A Novel Strategy for Colorectal Cancer
No full textColorectal cancer (CRC) remains one of the leading causes of cancerrelated morbidity and mortality worldwide. The growing body of evidence suggests that gut microbiota plays a critical role in CRC development and progression, thereby opening avenues for novel therapeutic strategies. Probiotics and curcumin have separately demonstrated beneficial effects in cancer prevention and treatment, but their combined potential remains underexplored. This paper explores the synergistic effects of probiotic–nanocurcumin combination therapy in CRC treatment. Probiotics, through modulation of the gut microbiome, enhance immune function and reduce inflammation, while nanocurcumin, a nanoparticle-based formulation of curcumin, improves the bioavailability and targeted delivery of curcumin to cancerous tissues. The combination of these therapies may offer a multi-targeted approach, reducing the side effects of traditional therapies, enhancing therapeutic outcomes, and promoting gut health. This review critically examines the underlying mechanisms of action, preclinical and clinical studies, and potential applications of probiotic–nanocurcumin therapy as a novel and effective adjunct in colorectal cancer management. Future research directions and clinical trials will be essential to validate the therapeutic potential of this combination approach
Development and Characterization of Albumin-Based Nanoparticles for Sustained Release of Repaglinide
No full textoai:ojs2.ijmsi.in:article/1The study focuses on the development and characterization of repaglinide-loaded albumin nanoparticles for sustained drug release, aimed at improving the management of Type 2 diabetes. The nanoparticles were synthesized using a solvent evaporation method, resulting in uniform particle size (150 ± 5 nm) with a low polydispersity index (PDI) of 0.23, and a negative zeta potential of -20 ± 1 mV, ensuring colloidal stability. The drug loading capacity and encapsulation efficiency were 4.5 ± 0.2% and 75 ± 3%, respectively. In vitro release studies demonstrated a controlled drug release profile, with 80 ± 8% of repaglinide released over 48 hours, suggesting potential for reducing dosing frequency and enhancing patient compliance. Kinetic analysis revealed that the release followed a Fickian diffusion mechanism (R² = 0.982). The nanoparticles showed good stability over 30 days, with only slight increases in particle size and PDI. Additionally, cytotoxicity studies confirmed the biocompatibility of the nanoparticles. Comparative analysis with other drug delivery systems showed that albumin nanoparticles offer superior controlled release and drug encapsulation efficiency, making them a promising alternative for repaglinide delivery in diabetes management. Further clinical validation is required for realworld applications
Design and Optimization of Thymoquinone-Loaded Nanosponges for Rheumatoid Arthritis Therapy
No full textRheumatoid arthritis (RA) is a chronic autoimmune disorder that leads to joint inflammation, pain, and deformities. Current treatments, including NSAIDs and DMARDs, offer symptom relief but do not address the disease\u27s root causes and come with side effects. Thymoquinone (TQ), a compound derived from Nigella sativa, has shown potent anti-inflammatory and antioxidant properties but suffers from low solubility and bioavailability. To enhance the therapeutic efficacy of TQ, we developed thymoquinone-loaded nanosponges (TQNS) as a drug delivery system. TQ-NS were characterized for particle size, zeta potential, drug loading, and release profiles. In vitro studies demonstrated that TQ-NS significantly enhanced drug solubility and provided sustained release. Cytotoxicity tests revealed that the formulations were biocompatible, with high cell viability. Antiinflammatory assays showed a significant reduction in TNF-α and IL-6 levels, and in vivo studies in collagen-induced arthritis rats demonstrated reduced joint swelling and inflammation. The statistical analysis confirmed the effectiveness of TQ-NS in RA therapy. TQ-NS offer a promising approach for improving the bioavailability, targeting, and therapeutic efficacy of thymoquinone in the treatment of RA. Further studies are warranted to evaluate their potential in clinical settings
Nanoparticle-Based Targeted Therapies in Cancer: Opportunities and Challenges
No full textNanoparticle-based targeted therapies have emerged as a promising strategy for the treatment of cancer, offering significant advantages over traditional therapeutic approaches. These therapies leverage the unique properties of nanoparticles, such as their size, surface characteristics, and ability to be functionalized with specific ligands, to deliver drugs directly to tumor cells, minimizing systemic toxicity and enhancing therapeutic efficacy. This paper explores the opportunities provided by nanoparticlebased therapies, including their ability to overcome biological barriers, improve drug solubility, and enable precise targeting of cancer cells. Additionally, we discuss the challenges involved in the development of nanoparticle-based cancer treatments, including issues related to biocompatibility, potential immune responses, and manufacturing scalability. The future of this technology is promising, with ongoing research aimed at overcoming these hurdles and optimizing the clinical translation of nanoparticle-based therapies in oncolog